{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:18:33Z","timestamp":1790738313293,"version":"4.1.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2019.00330","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T07:18:43Z","timestamp":1575962323000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Distinct Roles of Zmynd17 and PGC1\u03b1 in Mitochondrial Quality Control and Biogenesis in Skeletal Muscle"],"prefix":"10.3389","volume":"7","author":[{"given":"Kiyoshi","family":"Yoshioka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Seko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Suematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cmet.2010.02.006","article-title":"Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.","volume":"11","author":"Cant\u00f3","year":"2010","journal-title":"Cell Metab."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.cmet.2016.05.007","article-title":"Exercise Promotes Healthy Aging of Skeletal Muscle.","volume":"23","author":"Cartee","year":"2016","journal-title":"Cell Metab."},{"key":"B3","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1113\/jphysiol.2005.092031","article-title":"Mitofusins 1\/2 and ERR\u03b1 expression are increased in human skeletal muscle after physical exercise.","volume":"567","author":"Cartoni","year":"2005","journal-title":"J. Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"S157","DOI":"10.2337\/dc09-S302","article-title":"Skeletal muscle Insulin Resistance is the Primary Defect in Type 2 Diabetes.","volume":"32","author":"DeFronzo","year":"2009","journal-title":"Diabetes Care"},{"key":"B5","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.bbagen.2009.08.007","article-title":"Response of mitochondrial fusion and fission protein gene expression to exercise in rat skeletal muscle.","volume":"1800","author":"Ding","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B6","doi-asserted-by":"publisher","first-page":"5012","DOI":"10.1096\/fj.201701264R","article-title":"Zmynd17 controls muscle mitochondrial quality and whole-body metabolism.","volume":"32","author":"Fujita","year":"2018","journal-title":"FASEB J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1038\/sj.emboj.7601633","article-title":"Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1\/PGC-1\u03b1.","volume":"26","author":"Gerhart-Hines","year":"2007","journal-title":"EMBO J."},{"key":"B8","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature07206","article-title":"The role of exercise and PGC1\u03b1 in inflammation and chronic disease.","volume":"454","author":"Handschin","year":"2008","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nrendo.2016.104","article-title":"Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus.","volume":"12","author":"Hesselink","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0047-6374(91)90131-I","article-title":"Skeletal muscle atrophy in old rats: Differential changes in the three fiber types.","volume":"60","author":"Holloszy","year":"1991","journal-title":"Mech. Ageing Dev."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003614","article-title":"AMP-activated protein kinase-regulated activation of the PGC-1\u03b1 promoter in skeletal muscle cells.","volume":"3","author":"Irrcher","year":"2008","journal-title":"PLoS One"},{"key":"B12","doi-asserted-by":"publisher","first-page":"5105","DOI":"10.1113\/JP270659","article-title":"Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle.","volume":"594","author":"Joseph","year":"2016","journal-title":"J. Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cmet.2007.10.013","article-title":"Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.","volume":"7","author":"Koves","year":"2008","journal-title":"Cell Metab."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00520-529","article-title":"Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy.","volume":"8","author":"Laker","year":"2017","journal-title":"Nat. Commun."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-018-0660-665","article-title":"Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression.","volume":"19","author":"Lin","year":"2018","journal-title":"BMC Genet."},{"key":"B16","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/nature00904","article-title":"Transcriptional co-activator PGC-1\u03b1 drives the formation of slow-twitch muscle fibres.","volume":"418","author":"Lin","year":"2002","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"6968","DOI":"10.1074\/jbc.M112.431155","article-title":"Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis.","volume":"288","author":"Menzies","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.2353\/ajpath.2006.060034","article-title":"Overexpression of peroxisome proliferator-activated receptor \u03b3 co-activator-1\u03b1 leads to muscle atrophy with depletion of ATP.","volume":"169","author":"Miura","year":"2006","journal-title":"Am. J. Pathol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3233\/JND-150119","article-title":"Mammalian Mss51 is a Skeletal Muscle-Specific Gene Modulating Cellular Metabolism.","volume":"2","author":"Moyer","year":"2015","journal-title":"J. Neuromuscul. Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1210\/en.2017-2439","article-title":"PGC1a promoter methylation and nucleosome repositioning: Insights into exercise and metabolic regulation in skeletal muscle.","volume":"158","author":"Narkar","year":"2017","journal-title":"Endocrinology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"C670","DOI":"10.1152\/ajpcell.00213.2006","article-title":"The mitochondrial energy transduction system and the aging process.","volume":"292","author":"Navarro","year":"2007","journal-title":"Am. J. Physiol. Physiol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-015-0035-39","article-title":"Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice.","volume":"5","author":"Paolini","year":"2015","journal-title":"Skelet. Muscle"},{"key":"B23","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1113\/jphysiol.2002.034850","article-title":"Exercise induces transient transcriptional activation of the PGC-1\u03b1 gene in human skeletal muscle.","volume":"546","author":"Pilegaard","year":"2003","journal-title":"J. Physiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cmet.2012.04.003","article-title":"SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function.","volume":"15","author":"Price","year":"2012","journal-title":"Cell Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s10522-004-7386-7387","article-title":"Exercise and hormesis: Oxidative stress-related adaptation for successful aging.","volume":"6","author":"Radak","year":"2005","journal-title":"Biogerontology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.bbagen.2013.11.016","article-title":"Skeletal muscle mitochondria: A major player in exercise, health and disease.","volume":"1840","author":"Russell","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B27","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1073\/pnas.1019581108","article-title":"Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice.","volume":"108","author":"Safdar","year":"","journal-title":"Proc. Natl. Acad. Sci.U.S.A."},{"key":"B28","doi-asserted-by":"publisher","first-page":"10605","DOI":"10.1074\/jbc.M110.211466","article-title":"Exercise increases mitochondrial PGC-1\u03b1 content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.","volume":"286","author":"Safdar","year":"","journal-title":"J. Biol. Chem."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-016-0075-79","article-title":"Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice.","volume":"6","author":"Safdar","year":"2016","journal-title":"Skelet. Muscle"},{"key":"B30","doi-asserted-by":"publisher","first-page":"16260","DOI":"10.1073\/pnas.0607795103","article-title":"PGC-1\u03b1 protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.","volume":"103","author":"Sandri","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.bone.2015.02.008","article-title":"Skeletal muscle as an endocrine organ: PGC-1 \u03b1, myokines and exercise.","volume":"80","author":"Schnyder","year":"2015","journal-title":"Bone"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1096\/fj.15-280933","article-title":"\u03bc-Crystallin controls muscle function through thyroid hormone action.","volume":"30","author":"Seko","year":"2016","journal-title":"FASEB J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1194\/jlr.M060533","article-title":"PGC-1\u03b1-mediated changes in phospholipid profiles of exercise-trained skeletal muscle.","volume":"56","author":"Senoo","year":"2015","journal-title":"J. Lipid Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"10771","DOI":"10.1073\/pnas.91.23.10771","article-title":"Oxidative damage and mitochondrial decay in aging.","volume":"91","author":"Shigenaga","year":"1994","journal-title":"Proc. Natl. Acad. Sci.U.S.A."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028290","article-title":"Skeletal muscle-specific expression of PGC-1\u03b1-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake.","volume":"6","author":"Tadaishi","year":"2011","journal-title":"PLoS One"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46929-46928","article-title":"Metabolomic Analysis of Skeletal Muscle in Aged Mice.","volume":"9","author":"Uchitomi","year":"2019","journal-title":"Sci. Rep."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-015-0033-y","article-title":"PGC-1\u03b1 modulates denervation-induced mitophagy in skeletal muscle.","volume":"5","author":"Vainshtein","year":"2015","journal-title":"Skelet. Muscle"},{"key":"B38","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cmet.2013.09.008","article-title":"Exercise Induces Hippocampal BDNF through a PGC-1\u03b1\/FNDC5 Pathway.","volume":"18","author":"Wrann","year":"2013","journal-title":"Cell Metab."},{"key":"B39","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2019.00330\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T07:18:44Z","timestamp":1575962324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2019.00330\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,10]]},"references-count":39,"alternative-id":["10.3389\/fcell.2019.00330"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2019.00330","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,10]]},"article-number":"330"}}