{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:07:28Z","timestamp":1789135648855,"version":"build-2803163510"},"reference-count":261,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Radiomics has emerged as a transformative tool in medical imaging, offering the ability to extract complex quantitative features that are generally indiscernible to the human eye. These radiomic features can be interrogated non-invasively on medical imaging. Importantly, in contrast to traditional diagnostic methods reliant on a single, often scalar, measure, radiomics features can form a high-dimensional data space from imaging data suitable for machine learning. Within the framework of artificial intelligence, radiomic features can be harnessed for differentiating healthy from pathological tissue, risk-stratifying patients for benign and malignant fractures, and clinical outcome measures. This review presents an introduction to the methodology underlying radiomics feature selection, reproducibility, feature analysis and model building, assessment of model performance, and open-source libraries for extracting radiomics features from imaging. The review then highlights the application of radiomics in osseous and cartilaginous spinal imaging for identifying osteoporosis and the prediction of fragility vertebral fractures, chronic low back pain and the assessment of intervertebral disc degeneration and herniation, cancer metastatic spine disease and the differentiation of benign vs. malignant lesions and the classification of benign vs. malignant vertebral fractures. Throughout this stage, we endeavor to demonstrate how radiomics can analyze imaging biomarkers to detect subtle structural changes in vertebral bone microarchitecture, assess tissue quality and early-stage fractures, and identify radiomic biomarkers of low back pain chronicity and intervertebral disc heterogeneity that signal degeneration and herniation risk. The review culminates with the presentation of the current limitations and future research directions, including opportunities for integration with multi-omics analysis, highlighting radiomics\u2019 potential for enhanced diagnostic accuracy and more personalized patient care. The application of radiomics in spinal imaging offers a promising avenue for improving non-invasive image early detection, risk stratification, and personalized management of spinal pathology, paving the way for more effective interventions and improved patient outcomes.<\/jats:p>","DOI":"10.3389\/fbioe.2026.1769254","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:18:17Z","timestamp":1789132697000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiomics in spinal research: a narrative review"],"prefix":"10.3389","volume":"14","author":[{"given":"Brian S.","family":"Tao","sequence":"first","affiliation":[{"name":"Chobanian & Avedisian School of Medicine, Boston University","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn A.","family":"Tao","sequence":"additional","affiliation":[{"name":"Stony Brooke University","place":["Stony Brook, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Keko","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazim","family":"Haouchine","sequence":"additional","affiliation":[{"name":"Department of Radiology, Brigham and Women\u2019s Hospital","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron Noah","family":"Alkalay","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/wics.101","article-title":"Principal component analysis","volume":"2","author":"Abdi","year":"2010","journal-title":"Wiley Interdiscip. 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