{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:13:41Z","timestamp":1778130821794,"version":"3.51.4"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["\u4e0d\u3002PWZxk2025-14"],"award-info":[{"award-number":["\u4e0d\u3002PWZxk2025-14"]}],"id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Recurrent sacrococcygeal pilonidal disease (SPD) poses significant therapeutic challenges. Recently, minimally invasive techniques, notably laser ablation, have emerged as promising alternatives to conventional surgery. Concurrently, the application of acellular dermal matrix (ADM) has shown potential in facilitating wound healing and tissue regeneration. This small retrospective exploratory pilot study aims to evaluate the efficacy and safety of a combined therapeutic approach utilizing laser ablation and ADM implantation for the management of recurrent SPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed clinical data of our five patients who diagnosed with recurrent SPD between October 2023 and April 2024. All patients underwent laser ablation combined with ADM placement. Clinical outcomes, including healing rates, recurrence rates, and operative data, were recorded. Postoperative pain was quantified using the Visual Analog Scale (VAS), and the time to return to work and daily activities was documented. No sample size calculation was performed due to the exploratory nature of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of five patients underwent laser ablation combined with ADM. The median time to return to work was 10 (9, 11) days, and complete wound healing was achieved in a median of 34 (30, 35) days. Patients experienced minimal postoperative pain. Over a median follow-up period of 7 (6\u20137) months, all patients were successfully cured without recurrence and satisfied with this surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preliminary evidence suggests that laser ablation combined with ADM constitutes a feasible and promising minimally invasive strategy for recurrent SPD. This technique is associated with rapid wound healing, negligible pain, and the absence of recurrence in this cohort. This study is a small-sample retrospective pilot research with inherent limitations, and the findings warrant further verification by large-sample studies with medium and long-term follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbioe.2026.1792099","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:51:38Z","timestamp":1778129498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory pilot study of minimally invasive therapy: laser ablation combined with acellular dermal matrix implantation for recurrent sacrococcygeal pilonidal disease"],"prefix":"10.3389","volume":"14","author":[{"given":"Zhicheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Proctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caizhong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Proctology, Shanghai Pudong New Area Guangming Hospital of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Proctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingli","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Proctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Proctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Proctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Proctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"314","DOI":"10.23736\/S2724-5691.25.10615-1","article-title":"Endoscopic pilonidal sinus treatment versus excision with wound closure: a systematic review of the literature","volume":"80","author":"Agnesi","year":"2025","journal-title":"Minerva Surg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"Cd006213","DOI":"10.1002\/14651858.CD006213.pub2","article-title":"Healing by primary versus secondary intention after surgical treatment for pilonidal sinus","author":"Al-Khamis","year":"2010","journal-title":"Cochrane Database Syst. 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