{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T17:30:50Z","timestamp":1786815050046,"version":"build-2736575974"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2019.00161","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T15:12:31Z","timestamp":1566573151000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Long Non-coding RNA HOTTIP Promotes CCL3 Expression and Induces Cartilage Degradation by Sponging miR-455-3p"],"prefix":"10.3389","volume":"7","author":[{"given":"Guping","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziji","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function.","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-013-0353-z","article-title":"Epigenetic mechanisms and non-coding RNAs in osteoarthritis.","volume":"15","author":"Barter","year":"2013","journal-title":"Curr. Rheumatol. Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1002\/1529-0131(200008)43:8<1734::aid-anr9>3.0.co;2-b","article-title":"Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines.","volume":"43","author":"Borzi","year":"2000","journal-title":"Arthritis Rheum."},{"key":"B4","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s10067-009-1352-3","article-title":"Osteoarthritis: can anti-cytokine therapy play a role in treatment?","volume":"29","author":"Calich","year":"2010","journal-title":"Clin. Rheumatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.jbspin.2011.12.013","article-title":"Induction of the chemokine IL-8\/Kc by the articular cartilage: possible influence on osteoarthritis.","volume":"79","author":"Chauffier","year":"2012","journal-title":"Joint Bone Spine"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1016\/j.bbamcr.2016.09.010","article-title":"MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.","volume":"1863","author":"Chen","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.imlet.2005.03.012","article-title":"An essential role for CCL3 in the development of collagen antibody-induced arthritis.","volume":"100","author":"Chintalacharuvu","year":"2005","journal-title":"Immunol. Lett."},{"key":"B8","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.bone.2019.04.026","article-title":"HOXA cluster gene expression during osteoblast differentiation involves epigenetic control.","volume":"125","author":"Da","year":"2019","journal-title":"Bone"},{"key":"B9","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.joca.2014.12.001","article-title":"Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients.","volume":"23","author":"Fu","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"B10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/84209","article-title":"Chemokines and disease.","volume":"2","author":"Gerard","year":"2001","journal-title":"Nat. Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1002\/jcp.21258","article-title":"Osteoarthritis.","volume":"213","author":"Goldring","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","article-title":"Inflammation in osteoarthritis.","volume":"23","author":"Goldring","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1136\/ard.2004.020529","article-title":"Chemokines in joint disease: the key to inflammation?","volume":"63","author":"Haringman","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.bone.2015.05.026","article-title":"Non-coding RNAs: epigenetic regulators of bone development and homeostasis.","volume":"81","author":"Hassan","year":"2015","journal-title":"Bone"},{"key":"B15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1080\/03008207.2016.1194406","article-title":"Emerging roles for long noncoding RNAs in skeletal biology and disease.","volume":"58","author":"Huynh","year":"2017","journal-title":"Connect. Tissue Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1126\/science.1215157","article-title":"A stem cell-based approach to cartilage repair.","volume":"336","author":"Johnson","year":"2012","journal-title":"Science"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1016\/j.cellsig.2013.08.034","article-title":"Two non-coding RNAs, MicroRNA-101 and HOTTIP contribute cartilage integrity by epigenetic and homeotic regulation of integrin-alpha1.","volume":"25","author":"Kim","year":"2013","journal-title":"Cell. Signal."},{"key":"B18","doi-asserted-by":"publisher","first-page":"40294","DOI":"10.1074\/jbc.M110.126821","article-title":"Reactive oxygen species generated by NADPH oxidase 2 and 4 are required for chondrogenic differentiation.","volume":"285","author":"Kim","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1002\/art.38309","article-title":"Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis.","volume":"66","author":"Liu","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.joca.2016.11.006","article-title":"MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation.","volume":"25","author":"Mao","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"B21","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/art.11474","article-title":"A role for chemokines in the induction of chondrocyte phenotype modulation.","volume":"50","author":"Mazzetti","year":"2004","journal-title":"Arthritis Rheum."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1002\/jbm.a.34948","article-title":"Chondrogenic differentiation of ATDC5 and hMSCs could be induced by a novel scaffold-tricalcium phosphate-collagen-hyaluronan without any exogenous growth factors in vitro.","volume":"102","author":"Meng","year":"2014","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"B23","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.joca.2015.12.012","article-title":"MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1beta-induced chondrocyte responses.","volume":"24","author":"Meng","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"B24","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1302\/0301-620X.43B4.752","article-title":"The etiology of chondromalacia patellae.","author":"Outerbridge","year":"1961","journal-title":"J. Bone. Joint. Surg. Br."},{"key":"B25","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/art.39520","article-title":"Long intergenic noncoding RNAs mediate the human chondrocyte inflammatory response and are differentially expressed in Osteoarthritis Cartilage.","volume":"68","author":"Pearson","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.joca.2017.09.009","article-title":"Osteoarthritis year in review 2017: genetics and epigenetics.","volume":"26","author":"Peffers","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1016\/j.joca.2008.04.027","article-title":"Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta.","volume":"16","author":"Sandell","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"B28","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1002\/jor.23471","article-title":"Chemokines and inflammation in osteoarthritis: insights from patients and animal models.","volume":"35","author":"Scanzello","year":"2017","journal-title":"J. Orthop. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1002\/jor.22718","article-title":"A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis.","volume":"32","author":"Song","year":"2014","journal-title":"J. Orthop. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1007\/s00109-012-0895-y","article-title":"Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions.","volume":"90","author":"Steck","year":"2012","journal-title":"J. Mol. Med."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0565-2","article-title":"MiR-455-3p inhibits the degenerate process of chondrogenic differentiation through modification of DNA methylation.","volume":"9","author":"Sun","year":"2018","journal-title":"Cell Death Dis."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0113-5","article-title":"Long non-coding RNA HOTTIP promotes BCL-2 expression and induces chemoresistance in small cell lung cancer by sponging miR-216a.","volume":"9","author":"Sun","year":"2018","journal-title":"Cell Death Dis."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0729-1","article-title":"A long non-coding RNA HOTTIP expression is associated with disease progression and predicts outcome in small cell lung cancer patients.","volume":"16","author":"Sun","year":"2017","journal-title":"Mol. Cancer"},{"key":"B34","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.joca.2014.03.004","article-title":"The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics.","volume":"22","author":"Tonge","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"B35","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/s1063-4584(05)80088-3","article-title":"Induction of osteoarthritis by intra-articular injection of collagenase in mice. Strain and sex related differences.","volume":"1","author":"van Osch","year":"1993","journal-title":"Osteoarthr. Cartil."},{"key":"B36","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/os.12147","article-title":"Identification of long noncoding RNA associated with osteoarthritis in humans.","volume":"6","author":"Xing","year":"2014","journal-title":"Orthop. Surg."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1158\/1078-0432.CCR-16-0742","article-title":"A positive feedback loop of lncRNA-PVT1 and FOXM1 facilitates gastric cancer growth and invasion.","volume":"23","author":"Xu","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.tibs.2013","article-title":"Long noncoding RNAs: fresh perspectives into the RNA world.","volume":"39","author":"Yang","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"33092","DOI":"10.1074\/jbc.M110.130377","article-title":"CCAAT\/enhancer-binding protein beta and NF-kappaB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1beta.","volume":"285","author":"Zhang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.1016\/j.febslet.2015.09.032","article-title":"MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2.","volume":"589","author":"Zhang","year":"2015","journal-title":"FEBS Lett."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1016\/j.joca.2012.08.024","article-title":"Expression of microRNAs during chondrogenesis of human adipose-derived stem cells.","volume":"20","author":"Zhang","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.joca.2015.04.002","article-title":"CCL3 serves as a potential plasma biomarker in knee degeneration (osteoarthritis).","volume":"23","author":"Zhao","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1111\/jcmm.14068","article-title":"Long noncoding RNA HOTTIP mediates SRF expression through sponging miR-150 in hepatic stellate cells.","volume":"23","author":"Zheng","year":"2019","journal-title":"J. Cell Mol. Med."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2019.00161\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T15:12:34Z","timestamp":1566573154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2019.00161\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,23]]},"references-count":43,"alternative-id":["10.3389\/fcell.2019.00161"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2019.00161","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,23]]},"article-number":"161"}}