{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:13:02Z","timestamp":1788455582357,"version":"build-2803163510"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to compare lower-limb muscle strength and postural sway between individuals with KOA and healthy controls, and to examine the association between strength parameters and postural stability using clinically feasible assessment methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional analysis was conducted among 90 participants (45 KOA, 45 matched controls). The participants were older adults aged 50\u201375\u00a0years, and 40.0% of the KOA group and 42.22% of the control group were male. Participants with knee osteoarthritis were classified as having moderate disease severity based on Kellgren\u2013Lawrence grades II\u2013III. Strength and balance assessments were conducted in a counterbalanced order, with a standardized 10-min rest interval between testing sessions to minimize fatigue effects. Isometric quadriceps and hamstring strength were measured using handheld dynamometry. Postural sway metrics\u2014sway area, sway velocity, and single-leg stance time\u2014were assessed via static posturography. Limb symmetry index (LSI) and quadriceps-to-hamstrings (Q: H) ratio were calculated. Pearson correlation and multiple linear regression analyses examined associations between strength and postural control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>KOA participants showed significantly greater sway area and velocity, reduced stance time, and lower quadriceps and hamstrings strength compared to controls (all p &amp;lt; 0.001). Quadriceps strength (\u03b2 = \u22120.024, p &amp;lt; 0.001) and LSI (\u03b2 = \u22120.062, p = 0.001) were independent predictors of sway area under eyes-closed conditions. LSI and quadriceps strength were strongly correlated with sway parameters and stance performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lower limb strength deficits and inter-limb asymmetry significantly contribute to postural instability in individuals with KOA. Objective, clinically feasible tools such as handheld dynamometry and posturography can support evaluation and inform rehabilitation strategies targeting strength and balance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbioe.2026.1797065","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:15:47Z","timestamp":1779948947000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinically feasible biomechanical assessment of lower limb strength and postural stability in adults aged 50\u201375 years with moderate knee osteoarthritis: implications for technology-enabled healthy aging"],"prefix":"10.3389","volume":"14","author":[{"given":"Adel","family":"Alshahrani","sequence":"first","affiliation":[{"name":"Physical Therapy Program, Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, Najran University","place":["Najran, Saudi Arabia"]},{"name":"Health Research Center, Najran University","place":["Najran, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Shankar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Program of Physical Therapy, Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University","place":["Abha, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1287223","DOI":"10.3389\/fpubh.2023.1287223","article-title":"Exploring the nexus of lower extremity proprioception and postural stability in older adults with osteoporosis: a cross-sectional investigation","volume":"11","author":"Ahmad","year":"2023","journal-title":"Front. 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