{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:49:36Z","timestamp":1791355776055,"version":"4.3.1"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>\n                    Chronic osteomyelitis is difficult to treat due to the interplay of bacterial colonization, excessive inflammation, and impaired bone regeneration. Here, we developed an engineered natural polysaccharide POP@ZIF-67 nanoplatform to modulate these interrelated pathological processes. ZIF-67 is an antimicrobial framework with porous properties, peroxidase-like catalytic activity, and acid-responsive release behavior; purslane polysaccharide (POP) was incorporated as an immunomodulatory component to mitigate the excessive inflammatory stimulation induced by ZIF-67. POP@ZIF-67 exhibits effective antibacterial and antibiofilm activity against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ; more importantly, the incorporation of POP transforms the biological action of ZIF-67 from primarily antibacterial stimulation into a multifunctional platform capable of suppressing excessive M1-like macrophage responses, promoting repair-related polarization, and improving the osteogenic microenvironment. In a mouse model of chronic osteomyelitis, POP@ZIF-67 reduced local bacterial load and inflammatory damage while promoting collagen deposition, bone remodeling, and osteogenic maturation, without significant systemic toxicity. Overall, the study introduces an \u201cantimicrobial framework\u2013immune buffering\u201d strategy that reconciles the antimicrobial efficacy of metal-organic frameworks with their immunostimulatory limitations. By integrating various therapeutic approaches, POP@ZIF-67 provides a promising new synthetic paradigm for the treatment of chronic osteomyelitis and infectious bone defects.\n                  <\/jats:p>","DOI":"10.3389\/fbioe.2026.1935416","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:51:06Z","timestamp":1791352266000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural polysaccharide-engineered POP@ZIF-67 nanoparticles coordinate antibacterial activity, macrophage polarization, and osteogenesis for chronic osteomyelitis therapy"],"prefix":"10.3389","volume":"14","author":[{"given":"Yunchang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Medical Research Center for Trauma and Microsurgery","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Medical Research Center for Trauma and Microsurgery","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Medical Research Center for Trauma and Microsurgery","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yize","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Medical Research Center for Trauma and Microsurgery","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Medical Research Center for Trauma and Microsurgery","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Medical Research Center for Trauma and Microsurgery","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Medical Research Center for Trauma and Microsurgery","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Medical Research Center for Trauma and Microsurgery","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.actbio.2025.10.050","article-title":"Biomaterial surface-induced immunoglobulin G unfolding enhances phagocytosis of Staphylococcus aureus by macrophages","volume":"208","author":"Alemie","year":"2025","journal-title":"Acta Biomater."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro\u2013computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. 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