{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:12:41Z","timestamp":1794071561740,"version":"4.8.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009037","name":"Science and Technology Research Partnership for Sustainable Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009037","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2020.566617","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T04:59:37Z","timestamp":1602737977000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Fisetin Promotes Hair Growth by Augmenting TERT Expression"],"prefix":"10.3389","volume":"8","author":[{"given":"Chisato","family":"Kubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihisa","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Katakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.2174\/1389557516666160620095103","article-title":"Small molecules as SIRT modulators.","volume":"18","author":"Bai","year":"2018","journal-title":"Mini Rev. Med. Chem."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00175","article-title":"3,4,5-tri-O-caffeoylquinic acid promoted hair pigmentation through \u03b2-catenin and its target genes.","volume":"8","author":"Bejaoui","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.333","article-title":"P53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment.","volume":"8","author":"Chen","year":"2017","journal-title":"Cell Death Dis."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0040010","article-title":"TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program.","volume":"4","author":"Choi","year":"2008","journal-title":"PLoS Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jff.2019.01.017","article-title":"Identification of polyphenols that repair the ultraviolet-B-induced DNA damage via SIRT1-dependent XPC\/XPA activation.","volume":"54","author":"Chong","year":"2019","journal-title":"J. Funct. Foods"},{"key":"B6","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1038\/sj.onc.1210331","article-title":"TAK1 represses transcription of the human telomerase reverse transcriptase gene.","volume":"26","author":"Fujiki","year":"2007","journal-title":"Oncogene"},{"key":"B7","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/s0092-8674(00)81631-1","article-title":"De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin.","volume":"95","author":"Gat","year":"1998","journal-title":"Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1093\/jb\/mvu040","article-title":"Molecular mechanisms for the p38-induced cellular senescence in normal human fibroblast.","volume":"156","author":"Harada","year":"2014","journal-title":"J. Biochem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.jff.2016.01.016","article-title":"Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1.","volume":"23","author":"Harada","year":"2016","journal-title":"J. Funct. Foods"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1126\/science.1218370","article-title":"Wnt\/\u03b2-catenin signaling regulates telomerase in stem cells and cancer cells.","volume":"336","author":"Hoffmeyer","year":"2012","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1002\/ptr.5100","article-title":"Hair growth-promoting effect of Carthamus tinctorius floret extract.","volume":"28","author":"Junlatat","year":"2014","journal-title":"Phytother. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3746\/pnf.2014.19.3.136","article-title":"Platycarya strobilacea S. et Z. extract has a high antioxidant capacity and exhibits hair growth-promoting effects in male C57BL\/6 mice.","volume":"19","author":"Kim","year":"2014","journal-title":"Prev. Nutr. Food Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nature14306","article-title":"Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool.","volume":"522","author":"Mesa","year":"2015","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1242\/dev.016550","article-title":"Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation.","volume":"135","author":"N\u00e4rhi","year":"2008","journal-title":"Development"},{"key":"B15","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.bbrc.2017.07.069","article-title":"Promotion of hair growth by newly synthesized ceramide mimetic compound.","volume":"491","author":"Park","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B16","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/nature08137","article-title":"Telomerase modulates Wnt signalling by association with target gene chromatin.","volume":"460","author":"Park","year":"2009","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.lfs.2012.09.008","article-title":"Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt\/\u03b2-catenin signaling.","volume":"91","author":"Park","year":"2012","journal-title":"Life Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jdermsci.2004.12.025","article-title":"The hair growth promoting effect of Asiasari radix extract and its molecular regulation.","volume":"38","author":"Rho","year":"2005","journal-title":"J. Dermatol. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1038\/nature03836","article-title":"Conditional telomerase induction causes proliferation of hair follicle stem cells.","volume":"436","author":"Sarin","year":"2005","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.2174\/1381612824666180911114810","article-title":"Medicinal plants for the treatment of hair loss and the suggested mechanisms.","volume":"24","author":"Shen","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"B21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.5021\/ad.2016.28.1.15","article-title":"Enhancement of human hair growth using Ecklonia cava polyphenols.","volume":"28","author":"Shin","year":"2016","journal-title":"Ann. Dermatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ejphar.2014.02.024","article-title":"The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin.","volume":"730","author":"Shin","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.2147\/DDDT.S214907","article-title":"Minoxidil and its use in hair disorders: a review.","volume":"13","author":"Suchonwanit","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217394","article-title":"Carnosine induces intestinal cells to secrete exosomes that activate neuronal cells.","volume":"14","author":"Sugihara","year":"2019","journal-title":"PLoS One"},{"key":"B25","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0960-9822(03)00240-9","article-title":"Zebrafish prickle, a modulator of noncanonical Wnt\/Fz signaling, regulates gastrulation movements.","volume":"13","author":"Veeman","year":"2003","journal-title":"Curr. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/biof.1032","article-title":"Sirtuin activators and inhibitors.","volume":"38","author":"Villalba","year":"2012","journal-title":"Biofactors"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101864","article-title":"FOXO3a potentiates hTERT gene expression by activating c-MYC and extends the replicative life-span of human fibroblast.","volume":"9","author":"Yamashita","year":"2014","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.bbrc.2011.12.021","article-title":"SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene.","volume":"417","author":"Yamashita","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111835","article-title":"In vivo and in vitro evaluation of hair growth potential of Cacumen Platycladi, and GC-MS analysis of the active constituents of volatile oil.","volume":"238","author":"Zhang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"32494","DOI":"10.1074\/jbc.M112.368282","article-title":"Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt\/\u03b2-catenin pathway in human cancer.","volume":"287","author":"Zhang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2927131","article-title":"Pomegranate-derived polyphenols reduce reactive oxygen species production via SIRT3-mediated SOD2 activation.","volume":"2016","author":"Zhao","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112831","article-title":"Study on the chemical constituents of nuts oil from Prunus mira Koehne and the mechanism of promoting hair growth.","volume":"258","author":"Zhou","year":"2020","journal-title":"J. Ethnopharmacol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.566617\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T04:59:39Z","timestamp":1602737979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.566617\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,15]]},"references-count":32,"alternative-id":["10.3389\/fcell.2020.566617"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.566617","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,15]]},"article-number":"566617"}}