{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:17:44Z","timestamp":1778566664248,"version":"3.51.4"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>We propose the hypothesis that long-term alterations in the local biomechanical environment (a significant increase in stiffness and changes in stress distribution) induced by the implantation of bone cement for treating bone metastases may, by activating mechanotransduction pathways in tumor cells, potentially promote their proliferation, invasion, and therapy resistance, thereby affecting long-term disease progression. This effect is particularly noteworthy in specific patient populations with extended survival, low tumor burden, and radiosensitivity. For such patients without immediate structural instability risks, prioritizing non-invasive treatments like stereotactic radiotherapy can achieve effective symptom relief while avoiding the potential adverse biological effects associated with altering the bone\u2019s natural mechanical properties, which may lead to better long-term tumor control. This hypothesis does not challenge the critical role of bone cement in managing acute or impending pathological fractures. Instead, it advocates for a reassessment of its status as the \u201cdefault\u201d treatment option in certain specific patient populations, aiming to promote a more comprehensive balance between short-term symptom relief and long-term disease modulation in clinical decision-making.<\/jats:p>","DOI":"10.3389\/fbioe.2026.1766264","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:45:58Z","timestamp":1778564758000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A mechanobiological hypothesis on bone cement-induced progression of bone metastases"],"prefix":"10.3389","volume":"14","author":[{"given":"Qiyu","family":"Sun","sequence":"first","affiliation":[{"name":"The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA)","place":["Jinan, China"]},{"name":"The 960th Hospital of PLA","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[{"name":"The 960th Hospital of PLA","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqian","family":"Sun","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Pan","sequence":"additional","affiliation":[{"name":"The 960th Hospital of PLA","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Shen","sequence":"additional","affiliation":[{"name":"The 960th Hospital of PLA","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbo","family":"Hu","sequence":"additional","affiliation":[{"name":"The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA)","place":["Jinan, China"]},{"name":"The 960th Hospital of PLA","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cadre Diagnosis and Treatment, Eighth Medical Center, Chinese PLA General Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Du","sequence":"additional","affiliation":[{"name":"The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA)","place":["Jinan, China"]},{"name":"The 960th Hospital of PLA","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Hao","sequence":"additional","affiliation":[{"name":"The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA)","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Ma","sequence":"additional","affiliation":[{"name":"The 960th Hospital of PLA","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"The 960th Hospital of PLA","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"6187","DOI":"10.1007\/s00330-022-08742-2","article-title":"Reinforced cementoplasty for pelvic tumour lesions and pelvic traumatic fractures: preliminary experience","volume":"32","author":"Al Raaisi","year":"2022","journal-title":"Eur. 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