{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:06:39Z","timestamp":1767870399246,"version":"3.49.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"\n Objective<\/jats:title>\n \n Patient-specific aortic material properties play a critical role in aortic dissection development. In this study, a non-invasive method was employed to assess the\n in vivo<\/jats:italic>\n anisotropic mechanical properties of normal and dissected ascending aortas and compare them with their\n ex vivo<\/jats:italic>\n material properties.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Biaxial tensile testing was performed on 10 ascending aortic specimens (five patients with type-A aortic dissection and five donors without aortic diseases), with testing data fitted using anisotropic Mooney\u2013Rivlin models. An iterative algorithm was proposed to determine\n in vivo<\/jats:italic>\n aortic material properties by matching systolic and diastolic aortic geometries from echocardiography images with those from computed tomography-based computational models. Three settings of initial guesses of material parameters (M\n 01<\/jats:sub>\n : subject-specific\n ex vivo<\/jats:italic>\n parameters; M\n 02<\/jats:sub>\n :\n ex vivo<\/jats:italic>\n parameters of one subject with median stiffness; M\n 03<\/jats:sub>\n : a 5% variation applied to M\n 02<\/jats:sub>\n ) were investigated in the iterative algorithm for their influence on\n in vivo<\/jats:italic>\n property estimation and effective Young\u2019s moduli along the circumferential (YMc) and axial (YMa) directions.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n M\n 01<\/jats:sub>\n -derived\n in vivo<\/jats:italic>\n properties had a maximum relative error of \u221233.44% in YMc\/YMa among 10 subjects compared to\n ex vivo<\/jats:italic>\n material properties. The median relative error of YMc was \u221229.40% for M\n 02<\/jats:sub>\n . Furthermore, a 5% variation in initial parameters caused less than 1.5% change in the estimated\n in vivo<\/jats:italic>\n properties. The anisotropy difference between the initial material guess and real aortic tissue would exert a significant impact on YMa estimation but negligible effects on stress distributions.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Overall,\n in vivo<\/jats:italic>\n material properties estimated using the proposed method exhibited lower YMc values than the experimental results for normal and dissected ascending aortas.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fbioe.2025.1689692","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:34:55Z","timestamp":1767854095000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-invasive estimation of material properties of normal and dissected human ascending aortas in vivo: comparison with the ex vivo tensile experiment"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoya","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoliang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.jtcvs.2016.11.056","article-title":"Obtaining the biomechanical behavior of ascending aortic aneurysm via the use of novel speckle tracking echocardiography","volume":"153","author":"Alreshidan","year":"2017","journal-title":"J. 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