{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:45:54Z","timestamp":1792291554353,"version":"4.4.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>\n                    One of the main complications of diabetes is diabetic foot ulcers (DFUs), which have a substantial global impact on morbidity, medical expenses, and lower limb amputations. A complicated microenvironment\u2014characterized by bacterial infections, chronic inflammation, oxidative stress, and poor angiogenesis impedes the healing process of DFUs. Cerium oxide nanoparticles (CeO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles), owing to their antibacterial, anti-inflammatory, and antioxidant properties, have emerged as a promising treatment. These nanoparticles can scavenge reactive oxygen species (ROS), reduce inflammation, and stimulate tissue regeneration by modulating macrophage polarization and promoting angiogenesis. However, limitations such as poor biocompatibility, aggregation, and dose-dependent toxicity hinder their clinical application. Recent advances in coating strategies\u2014including polymeric, natural biomolecule, and hybrid coatings have improved the stability, targeting, and controlled release of CeO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles. This review discusses the design, therapeutic mechanisms, and safety considerations of coated CeO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles in DFU treatment, with emphasis on combination therapies and smart-responsive coatings. Clinical translation challenges and future research directions are also addressed.\n                  <\/jats:p>","DOI":"10.3389\/fbioe.2025.1695821","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:16:30Z","timestamp":1768205790000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Cerium oxide nanoparticles for enhanced healing of diabetic foot ulcers"],"prefix":"10.3389","volume":"13","author":[{"given":"Ziyue","family":"Fu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Guangdong Pharmaceutical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangdong Pharmaceutical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjiang","family":"Mo","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangdong Pharmaceutical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefu","family":"Zhan","sequence":"additional","affiliation":[{"name":"The Third People\u2019s Hospital of Longgang District Shenzhen","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liheng","family":"Ma","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangdong Pharmaceutical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8278","DOI":"10.3390\/ijms22158278","article-title":"Biofilms in diabetic foot ulcers: impact, risk factors and control strategies","volume":"22","author":"Afonso","year":"2021","journal-title":"Int. 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