{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:10:37Z","timestamp":1787026237568,"version":"build-2736575974"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Dental resin restorations often fail due to microcrack expansion, causing fractures and secondary caries. Self-healing resin composites based on Microbially Induced Calcium Carbonate Precipitation (MICP) offer a solution. In these composites, moisture and air activate bacteria to precipitate calcium carbonate (CaCO\n                      <jats:sub>3<\/jats:sub>\n                      ) and repair microcracks. When a crack seals, bacteria become dormant or form spores until the next crack forms, triggering repeated self-healing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study involved the optimization of nutrients to enhance biocompatibility, the preparation of dental resin composites incorporating eight different bacterial strains, the investigation of Mn\n                      <jats:sup>2+<\/jats:sup>\n                      to enhance self-healing properties, and the utilization of a method to evaluate self-healing efficiency tailored for the oral environment. This method took a microscopic view of the healing process in artificial saliva, and the self-healing efficiency was determined by quantifying the scratch area.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the final results,\n                      <jats:italic>Bacillus<\/jats:italic>\n                      sphaericus (ATCC 4525) cultured with Mn\n                      <jats:sup>2+<\/jats:sup>\n                      exhibited the most impressive self-healing effect, while\n                      <jats:italic>Bacillus<\/jats:italic>\n                      pasteurii (B80469) had the weakest self-healing effect in the study. Otherwise, Bifidobacterium longum showed no significant difference between its initial and secondary healing effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This dental self-healing resin composite can undergo multiple rounds of self-repair and boasts high biocompatibility, leading to a significant reduction in the failure rate of dental resin restorations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbioe.2025.1590348","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T01:22:05Z","timestamp":1748827325000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Optimization of a novel dental self-healing resin composite by bacteria-induced biomineralization"],"prefix":"10.3389","volume":"13","author":[{"given":"Yanyan","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiheng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.conbuildmat.2013.06.061","article-title":"Biogenic treatment improves the durability and remediates the cracks of concrete structures","volume":"48","author":"Achal","year":"2013","journal-title":"Constr. 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