{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:05:15Z","timestamp":1789635915094,"version":"4.0.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>\n                    Osteoporosis is a systemic bone disorder characterized by a disparity in bone restructure, leading to decreased bone strength and worsening microstructure. Among bioactive compounds incorporated into ceramics, recent attention has focused on the repair or regeneration of osteoarthritis-affected bone. \u03b2-tricalcium phosphate (\u03b2-TCP) remains a widely used material for bone regeneration due to its excellent biocompatibility and the ability of bone cells to restore it. In this study, a novel composite of \u03b2-TCP reinforced with Polymethylmethacrylate (PMMA) and allyl sulfide (AS) fiber composites was fabricated via the electrospinning technique. Fourier Transform Infrared Spectroscopy (FTIR) for functional group identification, X-ray Diffraction (XRD) for crystallinity assessment, Scanning Electron Microscopy (SEM) for surface morphology analysis, Energy-dispersive X-ray spectroscopy (EDX) for elemental distribution analysis, and Brunauer\u2013Emmett\u2013Teller (BET) analysis were used to characterize the fabricated fiber composite materials. The successful interaction between the \u03b2-TCP\/PMMA\/AS fibre composite and crystalline integrity was confirmed by FTIR and XRD investigation. The \u03b2-TCP\/PMMA\/AS exhibited a surface area of 45.410\u00a0m\n                    <jats:sup>2<\/jats:sup>\n                    \/g, a pore volume of 0.059\u00a0cm\n                    <jats:sup>3<\/jats:sup>\n                    \/g, and a pore diameter of 3.9\u00a0nm according to BET analysis.\n                    <jats:italic>In vitro<\/jats:italic>\n                    cell proliferation assays demonstrated improved osteoblast viability and adhesion compared to control formulations, with nearly 90.0% viability observed at 100\u00a0\u00b5g. Alizarin Red S (ARS) staining indicated enhanced calcium deposition in the osteoblast formation, confirming the mineralization potential of the \u03b2-TCP\/PMMA\/AS hybrid matrix. These studies show that the \u03b2-TCP\/PMMA\/AS fibre composite has promising potential for bone cell formation, repair\/regeneration, and suitability for osteoporosis-related bone tissue engineering applications.\n                  <\/jats:p>","DOI":"10.3389\/fbioe.2026.1792824","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T05:28:31Z","timestamp":1780291711000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Allyl sulfide incorporated polymethyl methacrylate and tricalcium phosphate fibrous composites for osteoblast proliferation investigation"],"prefix":"10.3389","volume":"14","author":[{"given":"Xunkai","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Trauma and Hand and Foot Surgery, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariappan","family":"Rajan","sequence":"additional","affiliation":[{"name":"Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University","place":["Madurai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Seles","family":"Mohan","sequence":"additional","affiliation":[{"name":"Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University","place":["Madurai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Mickymaray","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science- Al Zulfi, Majmaah University","place":["Al Majmaah, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Yan\u2019an People\u2019s Hospital","place":["Yan\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"6107","DOI":"10.1007\/s11664-020-08342-0","article-title":"Structural, optical, thermal, morphological, and electrical studies of PEMA\/PMMA blend filled with CoCl2 and LiBr as mixed filler","volume":"49","author":"Abdelrazek","year":"2020","journal-title":"J. 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