{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:57:03Z","timestamp":1785902223786,"version":"3.56.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Mitochondrial dysfunction contributes to cardiovascular disorders, especially post-infarction cardiac injury, through incompletely characterized mechanisms. Among the latter, increasing evidence points to alterations in mitochondrial quality control, a range of adaptive responses regulating mitochondrial morphology and function. Optic atrophy 1 (Opa1) is a mitochondrial inner membrane GTPase known to promote mitochondrial fusion. In this study, hypoxia-mediated cardiomyocyte damage was induced to mimic post-infarction cardiac injury <jats:italic>in vitro<\/jats:italic>. Loss- and gain-of-function assays were then performed to evaluate the impact of Opa1 expression on mitochondrial quality control and cardiomyocyte survival and function. Hypoxic stress reduced cardiomyocyte viability, impaired contractile\/relaxation functions, and augmented the synthesis of pro-inflammatory mediators. These effects were exacerbated by Opa1 knockdown, and significantly attenuated by Opa1 overexpression. Mitochondrial quality control was disturbed by hypoxia, as reflected by multiple mitochondrial deficits; i.e., increased fission, defective fusion, impaired mitophagy, decreased biogenesis, increased oxidative stress, and blunted respiration. By contrast, overexpression of Opa1 normalized mitochondrial quality control and sustained cardiomyocyte function. We also found that ERK, AMPK, and YAP signaling can regulate Opa1 expression. These results identify Opa1 as a novel regulator of mitochondrial quality control and highlight a key role for Opa1 in protecting cardiomyocytes against post-infarction cardiac injury.<\/jats:p>","DOI":"10.3389\/fcell.2020.00853","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T04:41:52Z","timestamp":1598589712000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["RETRACTED: Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control"],"prefix":"10.3389","volume":"8","author":[{"given":"Ting","family":"Xin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongle","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/s41418-018-0164-x","article-title":"M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila.","volume":"26","author":"Aalto","year":"2019","journal-title":"Cell Death Differ."},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-019-0730-5","article-title":"Calpains mediate isoproterenol-induced hypertrophy through modulation of GRK2.","volume":"114","author":"Aluja","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s10456-018-9605-x","article-title":"Serum\/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells.","volume":"21","author":"Araki","year":"2018","journal-title":"Angiogenesis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41418-018-0142-3","article-title":"Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2\/IP3 receptor disruptor BIRD-2.","volume":"26","author":"Bittremieux","year":"2019","journal-title":"Cell Death Differ."},{"key":"B5","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-018-0696-8","article-title":"Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection.","volume":"113","author":"Botker","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108430","article-title":"Severity and duration of hypoxic stress differentially regulates HIF-1alpha-mediated cardiomyocyte apoptotic signaling milieu during myocardial infarction.","volume":"690","author":"Chaudhuri","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5298483","article-title":"Melatonin attenuates calcium deposition from vascular smooth muscle cells by activating mitochondrial fusion and mitophagy via an AMPK\/OPA1 signaling pathway.","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"6550","DOI":"10.7150\/thno.35218","article-title":"Hypoxia-induced H19\/YB-1 cascade modulates cardiac remodeling after infarction.","volume":"9","author":"Choong","year":"2019","journal-title":"Theranostics"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0737-y","article-title":"E2f1 deletion attenuates infarct-induced ventricular remodeling without affecting O-GlcNAcylation.","volume":"114","author":"Dassanayaka","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0704-z","article-title":"The 10th biennial hatter cardiovascular institute workshop: cellular protection-evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology.","volume":"113","author":"Davidson","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"B11","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-018-0707-9","article-title":"Uncoupling protein 3 deficiency impairs myocardial fatty acid oxidation and contractile recovery following ischemia\/reperfusion.","volume":"113","author":"Edwards","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"B12","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-019-0720-7","article-title":"Protein kinase\/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling.","volume":"114","author":"Eiringhaus","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"B13","article-title":"Role of Pd(II)-Chitooligosaccharides-Gboxin analog in oxidative phosphorylation inhibition and energy depletion: targeting mitochondrial dynamics.","author":"Elshaarawy","year":"2020","journal-title":"Chem. Biol. Drug Des."},{"key":"B14","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-018-0670-5","article-title":"The SAFE pathway for cardioprotection: is this a promising target?","volume":"113","author":"Hadebe","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/s41418-018-0126-3","article-title":"TP53 gain-of-function mutation promotes inflammation in glioblastoma.","volume":"26","author":"Ham","year":"2019","journal-title":"Cell Death Differ."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00150","article-title":"An update on the multifaceted roles of STAT3 in the heart.","volume":"6","author":"Harhous","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"B17","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-018-0673-2","article-title":"25 years of remote ischemic conditioning: from laboratory curiosity to clinical outcome.","volume":"113","author":"Heusch","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"B18","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-019-0756-8","article-title":"Coronary microvascular obstruction: the new frontier in cardioprotection.","volume":"114","author":"Heusch","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.redox.2018.10.004","article-title":"Ascorbic acid metabolites are involved in intraocular pressure control in the general population.","volume":"20","author":"Hysi","year":"2019","journal-title":"Redox Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s10565-018-09458-0","article-title":"Interaction of EZH2 and P65 is involved in the arsenic trioxide-induced anti-angiogenesis in human triple-negative breast cancer cells.","volume":"35","author":"Jiang","year":"2019","journal-title":"Cell Biol. Toxicol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.redox.2017.11.004","article-title":"DUSP1 alleviates cardiac ischemia\/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.","volume":"14","author":"Jin","year":"2018","journal-title":"Redox Biol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0712-z","article-title":"Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction.","volume":"114","author":"Jung","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/FJC.0000000000000736","article-title":"Role of YAP\/TAZ in energy metabolism in the heart.","volume":"74","author":"Kashihara","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B24","article-title":"Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.","volume":"114","author":"Kohlhauer","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.apsb.2019.01.014","article-title":"Regulation of microbiota-GLP1 axis by sennoside A in diet-induced obese mice.","volume":"9","author":"Le","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"B26","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1111\/jcmm.14799","article-title":"Down-regulation of the mitochondrial i-AAA protease Yme1L induces muscle atrophy via FoxO3a and myostatin activation.","volume":"24","author":"Lee","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"12581","DOI":"10.1074\/jbc.RA119.007601","article-title":"In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way.","volume":"294","author":"Li","year":"2019","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10456-018-9645-2","article-title":"Angiogenesis in pancreatic cancer: current research status and clinical implications.","volume":"22","author":"Li","year":"2019","journal-title":"Angiogenesis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"6467","DOI":"10.18632\/aging.102972","article-title":"Role of mitochondrial quality control in the pathogenesis of nonalcoholic fatty liver disease.","volume":"12","author":"Li","year":"2020","journal-title":"Aging"},{"key":"B30","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1038\/s41418-018-0169-5","article-title":"TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.","volume":"26","author":"Lionnard","year":"2019","journal-title":"Cell Death Differ."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellsig.2018.09.009","article-title":"Sirt3 attenuates post-infarction cardiac injury via inhibiting mitochondrial fission and normalization of AMPK-Drp1 pathways.","volume":"53","author":"Liu","year":"2019","journal-title":"Cell. Signal."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2193019","article-title":"Inhibitor 1 of protein phosphatase 1 regulates Ca(2+)\/calmodulin-dependent protein kinase II to alleviate oxidative stress in hypoxia-reoxygenation injury of cardiomyocytes.","volume":"2019","author":"Luo","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1080\/10799893.2019.1690514","article-title":"NURR1 inhibition reduces hypoxia-mediated cardiomyocyte necrosis via blocking Mst1-JNK-mPTP pathway.","volume":"39","author":"Ma","year":"2019","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.redox.2018.11.011","article-title":"Proteomic analysis of microbial induced redox-dependent intestinal signaling.","volume":"20","author":"Matthews","year":"2019","journal-title":"Redox Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.redox.2018.10.005","article-title":"Increased SOD2 in the diaphragm contributes to exercise-induced protection against ventilator-induced diaphragm dysfunction.","volume":"20","author":"Morton","year":"2019","journal-title":"Redox Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s10456-018-9656-z","article-title":"TSPYL5-mediated inhibition of p53 promotes human endothelial cell function.","volume":"22","author":"Na","year":"2019","journal-title":"Angiogenesis"},{"key":"B37","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1080\/10799893.2018.1476544","article-title":"Pharmacophore modeling, molecular docking and molecular dynamics studies on natural products database to discover novel skeleton as non-purine xanthine oxidase inhibitors.","volume":"38","author":"Peng","year":"2018","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01404","article-title":"The role of myocardial mitochondrial quality control in heart failure.","volume":"10","author":"Qiu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1038\/s41418-019-0470-y","article-title":"Mitochondrial 4-HNE derived from MAO-A promotes mitoCa(2+) overload in chronic postischemic cardiac remodeling.","volume":"27","author":"Santin","year":"2020","journal-title":"Cell Death Differ."},{"key":"B40","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.cmet.2020.04.014","article-title":"OPA1 and angiogenesis: beyond the fusion function.","volume":"31","author":"Schuler","year":"2020","journal-title":"Cell Metab."},{"key":"B41","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1080\/10799893.2019.1676259","article-title":"Ripk3 mediates cardiomyocyte necrosis through targeting mitochondria and the JNK-Bnip3 pathway under hypoxia-reoxygenation injury.","volume":"39","author":"Song","year":"2019","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0728-z","article-title":"Exogenous GDF11 attenuates non-canonical TGF-beta signaling to protect the heart from acute myocardial ischemia-reperfusion injury.","volume":"114","author":"Su","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"8122","DOI":"10.1002\/jcp.27597","article-title":"Mitochondrial quality control in cardiac cells: mechanisms and role in cardiac cell injury and disease.","volume":"234","author":"Tahrir","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00382","article-title":"Mitochondrial quality control in aging and heart failure: influence of ketone bodies and mitofusin-stabilizing peptides.","volume":"10","author":"Thai","year":"2019","journal-title":"Front. Physiol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.113832","article-title":"Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R\/MCU pathways in cardiorenal syndrome type 3.","volume":"174","author":"Wang","year":"","journal-title":"Biochem. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104771","article-title":"Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: new insights into the mechanisms and therapeutic potentials.","volume":"156","author":"Wang","year":"","journal-title":"Pharmacol. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10456-020-09720-2","article-title":"New insights into the role of mitochondria in cardiac microvascular ischemia\/reperfusion injury.","volume":"23","author":"Wang","year":"","journal-title":"Angiogenesis"},{"key":"B48","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s10565-020-09513-9","article-title":"Pum2-Mff axis fine-tunes mitochondrial quality control in acute ischemic kidney injury.","volume":"36","author":"Wang","year":"","journal-title":"Cell Biol. Toxicol."},{"key":"B49","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-018-0085-1","article-title":"Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.","volume":"23","author":"Wang","year":"2018","journal-title":"Cell. Mol. Biol. Lett."},{"key":"B50","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10456-018-9635-4","article-title":"Cellular self-assembly into 3D microtissues enhances the angiogenic activity and functional neovascularization capacity of human cardiopoietic stem cells.","volume":"22","author":"Wolint","year":"2019","journal-title":"Angiogenesis"},{"key":"B51","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-019-0747-9","article-title":"Cardioprotection of post-ischemic moderate ROS against ischemia\/reperfusion via STAT3-induced the inhibition of MCU opening.","volume":"114","author":"Wu","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1953-y","article-title":"OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction, and neuronal apoptosis in prion diseases.","volume":"10","author":"Wu","year":"2019","journal-title":"Cell Death Dis."},{"key":"B53","first-page":"7094","article-title":"Protective effects of Ulinastatin on oxidative stress and inflammation of rat-derived cardiomyocytes H9c2.","volume":"11","author":"Xie","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.18632\/aging.102899","article-title":"Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction.","volume":"12","author":"Xin","year":"2020","journal-title":"Aging"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00180","article-title":"OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion.","volume":"8","author":"Yang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"22921","DOI":"10.1002\/jcp.28854","article-title":"KPC1 alleviates hypoxia\/reoxygenation-induced apoptosis in rat cardiomyocyte cells though BAX degradation.","volume":"234","author":"Yuan","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/FJC.0000000000000719","article-title":"Sirtuin 3, endothelial metabolic reprogramming, and heart failure with preserved ejection fraction.","volume":"74","author":"Zeng","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1002\/jcp.29190","article-title":"Melatonin attenuates ER stress and mitochondrial damage in septic cardiomyopathy: a new mechanism involving BAP31 upregulation and MAPK-ERK pathway.","volume":"235","author":"Zhang","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12542","article-title":"Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion\/mitophagy and activating the AMPK-OPA1 signaling pathways.","volume":"66","author":"Zhang","year":"","journal-title":"J. Pineal Res."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00381","article-title":"YiQiFuMai powder injection attenuates coronary artery ligation-induced heart failure through improving mitochondrial function via regulating ROS generation and CaMKII signaling pathways.","volume":"10","author":"Zhang","year":"","journal-title":"Front. Pharmacol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.freeradbiomed.2016.03.035","article-title":"Liraglutide protects cardiac microvascular endothelial cells against hypoxia\/reoxygenation injury through the suppression of the SR-Ca(2+)-XO-ROS axis via activation of the GLP-1R\/PI3K\/Akt\/survivin pathways.","volume":"95","author":"Zhang","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005328","article-title":"Mff-dependent mitochondrial fission contributes to the pathogenesis of cardiac microvasculature ischemia\/reperfusion injury via induction of mROS-mediated cardiolipin oxidation and HK2\/VDAC1 disassociation-involved mPTP opening.","volume":"6","author":"Zhou","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12471","article-title":"Protective role of melatonin in cardiac ischemia-reperfusion injury: from pathogenesis to targeted therapy.","volume":"64","author":"Zhou","year":"","journal-title":"J. Pineal Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s10456-018-9611-z","article-title":"BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways.","volume":"21","author":"Zhou","year":"","journal-title":"Angiogenesis"},{"key":"B65","article-title":"NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2alpha.","volume":"113","author":"Zhou","year":"","journal-title":"Basic Res. Cardiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.redox.2017.12.019","article-title":"Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission.","volume":"15","author":"Zhou","year":"","journal-title":"Redox Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1038\/s41418-018-0086-7","article-title":"Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2alpha-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy.","volume":"25","author":"Zhou","year":"","journal-title":"Cell Death Differ."},{"key":"B68","article-title":"DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy.","volume":"4","author":"Zhou","year":"2019","journal-title":"Signal Transduct. Target. Ther."},{"key":"B69","doi-asserted-by":"publisher","first-page":"11835","DOI":"10.1002\/jcp.27892","article-title":"Notch1 provides myocardial protection by improving mitochondrial quality control.","volume":"234","author":"Zhou","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.redox.2018.02.019","article-title":"Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: a mechanism involving calcium overload\/XO\/ROS\/mPTP pathway.","volume":"16","author":"Zhu","year":"2018","journal-title":"Redox Biol."}],"updated-by":[{"DOI":"10.3389\/fcell.2022.1014307","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"record-id":"38853"},{"DOI":"10.3389\/fcell.2022.1014307","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000}}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2020.00853\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T15:08:58Z","timestamp":1712588938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2020.00853\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":70,"alternative-id":["10.3389\/fcell.2020.00853"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.00853","relation":{"retraction":[{"id-type":"doi","id":"10.3389\/fcell.2022.1014307","asserted-by":"object"}]},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"article-number":"853"}}