{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:07:52Z","timestamp":1788617272719,"version":"build-2803163510"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>\n                    Intrauterine adhesions (IUAs) are essentially fibrosis of the endometrium within the uterine cavity. It is a common cause of infertility in women and seriously affects their physical and mental health. Current therapeutic strategies have failed to reach satisfactory outcomes. Injectable and self-healing uterine hydrogels with antifibrotic properties would be efficient in preventing IUA. In this work, we prepared curcumin-loaded carboxymethyl chitosan (CMC)\u2013oxidized hyaluronic acid (OHA) intrauterine hydrogel (Cur@CMC-OHA hydrogel) with antifibrotic properties, and its injectable and self-healing properties could be adapted to the morphostructures of the uterine cavity. The hydrogels exhibited tissue adhesive power, which is ideal for stable uterine cavity retention and therapeutic outcomes.\n                    <jats:italic>In vivo<\/jats:italic>\n                    experiments showed that\n                    <jats:italic>in situ<\/jats:italic>\n                    injection of the Cur@CMC-OHA hydrogel into a mouse model of IUA reduced fibrotic tissues, prevented IUA, and improved the reproductive outcomes. It effectively downregulated fibrosis-associated transforming growth factor-\u03b21 (TGF-\u03b21) expression and reversed epithelial\u2013mesenchymal transition (EMT), resulting in anti-fibrotic and fertility restoration. In conclusion, Cur@CMC-OHA hydrogel may be a promising alternative for clinical treatment of uterine adhesion.\n                  <\/jats:p>","DOI":"10.3389\/fbioe.2025.1640440","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T06:27:07Z","timestamp":1763360827000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Biodegradable and injectable curcumin-loaded hydrogel for the prevention of postoperative intrauterine adhesion"],"prefix":"10.3389","volume":"13","author":[{"given":"Qingmei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2014.08.016","article-title":"Curcumin as a wound healing agent","volume":"116","author":"Akbik","year":"2014","journal-title":"Life Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jtcme.2016.05.005","article-title":"Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives \u2013 a review","volume":"7","author":"Amalraj","year":"2017","journal-title":"J. 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