{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:59:50Z","timestamp":1757627990258,"version":"3.44.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Respiratory pathogens transmitted <jats:italic>via<\/jats:italic> clinical textiles represent a major source of hospital-acquired infections, yet current antibacterial fabric strategies are limited by poor durability and weak bacterial inhibition. Here, we reported a molecular-level strategy for the fabrication of copper-doped antibacterial cotton textiles (Cu@textile) <jats:italic>via<\/jats:italic> a simple immersion of common cotton in a Cu(II)-saturated NaOH solution. This process enabled stable coordination between the copper ions and cellulose hydroxyl groups, forming stable Cu-O bonds throughout the fiber matrix. Structural and spectroscopic analyses confirmed uniform copper integration and chemical bonding. The resulting Cu@textile exhibited potent, broad-spectrum antibacterial activity against key respiratory pathogens, including <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, <jats:italic>Acinetobacter baumannii<\/jats:italic>, and <jats:italic>Mycobacterium tuberculosis<\/jats:italic>, with &amp;gt;99% sterilization efficiency. Mechanistic studies revealed this efficacy as copper-induced reactive oxygen species (ROS) production and bacterial membrane disruption. This accessible and scalable antimicrobial textile eliminates the need for specialized equipment or nanoparticle synthesis, and may represent a strategic intervention to reduce bacteria propagation and contact infection risks in healthcare settings.<\/jats:p>","DOI":"10.3389\/fbioe.2025.1641123","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T05:26:46Z","timestamp":1757482006000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial Cu-doped cotton textile against respiratory pathogens for preventing hospital-acquired infections"],"prefix":"10.3389","volume":"13","author":[{"given":"Jianhui","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuojun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiafei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhou","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingbin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e2303967","DOI":"10.1002\/adhm.202303967","article-title":"Fast and stable antibacterial coating of photosensitive aggregation\u2010induced emission luminogens for disinfection on medical devices","volume":"13","author":"Chen","year":"2024","journal-title":"Adv. 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