{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:09:33Z","timestamp":1772244573125,"version":"3.50.1"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2020.00615","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:14:56Z","timestamp":1594772096000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses"],"prefix":"10.3389","volume":"8","author":[{"given":"Prathamesh T.","family":"Nadar-Ponniah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahar","family":"Taiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Caspi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Koffler-Brill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amiel A.","family":"Dror","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronen","family":"Siman-Tov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moran","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnanand","family":"Padmanabhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Luxenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen B.","family":"Avraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Rosin-Arbesfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.1093\/hmg\/ddg358","article-title":"PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23.","volume":"12","author":"Ahmed","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019183","article-title":"Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.","volume":"6","author":"Alagramam","year":"2011","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1113\/jphysiol.1987.sp016617","article-title":"A fast motile response in guinea-pig outer hair cells: the cellular basis of the cochlear amplifier.","volume":"388","author":"Ashmore","year":"1987","journal-title":"J. Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1080\/147342207012259120","article-title":"Phocein: a potential actor in vesicular trafficking at Purkinje cell dendritic spines.","volume":"6","author":"Bailly","year":"2007","journal-title":"Cerebellum"},{"key":"B5","doi-asserted-by":"publisher","first-page":"11048","DOI":"10.1073\/pnas.1902163116","article-title":"Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for hearing.","volume":"116","author":"Bartsch","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B6","doi-asserted-by":"publisher","first-page":"E10928","DOI":"10.1073\/pnas.1713535114","article-title":"STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo.","volume":"114","author":"Bazzi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B7","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jphysparis.2005.12.006","article-title":"The striatin family: a new signaling platform in dendritic spines.","volume":"99","author":"Benoist","year":"2006","journal-title":"J. Physiol. Paris"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1093\/hmg\/ddg210","article-title":"Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration.","volume":"12","author":"Ben-Yosef","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00335-015-9614-7","article-title":"The GPSM2\/LGN GoLoco motifs are essential for hearing.","volume":"27","author":"Bhonker","year":"2016","journal-title":"Mamm. Genome"},{"key":"B10","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/416874a","article-title":"Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.","volume":"416","author":"Boettger","year":"2002","journal-title":"Nature"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1016\/j.bbamcr.2008.04.017","article-title":"The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members.","volume":"1783","author":"Breitman","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"B12","doi-asserted-by":"publisher","first-page":"19970","DOI":"10.1074\/jbc.M909782199","article-title":"Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain.","volume":"275","author":"Castets","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/s41556-019-0426-y","article-title":"STRIPAK integrates upstream signals to initiate the Hippo kinase cascade.","volume":"21","author":"Chen","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s41586-018-0728-4","article-title":"Helios is a key transcriptional regulator of outer hair cell maturation.","volume":"563","author":"Chessum","year":"2018","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004712","article-title":"Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.","volume":"6","author":"Couzens","year":"2013","journal-title":"Sci. Signal."},{"key":"B16","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1523\/JNEUROSCI.12-12-04575.1992","article-title":"The active cochlea.","volume":"12","author":"Dallos","year":"1992","journal-title":"J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.conb.2008.08.016","article-title":"Cochlear amplification, outer hair cells and prestin.","volume":"18","author":"Dallos","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s00441-018-2968-x","article-title":"The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system.","volume":"375","author":"Domke","year":"2019","journal-title":"Cell Tissue Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00441-014-1906-9","article-title":"The cell-cell junctions of mammalian testes: I. The adhering junctions of the seminiferous epithelium represent special differentiation structures.","volume":"357","author":"Domke","year":"2014","journal-title":"Cell Tissue Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"21724","DOI":"10.1074\/jbc.M110.120188","article-title":"Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation.","volume":"285","author":"Dror","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/s0006-291x(03)00498-4","article-title":"Claudins in the tight junctions of stria vascularis marginal cells.","volume":"304","author":"Florian","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s00441-014-2053-z","article-title":"Striatins as plaque molecules of Zonulae adhaerentes in simple epithelia, of tessellate junctions in stratified epithelia, of cardiac composite junctions and of various size classes of lateral adherens junctions in cultures of epithelia- and carcinoma-derived cells.","volume":"359","author":"Franke","year":"2015","journal-title":"Cell Tissue Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.cell.2012.04.028","article-title":"Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions.","volume":"149","author":"Frost","year":"2012","journal-title":"Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1083\/jcb.200110122","article-title":"Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice.","volume":"156","author":"Furuse","year":"2002","journal-title":"J. Cell Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1074\/mcp.M800266-MCP200","article-title":"A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.","volume":"8","author":"Goudreault","year":"2009","journal-title":"Mol. Cell. Proteom."},{"key":"B26","doi-asserted-by":"publisher","first-page":"9236","DOI":"10.1523\/JNEUROSCI.4384-14.2015","article-title":"Adenomatous polyposis coli protein deletion in efferent olivocochlear neurons perturbs afferent synaptic maturation and reduces the dynamic range of hearing.","volume":"35","author":"Hickman","year":"2015","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120674","article-title":"Deficiency of angulin-2\/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice.","volume":"10","author":"Higashi","year":"2015","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1172\/JCI66911","article-title":"The LINC complex is essential for hearing.","volume":"123","author":"Horn","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3109\/00016487809122718","article-title":"A technique for preparation of cochlear specimens for assessment with the scanning electron microscope.","volume":"351","author":"Hunter-Duvar","year":"1978","journal-title":"Acta Otolaryngol. Suppl."},{"key":"B30","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.biocel.2013.11.021","article-title":"STRIPAK complexes: structure, biological function, and involvement in human diseases.","volume":"47","author":"Hwang","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1016\/j.str.2018.06.003","article-title":"Zooming in on cadherin-23: structural diversity and potential mechanisms of inherited deafness.","volume":"26","author":"Jaiganesh","year":"","journal-title":"Structure"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029280","article-title":"Beyond cell-cell adhesion: sensational cadherins for hearing and balance.","volume":"10","author":"Jaiganesh","year":"","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s12192-017-0816-7","article-title":"SG2NA is a regulator of endoplasmic reticulum (ER) homeostasis as its depletion leads to ER stress.","volume":"22","author":"Jain","year":"2017","journal-title":"Cell Stress Chaperon."},{"key":"B34","doi-asserted-by":"publisher","first-page":"13336","DOI":"10.1073\/pnas.97.24.13336","article-title":"High-resolution structure of hair-cell tip links.","volume":"97","author":"Kachar","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s10162-017-0620-1","article-title":"Spatial gradients in the size of inner hair cell ribbons emerge before the onset of hearing in rats.","volume":"18","author":"Kalluri","year":"2017","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/srep18402","article-title":"Deletion of tricellulin causes progressive hearing loss associated with degeneration of cochlear hair cells.","volume":"5","author":"Kamitani","year":"2015","journal-title":"Sci. Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"15582","DOI":"10.1523\/JNEUROSCI.1965-15.2015","article-title":"Progressive hearing loss in mice carrying a mutation in Usp53.","volume":"35","author":"Kazmierczak","year":"2015","journal-title":"J. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.febslet.2014.12.003","article-title":"Downregulation of striatin leads to hyperphosphorylation of MAP2, induces depolymerization of microtubules and inhibits proliferation of HEK293T cells.","volume":"589","author":"Kazmierczak-Baranska","year":"2015","journal-title":"FEBS Lett."},{"key":"B39","doi-asserted-by":"publisher","first-page":"25065","DOI":"10.1074\/jbc.M110.214486","article-title":"Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization.","volume":"286","author":"Kean","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/nature03418","article-title":"Hair cell synaptic ribbons are essential for synchronous auditory signalling.","volume":"434","author":"Khimich","year":"2005","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6137541","article-title":"Tricellular tight junctions in the inner ear.","volume":"2016","author":"Kitajiri","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"B42","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1242\/bio.20147799","article-title":"Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells.","volume":"3","author":"Kitajiri","year":"2014","journal-title":"Biol. Open"},{"key":"B43","doi-asserted-by":"publisher","first-page":"5087","DOI":"10.1242\/jcs.01393","article-title":"Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential.","volume":"117","author":"Kitajiri","year":"2004","journal-title":"J. Cell Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1515\/hsz-2019-0173","article-title":"STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases.","volume":"400","author":"Kuck","year":"2019","journal-title":"Biol. Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"4729","DOI":"10.1096\/fj.201801882R","article-title":"Striatin is a novel modulator of cell adhesion.","volume":"33","author":"Lahav-Ariel","year":"2019","journal-title":"FASEB J."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7449","article-title":"CCM-3\/STRIPAK promotes seamless tube extension through endocytic recycling.","volume":"6","author":"Lant","year":"2015","journal-title":"Nat. Commun."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.199","article-title":"Transcriptomes of cochlear inner and outer hair cells from adult mice.","volume":"5","author":"Li","year":"2018","journal-title":"Sci. Data"},{"key":"B48","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1523\/JNEUROSCI.3389-10.2011","article-title":"Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve\/hair-cell synapses.","volume":"31","author":"Liberman","year":"2011","journal-title":"J. Neurosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1126\/science.7079757","article-title":"Single-neuron labeling in the cat auditory nerve.","volume":"216","author":"Liberman","year":"1982","journal-title":"Science"},{"key":"B50","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/nature01059","article-title":"Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier.","volume":"419","author":"Liberman","year":"2002","journal-title":"Nature"},{"key":"B51","first-page":"1","article-title":"Acoustic trauma in cats. Cochlear pathology and auditory-nerve activity.","volume":"358","author":"Liberman","year":"1978","journal-title":"Acta Otolaryngol. Suppl."},{"key":"B52","doi-asserted-by":"publisher","first-page":"11085","DOI":"10.1523\/JNEUROSCI.1690-14.2014","article-title":"Characterization of transcriptomes of cochlear inner and outer hair cells.","volume":"34","author":"Liu","year":"2014","journal-title":"J. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5982397","article-title":"Analysis of the damage mechanism related to CO2 laser cochleostomy on guinea pig cochlea.","volume":"2016","author":"Liu","year":"2016","journal-title":"Neural Plast."},{"key":"B54","doi-asserted-by":"publisher","first-page":"17126","DOI":"10.1073\/pnas.0407492101","article-title":"Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha.","volume":"101","author":"Lu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B55","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/ncb3083","article-title":"STRIPAK components determine mode of cancer cell migration and metastasis.","volume":"17","author":"Madsen","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1083\/jcb.200203001","article-title":"The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells.","volume":"157","author":"Mogensen","year":"2002","journal-title":"J. Cell Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"5257","DOI":"10.1074\/jbc.275.8.5257","article-title":"WD40 repeat proteins striatin and S\/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A.","volume":"275","author":"Moreno","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B58","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.ceb.2007.09.006","article-title":"Protocadherin family: diversity, structure, and function.","volume":"19","author":"Morishita","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1093\/hmg\/ddu474","article-title":"ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells.","volume":"24","author":"Morozko","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.11.987396","article-title":"Striatin is required for hearing and affects inner hair cells and ribbon synapses.","author":"Nadar Ponniah","year":"2020","journal-title":"bioRxiv"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000610","article-title":"A claudin-9-based ion permeability barrier is essential for hearing.","volume":"5","author":"Nakano","year":"2009","journal-title":"PLoS Genet."},{"key":"B62","doi-asserted-by":"publisher","first-page":"4036","DOI":"10.1172\/JCI69031","article-title":"Tricellulin deficiency affects tight junction architecture and cochlear hair cells.","volume":"123","author":"Nayak","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B63","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1083\/jcb.201606082","article-title":"A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation.","volume":"216","author":"Neisch","year":"2017","journal-title":"J. Cell Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.ajhg.2015.03.001","article-title":"Mutations impairing GSK3-Mediated MAF phosphorylation cause cataract, deafness, intellectual disability, seizures, and a down syndrome-like facies.","volume":"96","author":"Niceta","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"B65","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1248\/bpb.b18-00559","article-title":"Disruption of gap junction-mediated intercellular communication in the spiral ligament causes hearing and outer hair cell loss in the cochlea of mice.","volume":"42","author":"Nishiyama","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"B66","doi-asserted-by":"publisher","first-page":"4819","DOI":"10.1242\/jcs.03233","article-title":"Distinct subdomain organization and molecular composition of a tight junction with adherens junction features.","volume":"119","author":"Nunes","year":"2006","journal-title":"J. Cell Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.heares.2011.01.010","article-title":"Ion flow in stria vascularis and the production and regulation of cochlear endolymph and the endolymphatic potential.","volume":"277","author":"Patuzzi","year":"2011","journal-title":"Hear. Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0378-5955(84)90041-8","article-title":"Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction.","volume":"15","author":"Pickles","year":"1984","journal-title":"Hear. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1093\/molbev\/msz077","article-title":"Inner ear genes underwent positive selection and adaptation in the mammalian lineage.","volume":"36","author":"Pisciottano","year":"2019","journal-title":"Mol. Biol. Evol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.str.2017.01.014","article-title":"A partial calcium-free linker confers flexibility to inner-ear protocadherin-15.","volume":"25","author":"Powers","year":"2017","journal-title":"Structure"},{"key":"B71","doi-asserted-by":"publisher","first-page":"L64","DOI":"10.1529\/biophysj.107.128082","article-title":"Generation of the endocochlear potential: a biophysical model.","volume":"94","author":"Quraishi","year":"2008","journal-title":"Biophys. J."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1016\/j.celrep.2019.02.053","article-title":"Insights into the biology of hearing and deafness revealed by single-cell RNA sequencing.","volume":"26","author":"Ranum","year":"2019","journal-title":"Cell Rep."},{"key":"B73","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.molcel.2010.08.002","article-title":"Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.","volume":"39","author":"Ribeiro","year":"2010","journal-title":"Mol. Cell."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-484","article-title":"Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways.","volume":"15","author":"Rudnicki","year":"2014","journal-title":"BMC Genom."},{"key":"B75","doi-asserted-by":"publisher","first-page":"6366","DOI":"10.1523\/JNEUROSCI.5126-14.2015","article-title":"Gene expression by mouse inner ear hair cells during development.","volume":"35","author":"Scheffer","year":"2015","journal-title":"J. Neurosci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"4549","DOI":"10.1038\/onc.2016.9","article-title":"STRIPAK complexes in cell signaling and cancer.","volume":"35","author":"Shi","year":"2016","journal-title":"Oncogene"},{"key":"B77","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.neuron.2010.03.028","article-title":"Structural determinants of cadherin-23 function in hearing and deafness.","volume":"66","author":"Sotomayor","year":"2010","journal-title":"Neuron"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-018-0077-3","article-title":"Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.","volume":"5","author":"Tang","year":"2019","journal-title":"Cell Discov."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2014.07.009","article-title":"SG2NA recruits DJ-1 and Akt into the mitochondria and membrane to protect cells from oxidative damage.","volume":"75","author":"Tanti","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1101\/gad.463208","article-title":"Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.","volume":"22","author":"Tran","year":"2008","journal-title":"Genes Dev."},{"key":"B81","doi-asserted-by":"publisher","first-page":"11484","DOI":"10.1523\/JNEUROSCI.5584-08.2009","article-title":"PP2A and GSK-3beta act antagonistically to regulate active zone development.","volume":"29","author":"Viquez","year":"2009","journal-title":"J. Neurosci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.semcdb.2013.03.009","article-title":"Inner ear supporting cells: rethinking the silent majority.","volume":"24","author":"Wan","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.joto.2016.01.003","article-title":"Cell junction proteins within the cochlea: a review of recent research.","volume":"10","author":"Wang","year":"2015","journal-title":"J. Otol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.neuroscience.2018.07.053","article-title":"Primary neural degeneration in the human cochlea: evidence for hidden hearing loss in the aging Ear.","volume":"407","author":"Wu","year":"2019","journal-title":"Neuroscience"},{"key":"B85","doi-asserted-by":"publisher","first-page":"8583","DOI":"10.1523\/JNEUROSCI.0295-17.2017","article-title":"An Atoh1-S193A phospho-mutant allele causes hearing deficits and motor impairment.","volume":"37","author":"Xie","year":"2017","journal-title":"J. Neurosci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1258\/la.2010.009142","article-title":"Conservation of endocochlear potential in mice with profound hearing loss induced by co-administration of kanamycin and furosemide.","volume":"45","author":"Xiong","year":"2011","journal-title":"Lab. Anim."},{"key":"B87","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s10162-014-0462-z","article-title":"Olivocochlear innervation maintains the normal modiolar-pillar and habenular-cuticular gradients in cochlear synaptic morphology.","volume":"15","author":"Yin","year":"2014","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00461","article-title":"Inactivation of cyclin-dependent kinase 5 in hair cells causes hearing loss in mice.","volume":"11","author":"Zhai","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.devcel.2013.09.021","article-title":"A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.","volume":"27","author":"Zhang","year":"2013","journal-title":"Dev. Cell"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.00615\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:15:00Z","timestamp":1594772100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.00615\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":89,"alternative-id":["10.3389\/fcell.2020.00615"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.00615","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.03.11.987396","asserted-by":"object"}]},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,15]]},"article-number":"615"}}