{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:34:13Z","timestamp":1792197253775,"version":"4.4.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Clin. Diabetes Healthc."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Diabetes is a major cause of disease burden with considerable public health significance. While the pancreas plays a significant role in glucose homeostasis, the association between pancreatitis and new onset diabetes is not well understood. The purpose of this study was to examine that association using large real-world data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Utilizing the IBM<jats:sup>\u00ae<\/jats:sup> MarketScan<jats:sup>\u00ae<\/jats:sup> commercial claims database from 2016 to 2019, pancreatitis and diabetes regardless of diagnostic category, were identified using <jats:italic>International Classification of Diseases, Tenth Revision<\/jats:italic> [<jats:italic>ICD-10<\/jats:italic>] codes. We then performed descriptive analyses characterizing non-pancreatitis (NP), acute pancreatitis (AP), and chronic pancreatitis (CP) cohort subjects. Stratified Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CI) of diabetes across the three clinical categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 310,962 individuals were included in the analysis. During 503,274 person\u2010years of follow\u2010up, we identified 15,951 incident diabetes cases. While men and women had higher incidence rates of CP and AP-related diabetes, the rates were significantly greater in men and highest among individuals with CP (91.6 per 1000 persons-years (PY)) followed by AP (75.9 per 1000-PY) as compared to those with NP (27.8 per 1000-PY). After adjustment for diabetes risk factors, relative to the NP group, the HR for future diabetes was 2.59 (95% CI: 2.45-2.74) (P&amp;lt;0.001) for the CP group, and 2.39 (95% CI: 2.30-2.48) (P&amp;lt;0.001) for the AP group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pancreatitis was associated with a high risk of diabetes independent of demographic, lifestyle, and comorbid conditions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcdhc.2023.1326239","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:23:09Z","timestamp":1704774189000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of pancreatitis with risk of diabetes: analysis of real-world data"],"prefix":"10.3389","volume":"4","author":[{"given":"Djibril M.","family":"Ba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon M.","family":"Chinchilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Cozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana R.","family":"Pichardo-Lowden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.068","article-title":"The epidemiology of pancreatitis and pancreatic cancer","volume":"144","author":"Yadav","year":"2013","journal-title":"Gastroenterology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1053\/j.gastro.2018.08.063","article-title":"Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018","volume":"156","author":"Peery","year":"2019","journal-title":"Gastroenterology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3180cac24b","article-title":"Direct medical costs of acute pancreatitis hospitalizations in the United States","volume":"35","author":"Fagenholz","year":"2007","journal-title":"Pancreas"},{"key":"B4","unstructured":"National diabetes statistics report"},{"key":"B5","unstructured":"National diabetes statistics report2022"},{"key":"B6","unstructured":"National diabetes statistics report2020"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S002","article-title":"2. 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