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The spotlight, however, shines on the development and application of novel biomaterials\u2014ranging from urethral bulking agents to nano-gel composites\u2014which aim to bolster urethral support and foster tissue regeneration. Furthermore, the exploration of stem cell therapies, particularly those derived from adipose tissues and urine, heralds a new era of regenerative medicine, offering potential for significant improvements in urinary function. This review encapsulates the progress in biomaterials and regenerative strategies, highlighting their pivotal role in advancing the treatment of SUI, thereby opening new avenues for effective and minimally invasive solutions.<\/jats:p>","DOI":"10.3389\/fbioe.2024.1414323","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T04:59:54Z","timestamp":1724907594000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Animal models, treatment options, and biomaterials for female stress urinary incontinence"],"prefix":"10.3389","volume":"12","author":[{"given":"Xiyang","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfan","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1097\/00005392-200110000-00089","article-title":"Effects of selective autonomic and pudendal denervation on the urethral function and development of retention in female dogs","volume":"166","author":"Ali-El-Dein","year":"2001","journal-title":"J. urology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1159\/000534651","article-title":"Prevalence and quality of life among overweight and obese women with different severity and types of urinary incontinence","volume":"33","author":"Alsannan","year":"2024","journal-title":"Med. 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