{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T06:18:14Z","timestamp":1775110694142,"version":"3.50.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Myocardial infarction (MI) triggers an excessive inflammatory response that drives adverse cardiac remodeling. Although colchicine has shown clinical promise, its narrow therapeutic window and lack of target specificity limit its efficacy. To address these limitations, we developed a biohybrid nanovesicle (MM\u2010LP@COL) that encapsulates colchicine, aiming to leverage natural inflammatory tropism for site-specific drug delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      MM\u2010LP@COL nanovesicles were fabricated by fusing macrophage membranes with liposomes. Physicochemical characterization was performed using DLS, TEM, and FRET analysis. Cytokine\u2010scavenging capacity was evaluated\n                      <jats:italic>in vitro<\/jats:italic>\n                      by ELISA. In a murine MI model, mice were treated with PBS, free colchicine, LP@COL, or MM\u2010LP@COL. Immune cell populations in blood, bone marrow, and spleen were analyzed by high\u2010dimensional flow cytometry (UMAP). Cardiac function and tissue remodeling were assessed by echocardiography and histology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MM\u2010LP@COL formed uniform spherical nanovesicles (\u223c200 nm) and demonstrated potent, dose\u2010dependent neutralization of multiple pro\u2010inflammatory cytokines\n                      <jats:italic>in vitro<\/jats:italic>\n                      , along with reduced circulating cytokine levels in MI mice. High\u2010dimensional cytometric analysis revealed that treatment significantly reduced neutrophil infiltration across key immune organs, including blood, bone marrow, and spleen. These effects translated into improved left ventricular function, reduced myocardial inflammation, and attenuated cardiomyocyte hypertrophy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study demonstrates that the macrophage-inspired nanovesicle system constitutes a potent and targeted combinatorial therapy for post-infarction inflammation and repair.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbioe.2026.1751640","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:24:12Z","timestamp":1775107452000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A biohybrid nanovesicle hijacks inflammatory chemotaxis to deliver colchicine for myocardial infarction therapy"],"prefix":"10.3389","volume":"14","author":[{"given":"Xiangyong","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Xiangxi Tujia and Miao Autonomous Prefecture People\u2019s Hospital, The First Affiliated Hospital of Jishou University","place":["Jishou, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Du","sequence":"additional","affiliation":[{"name":"Medical College of Jishou University","place":["Jishou, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongju","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Xiangxi Tujia and Miao Autonomous Prefecture People\u2019s Hospital, The First Affiliated Hospital of Jishou University","place":["Jishou, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiong","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Zhangjiajie People\u2019s Hospital, Jishou University","place":["Jishou, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1093\/eurheartj\/ehv318","article-title":"2015 ESC guidelines for the diagnosis and management of pericardial diseases: the task force for the diagnosis and management of pericardial diseases of the european society of cardiology (ESC)Endorsed by: the european association for cardio-thoracic surgery (EACTS)","volume":"36","author":"Adler","year":"2015","journal-title":"Eur. 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