{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:31:26Z","timestamp":1789497086819,"version":"build-2803163510"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["11Q3024N"],"award-info":[{"award-number":["11Q3024N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>\n                    Running imposes substantial repetitive loads on the musculoskeletal system, which can lead to running-related overuse injuries. Therefore, effective structure-specific load management is essential for both prevention and rehabilitation. However, the conventional method for estimating structure-specific load (SSL) is time intensive to execute, and the resulting data is computationally expensive to analyze. This study aims to estimate the SSL on the Achilles and the patellar tendons, and the knee and ankle joint during running from data collected by one or two inertial measurement units (IMUs). We proposed a long-short-term-memory-based model that is trained and evaluated on a dataset of 43 participants. The estimated SSL during the stance phase of a running step achieved\n                    <jats:inline-formula>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"m1\">\n                        <mml:mrow>\n                          <mml:msup>\n                            <mml:mrow>\n                              <mml:mtext>R<\/mml:mtext>\n                            <\/mml:mrow>\n                            <mml:mrow>\n                              <mml:mn>2<\/mml:mn>\n                            <\/mml:mrow>\n                          <\/mml:msup>\n                        <\/mml:mrow>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    scores of 0.93, 0.84, 0.89, and 0.86 compared to the ground truth values for the Achilles and patellar tendon force, and ankle and knee contact forces, respectively. Furthermore, the results indicate that the SSL can be estimated practically and reliably during running using only time series data from a single pelvis-mounted IMU. These findings highlight the potential of using machine learning models applied to IMU data for SSL monitoring in real-world running scenarios.\n                  <\/jats:p>","DOI":"10.3389\/fbioe.2026.1710980","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:37:01Z","timestamp":1770795421000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Machine learning-based estimation of structure-specific load around the ankle and knee joint during running using IMU data"],"prefix":"10.3389","volume":"14","author":[{"given":"Sieglinde","family":"Bogaert","sequence":"first","affiliation":[{"name":"Human Movements Biomechanics Research Group, Department of Movement Sciences, KU Leuven","place":["Leuven, Belgium"]},{"name":"KU Leuven Institute of Sports Science (LISS), KU Leuven","place":["Leuven, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Davis","sequence":"additional","affiliation":[{"name":"KU Leuven Institute of Sports Science (LISS), KU Leuven","place":["Leuven, Belgium"]},{"name":"Department of Computer Science, Leuven.AI, KU Leuven","place":["Leuven, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicte","family":"Vanwanseele","sequence":"additional","affiliation":[{"name":"Human Movements Biomechanics Research Group, Department of Movement Sciences, KU Leuven","place":["Leuven, Belgium"]},{"name":"KU Leuven Institute of Sports Science (LISS), KU Leuven","place":["Leuven, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0203839","DOI":"10.1371\/journal.pone.0203839","article-title":"Using wearable sensors to classify subject-specific running biomechanical gait patterns based on changes in environmental weather conditions","volume":"13","author":"Ahamed","year":"2018","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"646042","DOI":"10.3389\/fphys.2021.646042","article-title":"Biomechanical response of the lower extremity to running-induced acute fatigue: a systematic review","volume":"12","author":"Apte","year":"2021","journal-title":"Front. 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