{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T18:17:15Z","timestamp":1766600235349,"version":"3.41.2"},"reference-count":112,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2018.00115","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T04:17:22Z","timestamp":1537417042000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Genetic Models of Leukemia in Zebrafish"],"prefix":"10.3389","volume":"6","author":[{"given":"Jeremy T.","family":"Baeten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill L. O. de","family":"Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.devcel.2015.01.032","article-title":"A CRISPR\/Cas9 vector system for tissue-specific gene disruption in zebrafish.","volume":"32","author":"Ablain","year":"2015","journal-title":"Dev. Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1158\/0008-5472.CAN-14-3225","article-title":"Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance.","volume":"75","author":"Adorno-Cruz","year":"2015","journal-title":"Cancer Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1038\/leu.2013.132","article-title":"Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the Notch pathway.","volume":"27","author":"Alghisi","year":"2013","journal-title":"Leukemia"},{"key":"B4","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nature09650","article-title":"Genetic variegation of clonal architecture and propagating cells in leukaemia.","volume":"469","author":"Anderson","year":"2011","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0165-4608(01)00518-0","article-title":"The expression of ETV6\/CBFA2 (TEL\/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo.","volume":"130","author":"Andreasson","year":"2001","journal-title":"Cancer Genet. Cytogenet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/306277a0","article-title":"Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.","volume":"306","author":"Bartram","year":"1983","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/nprot.2010.170","article-title":"High-throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope.","volume":"6","author":"Blackburn","year":"2011","journal-title":"Nat. Protoc."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1038\/leu.2012.116","article-title":"Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.","volume":"26","author":"Blackburn","year":"2012","journal-title":"Leukemia"},{"key":"B9","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ccr.2014.01.032","article-title":"Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt\/mTORC1 pathway activation.","volume":"25","author":"Blackburn","year":"2014","journal-title":"Cancer Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1182\/blood-2009-02-207225","article-title":"Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.","volume":"115","author":"Bolli","year":"2010","journal-title":"Blood"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.3390\/cancers3022106","article-title":"Cancer stem cells and side population cells in breast cancer and metastasis.","volume":"3","author":"Britton","year":"2011","journal-title":"Cancers"},{"key":"B12","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/3049","article-title":"Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia.","volume":"20","author":"Brownlie","year":"1998","journal-title":"Nat. Genet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1016\/S0301-472X(02)00955-4","article-title":"Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators.","volume":"30","author":"Burns","year":"2002","journal-title":"Exp. Hematol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/sj.leu.2404546","article-title":"NOTCH1-induced T-cell leukemia in transgenic zebrafish.","volume":"21","author":"Chen","year":"2007","journal-title":"Leukemia"},{"key":"B15","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1146\/annurev.immunol.25.022106.141538","article-title":"Ontogeny of the hematopoietic system.","volume":"25","author":"Cumano","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.it.2007.01.006","article-title":"Is PU.1 a dosage-sensitive regulator of haemopoietic lineage commitment and leukaemogenesis?.","volume":"28","author":"Dakic","year":"2007","journal-title":"Trends Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1146\/annurev.genet.39.073003.095931","article-title":"Use of the zebrafish system to study primitive and definitive hematopoiesis.","volume":"39","author":"de Jong","year":"2005","journal-title":"Annu. Rev. Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"10713","DOI":"10.1073\/pnas.92.23.10713","article-title":"Intraembryonic hematopoietic cell migration during vertebrate development.","volume":"92","author":"Detrich","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exphem.2016.09.012","article-title":"Using zebrafish models of leukemia to streamline drug screening and discovery.","volume":"45","author":"Deveau","year":"2017","journal-title":"Exp. Hematol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1038\/leu.2015.126","article-title":"Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98\u2013HOXA9-induced myeloid disease.","volume":"29","author":"Deveau","year":"2015","journal-title":"Leukemia"},{"key":"B21","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature10738","article-title":"Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)92704-3","article-title":"Down\u2019s syndrome and leukemia.","volume":"300","author":"Evans","year":"1972","journal-title":"Lancet"},{"key":"B23","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1365-2141.2007.06625.x","article-title":"Heat-shock induction of T-cell lymphoma\/leukaemia in conditional Cre\/lox-regulated transgenic zebrafish.","volume":"138","author":"Feng","year":"2007","journal-title":"Br. J. Haematol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ccr.2010.09.009","article-title":"T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.","volume":"18","author":"Feng","year":"2010","journal-title":"Cancer Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1365-2141.2011.08810.x","article-title":"NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis.","volume":"155","author":"Forrester","year":"2011","journal-title":"Br. J. Haematol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1038\/leu.2009.116","article-title":"Heritable T-cell malignancy models established in a zebrafish phenotypic screen.","volume":"23","author":"Frazer","year":"2009","journal-title":"Leukemia"},{"key":"B27","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/ajh.24253","article-title":"Myelodysplastic syndromes: contemporary review and how we treat.","volume":"91","author":"Gangat","year":"2016","journal-title":"Am. J. Hematol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0130-0","article-title":"Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia.","author":"Garcia","year":"2018","journal-title":"Leukemia"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","article-title":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.","volume":"388","year":"2016","journal-title":"Lancet"},{"key":"B30","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1128\/MCB.00971-14","article-title":"A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.","volume":"35","author":"Gjini","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1084\/jem.183.4.1797","article-title":"Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.","volume":"183","author":"Goodell","year":"1996","journal-title":"J. Exp. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"6247","DOI":"10.1182\/blood-2011-07-328880","article-title":"NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights.","volume":"118","author":"Gough","year":"2011","journal-title":"Blood"},{"key":"B33","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0091-679X(04)77021-1","article-title":"Highly efficient zebrafish transgenesis mediated by the meganuclease I-SceI.","volume":"77","author":"Grabher","year":"2004","journal-title":"Methods Cell Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1084\/jem.20101691","article-title":"Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.","volume":"208","author":"Gutierrez","year":"2011","journal-title":"J. Exp. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1182\/blood-2009-02-206722","article-title":"High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.","volume":"114","author":"Gutierrez","year":"2009","journal-title":"Blood"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/srep19634","article-title":"Stable multilineage xenogeneic replacement of definitive hematopoiesis in adult zebrafish.","volume":"6","author":"Hess","year":"2016","journal-title":"Sci. Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/leu.2013.236","article-title":"Integration of cytogenetic and molecular alterations in risk stratification of 318 patients with de novo non-M3 acute myeloid leukemia.","volume":"28","author":"Hou","year":"2013","journal-title":"Leukemia"},{"key":"B38","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome.","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1242\/dev.099085","article-title":"Efficient CRISPR\/Cas9 genome editing with low off-target effects in zebrafish.","volume":"140","author":"Hruscha","year":"2013","journal-title":"Development"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1182\/blood-2003-09-3105","article-title":"The pu.1 promoter drives myeloid gene expression in zebrafish.","volume":"104","author":"Hsu","year":"2004","journal-title":"Blood"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605626","article-title":"Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant.","volume":"102","author":"Hu","year":"2010","journal-title":"Br. J. Cancer"},{"key":"B42","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nbt.2501","article-title":"Efficient genome editing in zebrafish using a CRISPR-Cas system.","volume":"31","author":"Hwang","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"5208","DOI":"10.1182\/blood-2007-01-069005","article-title":"Migratory path of definitive hematopoietic stem\/progenitor cells during zebrafish development.","volume":"109","author":"Jin","year":"2007","journal-title":"Blood"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad2197","article-title":"A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.","volume":"351","author":"Kaufman","year":"2016","journal-title":"Science"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3242","DOI":"10.1242\/dev.082586","article-title":"Multilayer mounting enables long-term imaging of zebrafish development in a light sheet microscope.","volume":"139","author":"Kaufmann","year":"2012","journal-title":"Development"},{"key":"B46","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish.","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1182\/blood-2007-08-104299","article-title":"Characterization and localization of side population (SP) cells in zebrafish kidney hematopoietic tissue.","volume":"111","author":"Kobayashi","year":"2008","journal-title":"Blood"},{"key":"B48","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1093\/emboj\/20.3.350","article-title":"NUP98\u2013HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice.","volume":"20","author":"Kroon","year":"2001","journal-title":"EMBO J."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3577","DOI":"10.1182\/blood-2014-06-578856","article-title":"Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations.","volume":"124","author":"La Starza","year":"2014","journal-title":"Blood"},{"key":"B50","doi-asserted-by":"publisher","first-page":"6068","DOI":"10.1073\/pnas.0408708102","article-title":"Cre\/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.","volume":"102","author":"Langenau","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B51","doi-asserted-by":"publisher","first-page":"7369","DOI":"10.1073\/pnas.0402248101","article-title":"In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.","volume":"101","author":"Langenau","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B52","doi-asserted-by":"publisher","first-page":"4242","DOI":"10.1038\/onc.2008.56","article-title":"Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish.","volume":"27","author":"Langenau","year":"2008","journal-title":"Oncogene"},{"key":"B53","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1126\/science.1080280","article-title":"Myc-induced T cell leukemia in transgenic zebrafish.","volume":"299","author":"Langenau","year":"2003","journal-title":"Science"},{"key":"B54","doi-asserted-by":"publisher","first-page":"9410","DOI":"10.1073\/pnas.0611302104","article-title":"Heat shock-inducible Cre\/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish.","volume":"104","author":"Le","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B55","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1101\/gad.12.5.621","article-title":"SCL\/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in?zebrafish.","volume":"12","author":"Liao","year":"1998","journal-title":"Genes Dev."},{"key":"B56","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1006\/dbio.2002.0657","article-title":"Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning.","volume":"246","author":"Lieschke","year":"2002","journal-title":"Dev. Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/leu.2016.170","article-title":"c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish.","volume":"31","author":"Liu","year":"2017","journal-title":"Leukemia"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1038\/leu.2016.132","article-title":"Overexpression of FLT3-ITD driven by spi-1 results in expanded myelopoiesis with leukemic phenotype in zebrafish.","volume":"30","author":"Lu","year":"2016","journal-title":"Leukemia"},{"key":"B59","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nrm1660","article-title":"Autophagy in metazoans: cell survival in the land of plenty.","volume":"6","author":"Lum","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1182\/blood.V97.9.2611","article-title":"A novel myeloid-restricted zebrafish CCAAT\/enhancer-binding protein with a potent transcriptional activation domain.","volume":"97","author":"Lyons","year":"2001","journal-title":"Blood"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1038\/leu.2010.206","article-title":"A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos.","volume":"24","author":"Ma","year":"2010","journal-title":"Leukemia"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","article-title":"Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets.","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"key":"B63","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.1158\/0008-5472.Can-05-3800","article-title":"Transplantable tumor lines generated in clonal zebrafish.","volume":"66","author":"Mizgireuv","year":"2006","journal-title":"Cancer Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"895","DOI":"10.4161\/cbt.9.11.11667","article-title":"A new zebrafish model for experimental leukemia therapy.","volume":"9","author":"Mizgirev","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"B65","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1084\/jem.20152013","article-title":"Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish.","volume":"213","author":"Moore","year":"2016","journal-title":"J. Exp. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1182\/blood.V100.3.998","article-title":"Heterozygous PU.1 mutations are associated with acute myeloid leukemia.","volume":"100","author":"Mueller","year":"2002","journal-title":"Blood"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1126\/science.1164266","article-title":"Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.","volume":"322","author":"Mullighan","year":"2008","journal-title":"Science"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/nature05883","article-title":"Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.","volume":"447","author":"North","year":"2007","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nature09733","article-title":"Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.","volume":"469","author":"Notta","year":"2011","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-4614-0106-3_15","article-title":"\u201cZebrafish: model for the study of inflammation and the innate immune response to infectious diseases,\u201d in","author":"Novoa","year":"2012","journal-title":"Current Topics in Innate Immunity II"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/nprot.2006.208","article-title":"High-throughput transgenesis in Xenopus using I-SceI meganuclease.","volume":"1","author":"Ogino","year":"2006","journal-title":"Nat. Protoc."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.3324\/haematol.2012.064659","article-title":"Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafish.","volume":"97","author":"Onnebo","year":"2012","journal-title":"Haematologica"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1387\/ijdb.093042ep","article-title":"Hematopoietic development in the zebrafish.","volume":"54","author":"Paik","year":"2010","journal-title":"Int. J. Dev. Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/S0301-472X(01)00669-5","article-title":"Yolk-sac hematopoiesis: the first blood cells of mouse and man.","volume":"29","author":"Palis","year":"2001","journal-title":"Exp. Hematol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"965","DOI":"10.4161\/cc.7.8.5753","article-title":"The role of the PTEN\/AKT Pathway in NOTCH1-induced leukemia.","volume":"7","author":"Palomero","year":"2008","journal-title":"Cell Cycle"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.exphem.2007.06.002","article-title":"The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.","volume":"35","author":"Pearce","year":"2007","journal-title":"Exp. Hematol."},{"key":"B77","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1182\/blood.V90.7.2535","article-title":"Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9; 12) in a lymphoid and t(9; 15; 12) in a myeloid leukemia.","volume":"90","author":"Peeters","year":"1997","journal-title":"Blood"},{"key":"B78","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1038\/leu.2015.154","article-title":"A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease.","volume":"29","author":"Peng","year":"2015","journal-title":"Leukemia"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1002\/stem.186","article-title":"Dual SP\/ALDH functionalities refine the human hematopoietic Lin-CD34+CD38- stem\/progenitor cell compartment.","volume":"27","author":"Pierre-Louis","year":"2009","journal-title":"Stem Cells"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3791\/55711","article-title":"Isolation of the side population in myc-induced T-cell acute lymphoblastic leukemia in zebrafish.","volume":"123","author":"Pruitt","year":"2017","journal-title":"J. Vis. Exp."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020237","article-title":"The zebrafish moonshine gene encodes transcriptional intermediary factor 1\u03b3, an essential regulator of hematopoiesis.","volume":"2","author":"Ransom","year":"2004","journal-title":"PLoS Biol."},{"key":"B82","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1242\/dev.123.1.311","article-title":"Characterization of zebrafish mutants with defects in embryonic hematopoiesis.","volume":"123","author":"Ransom","year":"1996","journal-title":"Development"},{"key":"B83","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1242\/dmm.007138","article-title":"A model 450 million years in the making: zebrafish and vertebrate immunity.","volume":"5","author":"Renshaw","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1038\/leu.2014.78","article-title":"Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.","volume":"28","author":"Reynolds","year":"2014","journal-title":"Leukemia"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/517237","article-title":"Side population cells as prototype of chemoresistant, tumor-initiating cells.","volume":"2013","author":"Richard","year":"2013","journal-title":"Biomed Res. Int."},{"key":"B86","doi-asserted-by":"publisher","first-page":"5621","DOI":"10.1182\/blood-2011-12-398818","article-title":"Zebrafish screen identifies novel compound with selective toxicity against leukemia.","volume":"119","author":"Ridges","year":"2012","journal-title":"Blood"},{"key":"B87","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1182\/blood.V86.11.4263.bloodjournal86114263","article-title":"High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.","volume":"86","author":"Romana","year":"1995","journal-title":"Blood"},{"key":"B88","doi-asserted-by":"publisher","first-page":"15166","DOI":"10.1073\/pnas.0603349103","article-title":"TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia.","volume":"103","author":"Sabaawy","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059070","article-title":"MYCN transgenic zebrafish model with the characterization of acute myeloid leukemia and altered hematopoiesis.","volume":"8","author":"Shen","year":"2013","journal-title":"PLoS One"},{"key":"B90","doi-asserted-by":"publisher","first-page":"3296","DOI":"10.1182\/blood-2009-10-246488","article-title":"High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia.","volume":"115","author":"Smith","year":"2010","journal-title":"Blood"},{"key":"B91","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.ymeth.2006.04.012","article-title":"Methods for reverse genetic screening in zebrafish by resequencing and TILLING.","volume":"39","author":"Sood","year":"2006","journal-title":"Methods"},{"key":"B92","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1034\/j.1600-065X.2000.17712.x","article-title":"Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines.","volume":"177","author":"Sotsios","year":"2000","journal-title":"Immunol. Rev."},{"key":"B93","doi-asserted-by":"publisher","first-page":"9118","DOI":"10.1073\/pnas.96.16.9118","article-title":"Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity.","volume":"96","author":"Storms","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B94","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1242\/dev.103.2.403","article-title":"Replication, integration and stable germ-line transmission of foreign sequences injected into early zebrafish embryos.","volume":"103","author":"Stuart","year":"1988","journal-title":"Development"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1038\/leu.2013.67","article-title":"Suppression of Pu.1 function results in expanded myelopoiesis in zebrafish.","volume":"27","author":"Sun","year":"2013","journal-title":"Leukemia"},{"key":"B96","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1756-8722-4-13","article-title":"Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications.","volume":"4","author":"Takahashi","year":"2011","journal-title":"J. Hematol. Oncol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/nmeth.3031","article-title":"Optimized cell transplantation using adult rag2 mutant zebrafish.","volume":"11","author":"Tang","year":"2014","journal-title":"Nat. Methods"},{"key":"B98","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1006\/dbio.1998.8887","article-title":"Theclocheandspadetailgenes differentially affect hematopoiesis and vasculogenesis.","volume":"197","author":"Thompson","year":"1998","journal-title":"Dev. Biol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1038\/leu.2016.98","article-title":"CREB engages C\/EBPdelta to initiate leukemogenesis.","volume":"30","author":"Tregnago","year":"2016","journal-title":"Leukemia"},{"key":"B100","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1534\/genetics.106.060244","article-title":"Functional dissection of the Tol2 transposable element identified the minimal cis sequence and a highly repetitive sequence in the subterminal region essential for transposition.","volume":"174","author":"Urasaki","year":"2006","journal-title":"Genetics"},{"key":"B101","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/genetics\/103.1.125","article-title":"Induction of mutations by \u03b3-rays in pregonial germ cells of zebrafish embryos.","volume":"103","author":"Walker","year":"1983","journal-title":"Genetics"},{"key":"B102","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/3041","article-title":"A zebrafish model for hepatoerythropoietic porphyria.","volume":"20","author":"Wang","year":"1998","journal-title":"Nat. Genet."},{"key":"B103","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1242\/dev.122.1.271","article-title":"Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos.","volume":"122","author":"Weinberg","year":"1996","journal-title":"Development"},{"key":"B104","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"B105","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.stem.2007.11.002","article-title":"Transparent adult zebrafish as a tool for in vivo transplantation analysis.","volume":"2","author":"White","year":"2008","journal-title":"Cell Stem Cell"},{"key":"B106","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s002510050221","article-title":"Characterization and expression of the recombination activating genes (rag1 and rag2) of zebrafish.","volume":"45","author":"Willett","year":"1997","journal-title":"Immunogenetics"},{"key":"B107","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1002\/dvdy.1223","article-title":"Ikaros expression as a marker for lymphoid progenitors during zebrafish development.","volume":"222","author":"Willett","year":"2001","journal-title":"Dev. Dyn."},{"key":"B108","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1242\/dev.008904","article-title":"AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression.","volume":"135","author":"Yeh","year":"2008","journal-title":"Development"},{"key":"B109","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/nchembio.147","article-title":"Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation.","volume":"5","author":"Yeh","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1158\/0008-5472.CAN-15-1907","article-title":"Single-cell sequencing for precise cancer research: progress and prospects.","volume":"76","author":"Zhang","year":"2016","journal-title":"Cancer Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/leu.2017.189","article-title":"Irf8 regulates the progression of myeloproliferative neoplasm-like syndrome via Mertk signaling in zebrafish.","volume":"32","author":"Zhao","year":"2018","journal-title":"Leukemia"},{"key":"B112","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1365-2141.2008.07362.x","article-title":"MOZ\/TIF2-induced acute myeloid leukaemia in transgenic fish.","volume":"143","author":"Zhuravleva","year":"2008","journal-title":"Br. J. Haematol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2018.00115\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:06:58Z","timestamp":1662077218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2018.00115\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,20]]},"references-count":112,"alternative-id":["10.3389\/fcell.2018.00115"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2018.00115","relation":{},"ISSN":["2296-634X"],"issn-type":[{"type":"electronic","value":"2296-634X"}],"subject":[],"published":{"date-parts":[[2018,9,20]]},"article-number":"115"}}