{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:22:52Z","timestamp":1788492172414,"version":"build-2803163510"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA021276"],"award-info":[{"award-number":["R01AA021276"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21AA023626"],"award-info":[{"award-number":["R21AA023626"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P50AA024333"],"award-info":[{"award-number":["P50AA024333"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2019.00368","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T07:47:52Z","timestamp":1578642472000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":44,"title":["Extracellular Vesicles From Hepatocytes Are Therapeutic for Toxin-Mediated Fibrosis and Gene Expression in the Liver"],"prefix":"10.3389","volume":"7","author":[{"given":"Xinlei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri","family":"Kemper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Brigstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0715-7","article-title":"Transcriptional analysis identifies key genes involved in metabolism, fibrosis\/tissue repair and the immune response against Fasciola hepatica in sheep liver.","volume":"8","author":"Alvarez Rojas","year":"2015","journal-title":"Parasit. Vectors"},{"key":"B2","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1172\/JCI41732","article-title":"Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice.","volume":"120","author":"Berres","year":"2010","journal-title":"J. Clin. Invest."},{"key":"B3","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1053\/jhep.2001.21996","article-title":"Expression and matrix deposition of latent transforming growth factor beta binding proteins in normal and fibrotic rat liver and transdifferentiating hepatic stellate cells in culture.","volume":"33","author":"Breitkopf","year":"2001","journal-title":"Hepatology"},{"key":"B4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymthe.2019.10.016","article-title":"HLSC-derived extracellular vesicles attenuate liver fibrosis and inflammation in a murine model of non-alcoholic steatohepatitis.","author":"Bruno","year":"2019","journal-title":"Mol. Ther."},{"key":"B5","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/hepr.12794","article-title":"Emerging role of exosomes in liver physiology and pathology.","volume":"47","author":"Cai","year":"2017","journal-title":"Hepatol. Res."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2017.2745","article-title":"Reelin expression in human liver of patients with chronic hepatitis C infection.","volume":"61","author":"Carotti","year":"2017","journal-title":"Eur. J. Histochem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.surg.2014.04.014","article-title":"Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver.","volume":"156","author":"Charrier","year":"","journal-title":"Surgery"},{"key":"B8","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/imm.12215","article-title":"Regulation of pancreatic inflammation by connective tissue growth factor (CTGF\/CCN2).","volume":"141","author":"Charrier","year":"","journal-title":"Immunology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/labinvest.2010.82","article-title":"Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis.","volume":"90","author":"Charrier","year":"2010","journal-title":"Lab. Invest."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1002\/hep.26768","article-title":"Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells.","volume":"59","author":"Chen","year":"2014","journal-title":"Hepatology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jhep.2010.11.025","article-title":"Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor.","volume":"55","author":"Chen","year":"2011","journal-title":"J. Hepatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/hep.28796","article-title":"Hepatocyte exosomes attenuate hepatic stellate cell activation in vitro and are anti-fibrotic in vivo.","volume":"64","author":"Chen","year":"","journal-title":"Hepatology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1016\/j.ajpath.2016.07.011","article-title":"Fibrogenic signaling is suppressed in hepatic stellate cells through targeting of connective tissue growth factor (CCN2) by cellular or exosomal MicroRNA-199a-5p.","volume":"186","author":"Chen","year":"","journal-title":"Am. J. Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s12079-017-0421-7","article-title":"Pathways of production and delivery of hepatocyte exosomes.","volume":"12","author":"Chen","year":"","journal-title":"J. Cell Commun. Signal."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1461505","article-title":"Therapeutic effects of serum extracellular vesicles in liver fibrosis.","volume":"7","author":"Chen","year":"","journal-title":"J. Extracell. Vesicles"},{"key":"B16","doi-asserted-by":"publisher","first-page":"G491","DOI":"10.1152\/ajpgi.00140.2015","article-title":"Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: role of exosomes in horizontal transfer of Twist1.","volume":"309","author":"Chen","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/hep.29409","article-title":"Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during HCV infection.","volume":"67","author":"Cobb","year":"2017","journal-title":"Hepatology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1177\/1756283X11413002","article-title":"Current status of novel antifibrotic therapies in patients with chronic liver disease.","volume":"4","author":"Cohen-Naftaly","year":"2011","journal-title":"Therap. Adv. Gastroenterol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"5157","DOI":"10.1021\/pr8004887","article-title":"Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes.","volume":"7","author":"Conde-Vancells","year":"2008","journal-title":"J. Proteome Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1385\/1-59259-940-0:237","article-title":"Modeling liver fibrosis in rodents.","volume":"117","author":"Constandinou","year":"2005","journal-title":"Methods Mol. Med."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02225-16","article-title":"Exosome-mediated intercellular communication between hepatitis C virus-infected hepatocytes and hepatic stellate cells.","volume":"91","author":"Devhare","year":"2017","journal-title":"J. Virol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner.","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.toxrep.2015.08.001","article-title":"Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis.","volume":"2","author":"Elgawish","year":"2015","journal-title":"Toxicol. Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1586\/17474124.2.6.803","article-title":"Advances in antifibrotic therapy.","volume":"2","author":"Ghiassi-Nejad","year":"2008","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1039\/c7mb00146k","article-title":"Emergent properties of extracellular vesicles: a holistic approach to decode the complexity of intercellular communication networks.","volume":"13","author":"Gho","year":"2017","journal-title":"Mol. Biosyst."},{"key":"B26","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/01480540600837944","article-title":"A 43-kDa protein from the leaves of the herb Cajanus indicus L. modulates chloroform induced hepatotoxicity in vitro.","volume":"29","author":"Ghosh","year":"2006","journal-title":"Drug Chem. Toxicol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3781","DOI":"10.3748\/wjg.v19.i24.3781","article-title":"Glycyrrhizic acid attenuates CCl(4)-induced hepatocyte apoptosis in rats via a p53-mediated pathway.","volume":"19","author":"Guo","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066106","article-title":"The chemokine CCL3 promotes experimental liver fibrosis in mice.","volume":"8","author":"Heinrichs","year":"2013","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1053\/j.gastro.2015.12.037","article-title":"Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes.","volume":"150","author":"Hirsova","year":"","journal-title":"Gastroenterology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1002\/hep.28814","article-title":"Extracellular vesicles in liver pathobiology: small particles with big impact.","volume":"64","author":"Hirsova","year":"","journal-title":"Hepatology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/hep.28252","article-title":"Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes.","volume":"63","author":"Ibrahim","year":"2016","journal-title":"Hepatology"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6079642","article-title":"Human umbilical cord MSC-derived exosomes suppress the development of CCl4-induced liver injury through antioxidant effect.","volume":"2018","author":"Jiang","year":"2018","journal-title":"Stem Cells Int."},{"key":"B33","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1194\/jlr.M063412","article-title":"Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1alpha-dependent manner.","volume":"57","author":"Kakazu","year":"2016","journal-title":"J. Lipid Res."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00335","article-title":"Extracellular vesicles including exosomes regulate innate immune responses to hepatitis B virus infection.","volume":"7","author":"Kouwaki","year":"2016","journal-title":"Front. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes.","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/labinvest.2012.121","article-title":"Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis.","volume":"92","author":"Krishnan","year":"2012","journal-title":"Lab. Invest."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03389-2","article-title":"Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells.","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nrgastro.2014.7","article-title":"The emerging roles of microvesicles in liver diseases.","volume":"11","author":"Lemoinne","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1089\/scd.2012.0395","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis.","volume":"22","author":"Li","year":"2013","journal-title":"Stem Cells Dev."},{"key":"B40","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"B41","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"15874","DOI":"10.1074\/jbc.M112.340588","article-title":"Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro.","volume":"287","author":"Lv","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"G194","DOI":"10.1152\/ajpgi.00216.2016","article-title":"Extracellular vesicles in liver diseases.","volume":"312","author":"Maji","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"9330","DOI":"10.1002\/jcp.26413","article-title":"Extracellular vesicles derived from human embryonic stem cell-MSCs ameliorate cirrhosis in thioacetamide-induced chronic liver injury.","volume":"233","author":"Mardpour","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/srep09991","article-title":"Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS.","volume":"5","author":"Momen-Heravi","year":"2015","journal-title":"Sci. Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1099\/vir.0.066910-0","article-title":"Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies.","volume":"95","author":"Nagashima","year":"2014","journal-title":"J. Gen. Virol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"4870","DOI":"10.1172\/JCI98156","article-title":"The innate immune receptor TREM-1 promotes liver injury and fibrosis.","volume":"128","author":"Nguyen-Lefebvre","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B48","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jhep.2015.07.030","article-title":"Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate.","volume":"64","author":"Nojima","year":"2016","journal-title":"J. Hepatol."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3212643","article-title":"Extracellular vesicles from amnion-derived mesenchymal stem cells ameliorate hepatic inflammation and fibrosis in rats.","volume":"2018","author":"Ohara","year":"2018","journal-title":"Stem Cells Int."},{"key":"B50","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s12079-018-0491-1","article-title":"The official unified nomenclature adopted by the HGNC calls for the use of the acronyms, CCN1-6, and discontinuation in the use of CYR61, CTGF, NOV and WISP 1-3 respectively.","volume":"12","author":"Perbal","year":"2018","journal-title":"J. Cell Commun. Signal."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113651","article-title":"Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease.","volume":"9","author":"Povero","year":"2014","journal-title":"PLoS One"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004512","article-title":"Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells.","volume":"6","author":"Povero","year":"2013","journal-title":"Sci. Signal."},{"key":"B53","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.jcmgh.2015.07.007","article-title":"Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-gamma.","volume":"1","author":"Povero","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125652","article-title":"Human induced pluripotent stem cell-derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis.","volume":"5","author":"Povero","year":"2019","journal-title":"JCI Insight"},{"key":"B55","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/hep.510300432","article-title":"Matrix metalloproteinase-2 activation in human hepatic fibrosis regulation by cell-matrix interactions.","volume":"30","author":"Preaux","year":"1999","journal-title":"Hepatology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1111\/jcmm.13170","article-title":"Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation.","volume":"21","author":"Qu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"13109","DOI":"10.1073\/pnas.1221899110","article-title":"Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells.","volume":"110","author":"Ramakrishnaiah","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092153","article-title":"Changes of circulating extracellular vesicles from the liver after roux-en-Y bariatric surgery.","volume":"20","author":"Rega-Kaun","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1204-2","article-title":"Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt\/beta-catenin pathway.","volume":"10","author":"Rong","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"B60","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/hep.28644","article-title":"Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by gammadelta T cells in liver fibrosis.","volume":"64","author":"Seo","year":"2016","journal-title":"Hepatology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"8453","DOI":"10.1074\/jbc.M116.716316","article-title":"Cancer cell-derived exosomes induce mitogen-activated protein kinase-dependent monocyte survival by transport of functional receptor tyrosine kinases.","volume":"291","author":"Song","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nrgastro.2017.71","article-title":"Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets.","volume":"14","author":"Szabo","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.virol.2011.11.009","article-title":"Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway.","volume":"422","author":"Tamai","year":"2012","journal-title":"Virology"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00671-1","article-title":"TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice.","volume":"7","author":"Thiele","year":"2017","journal-title":"Sci. Rep."},{"key":"B65","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.jhep.2015.11.020","article-title":"Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles.","volume":"64","author":"Verma","year":"2016","journal-title":"J. Hepatol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"30684","DOI":"10.1074\/jbc.M115.671735","article-title":"Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1-phosphate-dependent migration.","volume":"290","author":"Wang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6645","article-title":"Identification of key genes, pathways and potential therapeutic agents for liver fibrosis using an integrated bioinformatics analysis.","volume":"7","author":"Zhan","year":"2019","journal-title":"PeerJ"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2019.00368\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T07:47:55Z","timestamp":1578642475000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2019.00368\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,10]]},"references-count":67,"alternative-id":["10.3389\/fcell.2019.00368"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2019.00368","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,10]]},"article-number":"368"}}