{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:01:33Z","timestamp":1781157693209,"version":"3.54.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Prolonged bed rest leads to pressure wounds with skin infections and difficulties in long-term wound healing. Platelet-rich plasma (PRP) contains high concentrations of platelets and is used to promote chronic wound healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this patient, PRP was used several times to promote the healing of a chronic pressure wound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>The patient presented with a decreased level of consciousness. Due to prolonged bed rest, a pressure wound and skin infection developed. The pressure wound was cleansed daily with iodophor, filled with alginate, and covered with a foam dressing for approximately 5\u00a0months; however, the wound did not heal. After assessment of the patient\u2019s physical condition, autologous PRP was used in the treatment. A total of 150\u00a0mL of peripheral blood was collected from the patient for the preparation of autologous PRP. After debridement, autologous PRP and an activator (thrombin and 10% calcium chloride) were mixed in a 10:1 volume ratio and sprayed onto the surface of the pressure wound, and was given a sterile oiled gauze and gauze coverage with foam dressing for protection. After eight PRP treatments, the pressure ulcer healed within 3\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The patient\u2019s outcome suggests that PRP may be a promising adjunctive therapy for patients with nonhealing pressure ulcers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbioe.2026.1843937","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:48:55Z","timestamp":1781156935000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet-rich plasma for the treatment of a pressure wound: a case report and review of the literature"],"prefix":"10.3389","volume":"14","author":[{"given":"Yawen","family":"Guo","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Jia","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzhou","family":"Huang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1089\/wound.2016.0697","article-title":"Review of the current management of pressure ulcers","volume":"7","author":"Boyko","year":"2018","journal-title":"Adv. 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