{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:26:49Z","timestamp":1790465209331,"version":"4.1.0"},"reference-count":149,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R03HD096176"],"award-info":[{"award-number":["R03HD096176"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD086839"],"award-info":[{"award-number":["R21HD086839"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2019.00341","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T04:15:04Z","timestamp":1576642504000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":50,"title":["Signaling Enzymes Required for Sperm Maturation and Fertilization in Mammals"],"prefix":"10.3389","volume":"7","author":[{"given":"Souvik","family":"Dey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Brothag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Vijayaraghavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3031","DOI":"10.1091\/mbc.11.9.3031","article-title":"The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative Calpha mRNA expressed specifically in spermatogenic cells.","volume":"11","author":"Agustin","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"B2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/mrd.22996","article-title":"Signaling pathways involved in human sperm hyperactivated motility stimulated by Zn(2).","volume":"85","author":"Allouche-Fitoussi","year":"2018","journal-title":"Mol. Reprod. Dev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.febslet.2011.03.025","article-title":"Selective loss of glycogen synthase kinase-3alpha in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation.","volume":"585","author":"Alon","year":"2011","journal-title":"FEBS Lett."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1242\/dev.136499","article-title":"The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm.","volume":"143","author":"Alvau","year":"2016","journal-title":"Development"},{"key":"B5","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1095\/biolreprod27.3.723","article-title":"Yield, characteristics, motility and cAMP content of sperm isolated from seven regions of ram epididymis.","volume":"27","author":"Amann","year":"1982","journal-title":"Biol. Reprod."},{"key":"B6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1387\/ijdb.072555ea","article-title":"Identification of proteins undergoing tyrosine phosphorylation during mouse sperm capacitation.","volume":"52","author":"Arcelay","year":"2008","journal-title":"Int. J. Dev. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3109\/19396368.2010.512377","article-title":"Factors regulating sperm capacitation.","volume":"56","author":"Bailey","year":"2010","journal-title":"Syst. Biol. Reprod. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1242\/jcs.03055","article-title":"Identification of SRC as a key PKA-stimulated tyrosine kinase involved in the capacitation-associated hyperactivation of murine spermatozoa.","author":"Baker","year":"2006","journal-title":"J. Cell Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ydbio.2009.06.022","article-title":"Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa, its implications during capacitation.","volume":"333","author":"Baker","year":"2009","journal-title":"Dev. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.mce.2017.11.008","article-title":"Shedding light on the role of cAMP in mammalian sperm physiology.","volume":"468","author":"Balbach","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"B11","article-title":"The mammalian spermatozoon: morphology, biochemistry and physiology","volume":"379","author":"Bedford","year":"1990","journal-title":"Marshall\u2019s Physiology of Reproduction"},{"key":"B12","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/biolre\/ioy020","article-title":"Isoform-specific requirement for GSK3 alpha in sperm for male fertility.","volume":"99","author":"Bhattacharjee","year":"2018","journal-title":"Biol. Reprod."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.124495","article-title":"Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility.","volume":"92","author":"Bhattacharjee","year":"2015","journal-title":"Biol. Reprod."},{"key":"B14","doi-asserted-by":"publisher","first-page":"5276","DOI":"10.1002\/jcp.27337","article-title":"Tyrosine phosphorylation signaling regulates Ca(2+) entry by affecting intracellular pH during human sperm capacitation.","volume":"234","author":"Brukman","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1016\/j.bbadis.2014.07.013","article-title":"Central role of soluble adenylyl cyclase and cAMP in sperm physiology.","author":"Buffone","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1152\/physiol.00034.2006","article-title":"PKA, germ cells, and fertility.","volume":"22","author":"Burton","year":"2007","journal-title":"Physiology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"14864","DOI":"10.1073\/pnas.2536658100","article-title":"CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.","volume":"100","author":"Carlson","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B18","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1095\/biolreprod41.5.907","article-title":"Intracellular pH regulates bovine sperm motility and protein phosphorylation1.","volume":"41","author":"Carr","year":"2005","journal-title":"Biol. Reprod."},{"key":"B19","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1095\/biolreprod33.3.588","article-title":"Effects of pH, lactate, and viscoelastic drag on sperm motility: a species comparison.","volume":"33","author":"Carr","year":"1985","journal-title":"Biol. Reprod."},{"key":"B20","doi-asserted-by":"publisher","first-page":"26269","DOI":"10.1074\/jbc.M109.095752","article-title":"Calcineurin-mediated dephosphorylation of synaptotagmin VI is necessary for acrosomal exocytosis.","volume":"285","author":"Castillo Bennett","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1745-7262.2007.00307.x","article-title":"Protein phosphatase PP1 gamma 2 in sperm morphogenesis and epididymal initiation of sperm motility.","volume":"9","author":"Chakrabarti","year":"","journal-title":"Asian J. Androl."},{"key":"B22","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1095\/biolreprod.106.058610","article-title":"Analysis of Ppp1cc-null mice suggests a role for PP1gamma2 in sperm morphogenesis.","volume":"76","author":"Chakrabarti","year":"","journal-title":"Biol. Reprod."},{"key":"B23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1095\/biolreprod.110.089789","article-title":"Two distinct Ca(2+) signaling pathways modulate sperm flagellar beating patterns in mice.","volume":"85","author":"Chang","year":"2011","journal-title":"Biol. Reprod."},{"key":"B24","doi-asserted-by":"publisher","first-page":"32266","DOI":"10.1074\/jbc.M114.607556","article-title":"SLO3 K+ channels control calcium entry through CATSPER channels in sperm.","volume":"289","author":"Chavez","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1095\/biolreprod.108.068528","article-title":"Cl- is required for HCO3- entry necessary for sperm capacitation in guinea pig: involvement of a Cl-\/HCO3- exchanger (SLC26A3) and CFTR.","volume":"80","author":"Chen","year":"2009","journal-title":"Biol. Reprod."},{"key":"B26","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/nrurol.2012.167","article-title":"Testicular and epididymal ADAMs: expression and function during fertilization.","volume":"9","author":"Cho","year":"2012","journal-title":"Nat. Rev. Urol."},{"key":"B27","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms1153","article-title":"A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.","volume":"2","author":"Chung","year":"2011","journal-title":"Nat. Commun."},{"key":"B28","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.cell.2014.02.056","article-title":"Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility.","volume":"157","author":"Chung","year":"2014","journal-title":"Cell"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1007\/s12035-017-0434-5","article-title":"Expression of a novel ciliary protein, IIIG9, during the differentiation and maturation of ependymal cells.","volume":"55","author":"Cifuentes","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B30","first-page":"230","article-title":"The structure and regulation of protein phosphatases.","volume":"24","author":"Cohen","year":"1990","journal-title":"Adv. Second Messenger Phosphoprotein Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/0968-0004(90)90192-e","article-title":"Okadaic acid: a new probe for the study of cellular regulation.","volume":"15","author":"Cohen","year":"1990","journal-title":"Trends Biochem. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/s0962-8924(99)01558-5","article-title":"AKAPs: from structure to function.","volume":"9","author":"Colledge","year":"1999","journal-title":"Trends Cell Biol."},{"key":"B33","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-71471-9","author":"Cooper","year":"1986","journal-title":"The Epididymis, Sperm Maturation and Fertilization."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00024","article-title":"Unraveling the Function of lemur tyrosine kinase 2 network.","volume":"10","author":"Cruz","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1523\/jneurosci.15-05-03375.1995","article-title":"Differential expression of protein phosphatase 1 isoforms in mammalian brain.","volume":"15","author":"da Cruz e Silva","year":"1995","journal-title":"J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"6433","DOI":"10.1073\/pnas.97.12.6433","article-title":"Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development.","volume":"97","author":"Desseyn","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902163R","article-title":"Roles of glycogen synthase kinase 3 alpha and calcineurin in regulating the ability of sperms to fertilize eggs.","author":"Dey","year":"","journal-title":"FASEB J."},{"key":"B38","article-title":"Mechanistically interrelated roles of calcineurin and GSK3a in regulating the ability of sperm to fertilzie eggs","author":"Dey","year":"","journal-title":"Proceedings of the 44th meeting of the American Society of Andrology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"7239","DOI":"10.1002\/jcp.26557","article-title":"Cyclic AMP and glycogen synthase kinase 3 form a regulatory loop in spermatozoa.","volume":"233","author":"Dey","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.devcel.2007.04.001","article-title":"Functional redundancy of GSK-3 alpha and GSK-3 beta in Wnt\/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines.","volume":"12","author":"Doble","year":"2007","journal-title":"Dev. Cell"},{"key":"B41","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0015-0282(16)41836-4","article-title":"Caffeine, theophylline, and human sperm motility.","volume":"27","author":"Dougherty","year":"1976","journal-title":"Fertil. Steril."},{"key":"B42","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1093\/biolre\/ioy225","article-title":"The protein phosphatase isoform PP1gamma1 substitutes for PP1gamma2 to support spermatogenesis but not normal sperm function and fertilitydagger.","volume":"100","author":"Dudiki","year":"2019","journal-title":"Biol. Reprod."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141961","article-title":"Changes in carboxy methylation and tyrosine phosphorylation of protein phosphatase PP2A are associated with epididymal sperm maturation and motility.","volume":"10","author":"Dudiki","year":"2015","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.15252\/embj.201489054","article-title":"Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1.","volume":"33","author":"Eiteneuer","year":"2014","journal-title":"EMBO J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1038\/ncb-nm-fertilityS57","article-title":"The state of the union: the cell biology of fertilization.","volume":"4","author":"Evans","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2174\/0929867023371247","article-title":"Okadaic acid, useful tool for studying cellular processes.","volume":"9","author":"Fernandez","year":"2002","journal-title":"Curr. Med. Chem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1093\/molehr\/gaz009","article-title":"Isoform-specific GSK3A activity is negatively correlated with human sperm motility.","volume":"25","author":"Freitas","year":"2019","journal-title":"Mol. Hum. Reprod."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1095\/biolreprod.116.144337","article-title":"Signaling mechanisms in mammalian sperm motility.","volume":"96","author":"Freitas","year":"2017","journal-title":"Biol. Reprod."},{"key":"B49","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/bf01203964","article-title":"Protein phosphorylation regulates the mouse sperm acrosome reaction induced by the zona pellucida.","volume":"9","author":"Furuya","year":"","journal-title":"J. Assist. Reprod. Genet."},{"key":"B50","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/bf01203965","article-title":"Effects of modulators of protein kinases and phosphatases on mouse sperm capacitation.","volume":"9","author":"Furuya","year":"","journal-title":"J. Assist. Reprod. Genet."},{"key":"B51","doi-asserted-by":"publisher","first-page":"21838","DOI":"10.1074\/jbc.M701272200","article-title":"Expression of human protein phosphatase-1 in Saccharomyces cerevisiae highlights the role of phosphatase isoforms in regulating eukaryotic functions.","volume":"282","author":"Gibbons","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B52","author":"Goswami","year":"2018","journal-title":"Identification of Phosphoproteins Involved in Sperm Maturation and Fertility."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1002\/jcp.27130","article-title":"Regulators of the protein phosphatase PP1gamma2, PPP1R2, PPP1R7, and PPP1R11 are involved in epididymal sperm maturation.","volume":"234","author":"Goswami","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/humrep\/13.suppl_4.20","article-title":"Role of the ionic environment and internal pH on sperm activity.","volume":"13","author":"Hamamah","year":"1998","journal-title":"Hum. Reprod."},{"key":"B55","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/j.1742-4658.2012.08547.x","article-title":"The PP1 binding code: a molecular-lego strategy that governs specificity.","volume":"280","author":"Heroes","year":"2013","journal-title":"FEBS J."},{"key":"B56","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.devcel.2005.06.007","article-title":"The \u201csoluble\u201d adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.","volume":"9","author":"Hess","year":"2005","journal-title":"Dev. Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1530\/rep.0.1220519","article-title":"Hyperactivation of mammalian spermatozoa: function and regulation.","volume":"122","author":"Ho","year":"2001","journal-title":"Reproduction"},{"key":"B58","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/35017574","article-title":"Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation.","volume":"406","author":"Hoeflich","year":"2000","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1111\/j.1365-2443.2009.01355.x","article-title":"Identification of CENP-V as a novel microtubule-associating molecule that activates Src family kinases through SH3 domain interaction.","volume":"14","author":"Honda","year":"2009","journal-title":"Genes Cells"},{"key":"B60","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1530\/jrf.0.0370131","article-title":"Cyclic adenosine 3\u2032:5\u2032-monophosphate and protein kinase levels in developing bovine spermatozoa.","volume":"37","author":"Hoskins","year":"1974","journal-title":"J. Reprod. Fertil."},{"key":"B61","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ydbio.2011.12.002","article-title":"Hyper-activated motility in sperm capacitation is mediated by phospholipase D-dependent actin polymerization.","volume":"362","author":"Itach","year":"2012","journal-title":"Dev. Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/j.1365-2125.1984.tb02466.x","article-title":"The stimulatory effects of caffeine, theophylline, lysine-theophylline and 3-isobutyl-1-methylxanthine on human sperm motility.","volume":"18","author":"Jiang","year":"1984","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"3600","DOI":"10.18632\/oncotarget.12274","article-title":"Factors and pathways involved in capacitation: how are they regulated?","volume":"8","author":"Jin","year":"2017","journal-title":"Oncotarget"},{"key":"B64","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s11064-006-9128-5","article-title":"Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics.","volume":"32","author":"Jope","year":"2007","journal-title":"Neurochem. Res."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2011.00040","article-title":"GSK-3: functional insights from cell biology and animal models.","volume":"4","author":"Kaidanovich-Beilin","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"19344","DOI":"10.1073\/pnas.0603603103","article-title":"Azoospermia in mice with targeted disruption of the Brek\/Lmtk2 (brain-enriched kinase\/lemur tyrosine kinase 2) gene.","volume":"103","author":"Kawa","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/j.1476-5381.2011.01729.x","article-title":"Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments.","volume":"165","author":"Keravis","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/j.cell.2015.10.029","article-title":"Post-transcriptional Wnt signaling governs epididymal sperm maturation.","volume":"163","author":"Koch","year":"2015","journal-title":"Cell"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1002\/jcp.24571","article-title":"Calcineurin regulates progressive motility activation of Rhinella (Bufo) arenarum sperm through dephosphorylation of PKC substrates.","volume":"229","author":"Krapf","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0012-1606(83)90004-0","article-title":"Changes in internal pH associated with initiation of motility and acrosome reaction of sea urchin sperm.","volume":"95","author":"Lee","year":"1983","journal-title":"Dev. Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"R181","DOI":"10.1530\/Rep-18-0541","article-title":"Update on mammalian sperm capacitation: how much does the horse differ from other species?","volume":"157","author":"Leemans","year":"2019","journal-title":"Reproduction"},{"key":"B72","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1529\/biophysj.107.127951","article-title":"Insights into the mechanism of ADP action on flagellar motility derived from studies on bull sperm.","volume":"95","author":"Lesich","year":"2008","journal-title":"Biophys. J."},{"key":"B73","doi-asserted-by":"publisher","first-page":"4583","DOI":"10.1242\/dev.096578","article-title":"Release from meiotic arrest in ascidian eggs requires the activity of two phosphatases but not CaMKII.","volume":"140","author":"Levasseur","year":"2013","journal-title":"Development"},{"key":"B74","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1006\/mpev.1998.0560","article-title":"Molecular evolution of type 1 serine\/threonine protein phosphatases.","volume":"12","author":"Lin","year":"1999","journal-title":"Mol. Phylogenet. Evol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"27804","DOI":"10.1074\/jbc.270.46.27804","article-title":"Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells.","volume":"270","author":"Lin","year":"1995","journal-title":"J. Biol. Chem."},{"key":"B76","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0092-8674(78)90133-2","article-title":"A cAMP-induced increase in the motility of demembranated bull sperm models.","volume":"13","author":"Lindemann","year":"1978","journal-title":"Cell"},{"key":"B77","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1002\/cm.970080405","article-title":"Regulation of activation state and flagellar wave form in epididymal rat sperm: evidence for the involvement of both Ca2+ and cAMP.","volume":"8","author":"Lindemann","year":"1987","journal-title":"Cell Motil. Cytoskeleton"},{"key":"B78","doi-asserted-by":"publisher","first-page":"4667","DOI":"10.1113\/jphysiol.2010.194142","article-title":"The role of Hv1 and CatSper channels in sperm activation.","author":"Lishko","year":"2010","journal-title":"J. Physiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.cophys.2018.02.004","article-title":"CatSper: a unique calcium channel of the sperm flagellum.","volume":"2","author":"Lishko","year":"2018","journal-title":"Curr. Opin. Physiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1093\/gbe\/evx136","article-title":"New genes and functional innovation in mammals.","volume":"9","author":"Luis Villanueva-Canas","year":"2017","journal-title":"Genome Biol. Evol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/REP-13-0224","article-title":"PPP1CC2 can form a kinase\/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis.","volume":"147","author":"MacLeod","year":"2014","journal-title":"Reproduction"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1095\/biolreprod.103.026476","article-title":"Different signaling pathways in bovine sperm regulate capacitation and hyperactivation.","volume":"70","author":"Marquez","year":"2004","journal-title":"Biol. Reprod."},{"key":"B83","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1071\/RD07146","article-title":"Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation.","volume":"20","author":"Marquez","year":"2008","journal-title":"Reprod. Fertil. Dev."},{"key":"B84","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/mrd.22453","article-title":"TMEM225: a possible protein phosphatase 1 gamma 2 (PP1 gamma 2) regulator localizes to the equatorial segment in mouse spermatozoa.","volume":"82","author":"Matsuura","year":"2015","journal-title":"Mol. Reprod. Dev."},{"key":"B85","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/nrm2902","article-title":"When pathways collide: collaboration and connivance among signalling proteins in development.","volume":"11","author":"McNeill","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/479249","article-title":"Deconstructing GSK-3: the fine regulation of its activity.","volume":"2011","author":"Medina","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1006\/dbio.2002.0728","article-title":"Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility.","volume":"248","author":"Miki","year":"2002","journal-title":"Dev. Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1126\/science.aad0836","article-title":"Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.","volume":"350","author":"Miyata","year":"2015","journal-title":"Science"},{"key":"B89","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0014-4827(80)90426-7","article-title":"Characteristics of motor apparatus in testicular, epididymal and ejaculated spermatozoa.","volume":"127","author":"Mohri","year":"1980","journal-title":"Exp. Cell Res."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00072","article-title":"Molecular basis of human sperm capacitation.","volume":"6","author":"Molina","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1095\/biolreprod61.2.335","article-title":"Conservation and function of a bovine sperm A-kinase anchor protein homologous to mouse AKAP82.","volume":"61","author":"Moss","year":"1999","journal-title":"Biol. Reprod."},{"key":"B92","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/cm.970060203","article-title":"Regulation of sperm flagellar movement by protein phosphorylation and dephosphorylation.","volume":"6","author":"Murofushi","year":"1986","journal-title":"Cell Motil. Cytoskeleton"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1002\/jcp.24873","article-title":"Biphasic role of calcium in mouse sperm capacitation signaling pathways.","volume":"230","author":"Navarrete","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.bbrc.2014.05.100","article-title":"Intracellular pH in sperm physiology.","volume":"450","author":"Nishigaki","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B95","doi-asserted-by":"publisher","first-page":"13483","DOI":"10.1073\/pnas.0405580101","article-title":"Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility.","volume":"101","author":"Nolan","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B96","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1006\/geno.1997.4907","article-title":"Genomic organization and functional analysis of the murine protein phosphatase 1c gamma (Ppp1cc) gene.","volume":"45","author":"Okano","year":"1997","journal-title":"Genomics"},{"key":"B97","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1161\/01.res.0000256354.95791.f1","article-title":"Overview of PDEs and their regulation.","volume":"100","author":"Omori","year":"2007","journal-title":"Circ. Res."},{"key":"B98","doi-asserted-by":"publisher","first-page":"16830","DOI":"10.1074\/jbc.RA117.001566","article-title":"CatSper channels are regulated by protein kinase A.","volume":"293","author":"Orta","year":"2018","journal-title":"J. Biol. Chem."},{"key":"B99","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1432-1033.1982.tb05904.x","article-title":"Glycogen synthase from rabbit skeletal muscle. State of phosphorylation of the seven phosphoserine residues in vivo in the presence and absence of adrenaline.","volume":"124","author":"Parker","year":"1982","journal-title":"Eur. J. Biochem."},{"key":"B100","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.yjmcc.2016.12.006","article-title":"Calcineurin signaling in the heart: the importance of time and place.","volume":"103","author":"Parra","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B101","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1242\/jcs.115.1.195","article-title":"Essential functions of Sds22p in chromosome stability and nuclear localization of PP1.","author":"Peggie","year":"2002","journal-title":"J. Cell Sci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1073\/pnas.0610286104","article-title":"All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.","volume":"104","author":"Qi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B103","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1530\/Rep-13-0560","article-title":"PKA and CaMKII mediate PI3K activation in bovine sperm by inhibition of the PKC\/PP1 cascade.","volume":"147","author":"Rotfeld","year":"2014","journal-title":"Reproduction"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1152\/physrev.2000.80.4.1483","article-title":"Calcineurin: form and function.","volume":"80","author":"Rusnak","year":"2000","journal-title":"Physiol. Rev."},{"key":"B105","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1095\/biolreprod65.1.151","article-title":"Differential expression of the C(s) and Calpha1 isoforms of the catalytic subunit of cyclic 3\u2032,5\u2032-adenosine monophosphate-dependent protein kinase testicular cells.","volume":"65","author":"San Agustin","year":"2001","journal-title":"Biol. Reprod."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.febslet.2010.02.005","article-title":"The SLO3 sperm-specific potassium channel plays a vital role in male fertility.","volume":"584","author":"Santi","year":"2010","journal-title":"FEBS Lett."},{"key":"B107","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ejcb.2017.02.003","article-title":"Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia.","volume":"96","author":"Schwarz","year":"2017","journal-title":"Eur. J. Cell Biol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"16526","DOI":"10.1074\/jbc.271.28.16526","article-title":"Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation.","volume":"271","author":"Sette","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B109","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1095\/biolreprod61.1.305","article-title":"Mice carrying two t haplotypes: sperm populations with reduced zona pellucida binding are deficient in capacitation.","volume":"61","author":"Si","year":"1999","journal-title":"Biol. Reprod."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081286","article-title":"Protein phosphatases decrease their activity during capacitation: a new requirement for this event.","volume":"8","author":"Signorelli","year":"2013","journal-title":"PLoS One"},{"key":"B111","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.rbmo.2014.09.014","article-title":"CatSper channel, sperm function and male fertility.","volume":"30","author":"Singh","year":"2015","journal-title":"Reprod. Biomed. Online"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047623","article-title":"Significant expression levels of transgenic PPP1CC2 in testis and sperm are required to overcome the male infertility phenotype of Ppp1cc null mice.","volume":"7","author":"Sinha","year":"2012","journal-title":"PLoS One"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.110239","article-title":"Selective ablation of Ppp1cc gene in testicular germ cells causes oligo-teratozoospermia and infertility in mice.","volume":"89","author":"Sinha","year":"2013","journal-title":"Biol. Reprod."},{"key":"B114","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1095\/biolreprod54.3.719","article-title":"Primate sperm contain protein phosphatase 1, a biochemical mediator of motility.","volume":"54","author":"Smith","year":"1996","journal-title":"Biol. Reprod."},{"key":"B115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/j.1939-4640.1999.tb02495.x","article-title":"Motility potential of macaque epididymal sperm: the role of protein phosphatase and glycogen synthase kinase-3 activities.","volume":"20","author":"Smith","year":"1999","journal-title":"J. Androl."},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181091","article-title":"Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms.","volume":"12","author":"Soberg","year":"2017","journal-title":"PLoS One"},{"key":"B117","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1002\/j.1939-4640.2004.tb02831.x","article-title":"Changes in sperm glycogen synthase kinase-3 serine phosphorylation and activity accompany motility initiation and stimulation.","volume":"25","author":"Somanath","year":"2004","journal-title":"J. Androl."},{"key":"B118","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1096\/fj.201500136R","article-title":"A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA\/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation.","volume":"30","author":"Stanger","year":"2016","journal-title":"FASEB J."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/j.bbamcr.2019.02.016","article-title":"An element for development: calcium signaling in mammalian reproduction and development.","volume":"1866","author":"Stewart","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/978-3-319-30567-7_5","article-title":"Sperm capacitation and acrosome reaction in mammalian sperm.","volume":"220","author":"Stival","year":"2016","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-017-0281-2","article-title":"The Catsper channel and its roles in male fertility: a systematic review.","volume":"15","author":"Sun","year":"2017","journal-title":"Reprod. Biol. Endocrinol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1095\/biolreprod26.5.953","article-title":"Phosphoprotein phosphatase activity of sea urchin spermatozoa.","volume":"26","author":"Swarup","year":"1982","journal-title":"Biol. Reprod."},{"key":"B123","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1247\/csf.10.327","article-title":"Phosphoprotein phosphatase inhibits flagellar movement of Triton models of sea urchin spermatozoa.","volume":"10","author":"Takahashi","year":"1985","journal-title":"Cell Struct. Funct."},{"key":"B124","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/j.1939-4640.1994.tb00489.x","article-title":"Regulation of sperm motility: emerging evidence for a major role for protein phosphatases.","volume":"15","author":"Tash","year":"1994","journal-title":"J. Androl."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1083\/jcb.106.5.1625","article-title":"Identification, characterization, and functional correlation of calmodulin-dependent protein phosphatase in sperm.","volume":"106","author":"Tash","year":"1988","journal-title":"J. Cell Biol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1530\/jrf.0.1150175","article-title":"Influence of capacitation and fluids from the male and female genital tract on the zona binding ability of bull spermatozoa.","volume":"115","author":"Topper","year":"1999","journal-title":"J. Reprod. Fertil."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00230","article-title":"Importance of SLC26 transmembrane anion exchangers in sperm post-testicular maturation and fertilization potential.","volume":"7","author":"Toure","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.theriogenology.2019.01.036","article-title":"PKA and PI3K activities during capacitation protect sperm from undergoing spontaneous acrosome reaction.","volume":"128","author":"Tsirulnikov","year":"2019","journal-title":"Theriogenology"},{"key":"B129","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1093\/molehr\/5.9.816","article-title":"Relationship between sperm motility and the processing and tyrosine phosphorylation of two human sperm fibrous sheath proteins, pro-hAKAP82 and hAKAP82.","volume":"5","author":"Turner","year":"1999","journal-title":"Mol. Hum. Reprod."},{"key":"B130","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1006\/dbio.1998.9100","article-title":"Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.","volume":"205","author":"Varmuza","year":"1999","journal-title":"Dev. Biol."},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-12-40","article-title":"The testis-specific Calpha2 subunit of PKA is kinetically indistinguishable from the common Calpha1 subunit of PKA.","volume":"12","author":"Vetter","year":"2011","journal-title":"BMC Biochem."},{"key":"B132","first-page":"111","article-title":"Regulation of sperm function by protein phosphatase PP1gamma2.","volume":"63","author":"Vijayaraghavan","year":"2007","journal-title":"Soc. Reprod. Fertil. Suppl."},{"key":"B133","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1095\/biolreprod32.3.489","article-title":"Evidence for a role for cellular alkalinization in the cyclic adenosine 3\u2032,5\u2032-monophosphate-mediated initiation of motility in bovine caput spermatozoa.","volume":"32","author":"Vijayaraghavan","year":"1985","journal-title":"Biol. Reprod."},{"key":"B134","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0143-4160(89)90007-9","article-title":"Quantitation of bovine sperm cytoplasmic calcium with Quin-2 and Fura-2: evidence that external calcium does not have direct access to the sperm cytoplasm.","volume":"10","author":"Vijayaraghavan","year":"1989","journal-title":"Cell Calcium"},{"key":"B135","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/mrd.1120200309","article-title":"Low molecular weight factor in bovine caudal epididymal fluid that stimulates calcium uptake in caput spermatozoa.","volume":"20","author":"Vijayaraghavan","year":"1988","journal-title":"Gamete Res."},{"key":"B136","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/mrd.1080250212","article-title":"Changes in the mitochondrial calcium influx and efflux properties are responsible for the decline in sperm calcium during epididymal maturation.","volume":"25","author":"Vijayaraghavan","year":"1990","journal-title":"Mol. Reprod. Dev."},{"key":"B137","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1210\/mend.13.5.0278","article-title":"Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein.","volume":"13","author":"Vijayaraghavan","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1095\/biolreprod54.3.709","article-title":"Sperm motility development in the epididymis is associated with decreased glycogen synthase kinase-3 and protein phosphatase 1 activity.","volume":"54","author":"Vijayaraghavan","year":"1996","journal-title":"Biol. Reprod."},{"key":"B139","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/s0165-0378(01)00103-6","article-title":"Novel signaling pathways involved in sperm acquisition of fertilizing capacity.","volume":"53","author":"Visconti","year":"2002","journal-title":"J. Reprod. Immunol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"9325","DOI":"10.1073\/pnas.0611296104","article-title":"A sperm-specific Na+\/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC).","volume":"104","author":"Wang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B141","doi-asserted-by":"publisher","first-page":"4852","DOI":"10.1091\/mbc.E08-05-0460","article-title":"Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells.","volume":"19","author":"Wang","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"B142","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1093\/humrep\/dev243","article-title":"Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa.","volume":"30","author":"Williams","year":"2015","journal-title":"Hum. Reprod."},{"key":"B143","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1002\/j.1460-2075.1990.tb07419.x","article-title":"Molecular cloning and expression of glycogen synthase kinase-3\/factor A.","volume":"9","author":"Woodgett","year":"1990","journal-title":"EMBO J."},{"key":"B144","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ydbio.2006.05.038","article-title":"Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization.","volume":"296","author":"Xie","year":"2006","journal-title":"Dev. Biol."},{"key":"B145","first-page":"87","article-title":"Validation of a testis specific serine\/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets.","volume":"63","author":"Xu","year":"2007","journal-title":"Soc. Reprod. Fertil. Suppl."},{"key":"B146","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/mrd.1120090109","article-title":"Effects of cyclic AMP on the motility of mature and immature hamster epididymal spermatozoa studied by reactivation of the demembranated cells.","volume":"9","author":"Yeung","year":"1984","journal-title":"Gamete Res."},{"key":"B147","doi-asserted-by":"publisher","first-page":"31469","DOI":"10.1074\/jbc.m003041200","article-title":"Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression.","volume":"275","author":"Yuasa","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B148","first-page":"318","article-title":"A novel interaction between Glycogen Synthase Kinase-3alpha (GSK-3alpha) and the scaffold protein Receptor for Activated C-Kinase 1 (RACK1) regulates the circadian clock.","volume":"2","author":"Zeidner","year":"2011","journal-title":"Int. J. Biochem. Mol. Biol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"5879","DOI":"10.1073\/pnas.1100240108","article-title":"Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa.","volume":"108","author":"Zeng","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2019.00341\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T20:07:07Z","timestamp":1722197227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2019.00341\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":149,"alternative-id":["10.3389\/fcell.2019.00341"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2019.00341","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]},"article-number":"341"}}