{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T06:44:40Z","timestamp":1765349080724,"version":"3.46.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Knife-edge ridges in posterior mandible present challenges for implant placement due to insufficient horizontal bone width and inadequate keratinized tissue, traditionally requiring secondary donor site surgery with associated morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Description<\/jats:title>\n                    <jats:p>\n                      A 46-year-old female with severe mandibular atrophy underwent two-stage reconstruction. First-stage surgery involved harvesting bone blocks from the knife-edge ridge, rotating them 180\u00b0 counterclockwise, and securing for horizontal augmentation. After 7\u00a0months, second-stage surgery included implant placement with platelet-rich fibrin soft tissue augmentation using open-suture technique. Outcomes demonstrated horizontal bone gains of 4.3\u20134.8\u00a0mm, keratinized tissue increase of 2.9\u00a0mm, and absolute bone volume gain of 859.86\u00a0mm\n                      <jats:sup>3<\/jats:sup>\n                      . All three implants achieved successful osseointegration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Implications<\/jats:title>\n                    <jats:p>\n                      This novel staged protocol integrates\n                      <jats:italic>in situ<\/jats:italic>\n                      bone grafting with PRF-based soft tissue augmentation, specifically designed for posterior mandibular knife-edge ridges. By systematically combining these techniques, it eliminates donor site morbidity while achieving clinically significant tissue augmentation, offering practitioners a comprehensive autologous reconstruction approach that addresses the unique anatomical constraints and dual tissue deficiencies characteristic of this challenging region.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbioe.2025.1693842","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T06:41:36Z","timestamp":1765348896000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Innovative reconstruction protocol for complex alveolar ridge defects in posterior mandible: Case Report and technical analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Jian","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kewen","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sicong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhu","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mucong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s40729-021-00393-0","article-title":"Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review","volume":"7","author":"AL-Maawi","year":"2021","journal-title":"Int. J. Implant Dent."},{"key":"B2","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/clr.14046","article-title":"The influence of self-inflating soft tissue expander on the outcomes of horizontal alveolar ridge augmentation: a randomized controlled clinical and histological study","volume":"34","author":"Ali","year":"2023","journal-title":"Clin. Oral Implants Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1111\/clr.13515","article-title":"Hard tissue changes after guided bone regeneration of peri-implant defects comparing block versus particulate bone substitutes: 6-Month results of a randomized controlled clinical trial","volume":"30","author":"Benic","year":"2019","journal-title":"Clin. Oral Implants Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/clr.13571","article-title":"A retrospective 10-year mean follow-up of implants placed in ridges grafted using autogenous mandibular blocks covered with bovine bone mineral and collagen membrane","volume":"31","author":"Chiapasco","year":"2020","journal-title":"Clin. Oral Implants Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.bjoms.2016.07.016","article-title":"Rotational autotransplantation of mandibular alveolar ridge","volume":"55","author":"Damlar","year":"2017","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1902\/jop.2010.100093","article-title":"Reconstruction of posterior mandibular alveolar ridge deficiencies with the piezoelectric hinge-assisted ridge split technique: a retrospective observational report","volume":"81","author":"Holtzclaw","year":"2010","journal-title":"J. Periodontol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.joms.2009.09.110","article-title":"Island osteoperiosteal flap for alveolar bone reconstruction","volume":"68","author":"Jensen","year":"2010","journal-title":"J. Oral Maxillofac. Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.ijom.2019.04.009","article-title":"Pedicled segmental rotation techniques for posterior mandible augmentation: a preliminary study","volume":"48","author":"Khojasteh","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"B9","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/JPER.21-0076","article-title":"Ultrasonographic evaluation of the titanium-prepared platelet-rich fibrin effect in free gingival graft procedures","volume":"93","author":"Koca-Unsal","year":"2022","journal-title":"J. Periodontol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00784-019-02934-9","article-title":"PRF improves wound healing and postoperative discomfort after harvesting subepithelial connective tissue graft from palate: a randomized controlled trial","volume":"24","author":"Lektemur Alpan","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"B11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/cid.13147","article-title":"A minimally invasive method for titanium mesh fixation with resorbable sutures in guided bone regeneration: a retrospective study","volume":"25","author":"Li","year":"2023","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3390\/biology10040317","article-title":"Use of PRP, PRF and CGF in periodontal regeneration and facial Rejuvenation-A narrative review","volume":"10","author":"Mijiritsky","year":"2021","journal-title":"Biol. (Basel)"},{"key":"B13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/prd.12537","article-title":"Extended platelet-rich fibrin","volume":"94","author":"Miron","year":"2024","journal-title":"Periodontol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e31156","DOI":"10.7759\/cureus.31156","article-title":"Mandibular alveolar ridge split with simultaneous implant placement: a case report","volume":"14","author":"Pandey","year":"2022","journal-title":"Cureus"},{"key":"B15","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.jds.2020.08.014","article-title":"Platelet rich fibrin as a gingival tissue regeneration enhancer","volume":"16","author":"Petrescu","year":"2021","journal-title":"J. Dent. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1111\/jcpe.13609","article-title":"Efficacy of autogenous tooth roots for a combined vertical and horizontal alveolar ridge augmentation and staged implant placement. A prospective controlled clinical study","volume":"49","author":"Schwarz","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/cid.13299","article-title":"Clinical outcomes following a combined vertical and horizontal alveolar ridge augmentation and two-stage implant placement using either autogenous tooth roots or autogenous bone blocks","volume":"26","author":"Schwarz","year":"2024","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/cid.13144","article-title":"Marginal bone loss of tissue- or bone-level implants after simultaneous guided bone regeneration in the posterior mandibular region: a retrospective cohort study","volume":"25","author":"Shen","year":"2023","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40729-022-00421-7","article-title":"Horizontal augmentation techniques in the mandible: a systematic review","volume":"8","author":"Smeets","year":"2022","journal-title":"Int. J. Implant Dent."},{"key":"B20","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/jcpe.12841","article-title":"Randomized, controlled clinical two-centre study using xenogeneic block grafts loaded with recombinant human bone morphogenetic protein-2 or autogenous bone blocks for lateral ridge augmentation","volume":"45","author":"Thoma","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/jcpe.13714","article-title":"Clinical and radiographic outcomes of customized allogeneic bone block versus autogenous bone block for ridge augmentation: 6 month results of a randomized controlled clinical trial","volume":"50","author":"Wang","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"250","DOI":"10.12337\/zgkqzzxzz.2023.08.008","article-title":"Clinical applications of autologous platelet-rich concentrate in keratinized mucosal augmentation","volume":"28","author":"Yuemeng","year":"2023","journal-title":"Chin. J. Oral Implant."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1111\/jerd.12911","article-title":"Applications of maxillary tuberosity block autograft","volume":"34","author":"Zufia","year":"2022","journal-title":"J. Esthet. Restor. Dent."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2025.1693842\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T06:41:38Z","timestamp":1765348898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2025.1693842\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":23,"alternative-id":["10.3389\/fbioe.2025.1693842"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2025.1693842","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"article-number":"1693842"}}