{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:03:02Z","timestamp":1779951782609,"version":"3.53.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interstitial cystitis (IC) is a disease comprised of multiple symptoms, included persistent bladder pain syndrome (BPS), frequent urination, and urgency without getting infection or other identifiable causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In our study, 25 female patients diagnosed with IC\/BPS, the patients were performed low-intensity extracorporeal shockwave therapy (LI-ESWT) once a week for 8\u00a0weeks. The application sites for LI-ESWT are located above the pubic bone, in the middle and on both sides, with each session lasting about 20\u201330\u00a0min. High dosage of platelet-rich plasma (PRP) injections were administered in weeks 1, 5, and 9. All subjects had a baseline, 1-month and 6-month post-treatment assessment that included validated questionnaires and voiding diaries. Urodynamic studies were conducted at baseline and the 6-month follow-up after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed an 80% efficacy rate. Then, we showed significant improvements in VAS, OABSS, UDI-6, IIQ-7, and POP at the 1-month follow-up. However, only the ICIQ showed significant improvement at the 6-month follow-up. We further examined the urodynamic parameters and MCC revealed significant difference at 6-month follow-up. The voiding diaries, which tracks the number of urinations, voided volume, maximum volume, and nocturia significant improved at 1-month follow-up while only maximum volume showed improvement at the 6-month follow-up. Finally, ICSI, ICPI, and OSS, all showed significant differences at both the 1-month and 6-month follow-ups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of our study suggested that the combination treatment of PRP and LI-ESWT might show a therapeutic efficacy to IC\/BPS patients, However, the follow-ups at 1\u00a0month and 6\u00a0months post-treatment suggested that the treatment needs to be administered again over time to maintain its effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbioe.2026.1801578","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:19:50Z","timestamp":1779949190000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of combining low intensity-extracorporeal shockwave therapy with platelet-rich plasma among female patients with interstitial cystitis: a prospective single-arm pilot study"],"prefix":"10.3389","volume":"14","author":[{"given":"Cheng-Yu","family":"Long","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University","place":["Kaohsiung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kaohsiung Municipal Ta-Tung Hospital","place":["Kaohsiung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chieh","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University","place":["Kaohsiung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Ying","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University","place":["Kaohsiung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yu","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University","place":["Kaohsiung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"528","DOI":"10.4103\/ejd.ejd_49_18","article-title":"The anti-inflammatory effect of the platelet-rich plasma in the periodontal pocket","volume":"12","author":"Abdul Ameer","year":"2018","journal-title":"Eur. 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