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Amniotic membrane, as a biological scaffold with unique properties, has attracted the attention of many researchers in recent years. This membrane, extracted from the human placenta, contains growth factors, cytokines, and other biomolecules that play a crucial role in tissue repair. Its anti-inflammatory, antibacterial, and wound-healing properties have made amniotic membrane a promising option for the treatment of heart diseases. This review article examines the applications of amniotic membrane in cardiovascular diseases. By focusing on the mechanisms of action of this biological scaffold and the results of clinical studies, an attempt will be made to evaluate the potential of using amniotic membrane in the treatment of heart diseases. Additionally, the existing challenges and future prospects in this field will be discussed.<\/jats:p>","DOI":"10.3389\/fbioe.2024.1521462","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T11:14:39Z","timestamp":1734693279000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Amniotic membrane, a novel bioscaffold in cardiac diseases: from mechanism to applications"],"prefix":"10.3389","volume":"12","author":[{"given":"Hossein","family":"Rayat Pisheh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Darvishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Saeid","family":"Masoomkhah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/5584_2023_792","article-title":"Application of the human amniotic membrane as an adjuvant therapy for the treatment of hepatocellular carcinoma","author":"Abou-Shanab","year":"2023","journal-title":"Adv. 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