{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:40:10Z","timestamp":1763707210516,"version":"3.45.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>\n                    Placenta accreta spectrum (PAS) is a severe pregnancy complication characterized by abnormal placental invasion, leading to life-threatening hemorrhage during delivery. Current management strategies face challenges between the systemic side effects of pharmacological interventions and the risks of invasive surgery. This study develops a targeted nanotherapeutic platform using iRGD peptide-functionalized mesoporous silica nanoparticles (MSNs) coated with metal\u2013phenolic networks (MPNs) for mifepristone (MIF) delivery. The MPN-coated MSNs exhibited enhanced drug-loading capacity (275\u00a0\u03bcg\/mg) and sustained-release profiles (83.3% release over 48\u00a0h).\n                    <jats:italic>In vitro<\/jats:italic>\n                    studies demonstrated excellent biocompatibility and selective uptake in trophoblast cells via \u03b1v\u03b23 integrin targeting. In a pregnant mouse model, the internalization RGD peptide (iRGD)-modified nanoparticles showed preferential placental accumulation and induced significant abortion through targeted trophoblast apoptosis, as evidenced by reduced chorionic gonadotropin levels and histological analysis. Although this proof-of-concept study demonstrates a promising targeted therapeutic strategy using healthy animal models, we acknowledge the limitation of not using true PAS pathological models. Our findings establish a foundation for developing precision nanomedicines for placental disorders, with future studies required to validate efficacy in disease-specific models.\n                  <\/jats:p>","DOI":"10.3389\/fbioe.2025.1684943","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:30:14Z","timestamp":1763706614000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["iRGD-mediated MPN functionalization of MSNs for targeted delivery of MIF: a potential strategy for placenta accreta spectrum therapy"],"prefix":"10.3389","volume":"13","author":[{"given":"Fanying","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longxia","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guolin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/BF03296810","article-title":"The plethora of potential anti-HIV agents","volume":"711","year":"1989","journal-title":"InPharma"},{"key":"B2","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1111\/ajo.13338","article-title":"Quality of life and sexual function after a pregnancy complicated by Placenta accreta spectrum","volume":"61","author":"Bartels","year":"2021","journal-title":"Aust. 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