{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:06:17Z","timestamp":1784786777017,"version":"3.55.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study evaluates the impact of radiation dose, thermal effects, and mechanical factors on vertebral stability and safety in a finite element model of simulated osteolytic defects and compared\n                      <jats:sup>125<\/jats:sup>\n                      I seed brachytherapy alone with\n                      <jats:sup>125<\/jats:sup>\n                      I brachytherapy combined with percutaneous vertebroplasty (PVP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 3D FE model of the L3\u2013L5 lumbar spine was reconstructed from CT data of a healthy adult subject. Idealized osteolytic defects were introduced into the anterior\u2013middle L4 region at three volume grades: T \u2264 30%, 30% &amp;lt; T &amp;lt; 50%, and T \u2265 50%. Three scenarios were simulated for each grade: (i) osteolytic defect model, (ii)\n                      <jats:sup>125<\/jats:sup>\n                      I seed implantation alone, and (iii)\n                      <jats:sup>125<\/jats:sup>\n                      I-PVP combination. Ninety-day cumulative dose distributions (TG-43U1) were used to model dose-dependent degradation of material properties. PMMA polymerization was modeled using Arrhenius kinetics, and the temperature field was coupled into the structural analysis. Under physiological loading (500N + 7.5\u00a0N\u00a0m), maximum displacement, maximum von Mises stress, peak temperature, and thermally damaged tissue volume fraction were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For T \u2264 30%,\n                      <jats:sup>125<\/jats:sup>\n                      I implantation alone caused minimal changes in displacement and stress. Adding PMMA increased flexion displacement to 7.12\u00a0mm and maximum flexion von Mises stress to 36.29\u00a0MPa. For T &amp;gt; 30%,\n                      <jats:sup>125<\/jats:sup>\n                      I implantation alone did not substantially improve mechanical performance. Compared with\n                      <jats:sup>125<\/jats:sup>\n                      I implantation alone,\n                      <jats:sup>125<\/jats:sup>\n                      I seed brachytherapy combined with PVP reduced flexion displacement from 8.20 to 4.36\u00a0mm and maximum flexion von Mises stress from 32.41 to 28.92\u00a0MPa in the 30% &amp;lt; T &amp;lt; 50% group. In the T \u2265 50% group, the combined treatment reduced flexion displacement from 8.81 to 4.76\u00a0mm and maximum flexion von Mises stress from 53.53 to 29.97\u00a0MPa. PMMA polymerization generated peak interface temperatures of 74\u00a0\u00b0C\u201384\u00a0\u00b0C and thermally damaged tissue fractions of 8%\u201325%, while spinal canal temperatures remained below 43\u00a0\u00b0C.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      For T \u2264 30%,\n                      <jats:sup>125<\/jats:sup>\n                      I seed implantation maintained vertebral stability, whereas adding PVP increased local stiffness without clear mechanical benefits. For T &amp;gt; 30%, particularly T \u2265 50%,\n                      <jats:sup>125<\/jats:sup>\n                      I seed brachytherapy combined with PVP improved stress distribution and displacement control compared with\n                      <jats:sup>125<\/jats:sup>\n                      I alone. These findings represent model-based trends and should not be interpreted as failure-load predictions or clinical thresholds.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbioe.2026.1764181","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:39:29Z","timestamp":1784785169000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiphysics finite element analysis of vertebral stability in simulated osteolytic lumbar defects treated with 125I brachytherapy and vertebroplasty"],"prefix":"10.3389","volume":"14","author":[{"given":"Lulu","family":"Du","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, The Postgraduate Training Base of Jinzhou Medical University, The 960th Hospital of People\u2019s Liberation Army (PLA)","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Renhe Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA)","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Hu","sequence":"additional","affiliation":[{"name":"The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA)","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Sun","sequence":"additional","affiliation":[{"name":"The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA)","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Yin","sequence":"additional","affiliation":[{"name":"The Postgraduate Training Base of Jinzhou Medical University","place":["Jinzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The 960th Hospital of the PLA Joint Logistic Support Force","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The 960th Hospital of the PLA Joint Logistic Support Force","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1002\/jor.23154","article-title":"Mechanical assessment of the effects of metastatic lytic defect on the structural response of human thoracolumbar spine","volume":"34","author":"Alkalay","year":"2016","journal-title":"J. Orthop. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00270-009-9509-7","article-title":"Temperature measurement during polymerization of bone cement in percutaneous vertebroplasty: an in vivo study in humans","volume":"32","author":"Anselmetti","year":"2009","journal-title":"Cardiovasc Interv. Radiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"749914","DOI":"10.3389\/fbioe.2021.749914","article-title":"Stability evaluation of different oblique lumbar interbody fusion constructs in normal and osteoporotic condition - a finite element based study","volume":"9","author":"Bereczki","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1589325","DOI":"10.3389\/fonc.2025.1589325","article-title":"Dose and local efficacy analysis of iodine-125 seed implantation therapy for lung tumors","volume":"15","author":"Cao","year":"2025","journal-title":"Front. Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.3390\/nano14121059","article-title":"Magnetic particle imaging-guided thermal simulations for magnetic particle hyperthermia","volume":"14","author":"Carlton","year":"2024","journal-title":"Nanomater. (Basel)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"106766","DOI":"10.1016\/j.jmbbm.2024.106766","article-title":"Therapeutic radiation directly alters bone fatigue strength and microdamage accumulation","volume":"160","author":"Carney","year":"2024","journal-title":"J. Mech. Behav. Biomed. Mater"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1152358","DOI":"10.3389\/fbioe.2023.1152358","article-title":"Bone metastases do not affect the measurement uncertainties of a global digital volume correlation algorithm","volume":"11","author":"Cavazzoni","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1395197","DOI":"10.3389\/fbioe.2024.1395197","article-title":"Biomechanical analysis of the tandem spinal external fixation in a multiple-level noncontiguous lumbar fractures model: a finite element analysis","volume":"12","author":"Chen","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3390\/bioengineering11060592","article-title":"Assessment of thermal osteonecrosis during bone drilling using a three-dimensional finite element model","volume":"11","author":"Chen","year":"2024","journal-title":"Bioeng. (Basel)."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.3390\/diagnostics13061164","article-title":"Radiofrequency ablation in vertebral body metastasis with and without percutaneous cement augmentation: a systematic review addressing the need for SPINE stability evaluation","volume":"13","author":"Colonna","year":"2023","journal-title":"Diagn. (Basel)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jmbbm.2019.06.027","article-title":"Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models","volume":"98","author":"Costa","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater"},{"key":"B12","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13014-024-02454-1","article-title":"(125) I seed brachytherapy for non-central pelvic recurrence of cervical cancer after external beam radiotherapy","volume":"19","author":"Di","year":"2024","journal-title":"Radiat. Oncol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/bioengineering11010024","article-title":"Inter-specimen analysis of diverse finite element models of the lumbar spine","volume":"11","author":"Doulgeris","year":"2023","journal-title":"Bioeng. (Basel)"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1002\/jbmr.4828","article-title":"Relative effects of radiation-induced changes in bone mass, structure, and tissue material on vertebral strength in a rat model","volume":"38","author":"Emerzian","year":"2023","journal-title":"J. Bone Min. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.22203\/eCM.v035a03","article-title":"The thermal conductivity of cortical and cancellous bone","volume":"35","author":"Feldmann","year":"2018","journal-title":"Eur. Cell Mater"},{"key":"B16","doi-asserted-by":"publisher","first-page":"E1221","DOI":"10.1097\/BRS.0b013e3181e16ae2","article-title":"A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the spine oncology study group","volume":"35","author":"Fisher","year":"2010","journal-title":"Spine (Phila Pa 1976)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.tranon.2018.03.002","article-title":"The role of the size and location of the tumors and of the vertebral anatomy in determining the structural stability of the metastatically involved spine: a finite element study","volume":"11","author":"Galbusera","year":"2018","journal-title":"Transl. Oncol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s10237-025-01950-x","article-title":"Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements","volume":"24","author":"Garavelli","year":"2025","journal-title":"Biomech. Model Mechanobiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"117465","DOI":"10.1016\/j.bone.2025.117465","article-title":"Altered vertebral biomechanical properties in prostate cancer patients following androgen deprivation therapy","volume":"195","author":"Gibson","year":"2025","journal-title":"Bone"},{"key":"B20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13018-021-02237-4","article-title":"Biomechanical finite element analysis of vertebral column resection and posterior unilateral vertebral resection and reconstruction osteotomy","volume":"16","author":"Han","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1136\/bmj.p1973","article-title":"Spinal metastases and metastatic spinal cord compression: summary of updated NICE guidance","volume":"383","author":"Hawkins","year":"2023","journal-title":"Bmj"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1007\/s00330-025-11809-5","article-title":"A modified anterolateral transdiscal percutaneous vertebroplasty with curved needle technique for C2\/C3 metastases","volume":"36","author":"He","year":"2025","journal-title":"Eur. Radiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s10856-024-06839-2","article-title":"In vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel-based composite bone cements in ovariectomized and ovary-intact rats: a preliminary investigation","volume":"36","author":"Hossain","year":"2025","journal-title":"J. Mater Sci. Mater Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1007\/s12094-025-04094-7","article-title":"Local efficacy and safety of CT-guided Iodine-125 seed implantation in the treatment of recurrent malignant tumors: a retrospective study","volume":"28","author":"Jiang","year":"2025","journal-title":"Clin. Transl. Oncol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3746","DOI":"10.1002\/mp.16948","article-title":"RapidBrachyTG43: a Geant4-based TG-43 parameter and dose calculation module for brachytherapy dosimetry","volume":"51","author":"Kalinowski","year":"2024","journal-title":"Med. Phys."},{"key":"B26","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.1002\/mp.17054","article-title":"Characterizing the voxel-based approaches in radioembolization dosimetry with reDoseMC","volume":"51","author":"Kim","year":"2024","journal-title":"Med. Phys."},{"key":"B27","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s12032-025-02764-8","article-title":"Integrated management of metastatic spinal tumors: current status and future directions","volume":"42","author":"Kim","year":"","journal-title":"Med. Oncol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.actbio.2025.07.053","article-title":"Low modulus PMMA-Based bone cement for the reduction of adjacent vertebral fractures after vertebroplasty","volume":"203","author":"Kim","year":"","journal-title":"Acta Biomater."},{"key":"B29","doi-asserted-by":"publisher","first-page":"22227","DOI":"10.1038\/s41598-022-25581-9","article-title":"Effect of thermal osteonecrosis around implants in the rat tibia: numerical and histomorphometric results in context of implant removal","volume":"12","author":"Kniha","year":"2022","journal-title":"Sci. Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1594217","DOI":"10.3389\/fsurg.2025.1594217","article-title":"Incidence of new osteoporotic adjacent vertebral body fractures. A comparison between conservative treatment and vertebral body augmentation (vertebroplasty, kyphoplasty): a systematic review and meta-analysis","volume":"12","author":"Korovessis","year":"2025","journal-title":"Front. Surg."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00586-009-0936-6","article-title":"Segmental in vivo vertebral motion during functional human lumbar spine activities","volume":"18","author":"Li","year":"2009","journal-title":"Eur. Spine J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1084904","DOI":"10.3389\/fonc.2023.1084904","article-title":"Efficacy and safety of CT-guided (125)I seed implantation by coplanar template as a salvage therapy for vertebral metastases after failure of external beam radiation therapy: a retrospective study","volume":"13","author":"Li","year":"2023","journal-title":"Front. Oncol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10561-022-10013-9","article-title":"Effects of processing and gamma radiation on mechanical properties and organic composition of frozen, freeze-dried and demineralised human cortical bone allograft","volume":"24","author":"Mansor","year":"2023","journal-title":"Cell Tissue Bank."},{"key":"B34","doi-asserted-by":"publisher","first-page":"836587","DOI":"10.1155\/2011\/836587","article-title":"Titanium-based biomaterials for preventing stress shielding between implant devices and bone","volume":"2011","author":"Niinomi","year":"2011","journal-title":"Int. J. Biomater."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.3390\/cancers17081296","article-title":"Current concepts in the management and treatment of spinal Metastases-A systematic literature review","volume":"17","author":"Palacio Giraldo","year":"2025","journal-title":"Cancers (Basel)"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.1016\/j.jbiomech.2016.10.018","article-title":"Digital volume correlation can be used to estimate local strains in natural and augmented vertebrae: an organ-level study","volume":"49","author":"Palanca","year":"2016","journal-title":"J. Biomech."},{"key":"B37","doi-asserted-by":"publisher","first-page":"111005","DOI":"10.1115\/1.4040587","article-title":"The size of simulated lytic metastases affects the strain distribution on the anterior surface of the vertebra","volume":"140","author":"Palanca","year":"2018","journal-title":"J. Biomech. Eng."},{"key":"B38","doi-asserted-by":"publisher","first-page":"116814","DOI":"10.1016\/j.bone.2023.116814","article-title":"The role of bone metastases on the mechanical competence of human vertebrae","volume":"173","author":"Palanca","year":"2023","journal-title":"Bone"},{"key":"B39","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2106\/00004623-199403000-00012","article-title":"Mechanical behavior of the human lumbar and Lumbosacral spine as shown by three-dimensional load-displacement curves","volume":"76","author":"Panjabi","year":"1994","journal-title":"J. Bone Jt. Surg. Am."},{"key":"B40","doi-asserted-by":"publisher","first-page":"933341","DOI":"10.3389\/fbioe.2022.933341","article-title":"Kinematic and biomechanical responses of the spine to distraction surgery in children with early onset scoliosis: a 3-D finite element analysis","volume":"10","author":"Pei","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13014-024-02475-w","article-title":"Clinical efficacy and prognostic factors of CT-guided radioactive iodine-125 seed implantation for the treatment of superficial soft tissue metastasis: a 12-year retrospective analysis","volume":"19","author":"Qiang","year":"2024","journal-title":"Radiat. Oncol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3390\/polym16030367","article-title":"Poly(methyl methacrylate) in orthopedics: strategies, challenges, and prospects in bone tissue engineering","volume":"16","author":"Ramanathan","year":"2024","journal-title":"Polym. (Basel)"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1016\/j.jbiomech.2006.05.019","article-title":"Novel model to analyze the effect of a large compressive follower pre-load on range of motions in a lumbar spine","volume":"40","author":"Renner","year":"2007","journal-title":"J. Biomech."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1016\/j.jbiomech.2009.03.048","article-title":"Applying a follower load delivers realistic results for simulating standing","volume":"42","author":"Rohlmann","year":"","journal-title":"J. Biomech."},{"key":"B45","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/j.jbiomech.2009.01.017","article-title":"Realistic loading conditions for upper body bending","volume":"42","author":"Rohlmann","year":"","journal-title":"J. Biomech."},{"key":"B46","doi-asserted-by":"publisher","first-page":"958","DOI":"10.3390\/app13020958","article-title":"On the finite element modeling of the lumbar spine: a schematic review","volume":"13","author":"Sciortino","year":"2023","journal-title":"Appl. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1002\/pi.6136","article-title":"Poly(methyl methacrylate) bone cement, its rise, growth, downfall and future","volume":"70","author":"Soleymani Eil Bakhtiari","year":"2021","journal-title":"Polym. Int."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1424553","DOI":"10.3389\/fbioe.2024.1424553","article-title":"CT-based finite element simulating spatial bone damage accumulation predicts metastatic human vertebrae strength and stiffness","volume":"12","author":"Soltani","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1016\/j.jbiomech.2004.03.002","article-title":"Thermal analysis of bone cement polymerisation at the cement-bone interface","volume":"37","author":"Sta\u0144czyk","year":"2004","journal-title":"J. Biomech."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1673676","DOI":"10.3389\/fonc.2025.1673676","article-title":"(125) I seed brachytherapy with cement augmentation versus cement alone for acetabular metastases: a comparative study","volume":"15","author":"Sun","year":"2025","journal-title":"Front. Oncol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4786","DOI":"10.3390\/ijms26104786","article-title":"Low-temperature spine-specific PMMA enhances bone regeneration via localized thermal necrosis in an osteoporotic rat model","volume":"26","author":"Tanvir","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.nic.2023.03.005","article-title":"Percutaneous treatment of spinal metastases","volume":"33","author":"Tomasian","year":"2023","journal-title":"Neuroimaging Clin. N. Am."},{"key":"B53","doi-asserted-by":"publisher","first-page":"7107702","DOI":"10.1155\/2022\/7107702","article-title":"Three-dimensional biomechanical finite element analysis of lumbar disc herniation in middle aged and elderly","volume":"2022","author":"Wan","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1041973","DOI":"10.3389\/fbioe.2023.1041973","article-title":"Recent advancement in finite element analysis of spinal interbody cages: a review","volume":"11","author":"Wang","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41413-023-00273-w","article-title":"A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss","volume":"11","author":"Wei","year":"2023","journal-title":"Bone Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1097\/01.Brs.0000051910.97211.Ba","article-title":"Burst fracture in the metastatically involved spine: development, validation, and parametric analysis of a three-dimensional poroelastic finite-element model","volume":"28","author":"Whyne","year":"2003","journal-title":"Spine (Phila Pa 1976)"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e0151680","DOI":"10.1371\/journal.pone.0151680","article-title":"The effectiveness of percutaneous vertebroplasty is determined by the patient-specific bone condition and the treatment strategy","volume":"11","author":"Widmer Soyka","year":"2016","journal-title":"PLoS One"},{"key":"B58","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13014-022-02196-y","article-title":"Efficacy and toxicity of Iodine-125 seed implantation for lymph node recurrence secondary to esophageal cancer after radiotherapy: a multicenter retrospective study","volume":"18","author":"Wu","year":"2023","journal-title":"Radiat. Oncol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1186\/s12957-023-03268-3","article-title":"Prognostic analysis of percutaneous vertebroplasty (PVP) combined with (125)I implantation on Lumbosacral vertebral osteoblastic metastases","volume":"21","author":"Xu","year":"2023","journal-title":"World J. Surg. Oncol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3348\/kjr.2021.0914","article-title":"Efficacy and safety of the safe triangular working zone approach in percutaneous vertebroplasty for spinal metastasis","volume":"23","author":"Yan","year":"2022","journal-title":"Korean J. Radiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.3390\/ijms26083501","article-title":"Effects of thermal environment on bone microenvironment: a narrative review","volume":"26","author":"Yin","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1186\/s12891-022-05522-3","article-title":"A finite element analysis on different bone cement forms and injection volumes injected into lumbar vertebral body in percutaneous kyphoplasty","volume":"23","author":"Zhang","year":"2022","journal-title":"BMC Musculoskelet. Disord."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1606709","DOI":"10.3389\/fbioe.2025.1606709","article-title":"Biomechanical evaluation of percutaneous cement discoplasty combined with percutaneous vertebroplasty: a finite element analysis","volume":"13","author":"Zhou","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s13018-021-02225-8","article-title":"Finite element analysis of wedge and biconcave deformity in four different height restoration after augmentation of osteoporotic vertebral compression fractures","volume":"16","author":"Zuo","year":"2021","journal-title":"J. Orthop. Surg. Res."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2026.1764181\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:39:30Z","timestamp":1784785170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2026.1764181\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":64,"alternative-id":["10.3389\/fbioe.2026.1764181"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2026.1764181","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"article-number":"1764181"}}