{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T18:44:10Z","timestamp":1774896250556,"version":"3.50.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RE 1723\/1-3"],"award-info":[{"award-number":["RE 1723\/1-3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["OD 102\/1-3"],"award-info":[{"award-number":["OD 102\/1-3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RE 1723\/1-1"],"award-info":[{"award-number":["RE 1723\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TH 1327\/1-1"],"award-info":[{"award-number":["TH 1327\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["1172\/37-1"],"award-info":[{"award-number":["1172\/37-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2020.00567","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T07:29:07Z","timestamp":1596785347000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["SLC20A1 Is Involved in Urinary Tract and Urorectal Development"],"prefix":"10.3389","volume":"8","author":[{"given":"Johanna Magdalena","family":"Rieke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6znur","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna S.","family":"Japp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipa M.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pleschka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina C.","family":"Hilger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenda M.","family":"Beaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agneta","family":"Nordenskj\u00f6ld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Karoline","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Promm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang H.","family":"R\u00f6sch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimund","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank-Mattias","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Schmiedeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Boemers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich","family":"Kluth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Hendrik","family":"Gosemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Anderberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gundela","family":"Holmdahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"L\u00e4ckgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Keene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimondo M.","family":"Cervellione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Giorgio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Di Grazia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter F. J.","family":"Feitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo L. M.","family":"Marcelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris A. L. M.","family":"Van Rooij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arend","family":"B\u00f6kenkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goedele M. A.","family":"Beckers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine E.","family":"Keegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tikam Chand","family":"Dakal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Wittler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Grote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Zwink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekkehart","family":"Jenetzky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Brusco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian S.","family":"Woolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Reutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"B1","author":"Abraham","year":"2004","journal-title":"Role of Programmed Cell Death in Defining Zebrafish Development."},{"key":"B2","doi-asserted-by":"publisher","first-page":"31363","DOI":"10.1074\/jbc.M109.053132","article-title":"Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity.","volume":"284","author":"Beck","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.compbiolchem.2017.03.007","article-title":"Structural modeling of human organic cation transporters.","volume":"68","author":"Dakal","year":"2017","journal-title":"Comput Biol Chem"},{"key":"B4","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S0022-5347(17)49224-X","article-title":"Cloacal exstrophy: a 22-Year experience.","volume":"133","author":"Diamond","year":"1985","journal-title":"J. Urol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-23","article-title":"The Exstrophy-epispadias complex.","volume":"4","author":"Ebert","year":"2009","journal-title":"Orphanet J. Rare Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"29979","DOI":"10.1074\/jbc.M109.022566","article-title":"New structural arrangement of the extracellular regions of the phosphate transporter SLC20A1, the receptor for gibbon ape leukemia virus.","volume":"284","author":"Farrell","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1002\/dvg.20577","article-title":"Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1.","volume":"47","author":"Festing","year":"2009","journal-title":"Genesis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"D854","DOI":"10.1093\/nar\/gks938","article-title":"ZFIN, the zebrafish model organism database: increased support for mutants and transgenics.","volume":"41","author":"Howe","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053393","article-title":"High expression of the Pi-Transporter SLC20A1\/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1.","volume":"8","author":"Husseini","year":"2013","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1155\/2014\/587064","article-title":"Modern management of the exstrophy-epispadias complex.","volume":"14","author":"Inouye","year":"2014","journal-title":"Surg. Res. Pract."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/S0006-3495(99)77009-8","article-title":"Helix packing in polytopic membrane proteins: role of glycine in transmembrane helix association.","volume":"77","author":"Javadpour","year":"1999","journal-title":"Biophys. J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish.","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"B13","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.ajhg.2019.03.023","article-title":"Rare variants in BNC2 are implicated in autosomal-dominant congenital lower urinary-tract obstruction.","volume":"104","author":"Kolvenbach","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"B14","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0014-5793(92)81106-v","article-title":"Glycine and beta-branched residues support and modulate peptide helicity in membrane environments.","volume":"311","author":"Li","year":"1992","journal-title":"FEBS Lett."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1016\/S0022-3468(05)80328-8","article-title":"Cloacal exstrophy: experience with 20 cases.","volume":"28","author":"Lund","year":"1993","journal-title":"J. Pediat. Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.urology.2018.10.049","article-title":"Variant presentations of the exstrophy-epispadias complex: a 40-year experience.","volume":"125","author":"Maruf","year":"2019","journal-title":"Urology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.modgep.2006.01.005","article-title":"The Na+\/PO4 cotransporter SLC20A1 gene labels distinct restricted subdomains of the developing pronephros in Xenopus and zebrafish embryos.","volume":"6","author":"Nichane","year":"2006","journal-title":"Gene Expr. Patterns"},{"key":"B18","first-page":"119","article-title":"Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus.","volume":"1","author":"O\u2019Hara","year":"1990","journal-title":"Cell Growth Differ."},{"key":"B19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ydbio.2007.06.022","article-title":"The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros.","volume":"309","author":"Perner","year":"2007","journal-title":"Dev. Biol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-5-r84","article-title":"Organization of the pronephric kidney revealed by large-scale gene expression mapping.","volume":"9","author":"Raciti","year":"2008","journal-title":"Genome Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/1389202916666151014221806","article-title":"Genetics of bladder-exstrophy-epispadias complex (BEEC): systematic elucidation of mendelian and multifactorial phenotypes.","volume":"17","author":"Reutter","year":"2016","journal-title":"Curr. Genomics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/bdra.23512","article-title":"AGORA, a data- and biobank for birth defects and childhood cancer. Birth defects research.","volume":"106","author":"Rooij","year":"2016","journal-title":"Part A Clin. Mol. Teratol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction.","volume":"5","author":"Roy","year":"2010","journal-title":"Nat. Protoc."},{"key":"B24","doi-asserted-by":"publisher","first-page":"34408","DOI":"10.1074\/jbc.M110.130989","article-title":"Identification of a novel transport-independent function of PiT1\/SLC20A1 in the regulation of TNF-induced apoptosis.","volume":"285","author":"Sala\u00fcn","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.urology.2011.09.022","article-title":"Congenital renal anomalies in patients with classic bladder exstrophy.","volume":"79","author":"Stec","year":"2012","journal-title":"Urology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos.","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat. Protoc."},{"key":"B27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.mod.2014.08.001","article-title":"Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.","volume":"133","author":"Wallingford","year":"2014","journal-title":"Mech. Dev."},{"key":"B28","author":"Westerfield","year":"2000","journal-title":"The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio)"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/srep42170","article-title":"ISL1 is a major susceptibility gene for classic bladder exstrophy and a regulator of urinary tract development.","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.00567\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T07:29:16Z","timestamp":1596785356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.00567\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,7]]},"references-count":29,"alternative-id":["10.3389\/fcell.2020.00567"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.00567","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,7]]},"article-number":"567"}}