{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:40:06Z","timestamp":1783687206457,"version":"3.55.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec><jats:title>Purposes<\/jats:title><jats:p>The magnesium alloy bionic cannulated screw (MABCS) was designed in a previous study promoting cortical\u2013cancellous biphasic healing of femoral neck fractures. The main purpose was to analyze the bore diameters that satisfy the torsion standards and further analyze the optimal pore and implantation direction for stabilizing femoral neck fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The MABCS design with bionic holes with a screw diameter of less than 20% met the torsion standard for metal screws. The MABCS was utilized to repair the femoral neck fracture via Abaqus 6.14 software, which simulated the various stages of fracture healing to identify the optimal biomechanical environment for bionic hole size (5%, 10%, 15%, and 20%) and implantation direction (0\u00b0, 45\u00b0, 90\u00b0, and 135\u00b0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The stress distribution of the MABCS fracture fixation model is significantly improved with an implantation orientation of 90\u00b0. The MABCS with a bionic hole and a screw diameter of 10% provides optimal stress distribution compared with the bionic cannulated screw with diameters of 5%, 15%, and 20%. In addition, the cannulated screw fixation model with a 10% bionic hole size has optimal bone stress distribution and better internal fixation than the MABCS fixation models with 5%, 15%, and 20% screw diameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, the MABCS with 10% screw diameter bionic holes has favorable biomechanical characteristics for stabilizing femoral neck fractures. This study provides a biomechanical foundation for further optimization of the bionic cannulated screw.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fbioe.2024.1448527","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T10:56:10Z","timestamp":1725015370000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Biomechanical optimization of the magnesium alloy bionic cannulated screw for stabilizing femoral neck fractures: a finite element analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Yunwei","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e807","DOI":"10.1016\/s2214-109x(17)30222-x","article-title":"National incidence of traumatic fractures in China: a retrospective survey of 512 187 individuals","volume":"5","author":"Chen","year":"2017","journal-title":"Lancet Glob. Health"},{"key":"B2","doi-asserted-by":"publisher","first-page":"100261","DOI":"10.1016\/j.mtbio.2022.100261","article-title":"Hybridizing gellan\/alginate and thixotropic magnesium phosphate-based hydrogel scaffolds for enhanced osteochondral repair","volume":"14","author":"Chen","year":"2022","journal-title":"Mater Today Bio"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4561","DOI":"10.1016\/j.actbio.2014.07.005","article-title":"Recent advances on the development of magnesium alloys for biodegradable implants","volume":"10","author":"Chen","year":"2014","journal-title":"Acta Biomater."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.7507\/1002-1892.202206055","article-title":"Clinical study of a new biodegradable magnesium internal fixation screw in treatment of osteonecrosis of the femoral head","volume":"36","author":"Cheng","year":"2022","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010609","article-title":"Scaffold fabrication technologies and structure\/function properties in bone tissue engineering","volume":"31","author":"Collins","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"B6","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00264-019-04478-9","article-title":"Traditional and bionic dynamic hip screw fixation for the treatment of intertrochanteric fracture: a finite element analysis","volume":"44","author":"Cun","year":"2020","journal-title":"Int. Orthop."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2024.02.113","article-title":"The safety and efficacy of NOACs versus LMWH for thromboprophylaxis after THA or TKA: a systemic review and meta-analysis","author":"Ding","year":"2024","journal-title":"Asian J. Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1007\/s00264-021-05039-9","article-title":"Finite element analysis of biomechanical effects of residual varus\/valgus malunion after femoral fracture on knee joint","volume":"45","author":"Ding","year":"","journal-title":"Int. Orthop."},{"key":"B9","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1186\/s13018-021-02665-2","article-title":"Titanium alloy cannulated screws and biodegradable magnesium alloy bionic cannulated screws for treatment of femoral neck fractures: a finite element analysis","volume":"16","author":"Ding","year":"","journal-title":"J. Orthop. Surg. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"911141","DOI":"10.3389\/fsurg.2022.911141","article-title":"A comparative study of novel extramedullary fixation and dynamic hip screw in the fixation of intertrochanteric fracture: a finite-element analysis","volume":"9","author":"Ding","year":"2022","journal-title":"Front. Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1297507","DOI":"10.3389\/fbioe.2023.1297507","article-title":"Proximal femoral bionic nail-a novel internal fixation system for the treatment of femoral neck fractures: a finite element analysis","volume":"11","author":"Ding","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/bot.0000000000000291","article-title":"Femoral neck fractures: current management","volume":"29","author":"Florschutz","year":"2015","journal-title":"J. Orthop. Trauma"},{"key":"B13","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/jor.22978","article-title":"Cement augmentation of implants--no general cure in osteoporotic fracture treatment. A biomechanical study on non-displaced femoral neck fractures","volume":"34","author":"Hofmann-Fliri","year":"2016","journal-title":"J. Orthop. Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.actbio.2019.07.053","article-title":"In vitro evaluation of the ZX11 magnesium alloy as potential bone plate: degradability and mechanical integrity","volume":"97","author":"Hou","year":"2019","journal-title":"Acta Biomater."},{"key":"B15","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.actbio.2019.07.053","article-title":"A biomechanical study of modified cannulate screws in treatment of femoral neck fracture","volume":"16","author":"Houcheng","year":"2014","journal-title":"Chin. J. Orthop. Trauma"},{"key":"B16","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10534-019-00170-y","article-title":"Biodegradable magnesium alloys as temporary orthopaedic implants: a review","volume":"32","author":"Kamrani","year":"2019","journal-title":"Biometals"},{"key":"B17","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1073\/pnas.1518238113","article-title":"Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy","volume":"113","author":"Lee","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B18","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13018-019-1097-x","article-title":"Comparison of three different internal fixation implants in treatment of femoral neck fracture-a finite element analysis","volume":"14","author":"Li","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.injury.2014.11.017","article-title":"Anatomical considerations in adult femoral neck fractures: how anatomy influences the treatment issues?","volume":"46","author":"Li","year":"2015","journal-title":"Injury"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1111\/os.12973","article-title":"Titanium alloy gamma nail versus biodegradable magnesium alloy bionic gamma nail for treating intertrochanteric fractures: a finite element analysis","volume":"13","author":"Li","year":"2021","journal-title":"Orthop. Surg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1177\/1602400205","article-title":"Predictors of mortality in patients with femoral neck fracture","volume":"24","author":"Major","year":"2016","journal-title":"J. Orthop. Surg. Hong. Kong"},{"key":"B22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.actbio.2017.11.033","article-title":"Magnesium-based bioceramics in orthopedic applications","volume":"66","author":"Nabiyouni","year":"2018","journal-title":"Acta Biomater."},{"key":"B23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jmbbm.2019.04.019","article-title":"Engineered bio-nanocomposite magnesium scaffold for bone tissue regeneration","volume":"96","author":"Parai","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater"},{"key":"B24","first-page":"6","article-title":"Finite element analysis on a modified cannulated screw for fixation of femoral neck fracture","author":"Qi","year":"2013","journal-title":"J. Med. Biomechanics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0009-8981(99)00258-2","article-title":"Magnesium","volume":"294","author":"Saris","year":"2000","journal-title":"Clin. Chim. Acta"},{"key":"B26","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.msec.2016.03.016","article-title":"The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model","volume":"63","author":"Sun","year":"2016","journal-title":"Mater Sci. Eng. C Mater Biol. Appl."},{"key":"B27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.biomaterials.2018.07.018","article-title":"An innovative Mg\/Ti hybrid fixation system developed for fracture fixation and healing enhancement at load-bearing skeletal site","volume":"180","author":"Tian","year":"2018","journal-title":"Biomaterials"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.injury.2023.03.010","article-title":"Biomechanical properties and clinical significance of cancellous bone in proximal femur: a review","volume":"54","author":"Wang","year":"2023","journal-title":"Injury"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1902443","DOI":"10.1002\/advs.201902443","article-title":"Biodegradable magnesium-based implants in orthopedics-A general review and perspectives","volume":"7","author":"Wang","year":"2020","journal-title":"Adv. Sci. (Weinh)"},{"key":"B30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1475-925x-12-62","article-title":"Biodegradable magnesium-based screw clinically equivalent to titanium screw in hallux valgus surgery: short term results of the first prospective, randomized, controlled clinical pilot study","volume":"12","author":"Windhagen","year":"2013","journal-title":"Biomed. Eng. Online"},{"key":"B31","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1002\/jbm.a.31293","article-title":"Biodegradable magnesium scaffolds: Part II: peri-implant bone remodeling","volume":"81","author":"Witte","year":"2007","journal-title":"J. Biomed. Mater Res. A"},{"key":"B32","doi-asserted-by":"publisher","first-page":"034107","DOI":"10.1088\/1758-5090\/ac73b8","article-title":"A biodegradable 3D woven magnesium-based scaffold for orthopedic implants","volume":"14","author":"Xue","year":"2022","journal-title":"Biofabrication"},{"key":"B33","doi-asserted-by":"publisher","first-page":"108036","DOI":"10.1016\/j.cmpb.2024.108036","article-title":"Single-plane osteotomy model is inaccurate for evaluating the optimal strategy in treating vertical femoral neck fractures: a finite element analysis","volume":"245","author":"Zhan","year":"2024","journal-title":"Comput. Methods Programs Biomed."},{"key":"B34","doi-asserted-by":"publisher","first-page":"105645","DOI":"10.1016\/j.jmbbm.2022.105645","article-title":"Failure analysis of a locking compression plate with asymmetric holes and polyaxial screws","volume":"138","author":"Zhang","year":"2023","journal-title":"J. Mech. Behav. Biomed. Mater"},{"key":"B35","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.biomaterials.2015.11.038","article-title":"Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head","volume":"81","author":"Zhao","year":"2016","journal-title":"Biomaterials"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2024.1448527\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T10:56:14Z","timestamp":1725015374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2024.1448527\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":35,"alternative-id":["10.3389\/fbioe.2024.1448527"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2024.1448527","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]},"article-number":"1448527"}}