{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:22:48Z","timestamp":1787638968333,"version":"build-2736575974"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autogenous tooth transplantation is one of the treatment options for replacing missing or non-restorable teeth in appropriately selected patients, depending on patient-related factors, donor-tooth availability, and recipient-site conditions. Sticky bone was prepared by combining particulate deproteinized bovine bone mineral with autologous fibrin glue and was applied to the recipient-site osseous defects at the time of transplantation. We report a case series of autogenous tooth transplantation using sticky bone\u2013assisted recipient-site management in four complex scenarios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>Four patients underwent autogenous tooth transplantation with sticky bone grafting. Indications included vertical ridge defects, irregular extraction sockets, and a maxillary sinus-floor defect with an intact Schneiderian membrane. All procedures followed standard surgical protocols. Ethical approval was obtained and all patients provided written informed consent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the final follow-up examinations, ranging from 12 to 30 months, all four transplanted teeth remained\n                      <jats:italic>in situ<\/jats:italic>\n                      and clinically functional. Radiographic root-surface changes of varying degrees were observed in all four cases; however, qualitative comparison of the available serial images showed no clear progression of inflammatory or replacement root resorption, ankylosis-related changes, or progressive periapical pathology during the observation periods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this descriptive case series, sticky bone was used as an adjunct for managing peri-root defects during autogenous tooth transplantation at four anatomically compromised recipient sites. All transplanted teeth remained clinically functional during follow-up periods ranging from 12 to 30 months. Although radiographic root-surface changes were observed, no clear progression of inflammatory or replacement resorption was identified during the available follow-up. However, because of the small sample size, case heterogeneity, non-standardized radiographic assessment, and absence of a control group, the observed outcomes cannot be attributed to sticky bone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbioe.2026.1926597","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:35:58Z","timestamp":1787636158000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Sticky bone-assisted autogenous tooth transplantation for compromised alveolar recipient sites: a case series"],"prefix":"10.3389","volume":"14","author":[{"given":"Shenghui","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of General and Emergency Dentistry, Stomatological Hospital of Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou Liwan District Stomatology Hospital","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General and Emergency Dentistry, Stomatological Hospital of Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2019ao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of General and Emergency Dentistry, Stomatological Hospital of Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e70004","DOI":"10.1111\/cid.70004","article-title":"Application of biologics in maxillary sinus augmentation surgery: a narrative review","volume":"27","author":"Aghaloo","year":"2025","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.tripleo.2007.02.006","article-title":"Time of endodontic treatment in autogenic transplants of mature teeth: histological study in dogs","volume":"104","author":"Azevedo","year":"2007","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1016\/j.joen.2010.04.028","article-title":"Autotransplantation of teeth with complete root formation: a case series","volume":"36","author":"Bae","year":"2010","journal-title":"J. Endod."},{"key":"B4","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00784-016-2044-4","article-title":"Soft tissue substitutes in non-root coverage procedures: a systematic review and meta-analysis","volume":"21","author":"Bertl","year":"2017","journal-title":"Clin. Oral Investig."},{"key":"B5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.adaj.2019.10.025","article-title":"Endodontic management of an autotransplanted mandibular third molar: a simplified approach","volume":"151","author":"Boschini","year":"2020","journal-title":"J. Am. Dent. Assoc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/jcm14010017","article-title":"A narrative and case-illustrated review on dental autotransplantation identifying current gaps in knowledge","volume":"14","author":"Chhana","year":"2024","journal-title":"J. Clin. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.5005\/jp-journals-10005-1142","article-title":"Autogenous tooth transplantation as a treatment option","volume":"5","author":"Chugh","year":"2012","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"B8","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/eos.12364","article-title":"'guided bone regeneration: materials and biological mechanisms revisited","volume":"125","author":"Elgali","year":"2017","journal-title":"Eur. J. Oral Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/edt.12353","article-title":"Outcomes and prognostic factors that influence the success of tooth autotransplantation in children and adolescents","volume":"33","author":"Kafourou","year":"2017","journal-title":"Dent. Traumatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3290\/j.ohpd.b2403411","article-title":"Periodontal tissue healing after autologous tooth transplantation: a retrospective analysis of case series","volume":"19","author":"Kamata","year":"2021","journal-title":"Oral Health Prev. Dent."},{"key":"B11","doi-asserted-by":"publisher","first-page":"136","DOI":"10.5395\/rde.2012.37.3.136","article-title":"Minimizing the extra-oral time in autogeneous tooth transplantation: use of computer-aided rapid prototyping (CARP) as a duplicate model tooth","volume":"37","author":"Lee","year":"2012","journal-title":"Restor. Dent. Endod."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1186\/s12903-023-03733-1","article-title":"Effectiveness evaluation of autotransplanted teeth after performing extraoral endodontic surgery instead of conventional root canal therapy","volume":"23","author":"Liao","year":"2023","journal-title":"BMC Oral Health"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/1735-3327.111756","article-title":"'Tooth auto-transplantation as an alternative treatment option: a literature review","volume":"10","author":"Nimcenko","year":"2013","journal-title":"Dent. Res. J. (Isfahan)"},{"key":"B14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.17796\/jcpd.35.2.97816254u2140x88","article-title":"Tooth autotransplantation as a treatment option: a review","volume":"35","author":"Park","year":"2010","journal-title":"J. Clin. Pediatr. Dent."},{"key":"B15","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/iej.13456","article-title":"European Society of Endodontology position statement: surgical extrusion, intentional replantation and tooth autotransplantation: European Society of Endodontology developed by","volume":"54","author":"Plotino","year":"2021","journal-title":"Int. Endod. J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1007\/s00784-018-2408-z","article-title":"Autotransplantation of teeth with incomplete root formation: a systematic review and meta-analysis","volume":"22","author":"Rohof","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.3390\/ma17051221","article-title":"Soft tissue substitutes in periodontal and peri-implant soft tissue augmentation: a systematic review","volume":"17","author":"Rotundo","year":"2024","journal-title":"Mater. (Basel)"},{"key":"B18","doi-asserted-by":"publisher","first-page":"335","DOI":"10.4103\/ams.ams_40_20","article-title":"Efficacy of sticky bone as a novel autologous graft for mandibular third molar extraction socket healing - an evaluative study","volume":"10","author":"Rupawala","year":"2020","journal-title":"Ann. Maxillofac. Surg."},{"key":"B19","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/iej.12781","article-title":"European society of Endodontology position statement: the use of antibiotics in endodontics","volume":"51","author":"Segura-Egea","year":"2018","journal-title":"Int. Endod. J."},{"key":"B20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1186\/s12903-021-01686-x","article-title":"'Pre- and peri-operative factors influence autogenous tooth transplantation healing in insufficient bone sites","volume":"21","author":"Suwanapong","year":"2021","journal-title":"BMC Oral Health"},{"key":"B21","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jpor.2017.06.005","article-title":"Periodontal tactile sensation and occlusal loading condition of autotransplanted teeth: a retrospective pilot study","volume":"62","author":"Suzuki","year":"2018","journal-title":"J. Prosthodont Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/edt.12836","article-title":"Tooth autotransplantation: an umbrella review","volume":"39","author":"Tan","year":"2023","journal-title":"Dent. Traumatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1186\/s12903-024-04229-2","article-title":"Application of sticky bone combined with concentrated growth factor (CGF) for horizontal alveolar ridge augmentation of anterior teeth: a randomized controlled clinical study","volume":"24","author":"Xie","year":"2024","journal-title":"BMC Oral Health"},{"key":"B24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00784-018-2412-3","article-title":"Outcomes of autotransplanted teeth and prognostic factors: a 10-year retrospective study","volume":"23","author":"Yang","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"B25","doi-asserted-by":"publisher","first-page":"10151","DOI":"10.2147\/IJN.S524115","article-title":"Sticky bone: advances and applications","volume":"20","author":"Yang","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.3390\/molecules26103007","article-title":"Bone grafts and substitutes in dentistry: a review of current trends and developments","volume":"26","author":"Zhao","year":"2021","journal-title":"Molecules"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2026.1926597\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:36:06Z","timestamp":1787636166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2026.1926597\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":26,"alternative-id":["10.3389\/fbioe.2026.1926597"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2026.1926597","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"article-number":"1926597"}}