{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:16:49Z","timestamp":1788585409357,"version":"build-2803163510"},"reference-count":114,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natura l Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY23H130001"],"award-info":[{"award-number":["LY23H130001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY1086"],"award-info":[{"award-number":["2022KY1086"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005315","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2022J260"],"award-info":[{"award-number":["2022J260"]}],"id":[{"id":"10.13039\/501100005315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017525","name":"Huimin Technology Research and Development Projects of Ningbo Municipality","doi-asserted-by":"publisher","award":["2021S170"],"award-info":[{"award-number":["2021S170"]}],"id":[{"id":"10.13039\/501100017525","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Tympanic membrane perforation (TMP) is one of the most common conditions in otolaryngology worldwide, and hearing damage caused by inadequate or prolonged healing can be distressing for patients. This article examines the rationale for utilizing three-dimensional (3D) printing to produce scaffolds for repairing TMP, compares the advantages and disadvantages of 3D printed and bioprinted grafts with traditional autologous materials and other tissue engineering materials in TMP repair, and highlights the practical and clinical significance of 3D printing in TMP repair while discussing the current progress and promising future of 3D printing and bioprinting. There is a limited number of reviews specifically dedicated to 3D printing for TMP repair. The majority of reviews offer a general overview of the applications of 3D printing in the broader realm of tissue regeneration, with some mention of TMP repair. Alternatively, they explore the biopolymers, cells, and drug molecules utilized for TMP repair. However, more in-depth analysis is needed on the strategies for selecting bio-inks that integrate biopolymers, cells, and drug molecules for tympanic membrane repair.<\/jats:p>","DOI":"10.3389\/fbioe.2024.1439499","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T08:34:08Z","timestamp":1723451648000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Advances in 3D printing for the repair of tympanic membrane perforation: a comprehensive review"],"prefix":"10.3389","volume":"12","author":[{"given":"Hao","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jsamd.2020.01.007","article-title":"Porous scaffolds for bone regeneration","volume":"5","author":"Abbasi","year":"2020","journal-title":"J. Sci. Adv. Mater. Devices"},{"key":"B2","doi-asserted-by":"publisher","first-page":"031001","DOI":"10.1088\/1758-5090\/acd3b3","article-title":"Thermal inkjet bioprinting drastically alters cell phenotype","volume":"15","author":"Ablanedo Morales","year":"2023","journal-title":"Biofabrication"},{"key":"B3","doi-asserted-by":"publisher","first-page":"035025","DOI":"10.1088\/1758-5090\/ace07f","article-title":"Convergence of melt electrowriting and extrusion-based bioprinting for vascular patterning of a myocardial construct","volume":"15","author":"Ainsworth","year":"2023","journal-title":"Biofabrication"},{"key":"B4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10544-018-0287-3","article-title":"In-vitro perforation of the round window membrane via direct 3-D printed microneedles","volume":"20","author":"Aksit","year":"2018","journal-title":"Biomed. Microdevices"},{"key":"B5","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1089\/ten.teb.2020.0176","article-title":"Can tissue engineering bring hope to the development of human tympanic membrane?","volume":"27","author":"Aleemardani","year":"2021","journal-title":"Tissue Eng. Part B Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"359","DOI":"10.11607\/ijp.5305","article-title":"Comparison of cemented vs screw-retained, customized computer-aided design\/computer-assisted manufacture zirconia abutments for esthetically located single-tooth implants: a 10-year randomized prospective study","volume":"31","author":"Amorfini","year":"2018","journal-title":"Int. J. Prosthodont"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e2002082","DOI":"10.1002\/adhm.202002082","article-title":"Mimicking the human tympanic membrane: the significance of scaffold geometry","volume":"10","author":"Anand","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"B8","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3390\/nano14070563","article-title":"Three-dimensional-printed GelMA-KerMA composite patches as an innovative platform for potential tissue engineering of tympanic membrane perforations","volume":"14","author":"Bedir","year":"2024","journal-title":"Nanomater. (Basel)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1039\/d1bm01815a","article-title":"Development of electrospun, biomimetic tympanic membrane implants with tunable mechanical and oscillatory properties for myringoplasty","volume":"10","author":"Benecke","year":"2022","journal-title":"Biomater. Sci."},{"key":"B10","first-page":"206","volume-title":"Biomimetic tympanic membrane grafts","author":"Black","year":"2020"},{"key":"B11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.urology.2023.02.039","article-title":"Three dimensional printing technology used to create a high-fidelity ureteroscopy simulator: development and validity assessment (Rein-3D-Print-UroCCR-39)","volume":"176","author":"Boulenger de Hauteclocque","year":"2023","journal-title":"Urology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/j.jmrt.2021.07.050","article-title":"3D printing technology; methods, biomedical applications, future opportunities and trends","volume":"14","author":"Bozkurt","year":"2021","journal-title":"J. Mater. Res. Technol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.actbio.2017.03.030","article-title":"3D printing for the design and fabrication of polymer-based gradient scaffolds","volume":"56","author":"Bracaglia","year":"2017","journal-title":"Acta Biomater."},{"key":"B14","doi-asserted-by":"publisher","first-page":"124356","DOI":"10.1016\/j.ijpharm.2024.124356","article-title":"Toward high-resolution 3D-printing of pharmaceutical implants - a holistic analysis of relevant material properties and process parameters","volume":"660","author":"Brandl","year":"2024","journal-title":"Int. J. Pharm."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e010","DOI":"10.1097\/ono.0000000000000010","article-title":"A 3D printed human ear model for standardized testing of hearing protection devices to blast exposure","volume":"2","author":"Brown","year":"2022","journal-title":"Otol. Neurotol. Open"},{"key":"B16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00276-023-03276-8","article-title":"Are 3D-printed anatomical models of the ear effective for teaching anatomy? A comparative pilot study versus cadaveric models","volume":"46","author":"Brumpt","year":"2024","journal-title":"Surg. Radiol. Anat."},{"key":"B17","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s00266-021-02472-4","article-title":"Progress of 3D printing techniques for nasal cartilage regeneration","volume":"46","author":"Cao","year":"2022","journal-title":"Aesthetic Plast. Surg."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4325","DOI":"10.1007\/s00405-021-07186-6","article-title":"Tympanic membrane perforations: the importance of etiology, size and location","volume":"279","author":"Castelhano","year":"2022","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"032007","DOI":"10.1088\/2631-7990\/acd88f","article-title":"3D\/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering","volume":"5","author":"Chen","year":"2023","journal-title":"Int. J. Extreme Manuf."},{"key":"B20","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.bioactmat.2024.05.026","article-title":"3D printing of interferon \u03b3-preconditioned NSC-derived exosomes\/collagen\/chitosan biological scaffolds for neurological recovery after TBI","volume":"39","author":"Chen","year":"2024","journal-title":"Bioact. Mater"},{"key":"B21","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3760\/cma.j.issn.1001-9391.2019.03.004","article-title":"Three-dimensional printed electrospun fiber-based scaffold for cartilage regeneration","volume":"37","author":"Chen","year":"2019","journal-title":"Mater. Des."},{"key":"B22","doi-asserted-by":"publisher","first-page":"122174","DOI":"10.1016\/j.carbpol.2024.122174","article-title":"Biofunctionalized hydrogel composed of genipin-crosslinked gelatin\/hyaluronic acid incorporated with lyophilized platelet-rich fibrin for segmental bone defect repair","volume":"339","author":"Chuang","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.sna.2017.12.056","article-title":"Bio-inspired 3D-printed piezoelectric device for acoustic frequency selection","volume":"271","author":"Domingo-Roca","year":"2018","journal-title":"Sensors Actuators A Phys."},{"key":"B24","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/cben.202000037","article-title":"A state-of-the-art review of laser-assisted bioprinting and its future research trends","volume":"8","author":"Dou","year":"2021","journal-title":"ChemBioEng Rev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1002\/jbm.a.36702","article-title":"Corneal bioprinting utilizing collagen-based bioinks and primary human keratocytes","volume":"107","author":"Duarte Campos","year":"2019","journal-title":"J. Biomed. Mater Res. A"},{"key":"B26","doi-asserted-by":"publisher","first-page":"467","DOI":"10.5005\/jp-journals-10024-3322","article-title":"Silk hydrogel for tissue engineering: a review","volume":"23","author":"Ealla","year":"2022","journal-title":"J. Contemp. Dent. Pract."},{"key":"B27","doi-asserted-by":"publisher","first-page":"045004","DOI":"10.1088\/1758-5090\/ace5e0","article-title":"3D printing of vascularized hepatic tissues with a high cell density and heterogeneous microenvironment","volume":"15","author":"Fang","year":"2023","journal-title":"Biofabrication"},{"key":"B28","doi-asserted-by":"publisher","first-page":"847","DOI":"10.2174\/15672018mtexxndcs2","article-title":"Application of 3D printing technology in bone tissue engineering: a review","volume":"18","author":"Feng","year":"2021","journal-title":"Curr. Drug Deliv."},{"key":"B29","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.mattod.2022.01.001","article-title":"Responsive biomaterials for 3D bioprinting: a review","volume":"52","author":"Fu","year":"2022","journal-title":"Mater. Today"},{"key":"B30","doi-asserted-by":"publisher","first-page":"712","DOI":"10.18063\/ijb.712","article-title":"Characterization and assessment of new fibrillar collagen inks and bioinks for 3D printing and bioprinting","volume":"9","author":"Garcia-Villen","year":"2023","journal-title":"Int. J. Bioprint"},{"key":"B31","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/jbm.b.34699","article-title":"Evaluation of silk-based bioink during pre and post 3D bioprinting: a review","volume":"109","author":"Gupta","year":"2021","journal-title":"J. Biomed. Mater Res. B Appl. Biomater."},{"key":"B32","doi-asserted-by":"publisher","first-page":"9093","DOI":"10.1021\/acs.nanolett.1c02847","article-title":"Bringing electrochemical three-dimensional printing to the nanoscale","volume":"21","author":"Hengsteler","year":"2021","journal-title":"Nano Lett."},{"key":"B33","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1080\/09205063.2022.2147350","article-title":"3D printing technology and applied materials in eardrum regeneration","volume":"34","author":"Hu","year":"2023","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"B34","doi-asserted-by":"publisher","first-page":"101452","DOI":"10.1016\/j.addma.2020.101452","article-title":"Engineered dual-scale poly (\u03b5-caprolactone) scaffolds using 3D printing and rotational electrospinning for bone tissue regeneration","volume":"36","author":"Huang","year":"2020","journal-title":"Addit. Manuf."},{"key":"B35","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.ijbiomac.2017.09.030","article-title":"Preparation and characterization of gelatin\/\u03b1-TCP\/SF biocomposite scaffold for bone tissue regeneration","volume":"110","author":"Huh","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"032004","DOI":"10.1088\/1748-605x\/abcf5d","article-title":"Necessities, opportunities, and challenges for tympanic membrane perforation scaffolding-based bioengineering","volume":"16","author":"Hussain","year":"2021","journal-title":"Biomed. Mater."},{"key":"B37","doi-asserted-by":"publisher","first-page":"104219","DOI":"10.1016\/j.jmbbm.2020.104219","article-title":"Fabrication of tissue-engineered tympanic membrane patches using 3D-Printing technology","volume":"114","author":"Ilhan","year":"2021","journal-title":"J. Mech. Behav. Biomed. Mater"},{"key":"B38","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.msec.2016.11.094","article-title":"Mesenchymal stem cell-laden hybrid scaffold for regenerating subacute tympanic membrane perforation","volume":"72","author":"Jang","year":"2017","journal-title":"Mater Sci. Eng. C Mater Biol. Appl."},{"key":"B39","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1109\/tnb.2021.3085599","article-title":"Bioprinted collagen-based cell-laden scaffold with growth factors for tympanic membrane regeneration in chronic perforation model","volume":"21","author":"Jang","year":"2022","journal-title":"IEEE Trans. Nanobioscience"},{"key":"B40","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.reth.2024.03.010","article-title":"Multifunctional type lll recombinant human collagen incorporated sodium alginate hydrogel with sustained release of extra cellular vehicles for wound healing multimodal therapy in diabetic mice","volume":"27","author":"Jia","year":"2024","journal-title":"Regen. Ther."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/9656938","article-title":"Additive manufacturing technologies: an overview about 3D printing methods and future prospects","volume":"2019","author":"Jim\u00e9nez","year":"2019","journal-title":"Complexity"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e49800","DOI":"10.7759\/cureus.49800","article-title":"Cartilage's contribution in otology: a comprehensive review of its role in ear surgery","volume":"15","author":"Kakkad","year":"2023","journal-title":"Cureus"},{"key":"B43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.actbio.2022.03.011","article-title":"3D bioprinting of a gelatin-alginate hydrogel for tissue-engineered hair follicle regeneration","volume":"165","author":"Kang","year":"2023","journal-title":"Acta Biomater."},{"key":"B44","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ijbiomac.2022.03.191","article-title":"Fabrication strategies and biomedical applications of three-dimensional bacterial cellulose-based scaffolds: a review","volume":"209","author":"Khan","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e1800398","DOI":"10.1002\/adhm.201800398","article-title":"Ex vivo functionality of 3D bioprinted corneal endothelium engineered with ribonuclease 5-overexpressing human corneal endothelial cells","volume":"7","author":"Kim","year":"2018","journal-title":"Adv. Healthc. Mater"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e1900426","DOI":"10.1002\/marc.201900426","article-title":"Recombinant spider silk-silica hybrid scaffolds with drug-releasing properties for tissue engineering applications","volume":"41","author":"Kumari","year":"2020","journal-title":"Macromol. Rapid Commun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1089\/ten.tea.2017.0246","article-title":"Repair of tympanic membrane perforations with customized bioprinted ear grafts using Chinchilla models","volume":"24","author":"Kuo","year":"2018","journal-title":"Tissue Eng. Part A"},{"key":"B48","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3390\/pharmaceutics14010148","article-title":"Combined Antitumor Therapy Using in situ Injectable Hydrogels Formulated with Albumin Nanoparticles Containing Indocyanine Green, Chlorin e6, and Perfluorocarbon in Hypoxic Tumors","volume":"14","author":"Lee","year":"","journal-title":"Opt. Laser Technol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ijbiomac.2022.05.123","article-title":"Biocompatible fluorescent silk fibroin bioink for digital light processing 3D printing","volume":"213","author":"Lee","year":"","journal-title":"Int. J. Biol. Macromol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"3396","DOI":"10.1016\/j.bioactmat.2021.03.013","article-title":"3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration","volume":"6","author":"Li","year":"","journal-title":"Bioact. Mater"},{"key":"B51","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10856-021-06500-2","article-title":"The corticospinal tract structure of collagen\/silk fibroin scaffold implants using 3D printing promotes functional recovery after complete spinal cord transection in rats","volume":"32","author":"Li","year":"","journal-title":"J. Mater Sci. Mater Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.reth.2024.04.003","article-title":"Potential of gelatin hydrogel nonwoven fabrics (Genocel) as a skin substitute in a diabetic mouse skin defect model","volume":"27","author":"Li","year":"2024","journal-title":"Regen. Ther."},{"key":"B53","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/s41467-020-14557-w","article-title":"Ultrafast 3D printing with submicrometer features using electrostatic jet deflection","volume":"11","author":"Liashenko","year":"2020","journal-title":"Nat. Commun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"024102","DOI":"10.1088\/1758-5090\/aa7279","article-title":"Current and emerging applications of 3D printing in medicine","volume":"9","author":"Liaw","year":"2017","journal-title":"Biofabrication"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e2303648121","DOI":"10.1073\/pnas.2303648121","article-title":"Growing three-dimensional objects with light","volume":"121","author":"Lipkowitz","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B56","doi-asserted-by":"publisher","first-page":"139699","DOI":"10.1016\/j.foodchem.2024.139699","article-title":"Effect of 3D printing and traditional molding on phenolic compounds and antioxidant activity in steamed bread","volume":"454","author":"Ma","year":"2024","journal-title":"Food Chem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"109969","DOI":"10.1016\/j.ijporl.2020.109969","article-title":"Application of mesenchymal stem cell for tympanic membrane regeneration by tissue engineering approach","volume":"133","author":"Maharajan","year":"2020","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bioactmat.2023.02.007","article-title":"3D-printed fish gelatin scaffolds for cartilage tissue engineering","volume":"26","author":"Maihemuti","year":"2023","journal-title":"Bioact. Mater"},{"key":"B59","doi-asserted-by":"publisher","first-page":"104323","DOI":"10.1016\/j.jdent.2022.104323","article-title":"Custom-made computer-aided-design\/computer-assisted-manufacturing (CAD\/CAM) synthetic bone grafts for alveolar ridge augmentation: a retrospective clinical study with 3 years of follow-up","volume":"127","author":"Mangano","year":"2022","journal-title":"J. Dent."},{"key":"B60","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1097\/mao.0000000000002465","article-title":"The management of tympanic membrane perforation with endoscopic type I tympanoplasty","volume":"41","author":"Marchioni","year":"2020","journal-title":"Otology Neurotol. official Publ. Am. Otological Soc. Am. Neurotol. Soc. Eur. Acad. Otology Neurotol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"025006","DOI":"10.1088\/1758-5090\/ab4a20","article-title":"Tissue engineering of retina through high resolution 3-dimensional inkjet bioprinting","volume":"12","author":"Masaeli","year":"2020","journal-title":"Biofabrication"},{"key":"B62","doi-asserted-by":"publisher","first-page":"478","DOI":"10.3389\/fbioe.2019.00478","article-title":"Direct-write bioprinting approach to construct multilayer cellular tissues","volume":"7","author":"Masaeli","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.3390\/ph15111328","article-title":"Engineered-skin of single dermal layer containing printed hybrid gelatin-polyvinyl alcohol bioink via 3D-bioprinting: in vitro assessment under submerged vs. Air-lifting models","volume":"15","author":"Masri","year":"2022","journal-title":"Pharm. (Basel)"},{"key":"B64","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1021\/acsabm.3c00133","article-title":"Fabrication strategies for engineered thin membranous tissues","volume":"6","author":"McLoughlin","year":"","journal-title":"ACS Appl. Bio Mater."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e2300642","DOI":"10.1002\/adhm.202300642","article-title":"4D bioprinting via molecular network contraction for membranous tissue fabrication","volume":"12","author":"McLoughlin","year":"","journal-title":"Adv. Healthc. Mater"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e2203268","DOI":"10.1002\/adhm.202203268","article-title":"3D bioprinting in otolaryngology: a review","volume":"12","author":"McMillan","year":"2023","journal-title":"Adv. Healthc. Mater"},{"key":"B67","doi-asserted-by":"publisher","first-page":"213885","DOI":"10.1016\/j.bioadv.2024.213885","article-title":"Anisotropic hydrogel scaffold by flow-induced stereolithography 3D printing technique","volume":"161","author":"Mohammad Mehdipour","year":"2024","journal-title":"Biomater. Adv."},{"key":"B68","doi-asserted-by":"publisher","first-page":"e53593","DOI":"10.1002\/app.53593","article-title":"Extrusion 3D printing of a multiphase collagen-based material: an optimized strategy to obtain biomimetic scaffolds with high shape fidelity","volume":"140","author":"Montalbano","year":"2023","journal-title":"J. Appl. Polym. Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"e256","DOI":"10.1097\/mao.0000000000004132","article-title":"In vivo thickness of the healthy tympanic membrane determined by optical coherence tomography","volume":"45","author":"Morgenstern","year":"2024","journal-title":"Otol. Neurotol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"015020","DOI":"10.1088\/1758-5090\/acab34","article-title":"Hyaluronic acid based next generation bioink for 3D bioprinting of human stem cell derived corneal stromal model with innervation","volume":"15","author":"Moro","year":"2022","journal-title":"Biofabrication"},{"key":"B71","doi-asserted-by":"publisher","first-page":"105226","DOI":"10.1016\/j.jdent.2024.105226","article-title":"Accuracy of 3D printed implant surgical guides with the manufacturer workflow of four different printers. A comparative in vitro study","author":"Mor\u00f3n-Conejo","year":"2024","journal-title":"J. Dent."},{"key":"B72","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1089\/ten.tea.2023.0097","article-title":"Aspects of a suspended bioprinting system affect cell viability and support bath properties","volume":"30","author":"Navara","year":"2023","journal-title":"Tissue Eng. Part A"},{"key":"B73","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3390\/gels9080637","article-title":"3D printing type 1 bovine collagen scaffolds for tissue engineering applications-physicochemical characterization and in vitro evaluation","volume":"9","author":"Nayak","year":"2023","journal-title":"Gels"},{"key":"B74","doi-asserted-by":"publisher","first-page":"101145","DOI":"10.1016\/j.progpolymsci.2019.101145","article-title":"Print me an organ! Why we are not there yet","volume":"97","author":"Ng","year":"2019","journal-title":"Prog. Polym. Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"128279","DOI":"10.1016\/j.ijbiomac.2023.128279","article-title":"Evaluation of hyaluronic acid-polymacrolactone hydrogels with 3D printing capacity","volume":"256","author":"Nita","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"213827","DOI":"10.1016\/j.bioadv.2024.213827","article-title":"The importance of mechanical and biological cues of tympanic membrane grafts to ensure optimal regeneration","volume":"159","author":"Nobus","year":"2024","journal-title":"Biomater. Adv."},{"key":"B77","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s13346-023-01391-y","article-title":"Urethane dimethacrylate-based photopolymerizable resins for stereolithography 3D printing: a physicochemical characterisation and biocompatibility evaluation","volume":"14","author":"Pitzanti","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1080\/09205063.2022.2110480","article-title":"A review on the recent progress, opportunities, and challenges of 4D printing and bioprinting in regenerative medicine","volume":"34","author":"Pourmasoumi","year":"2023","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"B79","doi-asserted-by":"publisher","first-page":"e1902516","DOI":"10.1002\/adma.201902516","article-title":"Recent advances in enabling technologies in 3D printing for precision medicine","volume":"32","author":"Prendergast","year":"2020","journal-title":"Adv. Mater"},{"key":"B80","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3390\/ijms18030237","article-title":"A review of structure construction of silk fibroin biomaterials from single structures to multi-level structures","volume":"18","author":"Qi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.biomaterials.2016.11.046","article-title":"Silk based bioinks for soft tissue reconstruction using 3-dimensional (3D) printing with in vitro and in vivo assessments","volume":"117","author":"Rodriguez","year":"2017","journal-title":"Biomaterials"},{"key":"B82","doi-asserted-by":"publisher","first-page":"100205","DOI":"10.1016\/j.jcomc.2021.100205","article-title":"Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: a vibro-acoustic analysis","volume":"6","author":"Rostam-Alilou","year":"2021","journal-title":"Compos. Part C. Open Access"},{"key":"B83","doi-asserted-by":"publisher","first-page":"100046","DOI":"10.1016\/j.bbiosy.2022.100046","article-title":"Tissue engineering and regenerative medicine strategies for the repair of tympanic membrane perforations","volume":"6","author":"Sainsbury","year":"2022","journal-title":"Biomater. Biosyst."},{"key":"B84","doi-asserted-by":"publisher","first-page":"19935","DOI":"10.1038\/s41598-022-24275-6","article-title":"Melt electrowriting of PLA, PCL, and composite PLA\/PCL scaffolds for tissue engineering application","volume":"12","author":"Shahverdi","year":"2022","journal-title":"Sci. Rep."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-024-00649-x","article-title":"Desktop-stereolithography 3D printing of a decellularized extracellular matrix\/mesenchymal stem cell exosome bioink for vaginal reconstruction","author":"Shi","year":"2024","journal-title":"Tissue Eng. Regen. Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"034101","DOI":"10.1088\/1758-5090\/acc9de","article-title":"Bioprinting of pre-vascularized constructs for enhancedin vivoneo-vascularization","volume":"15","author":"Son","year":"2023","journal-title":"Biofabrication"},{"key":"B87","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.3390\/biomedicines11102678","article-title":"Perspectives on the current state of bioprinted skin substitutes for wound healing","volume":"11","author":"S\u00f6rgel","year":"2023","journal-title":"Biomedicines"},{"key":"B88","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.biomaterials.2018.04.034","article-title":"Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks","volume":"171","author":"Sorkio","year":"2018","journal-title":"Biomaterials"},{"key":"B89","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.heares.2018.12.005","article-title":"Effects of tympanic membrane perforation on middle ear transmission in gerbil","volume":"373","author":"Stomackin","year":"2019","journal-title":"Hear Res."},{"key":"B90","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.1039\/d4tb00214h","article-title":"3D printing of customized bioceramics for promoting bone tissue regeneration by regulating sympathetic nerve behavior","volume":"12","author":"Su","year":"2024","journal-title":"J. Mater Chem. B"},{"key":"B91","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1021\/acsbiomaterials.0c00368","article-title":"Stepwise cross-linking of fibroin and hyaluronic for 3D printing flexible scaffolds with tunable mechanical properties","volume":"7","author":"Sun","year":"","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.3390\/ijms22031499","article-title":"Silk fibroin as a functional biomaterial for tissue engineering","volume":"22","author":"Sun","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2186\/jpr.jpr_d_23_00146","article-title":"Changes in occlusal relationships observed using an intraoral scanner in patients with an acquired open bite: a case report","volume":"68","author":"Takaoka","year":"2024","journal-title":"J. Prosthodont Res."},{"key":"B94","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3390\/nano10040626","article-title":"Multi-layer scaffolds of poly(caprolactone), poly(glycerol sebacate) and bioactive glasses manufactured by combined 3D printing and electrospinning","volume":"10","author":"Tour\u00e9","year":"2020","journal-title":"Nanomater. (Basel)"},{"key":"B95","doi-asserted-by":"publisher","first-page":"042003","DOI":"10.1088\/1758-5090\/ac8cb2","article-title":"3D printing of inorganic-biopolymer composites for bone regeneration","volume":"14","author":"van der Heide","year":"2022","journal-title":"Biofabrication"},{"key":"B96","doi-asserted-by":"publisher","first-page":"4497","DOI":"10.1021\/acsabm.4c00379","article-title":"Gold-hydrogel nanocomposites for high-resolution laser-based 3D printing of scaffolds with SERS-sensing properties","volume":"7","author":"Ventisette","year":"2024","journal-title":"ACS Appl. Bio Mater"},{"key":"B97","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.actbio.2023.09.005","article-title":"Multimodal additive manufacturing of biomimetic tympanic membrane replacements with near tissue-like acousto-mechanical and biological properties","volume":"170","author":"von Witzleben","year":"2023","journal-title":"Acta Biomater."},{"key":"B98","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s10561-021-09975-z","article-title":"From 3D printing to 3D bioprinting: the material properties of polymeric material and its derived bioink for achieving tissue specific architectures","volume":"23","author":"Vrana","year":"2022","journal-title":"Cell Tissue Bank."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1234340","DOI":"10.3389\/fbioe.2023.1234340","article-title":"Biomaterials-based additive manufacturing for customized bioengineering in management of otolaryngology: a comprehensive review","volume":"11","author":"Vyas","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.actbio.2022.06.036","article-title":"Hyaluronic acid methacrylate\/pancreatic extracellular matrix as a potential 3D printing bioink for constructing islet organoids","volume":"165","author":"Wang","year":"2023","journal-title":"Acta Biomater."},{"key":"B101","doi-asserted-by":"publisher","first-page":"552","DOI":"10.18063\/ijb.v8i2.552","article-title":"Application of bioprinting in ophthalmology","volume":"8","author":"Wang","year":"2022","journal-title":"Int. J. Bioprint"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12818","article-title":"Evaluation of hard palate and cleft morphology in neonates with pierre robin sequence and cleft palate only","author":"Willershausen","year":"2024","journal-title":"Orthod. Craniofac Res."},{"key":"B103","doi-asserted-by":"publisher","first-page":"720383","DOI":"10.3389\/fcell.2021.720383","article-title":"High resolution and labeling free studying the 3D microstructure of the pars tensa-annulus unit of mice","volume":"9","author":"Wu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"e1804216","DOI":"10.1002\/smll.201804216","article-title":"Electro-assisted bioprinting of low-concentration GelMA microdroplets","volume":"15","author":"Xie","year":"2019","journal-title":"Small"},{"key":"B105","doi-asserted-by":"publisher","first-page":"137964","DOI":"10.1016\/j.foodchem.2023.137964","article-title":"Recent advances of silk fibroin materials: from molecular modification and matrix enhancement to possible encapsulation-related functional food applications","volume":"438","author":"Xu","year":"2024","journal-title":"Food Chem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"e2205878","DOI":"10.1002\/advs.202205878","article-title":"Biomimetic convex implant for corneal regeneration through 3D printing","volume":"10","author":"Xu","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"key":"B107","doi-asserted-by":"publisher","first-page":"103042","DOI":"10.1016\/j.amjoto.2021.103042","article-title":"Comparison of endoscopic type I tympanoplasty with and without assistance of customized 3D-printed guiding template for tympanic membrane","volume":"42","author":"Yang","year":"2021","journal-title":"Am. J. Otolaryngol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"213494","DOI":"10.1016\/j.bioadv.2023.213494","article-title":"3D bioprinting of tissue constructs employing dual crosslinking of decellularized extracellular matrix hydrogel","volume":"152","author":"Yeleswarapu","year":"2023","journal-title":"Biomater. Adv."},{"key":"B109","doi-asserted-by":"publisher","first-page":"045029","DOI":"10.1088\/1748-605x\/ad5483","article-title":"Development of bilayer tissue-engineered scaffolds: combination of 3D printing and electrospinning methodologies","volume":"19","author":"Yilmaz","year":"2024","journal-title":"Biomed. Mater"},{"key":"B110","doi-asserted-by":"publisher","first-page":"103408","DOI":"10.1016\/j.amjoto.2022.103408","article-title":"The latest progress of tympanic membrane repair materials","volume":"43","author":"Zhao","year":"2022","journal-title":"Am. J. Otolaryngology"},{"key":"B111","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.1007\/s00405-017-4743-0","article-title":"3D printing for clinical application in otorhinolaryngology","volume":"274","author":"Zhong","year":"2017","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcis.2024.05.045","article-title":"Direct 3D printing of triple-responsive nanocomposite hydrogel microneedles for controllable drug delivery","volume":"670","author":"Zhou","year":"","journal-title":"J. Colloid Interface Sci."},{"key":"B113","doi-asserted-by":"publisher","first-page":"045020","DOI":"10.1088\/1748-605x\/ad5244","article-title":"Harnessing oriented arrangement of collagen fibers by 3D printing for enhancing mechanical and osteogenic properties of mineralized collagen scaffolds","volume":"19","author":"Zhou","year":"","journal-title":"Biomed. Mater"},{"key":"B114","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.bioactmat.2024.04.032","article-title":"Strategies of functionalized GelMA-based bioinks for bone regeneration: recent advances and future perspectives","volume":"38","author":"Zhu","year":"2024","journal-title":"Bioact. Mater"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2024.1439499\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T08:34:17Z","timestamp":1723451657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2024.1439499\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":114,"alternative-id":["10.3389\/fbioe.2024.1439499"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2024.1439499","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,12]]},"article-number":"1439499"}}