{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:52:53Z","timestamp":1785909173941,"version":"3.56.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"\n Background<\/jats:title>\n Wound healing is a common issue in dermatology and plastic surgery practice and is jointly regulated by multiple factors, including cell proliferation, inflammatory responses, oxidative stress, bacterial infection, and tissue remodeling. Complex wounds still face challenges such as delayed repair, persistent inflammation, increased infection risk, and scar formation, while conventional treatments are difficult to achieve coordinated intervention across multiple stages. Therefore, developing biomaterials with pro-repair, anti-inflammatory, antibacterial, and healing quality-improving functions is of great significance.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n This study aimed to construct a Cu\u2013CeO\n 2<\/jats:sub>\n nanoparticle (NP)-loaded hyaluronic acid methacrylate composite hydrogel patch, named Cu\u2013CeO\n 2<\/jats:sub>\n -loaded HAMA (CCH), to improve the wound repair microenvironment and promote high-quality wound healing through multifunctional synergistic effects.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Cu\u2013CeO\n 2<\/jats:sub>\n NPs were synthesized using a hydrothermal method and loaded into HAMA hydrogel to prepare CCH hydrogel patches.\n In vitro<\/jats:italic>\n experiments were performed to evaluate their biocompatibility, cell proliferation- and migration-promoting abilities, antioxidative\/anti-inflammatory properties, nanozyme activity, and antibacterial effects. Meanwhile, a mouse full-thickness skin wound model was established to further verify the\n in vivo<\/jats:italic>\n wound healing-promoting efficacy of CCH hydrogel patches.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Cu\u2013CeO\n 2<\/jats:sub>\n NPs and CCH hydrogel patches were successfully prepared.\n In vitro<\/jats:italic>\n results showed that Cu\u2013CeO\n 2<\/jats:sub>\n NPs exhibited favorable biocompatibility, promoted fibroblast proliferation and migration, enhanced endothelial cell viability, and facilitated macrophage polarization toward the M2 phenotype. In addition, these NPs exhibited reactive oxygen species (ROS)-scavenging capacity and hydrogen peroxide (H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n ) decomposition-mediated oxygen generation ability, and markedly inhibited methicillin-resistant\n Staphylococcus aureus<\/jats:italic>\n (MRSA) and\n Escherichia coli<\/jats:italic>\n (\n E. coli<\/jats:italic>\n ).\n In vivo<\/jats:italic>\n results further demonstrated that CCH hydrogel patches accelerated wound closure, improved healing quality, and attenuated scar-like changes in mice.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study developed Cu\u2013CeO\n 2<\/jats:sub>\n NP-loaded CCH hydrogel patches that can synergistically regulate the wound microenvironment through multiple effects, including pro-repair, antioxidative\/anti-inflammatory, antibacterial, and tissue remodeling-improving activities, providing a promising biomaterial strategy for high-quality repair of complex skin wounds.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fbioe.2026.1872283","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:41:53Z","timestamp":1785908513000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cu\u2013CeO2 NP-loaded HAMA hydrogel patches for promoting high-quality cutaneous wound healing"],"prefix":"10.3389","volume":"14","author":[{"given":"Jiahao","family":"Ji","sequence":"first","affiliation":[{"name":"The Affiliated Zhangjiagang Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Ni","sequence":"additional","affiliation":[{"name":"The Affiliated Zhangjiagang Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Chang","sequence":"additional","affiliation":[{"name":"The Affiliated Zhangjiagang Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Like","family":"Qian","sequence":"additional","affiliation":[{"name":"The Affiliated Zhangjiagang Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Zhangjiagang Hospital of Soochow University","place":["Suzhou, China"]},{"name":"Department of Plastic Surgery, Ear Reconstruction Institute, Shanghai East Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Chen","sequence":"additional","affiliation":[{"name":"The Affiliated Zhangjiagang Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3390\/gels10030176","article-title":"Development of a sprayable hydrogel-based wound dressing: an in vitro model","volume":"10","author":"Altunbek","year":"2024","journal-title":"Gels"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.3390\/cells12232745","article-title":"Skin barrier function: the interplay of physical, chemical, and immunologic properties","volume":"12","author":"Baker","year":"2023","journal-title":"Cells"},{"key":"B3","doi-asserted-by":"publisher","first-page":"rbad023","DOI":"10.1093\/rb\/rbad023","article-title":"Hyaluronic acid methacrylate\/laponite hydrogel loaded with BMP4 and maintaining its bioactivity for scar-free wound healing","volume":"10","author":"Chang","year":"2023","journal-title":"Regen. 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