{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:53:35Z","timestamp":1789275215152,"version":"build-2803163510"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2018.00073","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T14:55:52Z","timestamp":1531148152000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Lamin A, Chromatin and FPLD2: Not Just a Peripheral M\u00e9nage-\u00e0-Trois"],"prefix":"10.3389","volume":"6","author":[{"given":"Nolwenn","family":"Briand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inswasti","family":"Cahyani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Madsen-\u00d8sterbye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torunn","family":"R\u00f8nningen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita L.","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Collas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nmeth.4533","article-title":"Biotinylation by antibody recognition-a method for proximity labeling","volume":"15","author":"Bar","year":"2018","journal-title":"Nat. Methods"},{"key":"B2","doi-asserted-by":"publisher","first-page":"118","DOI":"10.15252\/embr.201744201","article-title":"BRACHYURY directs histone acetylation to target loci during mesoderm development","volume":"19","author":"Beisaw","year":"2018","journal-title":"EMBO Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1161\/ATVBAHA.113.301933","article-title":"Lipodystrophy-linked LMNA p.R482W mutation induces clinical early atherosclerosis and in vitro endothelial dysfunction","volume":"33","author":"Bidault","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1093\/hmg\/ddy055","article-title":"The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T\/Brachyury and early vascular differentiation gene networks","volume":"27","author":"Briand","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"8044","DOI":"10.1038\/ncomms9044","article-title":"Loss of lamin A function increases chromatin dynamics in the nuclear interior","volume":"6","author":"Bronshtein","year":"2015","journal-title":"Nat. Commun."},{"key":"B6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrm3488","article-title":"The nuclear lamins: flexibility in function","volume":"14","author":"Burke","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/hmg\/9.1.109","article-title":"Nuclear lamin A\/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy","volume":"9","author":"Cao","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1083\/jcb.201504035","article-title":"Lamin A\/C sustains PcG protein architecture, maintaining transcriptional repression at target genes","volume":"211","author":"Cesarini","year":"2015","journal-title":"J. Cell Biol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.1210\/jc.2007-0654","article-title":"New metabolic phenotypes in laminopathies: LMNA mutations in patients with severe metabolic syndrome","volume":"92","author":"Decaudain","year":"2007","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"B10","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1080\/19491034.2016.1183848","article-title":"The nuclear lamina in health and disease","volume":"7","author":"Dobrzynska","year":"2016","journal-title":"Nucleus"},{"key":"B11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1083\/jcb.136.3.531","article-title":"Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope","volume":"136","author":"Fricker","year":"1997","journal-title":"J. Cell Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.15252\/embj.201796717","article-title":"Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis","volume":"36","author":"Garc\u00eda-Nieto","year":"2017","journal-title":"EMBO J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1210\/jcem.85.5.6605","article-title":"Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety)","volume":"85","author":"Garg","year":"2000","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"B14","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1242\/dev.024703","article-title":"Identification of direct T-box target genes in the developing zebrafish mesoderm","volume":"136","author":"Garnett","year":"2009","journal-title":"Development"},{"key":"B15","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1101\/gr.196220.115","article-title":"A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha","volume":"26","author":"Gesson","year":"2016","journal-title":"Genome Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1038\/nature06947","article-title":"Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions","volume":"453","author":"Guelen","year":"2008","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.semcdb.2013.12.015","article-title":"Nuclear envelope-related lipodystrophies","volume":"29","author":"Guenantin","year":"2014","journal-title":"Semin. Cell Dev. Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1101\/gr.10.5.652","article-title":"Association between nuclear lamin A\/C R482Q mutation and partial lipodystrophy with hyperinsulinemia, dyslipidemia, hypertension, and diabetes","volume":"10","author":"Hegele","year":"2000","journal-title":"Genome Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1161\/01.CIR.103.18.2225","article-title":"Premature atherosclerosis associated with monogenic insulin resistance","volume":"103","author":"Hegele","year":"2001","journal-title":"Circulation"},{"key":"B20","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.cell.2015.08.040","article-title":"Genome-wide maps of nuclear lamina interactions in single human cells","volume":"163","author":"Kind","year":"2015","journal-title":"Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.cell.2013.02.028","article-title":"Single-cell dynamics of genome-nuclear lamina interactions","volume":"153","author":"Kind","year":"2013","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"425","DOI":"10.4161\/nucl.2.5.17765","article-title":"Lamin A and lamin C form homodimers and coexist in higher complex forms both in the nucleoplasmic fraction and in the lamina of cultured human cells","volume":"2","author":"Kolb","year":"2011","journal-title":"Nucleus"},{"key":"B23","doi-asserted-by":"publisher","first-page":"513","DOI":"10.4161\/nucl.1.6.13512","article-title":"Identification of differential protein interactors of lamin A and progerin","volume":"1","author":"Kubben","year":"2010","journal-title":"Nucleus"},{"key":"B24","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1194\/jlr.M071381","article-title":"Extracellular Matrix Remodeling and Transforming Growth Factor-beta Signaling Abnormalities Induced by Lamin A\/C Variants that Cause Lipodystrophy","volume":"58","author":"Le Dour","year":"2017","journal-title":"J. Lipid Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s13059-017-1264-5","article-title":"The three-dimensional genome organization of Drosophila melanogaster through data integration","volume":"18","author":"Li","year":"2017","journal-title":"Genome Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1101\/gr.159400.113","article-title":"Lamin A\/C-promoter interactions specify chromatin state-dependent transcription outcomes","volume":"23","author":"Lund","year":"2013","journal-title":"Genome Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"30","DOI":"10.4161\/19491034.2014.990855","article-title":"Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin","volume":"6","author":"Lund","year":"2015","journal-title":"Nucleus"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e92","DOI":"10.1093\/nar\/gku324","article-title":"Enriched Domain Detector: a program for detection of wide genomic enrichment domains robust against local variations","volume":"42","author":"Lund","year":"2014","journal-title":"Nucleic Acids Re."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1242\/jcs.046284","article-title":"Lamin B1 maintains the functional plasticity of nucleoli","volume":"122","author":"Martin","year":"2009","journal-title":"J. Cell Sci"},{"key":"B30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1080\/19491034.2016.1157675","article-title":"Nucleoplasmic Lamin A\/C and Polycomb group of proteins: an evolutionarily conserved interplay","volume":"7","author":"Marullo","year":"2016","journal-title":"Nucleus"},{"key":"B31","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1101\/gr.141028.112","article-title":"Constitutive nuclear lamina-genome interactions are highly conserved and associated with A\/T-rich sequence","volume":"23","author":"Meuleman","year":"2013","journal-title":"Genome Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e1000889","DOI":"10.1371\/journal.pgen.1000889","article-title":"Initial genomics of the human nucleolus","volume":"6","author":"N\u00e9meth","year":"2010","journal-title":"PLoS Genet."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1083\/jcb.201701043","article-title":"A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus","volume":"216","author":"Oldenburg","year":"2017","journal-title":"J. Cell Biol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/hmg\/ddt509","article-title":"Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A p.R482W mutation elicits a myogenic gene expression program in preadipocytes","volume":"23","author":"Oldenburg","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1038\/nprot.2018.009","article-title":"Computational 3D genome modeling using Chrom3D","volume":"13","author":"Paulsen","year":"2018","journal-title":"Nat. Protoc"},{"key":"B36","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13059-016-1146-2","article-title":"Chrom3D: three-dimensional genome modeling from Hi-C and lamin-genome contacts","volume":"18","author":"Paulsen","year":"2017","journal-title":"Genome Biol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"335r","DOI":"10.1126\/scitranslmed.aad4991","article-title":"Laminopathies disrupt epigenomic developmental programs and cell fate","volume":"8","author":"Perovanovic","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nature06727","article-title":"Transcriptional repression mediated by repositioning of genes to the nuclear lamina","volume":"452","author":"Reddy","year":"2008","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1101\/gr.193748.115","article-title":"Prepatterning of differentiation-driven nuclear lamin A\/C-associated chromatin domains by GlcNAcylated histone H2B","volume":"25","author":"R\u00f8nningen","year":"2015","journal-title":"Genome Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.cell.2015.07.035","article-title":"Identification of gene positioning factors using high-throughput imaging mapping","volume":"162","author":"Shachar","year":"2015","journal-title":"Cell"},{"key":"B41","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/72807","article-title":"LMNA, encoding lamin A\/C, is mutated in partial lipodystrophy","volume":"24","author":"Shackleton","year":"2000","journal-title":"Nat. Genet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.cell.2013.01.009","article-title":"LBR and lamin A\/C sequentially tether peripheral heterochromatin and inversely regulate differentiation","volume":"152","author":"Solovei","year":"2013","journal-title":"Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"4819","DOI":"10.1021\/bi020704g","article-title":"The carboxyl-terminal region common to lamins A and C contains a DNA binding domain","volume":"42","author":"Stierle","year":"2003","journal-title":"Biochem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12915-014-0063-7","article-title":"Brachyury cooperates with Wnt\/beta-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells","volume":"12","author":"Turner","year":"2014","journal-title":"BMC Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1093\/hmg\/ddu728","article-title":"The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy","volume":"24","author":"Vadrot","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3735","DOI":"10.1091\/mbc.e10-06-0508","article-title":"High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli","volume":"21","author":"van Koningsbruggen","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.cell.2017.04.022","article-title":"Lamina-associated domains: links with chromosome architecture, heterochromatin, and gene repression","volume":"169","author":"van Steensel","year":"2017","journal-title":"Cell"},{"key":"B48","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1242\/jcs.114.24.4459","article-title":"Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q\/W mutations in the lamin A\/C gene","volume":"114","author":"Vigouroux","year":"2001","journal-title":"J. Cell Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.biocel.2011.03.002","article-title":"Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity","volume":"43","author":"Vigouroux","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ceb.2015.06.003","article-title":"Nuclear membrane diversity: underlying tissue-specific pathologies in disease?","volume":"34","author":"Worman","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1016\/j.cell.2012.04.035","article-title":"DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina","volume":"149","author":"Zullo","year":"2012","journal-title":"Cell"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2018.00073\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T04:01:51Z","timestamp":1661572911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2018.00073\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,9]]},"references-count":51,"alternative-id":["10.3389\/fcell.2018.00073"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2018.00073","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,9]]},"article-number":"73"}}