{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:09:48Z","timestamp":1790287788144,"version":"4.1.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560299"],"award-info":[{"award-number":["81560299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660163"],"award-info":[{"award-number":["81660163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2020.00479","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T04:36:08Z","timestamp":1591936568000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":119,"title":["The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia"],"prefix":"10.3389","volume":"8","author":[{"given":"Ziteng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/ptr.5998","article-title":"Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: a randomized clinical trial.","volume":"32","author":"Alizadeh","year":"2018","journal-title":"Phytother. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1089\/jmf.2017.3930","article-title":"A novel highly bioavailable curcumin formulation improves symptoms and diagnostic indicators in rheumatoid arthritis patients: a randomized, double-blind, placebo-controlled, two-dose, three-arm, and parallel-group study.","volume":"20","author":"Amalraj","year":"2017","journal-title":"J. Med. Food"},{"key":"B3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.22088\/ijmcm.Bums.7.4.212","article-title":"Curcumin mitigates radiation-induced lung pneumonitis and fibrosis in rats.","volume":"7","author":"Amini","year":"2018","journal-title":"Int. J. Mol. Cell. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ctim.2019.02.014","article-title":"Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: a randomized double-blind placebo- controlled clinical trial.","volume":"43","author":"Asadi","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057285","article-title":"Curcumin modulates the inflammatory response and inhibits subsequent fibrosis in a mouse model of viral-induced acute respiratory distress syndrome.","volume":"8","author":"Avasarala","year":"2013","journal-title":"PLoS One"},{"key":"B6","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-\u03baB and I\u03baB proteins: new discoveries and insights.","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1172\/jci40008","article-title":"Conventional DCs reduce liver ischemia\/reperfusion injury in mice via IL-10 secretion.","volume":"120","author":"Bamboat","year":"2010","journal-title":"J. Clin. Investig."},{"key":"B8","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1099\/jmm.0.016873-0","article-title":"Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB\/c mice.","volume":"59","author":"Bansal","year":"2010","journal-title":"J. Med. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"5753","DOI":"10.7314\/apjcp.2013.14.10.5753","article-title":"Clearance of cervical human papillomavirus infection by topical application of curcumin and curcumin containing polyherbal cream: a phase II randomized controlled study.","volume":"14","author":"Basu","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/art.40071","article-title":"Cytokine storm syndrome: looking toward the precision medicine era.","volume":"69","author":"Behrens","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/00004836-200110000-00006","article-title":"Side effects of corticosteroid therapy.","volume":"33","author":"Buchman","year":"2001","journal-title":"J. Clin. Gastroenterol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109946","article-title":"Curcumin regulates the differentiation of na\u00efve CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice.","volume":"125","author":"Chai","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B13","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.chom.2016.01.007","article-title":"Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice.","volume":"19","author":"Channappanavar","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B14","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00281-017-0629-x","article-title":"\u201cPathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology.","volume":"39","author":"Channappanavar","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1974-z","article-title":"Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of I\u03baB\u03b1 and blocking mitochondrial damage.","volume":"21","author":"Chen","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"B16","first-page":"973","article-title":"Effects of curcumin on pulmonary fibrosis and functions of paraquat-challenged rats.","volume":"29","author":"Chen","year":"2017","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.intimp.2018.04.041","article-title":"Curcumin attenuates sepsis-induced acute organ dysfunction by preventing inflammation and enhancing the suppressive function of Tregs.","volume":"61","author":"Chen","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa449","article-title":"Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients.","author":"Chen","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.12659\/msm.908714","article-title":"Curcumin attenuates pulmonary inflammation in lipopolysaccharide induced acute lung injury in neonatal rat model by activating peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) pathway.","volume":"24","author":"Cheng","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"B20","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1001\/archotol.135.2.190","article-title":"Suppression of interleukin 6 and 8 production in head and neck cancer cells with curcumin via inhibition of I\u03ba\u03b2 kinase.","volume":"135","author":"Cohen","year":"2009","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.intimp.2017.11.009","article-title":"Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2\/4, p38\/JNK MAPK and NF-\u03baB pathways.","volume":"54","author":"Dai","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-11-79","article-title":"Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people.","volume":"11","author":"DiSilvestro","year":"2012","journal-title":"Nutr. J."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1218-x","article-title":"Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection.","volume":"13","author":"Du","year":"2017","journal-title":"BMC Vet. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1161\/circresaha.117.311401","article-title":"Reactive oxygen species in metabolic and inflammatory signaling.","volume":"122","author":"Forrester","year":"2018","journal-title":"Circ. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/s0140-6736(20)30630-9","article-title":"Did the hesitancy in declaring COVID-19 a pandemic reflect a need to redefine the term?","volume":"395","author":"Green","year":"2020","journal-title":"Lancet"},{"key":"B26","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/1440-1681.12848","article-title":"Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production.","volume":"45","author":"Han","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12943","article-title":"Neutrophil phenotypes in health and disease.","volume":"48","author":"Hellebrekers","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"key":"B28","first-page":"141","article-title":"Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.","volume":"20","author":"Hemeida","year":"2008","journal-title":"J. Egypt. Natl. Canc. Inst."},{"key":"B29","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/jmv.20255","article-title":"An interferon-\u03b3-related cytokine storm in SARS patients.","volume":"75","author":"Huang","year":"2005","journal-title":"J. Med. Virol."},{"key":"B30","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.163.6.3474","article-title":"Curcumin blocks cytokine-mediated NF-\u03baB activation and pro-inflammatory gene expression by inhibiting inhibitory factor I-\u03baB kinase activity.","volume":"163","author":"Jobin","year":"1999","journal-title":"J. Immunol."},{"key":"B31","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-019-2539-x","article-title":"Influenza virus-related critical illness: pathophysiology and epidemiology.","volume":"23","author":"Kalil","year":"2019","journal-title":"Crit. Care"},{"key":"B32","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.compbiolchem.2017.11.001","article-title":"Antiviral potential of natural compounds against influenza virus hemagglutinin.","volume":"71","author":"Kannan","year":"2017","journal-title":"Comput. Biol. Chem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1080\/21691401.2018.1446968","article-title":"Nano-gold displayed anti-inflammatory property via NF-kB pathways by suppressing COX-2 activity.","volume":"46","author":"Khan","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"5953","DOI":"10.1158\/1078-0432.ccr-11-1272","article-title":"Curcumin treatment suppresses IKK\u03b2 kinase activity of salivary cells of patients with head and neck cancer: a pilot study.","volume":"17","author":"Kim","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-020-01230-5","article-title":"3D-quantitative structure-activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase.","author":"Lai","year":"2020","journal-title":"Arch Pharm Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"G1079","DOI":"10.1152\/ajpgi.90365.2008","article-title":"Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection.","volume":"295","author":"Larmonier","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1099\/vir.0.055533-0","article-title":"Delayed induction of pro-inflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment.","volume":"94","author":"Lau","year":"2013","journal-title":"J. Gen. Virol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/cmi.2015.74","article-title":"The cytokine storm of severe influenza and development of immunomodulatory therapy.","volume":"13","author":"Liu","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1165\/rcmb.F305","article-title":"Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management.","volume":"33","author":"Matthay","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102537","article-title":"The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease.","volume":"19","author":"McGonagle","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation.","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/10408398.2017.1358139","article-title":"Immune modulation by curcumin: the role of interleukin-10.","volume":"59","author":"Mollazadeh","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B43","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.4049\/jimmunol.151.10.5666","article-title":"Protective effects of IL-4 and IL-10 against immune complex-induced lung injury.","volume":"151","author":"Mulligan","year":"1993","journal-title":"J. Immunol."},{"key":"B44","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/ni.3790","article-title":"A guiding map for inflammation.","volume":"18","author":"Netea","year":"2017","journal-title":"Nat. Immunol."},{"key":"B45","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1378\/chest.117.4.1162","article-title":"Anti-inflammatory cytokines.","volume":"117","author":"Opal","year":"2000","journal-title":"Chest"},{"key":"B46","doi-asserted-by":"publisher","first-page":"5829","DOI":"10.1111\/febs.12503","article-title":"Structure\u2013activity relationship analysis of curcumin analogues on anti-influenza virus activity.","volume":"280","author":"Ou","year":"2013","journal-title":"FEBS J."},{"key":"B47","doi-asserted-by":"publisher","first-page":"S88","DOI":"10.1038\/nm1143","article-title":"Severe acute respiratory syndrome.","volume":"10","author":"Peiris","year":"2004","journal-title":"Nat. Med."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00912","article-title":"Anti-infective properties of the golden spice curcumin.","volume":"10","author":"Praditya","year":"2019","journal-title":"Front. Microbiol."},{"key":"B49","first-page":"5032","article-title":"Curcumin relieves paraquat-induced lung injury through inhibiting the thioredoxin interacting protein\/NLR pyrin domain containing 3-mediated inflammatory pathway.","volume":"20","author":"Ren","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.jfda.2017.12.006","article-title":"Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection.","volume":"26","author":"Richart","year":"2018","journal-title":"J. Food Drug Anal."},{"key":"B51","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00109-011-0748-0","article-title":"AMP-activated protein kinase inhibits NF-\u03baB signaling and inflammation: impact on healthspan and lifespan.","volume":"89","author":"Salminen","year":"2011","journal-title":"J. Mol. Med."},{"key":"B52","first-page":"1","article-title":"Curcumin suppression of cytokine release and cytokine storm. A potential therapy for patients with Ebola and other severe viral infections.","volume":"29","author":"Sordillo","year":"2015","journal-title":"In Vivo"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1007\/s00432-015-1974-6","article-title":"Radiation-induced fibrosis: mechanisms and implications for therapy.","volume":"141","author":"Straub","year":"2015","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1165\/rcmb.2011-0175OC","article-title":"Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury.","volume":"47","author":"Suresh","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nri.2017.142","article-title":"NF-\u03baB, inflammation, immunity and cancer: coming of age.","volume":"18","author":"Taniguchi","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"B56","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"F, Peyrin-Biroulet L. Crohn\u2019s disease.","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"B57","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s10787-016-0286-z","article-title":"Curcumin inhibits paraquat induced lung inflammation and fibrosis by extracellular matrix modifications in mouse model.","volume":"24","author":"Tyagi","year":"2016","journal-title":"Inflammopharmacology"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010337","article-title":"Curcumin can decrease tissue inflammation and the severity of HSV-2 infection in the female reproductive mucosa.","volume":"21","author":"Vitali","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virusres.2007.02.007","article-title":"Up-regulation of IL-6 and TNF-alpha induced by SARS-coronavirus spike protein in murine macrophages via NF-kappaB pathway.","volume":"128","author":"Wang","year":"2007","journal-title":"Virus Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.biopha.2017.12.100","article-title":"Curcumin ameliorated ventilator-induced lung injury in rats.","volume":"98","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B61","first-page":"94","article-title":"Scavenging effects of curcumin on active oxygens and its anti-oxidation in vitro.","volume":"7","author":"Wang","year":"2008","journal-title":"Sci. Technol. Food Ind."},{"key":"B62","article-title":"Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures.","author":"Wang","year":"2020","journal-title":"J. Med. Virol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1021\/jm070295s","article-title":"Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.","volume":"50","author":"Wen","year":"2007","journal-title":"J. Med. Chem."},{"key":"B64","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0140-6736(07)60604-7","article-title":"Acute lung injury and the acute respiratory distress syndrome: a clinical review.","volume":"369","author":"Wheeler","year":"2007","journal-title":"Lancet"},{"key":"B65","doi-asserted-by":"crossref","DOI":"10.1001\/jamainternmed.2020.0994","article-title":"Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 Pneumonia in Wuhan, China.","author":"Wu","year":"2020","journal-title":"JAMA Intern. Med"},{"key":"B66","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.2147\/dddt.S215712","article-title":"Inhibition Of JNK phosphorylation by curcumin analog C66 Protects LPS-induced acute lung injury.","volume":"13","author":"Xiao","year":"2019","journal-title":"Drug Des. Dev. Ther."},{"key":"B67","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/crj.12113","article-title":"Curcumin attenuates staphylococcus aureus-induced acute lung injury.","volume":"9","author":"Xu","year":"2015","journal-title":"Clin. Respir. J."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101553","article-title":"Bioactivity, health benefits, and related molecular mechanisms of curcumin: current progress, challenges, and perspectives.","volume":"10","author":"Xu","year":"2018","journal-title":"Nutrients"},{"key":"B69","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/irv.12459","article-title":"Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF-\u03baB signaling pathway.","volume":"11","author":"Xu","year":"2017","journal-title":"Influenza Other Respir. Viruses"},{"key":"B70","doi-asserted-by":"publisher","first-page":"16086","DOI":"10.1039\/c7nr06520e","article-title":"Synergistic antiviral effect of curcumin functionalized graphene oxide against respiratory syncytial virus infection.","volume":"9","author":"Yang","year":"2017","journal-title":"Nanoscale"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1002\/ptr.5197","article-title":"Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial.","volume":"28","author":"Yang","year":"2014","journal-title":"Phytother. Res."},{"key":"B72","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciaa237","article-title":"In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).","author":"Yao","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1007\/s10753-018-0823-6","article-title":"Curcumin attenuates airway inflammation and airway remolding by inhibiting NF-\u03baB signaling and COX-2 in cigarette smoke-induced COPD mice.","volume":"41","author":"Yuan","year":"2018","journal-title":"Inflammation"},{"key":"B74","doi-asserted-by":"publisher","first-page":"13294","DOI":"10.1096\/fj.201901047rr","article-title":"Direct pulmonary delivery of solubilized curcumin reduces severity of lethal pneumonia.","volume":"33","author":"Zhang","year":"2019","journal-title":"FASEB J."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4350965","article-title":"ROS and ROS-mediated cellular signaling.","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B76","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-015-0199-1","article-title":"Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury.","volume":"16","author":"Zhang","year":"2015","journal-title":"Respir. Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/ptr.6257","article-title":"Curcumin intervention for cognitive function in different types of people: a systematic review and meta-analysis.","volume":"33","author":"Zhu","year":"2019","journal-title":"Phytother. Res."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.00479\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:21:12Z","timestamp":1696234872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.00479\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,12]]},"references-count":77,"alternative-id":["10.3389\/fcell.2020.00479"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.00479","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,12]]},"article-number":"479"}}