{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:28:37Z","timestamp":1790465317363,"version":"4.1.0"},"reference-count":164,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD095341"],"award-info":[{"award-number":["R01 HD095341"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2020.00061","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T04:16:07Z","timestamp":1582690567000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive Targets"],"prefix":"10.3389","volume":"8","author":[{"given":"Katarzyna","family":"Kent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelaine","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Strump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas X.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.221648","article-title":"RSPH6A is required for sperm flagellum formation and male fertility in mice.","volume":"131","author":"Abbasi","year":"2018","journal-title":"J. Cell Sci."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10324","article-title":"Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.","volume":"7","author":"Abby","year":"2016","journal-title":"Nat. Commun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/s0165-0378(02)00010-4","article-title":"Immunocontraceptive vaccines for human use.","volume":"57","author":"Aitken","year":"2002","journal-title":"J. Reprod. Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2174\/1874467208666150126153830","article-title":"Metabolic cooperation in testis as a pharmacological target: from disease to contraception.","volume":"7","author":"Alves","year":"2014","journal-title":"Curr. Mol. Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.098673","article-title":"Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice.","volume":"88","author":"Arango","year":"2013","journal-title":"Biol. Reprod."},{"key":"B6","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ando.2014.04.006","article-title":"Disrupting the male germ line to find infertility and contraception targets.","volume":"75","author":"Archambeault","year":"2014","journal-title":"Ann. Endocrinol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1538\/expanim.58.525","article-title":"Characterization and linkage mapping of an ENU-induced mutant mouse with defective spermatogenesis.","volume":"58","author":"Asano","year":"2009","journal-title":"Exp. Anim."},{"key":"B8","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1210\/jcem.77.2.8345047","article-title":"Comparison of a gonadotropin releasing-hormone antagonist plus testosterone (T) versus T alone as potential male contraceptive regimens.","volume":"77","author":"Bagatell","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1021\/acschembio.9b00640","article-title":"ABHD2 inhibitor identified by activity-based protein profiling reduces acrosome reaction.","volume":"14","author":"Baggelaar","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.gep.2016.03.003","article-title":"New insights into the role of the Brdt protein in the regulation of development and spermatogenesis in the mouse.","volume":"20","author":"Barda","year":"2016","journal-title":"Gene Expr. Patterns"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.febslet.2013.04.031","article-title":"Cell-penetrating peptides: 20 years later, where do we stand?","volume":"587","author":"Bechara","year":"2013","journal-title":"FEBS Lett."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.202","article-title":"The BET\/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice.","volume":"7","author":"Benito","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02637","article-title":"Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes.","volume":"3","author":"Bonasio","year":"2014","journal-title":"eLife"},{"key":"B14","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/nchembio.1858","article-title":"Catalytic in vivo protein knockdown by small-molecule PROTACs.","volume":"11","author":"Bondeson","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"78.e5","DOI":"10.1016\/j.chembiol.2017.09.010","article-title":"Lessons in PROTAC design from selective degradation with a promiscuous warhead.","volume":"25","author":"Bondeson","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"771.e11","DOI":"10.1053\/j.gastro.2014.12.034","article-title":"Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstruction.","volume":"148","author":"Bonora","year":"2015","journal-title":"Gastroenterology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2353\/ajpath.2007.061171","article-title":"A sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis.","volume":"171","author":"Brehm","year":"2007","journal-title":"Am. J. Pathol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.addr.2004.12.001","article-title":"Tat peptide-mediated cellular delivery: back to basics.","volume":"57","author":"Brooks","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4348","DOI":"10.1210\/en.2009-0201","article-title":"Inactivation of insulin-like factor 6 disrupts the progression of spermatogenesis at late meiotic prophase.","volume":"150","author":"Burnicka-Turek","year":"2009","journal-title":"Endocrinology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"E5370","DOI":"10.1073\/pnas.1621279114","article-title":"TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa.","volume":"114","author":"Castaneda","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B21","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/978-1-4939-7698-0_17","article-title":"Monitoring the integrity of the blood-testis barrier (BTB): an in vivo assay.","volume":"1748","author":"Chen","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"701","DOI":"10.2174\/0929867323666160112122724","article-title":"Effective delivery of male contraceptives behind the blood-testis barrier (BTB) - lesson from adjudin.","volume":"23","author":"Chen","year":"","journal-title":"Curr. Med. Chem."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.344","article-title":"The control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon\u2019s head to tail.","volume":"7","author":"Chen","year":"","journal-title":"Cell Death Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature13985","article-title":"Principles of regulatory information conservation between mouse and human.","volume":"515","author":"Cheng","year":"2014","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1153","article-title":"A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.","volume":"2","author":"Chung","year":"2011","journal-title":"Nat. Commun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/ncb2213","article-title":"Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.","volume":"13","author":"Daniel","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1095\/biolreprod.109.079699","article-title":"Phosphoglycerate kinase 2 (PGK2) is essential for sperm function and male fertility in mice.","volume":"82","author":"Danshina","year":"2010","journal-title":"Biol. Reprod."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/srep16932","article-title":"Dual transcriptome sequencing reveals resistance of TLR4 ligand-activated bone marrow-derived macrophages to inflammation mediated by the BET inhibitor JQ1.","volume":"5","author":"Das","year":"2015","journal-title":"Sci. Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"8642","DOI":"10.1128\/MCB.24.19.8642-8648.2004","article-title":"Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility.","volume":"24","author":"Davies","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1093\/nar\/gkl609","article-title":"Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice.","volume":"34","author":"De Souza","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.ajhg.2012.04.019","article-title":"RAD21 mutations cause a human cohesinopathy.","volume":"90","author":"Deardorff","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"B32","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nature19356","article-title":"High-throughput discovery of novel developmental phenotypes.","volume":"537","author":"Dickinson","year":"2016","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1093\/molehr\/gau018","article-title":"The human testis-specific proteome defined by transcriptomics and antibody-based profiling.","volume":"20","author":"Djureinovic","year":"2014","journal-title":"Mol. Hum. Reprod."},{"key":"B34","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1083\/jcb.201304076","article-title":"Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.","volume":"204","author":"Dong","year":"2014","journal-title":"J. Cell Biol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s12610-018-0078-y","article-title":"Epididymal approaches to male contraception.","volume":"28","author":"Drevet","year":"2018","journal-title":"Basic Clin. Androl."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17854-5","article-title":"SOX30 is required for male fertility in mice.","volume":"7","author":"Feng","year":"2017","journal-title":"Sci. Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.ymgme.2012.05.015","article-title":"A new variant of phosphoglycerate kinase deficiency (p.I371K) with multiple tissue involvement: molecular and functional characterization.","volume":"106","author":"Fermo","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006393","article-title":"Alignment of homologous chromosomes and effective repair of programmed DNA double-strand breaks during mouse meiosis require the minichromosome maintenance domain containing 2 (MCMDC2) protein.","volume":"12","author":"Finsterbusch","year":"2016","journal-title":"PLoS Genet."},{"key":"B39","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/andr.12165","article-title":"The Sertoli cell: one hundred fifty years of beauty and plasticity.","volume":"4","author":"Franca","year":"2016","journal-title":"Andrology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1038\/sj.onc.1210852","article-title":"BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.","volume":"27","author":"French","year":"2008","journal-title":"Oncogene"},{"key":"B41","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/oxfordjournals.humrep.a136664","article-title":"Male contraception.","volume":"3","author":"Frick","year":"1988","journal-title":"Hum. Reprod."},{"key":"B42","doi-asserted-by":"publisher","first-page":"11847","DOI":"10.1073\/pnas.1007158107","article-title":"MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs.","volume":"107","author":"Frost","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102208","article-title":"Human globozoospermia-related gene Spata16 is required for sperm formation revealed by CRISPR\/Cas9-mediated mouse models.","volume":"18","author":"Fujihara","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.112888","article-title":"GPI-anchored protein complex, LY6K\/TEX101, is required for sperm migration into the oviduct and male fertility in mice.","volume":"90","author":"Fujihara","year":"2014","journal-title":"Biol. Reprod."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1242\/dev.081778","article-title":"SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia.","volume":"139","author":"Fujihara","year":"2012","journal-title":"Development"},{"key":"B46","doi-asserted-by":"publisher","first-page":"8111","DOI":"10.1073\/pnas.1222166110","article-title":"Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa.","volume":"110","author":"Fujihara","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B47","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.drudis.2008.10.009","article-title":"Predicting druggable binding sites at the protein-protein interface.","volume":"14","author":"Fuller","year":"2009","journal-title":"Drug Discov. Today"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13298","article-title":"C14ORF39\/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility.","volume":"7","author":"Gomez","year":"2016","journal-title":"Nat. Commun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.celrep.2017.06.033","article-title":"Emi2 is essential for mouse spermatogenesis.","volume":"20","author":"Gopinathan","year":"2017","journal-title":"Cell Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.mce.2005.12.024","article-title":"New approaches for male fertility control: HE6 as an example of a putative target.","volume":"250","author":"Gottwald","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1073\/pnas.0505123103","article-title":"TEX14 is essential for intercellular bridges and fertility in male mice.","volume":"103","author":"Greenbaum","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B52","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project.","volume":"45","year":"2013","journal-title":"Nat. Genet."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003383","article-title":"Mouse HFM1\/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis.","volume":"9","author":"Guiraldelli","year":"2013","journal-title":"PLoS Genet."},{"key":"B54","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1161\/01.res.88.3.333","article-title":"Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43.","volume":"88","author":"Gutstein","year":"2001","journal-title":"Circ. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/gbe\/evp043","article-title":"Evolutionary persistence of functional compensation by duplicate genes in Arabidopsis.","volume":"1","author":"Hanada","year":"2009","journal-title":"Genome Biol. Evol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.devcel.2015.01.014","article-title":"SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.","volume":"32","author":"Hasegawa","year":"2015","journal-title":"Dev. Cell"},{"key":"B57","first-page":"20","article-title":"Looking for the \u201cmale pill\u201d.","volume":"13","author":"Herndon","year":"1992","journal-title":"Netw. Res. Triangle Park N. C."},{"key":"B58","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1038\/emboj.2011.222","article-title":"The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility.","volume":"30","author":"Herran","year":"2011","journal-title":"EMBO J."},{"key":"B59","doi-asserted-by":"publisher","first-page":"621","DOI":"10.2164\/jandrol.106.002295","article-title":"Acute adverse effects of the indenopyridine CDB-4022 on the ultrastructure of sertoli cells, spermatocytes, and spermatids in rat testes: comparison to the known sertoli cell toxicant Di-n-pentylphthalate (DPP).","volume":"28","author":"Hild","year":"2007","journal-title":"J. Androl."},{"key":"B60","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1093\/biolre\/ioz158","article-title":"The testis-specific serine proteases Prss44, Prss46, and Prss54 are dispensable for male mouse fertility\u2020.","volume":"102","author":"Holcomb","year":"2020","journal-title":"Biol. Reprod."},{"key":"B61","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/nrd892","article-title":"The druggable genome.","volume":"1","author":"Hopkins","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1083\/jcb.201304004","article-title":"A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton.","volume":"202","author":"Horn","year":"2013","journal-title":"J. Cell Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"5639","DOI":"10.1074\/jbc.M110.140152","article-title":"Calsperin is a testis-specific chaperone required for sperm fertility.","volume":"286","author":"Ikawa","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B64","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.1210\/jc.2012-1384","article-title":"A new combination of testosterone and nestorone transdermal gels for male hormonal contraception.","volume":"97","author":"Ilani","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B65","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1073\/pnas.1016902108","article-title":"Na,K-ATPase alpha4 isoform is essential for sperm fertility.","volume":"108","author":"Jimenez","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B66","doi-asserted-by":"publisher","first-page":"5793","DOI":"10.1039\/c8ob01460d","article-title":"Synthesis of 6-SF5-indazoles and an SF5-analog of gamendazole.","volume":"16","author":"Kanishchev","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1262\/jrd.2016-023","article-title":"Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.","volume":"62","author":"Kashiwabara","year":"2016","journal-title":"J. Reprod. Dev."},{"key":"B68","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature14097","article-title":"Meikin is a conserved regulator of meiosis-I-specific kinetochore function.","volume":"517","author":"Kim","year":"2015","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1111\/gtc.12005","article-title":"HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity.","volume":"17","author":"Kogo","year":"","journal-title":"Genes Cells"},{"key":"B70","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1365-2443.2012.01600.x","article-title":"HORMAD1-dependent checkpoint\/surveillance mechanism eliminates asynaptic oocytes.","volume":"17","author":"Kogo","year":"","journal-title":"Genes Cells"},{"key":"B71","doi-asserted-by":"publisher","first-page":"9063","DOI":"10.1021\/acs.jmedchem.5b00586","article-title":"New frontiers in druggability.","volume":"58","author":"Kozakov","year":"2015","journal-title":"J. Med. Chem."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003960","article-title":"CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending.","volume":"9","author":"Krahling","year":"2013","journal-title":"PLoS Genet."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.095752","article-title":"Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells.","volume":"86","author":"La Salle","year":"2012","journal-title":"Biol. Reprod."},{"key":"B74","doi-asserted-by":"publisher","first-page":"621.e17","DOI":"10.1016\/j.molcel.2018.11.006","article-title":"Interactome rewiring following pharmacological targeting of BET bromodomains.","volume":"73","author":"Lambert","year":"2019","journal-title":"Mol. Cell"},{"key":"B75","doi-asserted-by":"publisher","first-page":"29108","DOI":"10.1074\/jbc.M111.244905","article-title":"Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes.","volume":"286","author":"Lee","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B76","author":"Lee","year":"2019","journal-title":"CITDBase: Contraceptive Infertility Target DataBase."},{"key":"B77","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/jmcb\/mjt031","article-title":"Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice.","volume":"5","author":"Li","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1095\/biolreprod.116.141408","article-title":"A nonsense mutation in Ccdc62 gene is responsible for spermiogenesis defects and male infertility in repro29\/repro29 mice.","volume":"96","author":"Li","year":"2017","journal-title":"Biol. Reprod."},{"key":"B79","doi-asserted-by":"publisher","first-page":"9989","DOI":"10.1073\/pnas.171305298","article-title":"Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice.","volume":"98","author":"Liao","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B80","doi-asserted-by":"publisher","first-page":"17224","DOI":"10.1073\/pnas.1413624111","article-title":"Comparison of the transcriptional landscapes between human and mouse tissues.","volume":"111","author":"Lin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005090","article-title":"LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.","volume":"11","author":"Liu","year":"2015","journal-title":"PLoS Genet."},{"key":"B82","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.chembiol.2015.05.009","article-title":"Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4.","volume":"22","author":"Lu","year":"2015","journal-title":"Chem. Biol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/biolre\/ioz103","article-title":"CRISPR\/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice.","volume":"101","author":"Lu","year":"2019","journal-title":"Biol. Reprod."},{"key":"B84","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ydbio.2015.09.002","article-title":"TOPAZ1, a germ cell specific factor, is essential for male meiotic progression.","volume":"406","author":"Luangpraseuth-Prosper","year":"2015","journal-title":"Dev. Biol."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3788","article-title":"MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination.","volume":"4","author":"Luo","year":"2013","journal-title":"Nat. Commun."},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000635","article-title":"GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline.","volume":"5","author":"Ma","year":"2009","journal-title":"PLoS Genet."},{"key":"B87","doi-asserted-by":"publisher","first-page":"4957","DOI":"10.1073\/pnas.1804512115","article-title":"Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline.","volume":"115","author":"Maezawa","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B88","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.1128\/mcb.24.9.3782-3793.2004","article-title":"Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.","volume":"24","author":"Marschang","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.cell.2012.06.045","article-title":"Small-molecule inhibition of BRDT for male contraception.","volume":"150","author":"Matzuk","year":"2012","journal-title":"Cell"},{"key":"B90","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1091\/mbc.E15-02-0121","article-title":"CFAP54 is required for proper ciliary motility and assembly of the central pair apparatus in mice.","volume":"26","author":"McKenzie","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"B91","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/ijan.1995.18.5.237","article-title":"Testosterone enanthate at a dose of 200 mg\/week decreases HDL-cholesterol levels in healthy men.","volume":"18","author":"Meriggiola","year":"1995","journal-title":"Int. J. Androl."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13855","article-title":"A bromodomain-DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT.","volume":"7","author":"Miller","year":"2016","journal-title":"Nat. Commun."},{"key":"B93","doi-asserted-by":"publisher","first-page":"7704","DOI":"10.1073\/pnas.1608458113","article-title":"Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.","volume":"113","author":"Miyata","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B94","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1126\/science.aad0836","article-title":"Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.","volume":"350","author":"Miyata","year":"2015","journal-title":"Science"},{"key":"B95","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/978-1-4614-4711-5_17","article-title":"The apical ectoplasmic specialization-blood-testis barrier functional axis is a novel target for male contraception.","volume":"763","author":"Mok","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1530\/REP-10-0464","article-title":"Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes.","volume":"141","author":"Mok","year":"2011","journal-title":"Reproduction"},{"key":"B97","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s12522-009-0018-9","article-title":"Antireproductive effect of calcium channel blockers on male rats.","volume":"8","author":"Morakinyo","year":"2009","journal-title":"Reprod. Med. Biol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.tem.2007.11.002","article-title":"New perspectives in non-hormonal male contraception.","volume":"19","author":"Mruk","year":"2008","journal-title":"Trends Endocrinol. Metab."},{"key":"B99","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4161\/spmg.1.2.16449","article-title":"Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testis.","volume":"1","author":"Mruk","year":"2011","journal-title":"Spermatogenesis"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1038\/nm1420","article-title":"A male contraceptive targeting germ cell adhesion.","volume":"12","author":"Mruk","year":"2006","journal-title":"Nat. Med."},{"key":"B101","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1007\/s10592-018-1072-9","article-title":"The international mouse phenotyping consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation.","volume":"19","author":"Munoz-Fuentes","year":"2018","journal-title":"Conserv. Genet."},{"key":"B102","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.bmcl.2013.12.004","article-title":"Male contraception: another Holy Grail.","volume":"24","author":"Murdoch","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B103","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.febslet.2011.02.002","article-title":"Mice lacking Ran binding protein 1 are viable and show male infertility.","volume":"585","author":"Nagai","year":"2011","journal-title":"FEBS Lett."},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.107128","article-title":"Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility.","volume":"88","author":"Nakamura","year":"2013","journal-title":"Biol. Reprod."},{"key":"B105","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1210\/jcem.83.3.4626","article-title":"Cytokines and thyroid epithelial integrity: interleukin-1alpha induces dissociation of the junctional complex and paracellular leakage in filter-cultured human thyrocytes.","volume":"83","author":"Nilsson","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201744957","article-title":"PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development.","volume":"19","author":"Nishimura","year":"2018","journal-title":"EMBO Rep."},{"key":"B107","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nchembio.2538","article-title":"Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.","volume":"14","author":"Olson","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195953","article-title":"Inhibition of sperm motility in male macaques with EP055, a potential non-hormonal male contraceptive.","volume":"13","author":"O\u2019Rand","year":"2018","journal-title":"PLoS One"},{"key":"B109","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.pharmthera.2015.11.004","article-title":"Non-hormonal male contraception: a review and development of an Eppin based contraceptive.","volume":"157","author":"O\u2019Rand","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"B110","doi-asserted-by":"publisher","first-page":"698","DOI":"10.2164\/jandrol.110.012781","article-title":"Epididymal protein targets: a brief history of the development of epididymal protease inhibitor as a contraceptive.","volume":"32","author":"O\u2019Rand","year":"2011","journal-title":"J. Androl."},{"key":"B111","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1021\/acschembio.7b00485","article-title":"Assessing different E3 ligases for small molecule induced protein ubiquitination and degradation.","volume":"12","author":"Ottis","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ydbio.2009.03.022","article-title":"Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia.","volume":"330","author":"Pan","year":"2009","journal-title":"Dev. Biol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"16492","DOI":"10.1073\/pnas.1316316110","article-title":"Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.","volume":"110","author":"Pandey","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B114","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.ydbio.2016.01.042","article-title":"Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouse.","volume":"412","author":"Pasek","year":"2016","journal-title":"Dev. Biol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1556\/650.2017.30876","article-title":"[Male hormonal contraception: past, present, future].","volume":"158","author":"Pasztor","year":"2017","journal-title":"Orv. Hetil."},{"key":"B116","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/1874467208666150206105636","article-title":"Male contraception: past, present and future.","volume":"7","author":"Payne","year":"2014","journal-title":"Curr. Mol. Pharmacol."},{"key":"B117","first-page":"263","article-title":"Target sites for suppressing fertility in the male.","volume":"2","author":"Prasad","year":"1976","journal-title":"Adv. Sex. Horm. Res."},{"key":"B118","doi-asserted-by":"publisher","first-page":"D877","DOI":"10.1093\/nar\/gkw1012","article-title":"MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search.","volume":"45","author":"Rappaport","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35098027","article-title":"A sperm ion channel required for sperm motility and male fertility.","volume":"413","author":"Ren","year":"2001","journal-title":"Nature"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1016\/j.cub.2010.08.024","article-title":"Oocyte cohesin expression restricted to predictyate stages provides full fertility and prevents aneuploidy.","volume":"20","author":"Revenkova","year":"2010","journal-title":"Curr. Biol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.mce.2005.12.034","article-title":"Epididymal secreted protein Crisp-1 and sperm function.","volume":"250","author":"Roberts","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"D1153","DOI":"10.1093\/nar\/gkz974","article-title":"ProteomicsDB: a multi-omics and multi-organism resource for life science research.","volume":"48","author":"Samaras","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.febslet.2010.02.005","article-title":"The SLO3 sperm-specific potassium channel plays a vital role in male fertility.","volume":"584","author":"Santi","year":"2010","journal-title":"FEBS Lett."},{"key":"B124","doi-asserted-by":"publisher","first-page":"D1271","DOI":"10.1093\/nar\/gkx1029","article-title":"ProteomicsDB.","volume":"46","author":"Schmidt","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002088","article-title":"A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.","volume":"7","author":"Schramm","year":"2011","journal-title":"PLoS Genet."},{"key":"B126","doi-asserted-by":"publisher","first-page":"12201","DOI":"10.1073\/pnas.1635054100","article-title":"A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets.","volume":"100","author":"Schultz","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B127","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1242\/dev.004481","article-title":"The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation.","volume":"134","author":"Shang","year":"2007","journal-title":"Development"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28199","article-title":"Essential role for SUN5 in anchoring sperm head to the tail.","volume":"6","author":"Shang","year":"2017","journal-title":"eLife"},{"key":"B129","doi-asserted-by":"publisher","first-page":"7090","DOI":"10.1158\/0008-5472.CAN-14-0305","article-title":"BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo.","volume":"74","author":"Shao","year":"2014","journal-title":"Cancer Res."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.107086","article-title":"Prss37 is required for male fertility in the mouse.","volume":"88","author":"Shen","year":"2013","journal-title":"Biol. Reprod."},{"key":"B131","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.ccr.2014.01.028","article-title":"Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.","volume":"25","author":"Shi","year":"2014","journal-title":"Cancer Cell"},{"key":"B132","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/ncb2896","article-title":"The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.","volume":"16","author":"Shibuya","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001190","article-title":"Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.","volume":"6","author":"Shin","year":"2010","journal-title":"PLoS Genet."},{"key":"B134","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1002\/mrd.22119","article-title":"Epididymal protease inhibitor (EPPIN) is differentially expressed in the male rat reproductive tract and immunolocalized in maturing spermatozoa.","volume":"79","author":"Silva","year":"2012","journal-title":"Mol. Reprod. Dev."},{"key":"B135","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1530\/REP-08-0132","article-title":"Novel epididymal proteins as targets for the development of post-testicular male contraception.","volume":"137","author":"Sipila","year":"2009","journal-title":"Reproduction"},{"key":"B136","doi-asserted-by":"publisher","first-page":"D836","DOI":"10.1093\/nar\/gkx1006","article-title":"Mouse genome database (MGD)-2018: knowledgebase for the laboratory mouse.","volume":"46","author":"Smith","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003784","article-title":"MEIOB targets single-strand DNA and is necessary for meiotic recombination.","volume":"9","author":"Souquet","year":"2013","journal-title":"PLoS Genet."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses.","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinform."},{"key":"B139","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1024\/0040-5930\/a000230","article-title":"[Immunosuppressive drugs - how they work, their side effects and interactions].","volume":"68","author":"Stucker","year":"2011","journal-title":"Ther. Umsch."},{"key":"B140","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1093\/humupd\/dmw015","article-title":"The human epididymis: its function in sperm maturation.","volume":"22","author":"Sullivan","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1095\/biolreprod.106.057810","article-title":"A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose.","volume":"78","author":"Tash","year":"","journal-title":"Biol. Reprod."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1095\/biolreprod.107.062679","article-title":"Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells.","volume":"78","author":"Tash","year":"","journal-title":"Biol. Reprod."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.bbrc.2006.01.175","article-title":"A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis.","volume":"342","author":"Teng","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B144","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1073\/pnas.1618465114","article-title":"Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation.","volume":"114","author":"Tu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome.","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"key":"B146","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1093\/hmg\/ddq109","article-title":"A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule.","volume":"19","author":"VanGompel","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"B147","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1093\/oxfordjournals.bmb.a072599","article-title":"Male fertility regulation: the challenges for the year 2000.","volume":"49","author":"Waites","year":"1993","journal-title":"Br. Med. Bull."},{"key":"B148","first-page":"545","article-title":"Mutational insertion of a ROSA26-EGFP transgene leads to defects in spermiogenesis and male infertility in mice.","volume":"59","author":"Walters","year":"2009","journal-title":"Comp. Med."},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.124834","article-title":"Rhox8 ablation in the sertoli cells using a tissue-specific RNAi approach results in impaired male fertility in mice.","volume":"93","author":"Welborn","year":"2015","journal-title":"Biol. Reprod."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/nature06526","article-title":"Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.","volume":"450","author":"Wells","year":"2007","journal-title":"Nature"},{"key":"B151","doi-asserted-by":"publisher","first-page":"879","DOI":"10.3892\/ijo.2019.4863","article-title":"Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF\/PI3K\/AKT signaling pathway.","volume":"55","author":"Wen","year":"2019","journal-title":"Int. J. Oncol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nchembio0306-112","article-title":"Between a rock and a hard place?","volume":"2","author":"Whitty","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1083\/jcb.201009043","article-title":"TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.","volume":"192","author":"Yabuta","year":"2011","journal-title":"J. Cell Biol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1091\/mbc.E11-12-1025","article-title":"Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa.","volume":"23","author":"Yamaguchi","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"B155","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1128\/MCB.06158-11","article-title":"The small heat shock protein ODF1\/HSPB10 is essential for tight linkage of sperm head to tail and male fertility in mice.","volume":"32","author":"Yang","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"24732","DOI":"10.3390\/ijms161024732","article-title":"CRISPR\/Cas9-mediated rapid generation of multiple mouse lines identified Ccdc63 as essential for spermiogenesis.","volume":"16","author":"Young","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"4683","DOI":"10.1073\/pnas.97.9.4683","article-title":"Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice.","volume":"97","author":"Yu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3390\/life6030039","article-title":"Functional annotations of paralogs: a blessing and a curse.","volume":"6","author":"Zallot","year":"2016","journal-title":"Life"},{"key":"B159","doi-asserted-by":"publisher","first-page":"5879","DOI":"10.1073\/pnas.1100240108","article-title":"Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa.","volume":"108","author":"Zeng","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B160","doi-asserted-by":"publisher","first-page":"17055","DOI":"10.1073\/pnas.0906414106","article-title":"MEIG1 is essential for spermiogenesis in mice.","volume":"106","author":"Zhang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B161","doi-asserted-by":"publisher","first-page":"11841","DOI":"10.1073\/pnas.1003953107","article-title":"Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.","volume":"107","author":"Zheng","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B162","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1242\/dev.030858","article-title":"RIM-BP3 is a manchette-associated protein essential for spermiogenesis.","volume":"136","author":"Zhou","year":"2009","journal-title":"Development"},{"key":"B163","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1007\/s13277-015-4109-4","article-title":"Downregulation of miR-329 promotes cell invasion by regulating BRD4 and predicts poor prognosis in hepatocellular carcinoma.","volume":"37","author":"Zhou","year":"2016","journal-title":"Tumour Biol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"453.e5","DOI":"10.1016\/j.devcel.2017.02.007","article-title":"BTBD18 regulates a subset of piRNA-generating loci through transcription elongation in mice.","volume":"40","author":"Zhou","year":"2017","journal-title":"Dev. Cell"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.00061\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T04:16:11Z","timestamp":1582690571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.00061\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,26]]},"references-count":164,"alternative-id":["10.3389\/fcell.2020.00061"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.00061","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,26]]},"article-number":"61"}}