{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:01:49Z","timestamp":1780038109696,"version":"3.53.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007531","name":"Southern Taiwan Science Park","doi-asserted-by":"publisher","award":["CY-05-08-38-107"],"award-info":[{"award-number":["CY-05-08-38-107"]}],"id":[{"id":"10.13039\/501100007531","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Osteoporotic vertebral compression fracture (OVCF) has been increasing over the last decades. In addition to primary OVCF, the adjacent vertebral fracture (AVF) is a frequent serious complication in OVCF patients receiving percutaneous vertebroplasty or kyphoplasty, resulting in poor long-term outcome and recurrent symptoms. The aim of the present study is to investigate the bone regeneration behavior of a novel Ca\/P\/S-based resorbable cement (Ezechbone\u00ae Cement CBC-400) implanted into surgically created vertebral defects of ovariectomized (OVX) goats. Furthermore, the present study provides a preliminary clinical result of minimally invasive injection of this cement into the osteoporotic vertebral bodies adjacent to polymethyl methacrylate (PMMA)-filled primary OVCF bodies as a preventive measure. After implantation, a new bone network developed within the CBC-400 cement, and the cement residues were intimately integrated into the surrounding newly formed bone structures without interposition of fibrous tissues. The newly formed trabecular networks in the OVX_CBC goat were much denser and thicker than the native networks in the OVX goat and those even in the healthy control goat. Under polarized light, a much more randomly oriented, smaller-sized, and more vibrant lamellar bone morphology was observed in the OVX_CBC goat compared to that in the OVX goat, indicating an excellent bone-regenerative efficacy of CBC-400 cement. The treatment results of 10 consecutive clinical OVCF cases, in which their adjacent vertebral bodies preventively augmented with CBC-400, showed that even at an average age of almost 80 years, with half of the patients having prior osteoporotic vertebral fractures and all having multiple comorbidities, none of these patients developed any new AVF in the following 3 years. Prophylactically augmenting adjacent osteoporotic vertebrae with Ezechbone\u00ae Cement CBC-400 in combination with conventional PMMA vertebroplasty for OVCF has demonstrated a high potential for effectively reducing the risk of future adjacent vertebral fractures.<\/jats:p>","DOI":"10.3389\/fbioe.2026.1784212","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:03:30Z","timestamp":1780034610000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Study of a novel Ca\/P\/S-based cement implanted in the osteoporotic goat spine and its clinical application in preventing adjacent vertebral fractures"],"prefix":"10.3389","volume":"14","author":[{"given":"Sheng-Min","family":"Lan","sequence":"first","affiliation":[{"name":"National Cheng-Kung University Hospital, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"Department of Orthopedics, National Cheng-Kung University Medical College and Hospital Dou-Liou Branch","place":["Yunlin, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Joy Medical Devices Corp.","place":["Kaohsiung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ping","family":"Ju","sequence":"additional","affiliation":[{"name":"Joy Medical Devices Corp.","place":["Kaohsiung, Taiwan"]},{"name":"Center for Biomaterials Research, National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"Department of Materials Science and Engineering, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiin-Huey","family":"Chern Lin","sequence":"additional","affiliation":[{"name":"Joy Medical Devices Corp.","place":["Kaohsiung, Taiwan"]},{"name":"Center for Biomaterials Research, National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"Department of Materials Science and Engineering, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s13287-017-0713-0","article-title":"Calcium-containing scaffolds induce bone regeneration by regulating mesenchymal stem cell differentiation and migration","volume":"8","author":"Aquino-Mart\u00ednez","year":"2017","journal-title":"Stem. 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