{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:02:59Z","timestamp":1789448579204,"version":"build-2803163510"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical management of osteosarcoma is challenged by its aggressive growth and deep anatomical location. Photothermal therapy offers a minimally invasive approach through localized thermal ablation, but its effectiveness is constrained by poor tissue penetration and inaccurate targeting of deep tumors without real-time guidance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We synthesized flower-like Fe\n                      <jats:sub>3<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      @Au nanoparticles coated with hyperbranched polyglycerol (HPG) and conjugated with glucose (Glc) (Fe\n                      <jats:sub>3<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      @Au-HPG-Glc). In an osteosarcoma mouse model, the photothermal efficacy of the nanoprobes was evaluated by comparing two groups: the control group receiving phosphate-buffered saline plus laser irradiation (phosphate-buffered saline (PBS) + Laser) and the treatment group receiving Fe\n                      <jats:sub>3<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      @Au-HPG-Glc nanoprobes plus laser irradiation (NPs + Laser). Intratumoral temperature was monitored by infrared thermography, with longitudinal tracking of tumor volume and body weight. Major organs were examined by H&amp;amp;E staining. Tumor accumulation was assessed via whole-body fluorescence and T\n                      <jats:sub>2<\/jats:sub>\n                      -weighted magnetic resonance imaging (MRI); pharmacokinetics and biodistribution were quantified by inductively coupled plasma mass spectrometry (ICP-MS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The NPs + Laser regimen produced rapid intratumoral heating during the 0\u20134\u00a0min irradiation window and significantly delayed tumor growth compared with the PBS + Laser control group, with stable body weight and no overt organ lesions on H&amp;amp;E staining. Whole-body fluorescence and T\n                      <jats:sub>2<\/jats:sub>\n                      -weighted MRI confirmed tumor-site accumulation of the nanoprobes. ICP-MS-based pharmacokinetic and biodistribution analyses provided quantitative exposure context, including systemic clearance, reticuloendothelial system capture, and measurable tumor uptake. Together, these data facilitated interpretation of the subsequent photothermal response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Flower-like Fe\n                      <jats:sub>3<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      @Au-HPG-Glc enables image-guided photothermal treatment in an osteosarcoma model, supported by quantitative pharmacokinetic and biodistribution measurements and an acceptable short-course safety profile. This work establishes a clear imaging-exposure-response relationship and provides a strong foundation for further optimization of magnetic-optical combination strategies in precision cancer therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbioe.2026.1868939","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:27:20Z","timestamp":1789446440000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A multifunctional Fe3O4@Au-HPG-Glc theranostic platform for MRI\/fluorescence-guided photothermal ablation of osteosarcoma"],"prefix":"10.3389","volume":"14","author":[{"given":"Shengren","family":"Xiong","sequence":"first","affiliation":[{"name":"Fuzhou Second General Hospital","place":["Fuzhou, Fujian, China"]},{"name":"Department of Orthopaedics, Fujian Medical University Union Hospital, Fujian Medical University","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sports Injury Division, Fujian Medical University Union Hospital, Fujian Medical University","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Fujian Medical University Union Hospital, Fujian Medical University","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Fujian Medical University Union Hospital, Fujian Medical University","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongliang","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Materials and Packaging Engineering, Fujian Polytechnic Normal University","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Materials and Packaging Engineering, Fujian Polytechnic Normal University","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"20098","DOI":"10.1021\/acsnano.3c05790","article-title":"Porous molybdenum nitride nanosphere as carrier-free and efficient nitric oxide donor for synergistic nitric oxide and chemo\/sonodynamic therapy","volume":"17","author":"Bai","year":"2023","journal-title":"ACS Nano"},{"key":"B2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41572-022-00409-y","article-title":"Osteosarcoma","volume":"8","author":"Beird","year":"2022","journal-title":"Nat. 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