{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:17:11Z","timestamp":1788437831494,"version":"build-2803163510"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Clin. Diabetes Healthc."],"abstract":"<jats:p>\n                    Diabetic foot ulcer (DFU), a common diabetic complication driven by impaired angiogenesis, neuropathy and metabolic disorders, has complex pathogenesis and poses great challenges to clinical management. Single-cell RNA sequencing (scRNA-seq), an emerging transcriptomic technique, allows disease profiling at single-cell resolution. This review summarizes recent advances in scRNA-seq-based DFU research, revealing that JMJD3-mediated macrophage polarization failure and dysregulated IGF-1-SP1-CD248 pathway hinder wound repair, with\n                    <jats:italic>MMP1, MMP3, MMP11<\/jats:italic>\n                    , JMJD3 and\n                    <jats:italic>HIF1A<\/jats:italic>\n                    identified as valuable biomarkers and therapeutic targets. It highlights scRNA-seq\u2019s utility in unraveling pathogenic mechanisms, discovering therapeutic targets and biomarkers, and facilitating precision medicine, to provide new insights and research directions for DFU therapy.\n                  <\/jats:p>","DOI":"10.3389\/fcdhc.2026.1833678","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:53:50Z","timestamp":1788436430000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-cell RNA sequencing in diabetic foot ulcers: pathogenesis, biomarkers, and translational potential"],"prefix":"10.3389","volume":"7","author":[{"given":"Shuhan","family":"Yang","sequence":"first","affiliation":[{"name":"Emergency Department of the Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, 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