{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:55:25Z","timestamp":1790920525412,"version":"4.1.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>\n                    Electrospun nanofibrous dressings are attractive for wound-care applications in space-related healthcare; however, limited information is available on the stability of UV-C-treated, water-stabilized nanofiber mats after exposure to simulated microgravity and on their cytocompatibility after pre-use treatment. To address this gap, fully aqueous poly(vinyl alcohol) (PVA) and poly (vinyl alcohol)\/hyaluronic acid (PVA\/HA) electrospun mats were stabilized through citric acid-mediated ester crosslinking and evaluated after UV-C treatment followed by 48\u00a0h incubation under static or simulated microgravity conditions. Both x-PVA and x-PVA\/HA retained a continuous fibrous architecture without network collapse, although simulated microgravity was associated with formulation-dependent morphological remodeling. x-PVA showed a more pronounced increase in fiber diameter and a coarser network, whereas x-PVA\/HA exhibited a more moderate diameter increase while retaining a highly interconnected fibrous organization. Water vapor transmission rates of 2,552.6 \u00b1 66.7 and 2,492.6 \u00b1 21.6\u00a0g\u00a0m\n                    <jats:sup>\u22122<\/jats:sup>\n                    day\n                    <jats:sup>\u22121<\/jats:sup>\n                    were measured for x-PVA and x-PVA\/HA, respectively, indicating substantial vapor transport under the investigated conditions. FTIR-ATR analysis showed preservation of the characteristic bands of the ester-crosslinked PVA-based networks, without evidence of marked chemical degradation. DSC revealed treatment-dependent changes in thermal transitions, whereas simulated microgravity produced no pronounced additional shift compared with the corresponding static controls.\n                    <jats:italic>In vitro<\/jats:italic>\n                    assays performed on UV-C-treated x-PVA\/HA supported cytocompatibility across the tested cell models, including human keratinocytes. Overall, citric-acid-crosslinked x-PVA\/HA nanofibrous mats combined breathable vapor-regulating behavior with preserved fibrous architecture and physicochemical stability after UV-C treatment and short-term simulated microgravity exposure. Together with the observed\n                    <jats:italic>in vitro<\/jats:italic>\n                    cytocompatibility, these findings support their further investigation as wound-contact materials for space-related healthcare.\n                  <\/jats:p>","DOI":"10.3389\/fbioe.2026.1946755","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:35:53Z","timestamp":1790919353000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrospun poly(vinyl alcohol)\/hyaluronic acid nanofiber mats for wound care in space: cytocompatibility and effects of UV-C treatment and simulated microgravity"],"prefix":"10.3389","volume":"14","author":[{"given":"Gianluca","family":"Ciarleglio","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering Materials Environment, Sapienza University of Rome","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Di Pauli","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Forensic-Medicine and Orthopaedics, Sapienza University of Rome","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Berardini","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Forensic-Medicine and Orthopaedics, Sapienza University of Rome","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Campolo","sequence":"additional","affiliation":[{"name":"Unicamillus-Saint Camillus International, University of Health Sciences","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Catizone","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Forensic-Medicine and Orthopaedics, Sapienza University of Rome","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gabriella","family":"Santonicola","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Materials Environment, Sapienza University of Rome","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"95S","DOI":"10.1177\/10806032241310386","article-title":"Development of progressively earth-independent medical operations to enable NASA exploration missions","volume":"36","author":"Anderson","year":"2025","journal-title":"Wilderness Environ. 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