{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:33:15Z","timestamp":1793298795404,"version":"4.5.0"},"reference-count":183,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012692","name":"K. C. Wong Education Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2020.568889","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T05:04:15Z","timestamp":1602738255000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":84,"title":["The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases"],"prefix":"10.3389","volume":"8","author":[{"given":"Tahereh","family":"Gharbi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4763","article-title":"Exosomes in cancer: small vesicular transporters for cancer progression and metastasis, biomarkers in cancer therapeutics.","volume":"6","author":"Abak","year":"2018","journal-title":"PeerJ."},{"key":"B2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier.","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41593-017-0033-9","article-title":"The diversity and disparity of the glial scar.","volume":"21","author":"Adams","year":"2018","journal-title":"Nat. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.tins.2010.12.001","article-title":"Astrocyte-neuron metabolic relationships: for better and for worse.","volume":"34","author":"Allaman","year":"2011","journal-title":"Trends Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/s41386-019-0579-1","article-title":"Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics.","volume":"45","author":"Amoah","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neulet.2013.12.030","article-title":"Heterogeneity of reactive astrocytes.","volume":"565","author":"Anderson","year":"2014","journal-title":"Neurosci. Lett."},{"key":"B7","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature09613","article-title":"Glial and neuronal control of brain blood flow.","volume":"468","author":"Attwell","year":"2010","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0116-z","article-title":"Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species.","volume":"6","author":"Baglio","year":"2015","journal-title":"Stem. Cell Res. Ther."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00211","article-title":"Mesenchymal stem cell-derived extracellular vesicle therapy for stroke: challenges and progress.","volume":"10","author":"Bang","year":"2019","journal-title":"Front. Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"15699","DOI":"10.1074\/jbc.M112.425066","article-title":"Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis.","volume":"288","author":"Basso","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nn.4201","article-title":"Astrocyte calcium signaling: the third wave.","volume":"19","author":"Bazargani","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.4065\/80.10.1326","article-title":"Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system.","volume":"80","author":"Benarroch","year":"2005","journal-title":"Mayo Clin. Proc."},{"key":"B13","doi-asserted-by":"publisher","first-page":"713","DOI":"10.3892\/ijo.2018.4644","article-title":"Exosomal lncRNAATB activates astrocytes that promote glioma cell invasion.","volume":"54","author":"Bian","year":"2019","journal-title":"Int. J. Oncol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1590\/1414-431X20132964","article-title":"Extracellular vesicles: structure, function, and potential clinical uses in renal diseases.","volume":"46","author":"Borges","year":"2013","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00455","article-title":"Use of stem cell extracellular vesicles as a \u201cHolistic\u201d approach to CNS repair.","volume":"8","author":"Branscome","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00476","article-title":"Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation.","volume":"9","author":"Brites","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/nrendo.2010.123","article-title":"The growth hormone receptor: mechanism of activation and clinical implications.","volume":"6","author":"Brooks","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.2147\/NDT.S260748","article-title":"Protective role of astrocyte-derived exosomal microRNA-361 in cerebral ischemic-reperfusion injury by regulating the AMPK\/mTOR signaling pathway and targeting CTSB.","volume":"16","author":"Bu","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B19","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/ki.2010.278","article-title":"Exosomes\/microvesicles as a mechanism of cell-to-cell communication.","volume":"78","author":"Camussi","year":"2010","journal-title":"Kidney Int."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.3892\/mmr.2019.10351","article-title":"A 3Dscaffold of PLLA induces the morphological differentiation and migration of primary astrocytes and promotes the production of extracellular vesicles.","volume":"20","author":"Carfi Pavia","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0369-4","article-title":"TNFalpha and IL-1beta modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons.","volume":"9","author":"Chaudhuri","year":"2018","journal-title":"Cell Death Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s12195-016-0458-3","article-title":"Elucidation of exosome migration across the blood-brain barrier model in vitro.","volume":"9","author":"Chen","year":"2016","journal-title":"Cell Mol. Bioeng."},{"key":"B23","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/term.3002","article-title":"Astrocytes-derived exosomes induce neuronal recovery after traumatic brain injury via delivering GJA1-20k.","volume":"14","author":"Chen","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00574","article-title":"Increased interleukin-6 levels in the astrocyte-derived exosomes of sporadic amyotrophic lateral sclerosis patients.","volume":"13","author":"Chen","year":"2019","journal-title":"Front. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neures.2019.07.007","article-title":"Reactive astrocytes increase expression of proNGF in the mouse model of contused spinal cord injury.","volume":"157","author":"Cheng","year":"2019","journal-title":"Neurosci. Res."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00217","article-title":"Amyloid beta-exposed human astrocytes overproduce phospho-tau and overrelease it within exosomes, effects suppressed by calcilytic nps 2143-further implications for Alzheimer\u2019s Therapy.","volume":"11","author":"Chiarini","year":"2017","journal-title":"Front. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011803","article-title":"Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs.","volume":"5","author":"Collino","year":"2010","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/s41583-018-0080-6","article-title":"Versatile control of synaptic circuits by astrocytes: where, when and how?","volume":"19","author":"Dallerac","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/glia.23708","article-title":"Stimulus-dependent modifications in astrocyte-derived extracellular vesicle cargo regulate neuronal excitability.","volume":"68","author":"Datta Chaudhuri","year":"2020","journal-title":"Glia"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-019-0193-0","article-title":"Exosomes derived from microRNA-138-5p-overexpressing bone marrow-derived mesenchymal stem cells confer neuroprotection to astrocytes following ischemic stroke via inhibition of LCN2.","volume":"13","author":"Deng","year":"2019","journal-title":"J. Biol. Eng."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aai7696","article-title":"Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions.","volume":"10","author":"Dickens","year":"2017","journal-title":"Sci. Signal"},{"key":"B32","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities.","volume":"12","author":"EL Andaloussi","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"B33","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.jalz.2019.09.004","article-title":"Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer\u2019s disease.","volume":"16","author":"Elahi","year":"2019","journal-title":"Alzheimers Dement"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1002\/glia.20579","article-title":"STI1 promotes glioma proliferation through MAPK and PI3K pathways.","volume":"55","author":"Erlich","year":"2007","journal-title":"Glia"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00182","article-title":"Extracellular vesicles as mediators of neuron-glia communication.","volume":"7","author":"Fruhbeis","year":"2013","journal-title":"Front. Cell Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1002\/ijc.32521","article-title":"Melanoma-derived extracellular vesicles instigate proinflammatory signaling in the metastatic microenvironment.","volume":"145","author":"Gener Lahav","year":"2019","journal-title":"Int. J. Cancer"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1021\/acschemneuro.0c00368","article-title":"Cell-derived exosome therapy: a novel approach to treat post-traumatic brain injury mediated neural injury.","volume":"11","author":"Ghosh","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1096\/fj.201600756R","article-title":"Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer\u2019s disease.","volume":"30","author":"Goetzl","year":"2016","journal-title":"FASEB J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1096\/fj.201801001","article-title":"Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease.","volume":"33","author":"Goetzl","year":"2019","journal-title":"FASEB J."},{"key":"B40","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/ana.25172","article-title":"High complement levels in astrocyte-derived exosomes of Alzheimer disease.","volume":"83","author":"Goetzl","year":"2018","journal-title":"Ann. Neurol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1096\/fj.201902842R","article-title":"Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins.","volume":"34","author":"Goetzl","year":"2020","journal-title":"FASEB J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/ijnp\/pyy098","article-title":"Small extracellular vesicles in rat serum contain astrocyte-derived protein biomarkers of repetitive stress.","volume":"22","author":"Gomez-Molina","year":"2019","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00251","article-title":"Extracellular microvesicles from astrocytes contain functional glutamate transporters: regulation by protein kinase C and cell activation.","volume":"7","author":"Gosselin","year":"2013","journal-title":"Front. Cell Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1002\/glia.22963","article-title":"Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein.","volume":"64","author":"Guitart","year":"2016","journal-title":"Glia"},{"key":"B45","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/cdd.2011.154","article-title":"Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.","volume":"19","author":"Gupta","year":"2012","journal-title":"Cell Death Differ."},{"key":"B46","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41593-020-0624-8","article-title":"Disease-associated astrocytes in Alzheimer\u2019s disease and aging.","volume":"23","author":"Habib","year":"2020","journal-title":"Nat. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1007\/s00018-013-1328-y","article-title":"The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles.","volume":"70","author":"Hajj","year":"2013","journal-title":"Cell Mol. Life Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"4566","DOI":"10.1007\/s12035-018-1385-1","article-title":"Extracellular vesicles released by glioblastoma cells stimulate normal astrocytes to acquire a tumor-supportive phenotype Via p53 and MYC signaling pathways.","volume":"56","author":"Hallal","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nrn2803","article-title":"Do astrocytes really exocytose neurotransmitters?","volume":"11","author":"Hamilton","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1089\/cbr.2007.368-R","article-title":"Review: cancer immunotherapy by exosome-based vaccines.","volume":"22","author":"Hao","year":"2007","journal-title":"Cancer Biother Radiopharm."},{"key":"B51","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/0006-291x(83)91776-x","article-title":"Transferrin recycling in reticulocytes: pH and iron are important determinants of ligand binding and processing.","volume":"113","author":"Harding","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1161\/STROKEAHA.118.021272","article-title":"Astrocyte-derived exosomes treated with a semaphorin 3A inhibitor enhance stroke recovery via prostaglandin D2 synthase.","volume":"49","author":"Hira","year":"2018","journal-title":"Stroke"},{"key":"B53","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.tins.2018.03.006","article-title":"Extracellular vesicles: multimodal envoys in neural maintenance and repair.","volume":"41","author":"Holm","year":"2018","journal-title":"Trends Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/s12276-020-0450-9","article-title":"Emerging role of extracellular vesicles in the respiratory system.","volume":"52","author":"Holtzman","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030538","article-title":"Exosomes: from garbage bins to promising therapeutic targets.","volume":"18","author":"H Rashed","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.omtn.2018.09.019","article-title":"Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: implications for Morphine-Mediated Neurodegeneration.","volume":"13","author":"Hu","year":"2018","journal-title":"Mol. Ther. Nucleic Acids."},{"key":"B57","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.expneurol.2016.05.003","article-title":"Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy.","volume":"283","author":"Hubbard","year":"2016","journal-title":"Exp. Neurol."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1529-x","article-title":"TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles.","volume":"16","author":"Ibanez","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"B59","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.freeradbiomed.2018.09.002","article-title":"Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis.","volume":"133","author":"Ishii","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2174\/1570159x14666160825160421","article-title":"Exosomes: the Messengers of Health and Disease.","volume":"15","author":"Isola","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/1073858418783959","article-title":"Microglia-astrocyte crosstalk: an intimate molecular conversation.","volume":"25","author":"Jha","year":"2019","journal-title":"Neuroscientist"},{"key":"B62","doi-asserted-by":"crossref","first-page":"9412","DOI":"10.1016\/S0021-9258(18)48095-7","article-title":"Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes).","volume":"262","author":"Johnstone","year":"1987","journal-title":"J. Biol. Chem."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171418","article-title":"Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes.","volume":"12","author":"Jovicic","year":"2017","journal-title":"PLoS One"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1172\/JCI81135","article-title":"The biology and function of exosomes in cancer.","volume":"126","author":"Kalluri","year":"2016","journal-title":"J. Clin. Invest."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44569-6","article-title":"Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood-brain barrier penetration.","volume":"9","author":"Khongkow","year":"2019","journal-title":"Sci. Rep."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/426125a","article-title":"Cancer robustness: tumour tactics.","volume":"426","author":"Kitano","year":"2003","journal-title":"Nature"},{"key":"B67","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nrc1300","article-title":"Cancer as a robust system: implications for anticancer therapy.","volume":"4","author":"Kitano","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/srep31215","article-title":"Smartphone-enabled optofluidic exosome diagnostic for concussion recovery.","volume":"6","author":"Ko","year":"2016","journal-title":"Sci. Rep."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204252","article-title":"An enriched environment prevents diabetes-induced cognitive impairment in rats by enhancing exosomal miR-146a secretion from endogenous bone marrow-derived mesenchymal stem cells.","volume":"13","author":"Kubota","year":"2018","journal-title":"PLoS One"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000643","article-title":"Neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo.","volume":"18","author":"Kur","year":"2020","journal-title":"PLoS Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4137\/JEN.S39916","article-title":"MiRNAs in astrocyte-derived exosomes as possible mediators of neuronal plasticity.","volume":"10","author":"Lafourcade","year":"2016","journal-title":"J. Exp. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/jnc.14305","article-title":"Loss of STI1-mediated neuronal survival and differentiation in disease-associated mutations of prion protein.","volume":"145","author":"Landemberger","year":"2018","journal-title":"J. Neurochem."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2017.00051","article-title":"Stem cell-induced biobridges as possible tools to aid neuroreconstruction after CNS injury.","volume":"5","author":"Lee","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nrm.2016.122","article-title":"Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors.","volume":"17","author":"Levin","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jconrel.2019.08.037","article-title":"Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine.","author":"Lin","year":"2019","journal-title":"J. Control Release"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/srep17543","article-title":"Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse.","volume":"5","author":"Liu","year":"2015","journal-title":"Sci. Rep."},{"key":"B77","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.pneurobio.2015.09.008","article-title":"Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke.","volume":"144","author":"Liu","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/aps.2017.12","article-title":"Engineering exosomes as refined biological nanoplatforms for drug delivery.","volume":"38","author":"Luan","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5736059","article-title":"Potential therapies by stem cell-derived exosomes in CNS diseases: focusing on the neurogenic niche.","volume":"2016","author":"Luarte","year":"2016","journal-title":"Stem. Cells Int."},{"key":"B80","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4103\/1673-5374.224361","article-title":"Brain injury and neural stem cells.","volume":"13","author":"Ludwig","year":"2018","journal-title":"Neural Regen. Res."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00089","article-title":"The role of bone-derived exosomes in regulating skeletal metabolism and extraosseous Diseases.","volume":"8","author":"Lyu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.bbrc.2019.08.057","article-title":"Exosomal and extracellular HMGB1 have opposite effects on SASH1 expression in rat astrocytes and glioma C6 cells.","volume":"518","author":"Ma","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B83","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.bbi.2019.06.040","article-title":"Neuroinflammation in Gulf War llness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood.","volume":"81","author":"Madhu","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"B84","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1093\/neuonc\/not218","article-title":"A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool.","volume":"16","author":"Manterola","year":"2014","journal-title":"Neuro Oncol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s13238-015-0168-y","article-title":"Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2.","volume":"6","author":"Mao","year":"2015","journal-title":"Protein Cell"},{"key":"B86","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.neuint.2017.02.006","article-title":"Neural stem cell therapy for neurodegenerative disorders: the role of neurotrophic support.","volume":"106","author":"Marsh","year":"2017","journal-title":"Neurochem. Int."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11534-w","article-title":"Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS.","volume":"10","author":"Men","year":"2019","journal-title":"Nat. Commun."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1285","article-title":"Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells.","volume":"2","author":"Mittelbrunn","year":"2011","journal-title":"Nat. Commun."},{"key":"B89","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/s41584-019-0323-6","article-title":"Chemokines in rheumatic diseases: pathogenic role and therapeutic implications.","volume":"15","author":"Miyabe","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-198","article-title":"Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity.","volume":"9","author":"Moidunny","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00144","article-title":"Extracellular vesicles as modulators of tumor microenvironment and disease progression in Glioma.","volume":"7","author":"Mondal","year":"2017","journal-title":"Front. Oncol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1182\/blood-2011-02-338004","article-title":"Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.","volume":"119","author":"Montecalvo","year":"2012","journal-title":"Blood"},{"key":"B93","doi-asserted-by":"publisher","first-page":"7105","DOI":"10.1074\/jbc.M112.410944","article-title":"Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1.","volume":"288","author":"Morel","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.5772\/62975","article-title":"Exosome secretion - more than simple waste disposal? Implications for physiology, diagnostics and therapeutics.","volume":"5","author":"Nagarajah","year":"2016","journal-title":"J. Circ. Biomark"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/srep24805","article-title":"Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes.","volume":"6","author":"Nakano","year":"2016","journal-title":"Sci. Rep."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00014","article-title":"Exosomes derived from bone mesenchymal stem cells ameliorate early inflammatory responses following traumatic brain injury.","volume":"13","author":"Ni","year":"2019","journal-title":"Front. Neurosci."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-020-0100-9","article-title":"Exosomes: roles and therapeutic potential in osteoarthritis.","volume":"8","author":"Ni","year":"2020","journal-title":"Bone Res."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071618","article-title":"Astrocyte- and neuron-derived extracellular vesicles from alzheimer\u2019s disease patients effect complement-mediated neurotoxicity.","volume":"9","author":"Nogueras-Ortiz","year":"2020","journal-title":"Cells"},{"key":"B99","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s41580-020-0251-y","article-title":"RNA delivery by extracellular vesicles in mammalian cells and its applications.","volume":"21","author":"O\u2019Brien","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.parkreldis.2018.11.021","article-title":"Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson\u2019s and related diseases.","volume":"61","author":"Ohmichi","year":"2019","journal-title":"Parkinsonism Relat. Disord."},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0477","article-title":"Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype.","volume":"373","author":"Oushy","year":"2018","journal-title":"Philos. Trans. R Soc. Lond. B Biol. Sci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","article-title":"Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor.","volume":"33","author":"Pan","year":"1983","journal-title":"Cell"},{"key":"B103","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neuroscience.2018.04.003","article-title":"Cell-to-cell communication by extracellular vesicles: focus on microglia.","volume":"405","author":"Paolicelli","year":"2019","journal-title":"Neuroscience"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00526","article-title":"Extracellular vesicles secreted by astroglial cells transport apolipoprotein D to neurons and mediate neuronal survival upon oxidative stress.","volume":"12","author":"Pascua-Maestro","year":"2018","journal-title":"Front. Cell Neurosci."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.06.019","article-title":"Astrocyte-derived exosomes suppress autophagy and ameliorate neuronal damage in experimental ischemic stroke.","volume":"382","author":"Pei","year":"2019","journal-title":"Exp. Cell Res."},{"key":"B106","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1080\/15384101.2020.1731649","article-title":"Astrocyte-derived exosomes transfer miR-190b to inhibit oxygen and glucose deprivation-induced autophagy and neuronal apoptosis.","volume":"19","author":"Pei","year":"2020","journal-title":"Cell Cycle"},{"key":"B107","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neulet.2018.07.021","article-title":"Astrocyte activation and reactive gliosis-A new target in stroke?","volume":"689","author":"Pekny","year":"2019","journal-title":"Neurosci. Lett."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3390\/biom8030094","article-title":"Plasma membrane lipid domains as platforms for vesicle biogenesis and shedding?","volume":"8","author":"Pollet","year":"2018","journal-title":"Biomolecules"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/nm1196-1174","article-title":"Chemokine receptors: gateways to inflammation and infection.","volume":"2","author":"Premack","year":"1996","journal-title":"Nat. Med."},{"key":"B110","doi-asserted-by":"publisher","first-page":"2618","DOI":"10.7150\/thno.32363","article-title":"Tumor-derived nanovesicles promote lung distribution of the therapeutic nanovector through repression of Kupffer cell-mediated phagocytosis.","volume":"9","author":"Qiu","year":"2019","journal-title":"Theranostics"},{"key":"B111","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends.","volume":"200","author":"Raposo","year":"2013","journal-title":"J. Cell Biol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1038\/sj.leu.2404296","article-title":"Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication.","volume":"20","author":"Ratajczak","year":"2006","journal-title":"Leukemia"},{"key":"B113","doi-asserted-by":"publisher","first-page":"6670","DOI":"10.1021\/acsnano.9b01004","article-title":"Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders.","volume":"13","author":"Riazifar","year":"2019","journal-title":"ACS Nano"},{"key":"B114","doi-asserted-by":"publisher","first-page":"3857","DOI":"10.1111\/bph.14789","article-title":"A novel and potent brain penetrant inhibitor of extracellular vesicle release.","volume":"176","author":"Rojas","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1571-8","article-title":"Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy.","volume":"10","author":"Rong","year":"2019","journal-title":"Cell Death Dis."},{"key":"B116","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s10014-016-0259-3","article-title":"MicroRNA and extracellular vesicles in glioblastoma: small but powerful.","volume":"33","author":"Rooj","year":"2016","journal-title":"Brain Tumor. Pathol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"388","DOI":"10.2174\/1567205016666190321155422","article-title":"Characterization of serum exosomes from a transgenic mouse model of Alzheimer\u2019s Disease.","volume":"16","author":"Rosas-Hernandez","year":"2019","journal-title":"Curr. Alzheimer Res."},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0459-9","article-title":"The emerging role of exosomes in mental disorders.","volume":"9","author":"Saeedi","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.2147\/OTT.S61562","article-title":"MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer.","volume":"7","author":"Salido-Guadarrama","year":"2014","journal-title":"Onco. Targets Ther."},{"key":"B120","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/aps.2017.162","article-title":"Exosomes: new molecular targets of diseases.","volume":"39","author":"Samanta","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"B121","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1586\/14737159.2014.943193","article-title":"Extracellular vesicles as a platform for \u2018liquid biopsy\u2019 in glioblastoma patients.","volume":"14","author":"Santiago-Dieppa","year":"2014","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010266","article-title":"Cell-to-cell communication in learning and memory: from neuro- and glio-transmission to information exchange mediated by extracellular vesicles.","volume":"21","author":"Schiera","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B123","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1601-183X.2007.00378.x","article-title":"Neurotrophic factors in Alzheimer\u2019s disease: role of axonal transport.","volume":"7","author":"Schindowski","year":"2008","journal-title":"Genes Brain Behav."},{"key":"B124","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1111\/j.1600-0854.2008.00734.x","article-title":"Exosome function: from tumor immunology to pathogen biology.","volume":"9","author":"Schorey","year":"2008","journal-title":"Traffic"},{"key":"B125","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/tra.12558","article-title":"The biology of extracellular microvesicles.","volume":"19","author":"Sedgwick","year":"2018","journal-title":"Traffic"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1007\/s11064-020-02977-5","article-title":"Astrocyte-derived exosomal microRNA miR-200a-3p prevents MPP(+)-induced apoptotic cell death through down-regulation of MKK4.","volume":"45","author":"Shakespear","year":"2020","journal-title":"Neurochem. Res."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7999","article-title":"Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.","volume":"6","author":"Shao","year":"2015","journal-title":"Nat. Commun."},{"key":"B128","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.1074\/jbc.RA118.004825","article-title":"CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)(G93A) ALS mice originate from astrocytes and neurons and carry misfolded SOD1.","volume":"294","author":"Silverman","year":"2019","journal-title":"J. Biol. Chem."},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0878-x","article-title":"Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma.","volume":"17","author":"Simon","year":"2018","journal-title":"Mol. Cancer"},{"key":"B130","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.ceb.2009.03.007","article-title":"Exosomes\u2013vesicular carriers for intercellular communication.","volume":"21","author":"Simons","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.","volume":"10","author":"Skog","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1002\/glia.23299","article-title":"Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes.","volume":"66","author":"Sobue","year":"2018","journal-title":"Glia"},{"key":"B133","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nrn3898","article-title":"Astrocyte barriers to neurotoxic inflammation.","volume":"16","author":"Sofroniew","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000502694","article-title":"Cortical neuron-derived exosomal MicroRNA-181c-3p inhibits neuroinflammation by downregulating CXCL1 in astrocytes of a rat model with ischemic brain injury.","volume":"26","author":"Song","year":"2019","journal-title":"Neuroimmunomodulation"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2018.04.005","article-title":"Pluripotent stem cell-based therapy for Parkinson\u2019s disease: current status and future prospects.","volume":"168","author":"Sonntag","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-019-01977-2","article-title":"alpha-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease.","volume":"138","author":"Sorrentino","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/jnc.14704","article-title":"How is alpha-synuclein cleared from the cell?","volume":"150","author":"Stefanis","year":"2019","journal-title":"J. Neurochem."},{"key":"B138","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1748-1716.2011.02337.x","article-title":"Amyotrophic lateral sclerosis immunoglobulins G enhance the mobility of Lysotracker-labelled vesicles in cultured rat astrocytes.","volume":"203","author":"Stenovec","year":"2011","journal-title":"Acta Physiol."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153691","article-title":"Extracellular vesicle-induced differentiation of neural stem progenitor cells.","volume":"20","author":"Stronati","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-3-319-74470-4_5","article-title":"Stem cell therapies for Neurodegenerative Diseases.","volume":"1056","author":"Sugaya","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00394","article-title":"Stem cell-derived exosomes protect astrocyte cultures from in vitro ischemia and decrease injury as post-stroke intravenous therapy.","volume":"13","author":"Sun","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1002\/dneu.20559","article-title":"Regulation of heat shock protein 70 release in astrocytes: role of signaling kinases.","volume":"67","author":"Taylor","year":"2007","journal-title":"Dev. Neurobiol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/84224","article-title":"Dancing to the tune of chemokines.","volume":"2","author":"Thelen","year":"2001","journal-title":"Nat. Immunol."},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.","volume":"7","author":"Thery","year":"2018","journal-title":"J. Extracell Vesicles"},{"key":"B145","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/nrn1116","article-title":"Chemokine receptors: signposts to brain development and disease.","volume":"4","author":"Tran","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.jconrel.2020.04.017","article-title":"Astrocyte-derived extracellular vesicles: neuroreparative properties and role in the pathogenesis of neurodegenerative disorders.","volume":"323","author":"Upadhya","year":"2020","journal-title":"J. Control Release"},{"key":"B147","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66536-2","article-title":"RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans.","volume":"10","author":"Van der Auwera","year":"2020","journal-title":"Sci. Rep."},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01452","article-title":"Exosomes from astrocyte processes: signaling to neurons.","volume":"10","author":"Venturini","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of astroglia.","volume":"98","author":"Verkhratsky","year":"2018","journal-title":"Physiol. Rev."},{"key":"B151","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ebiom.2018.11.026","article-title":"Neural stem cell derived extracellular vesicles: attributes and prospects for treating neurodegenerative disorders.","volume":"38","author":"Vogel","year":"2018","journal-title":"EBioMedicine"},{"key":"B152","doi-asserted-by":"publisher","first-page":"8001","DOI":"10.7150\/thno.37097","article-title":"Extracellular vesicle-based drug delivery systems for cancer treatment.","volume":"9","author":"Walker","year":"2019","journal-title":"Theranostics"},{"key":"B153","doi-asserted-by":"publisher","first-page":"21384","DOI":"10.1074\/jbc.M112.340513","article-title":"Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD).","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1159\/000494652","article-title":"Mesenchymal stem cell-derived exosomes reduce A1 astrocytes via downregulation of phosphorylated NFkappaB P65 subunit in spinal cord injury.","volume":"50","author":"Wang","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"B155","doi-asserted-by":"publisher","first-page":"7275","DOI":"10.1523\/JNEUROSCI.6476-10.2011","article-title":"Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes.","volume":"31","author":"Wang","year":"2011","journal-title":"J. Neurosci."},{"key":"B156","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1007\/s12975-017-0599-2","article-title":"Human neural stem cell extracellular vesicles improve tissue and functional recovery in the murine thromboembolic stroke model.","volume":"9","author":"Webb","year":"2018","journal-title":"Transl. Stroke Res."},{"key":"B157","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.pneurobio.2017.03.003","article-title":"Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke.","volume":"157","author":"Wei","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57663-x","article-title":"Astrocyte support for oligodendrocyte differentiation can be conveyed via extracellular vesicles but diminishes with age.","volume":"10","author":"Willis","year":"","journal-title":"Sci. Rep."},{"key":"B159","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1007\/s11064-019-02937-8","article-title":"The effects of IL-1beta on astrocytes are conveyed by extracellular vesicles and influenced by age.","volume":"45","author":"Willis","year":"","journal-title":"Neurochem. Res."},{"key":"B160","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.dadm.2018.11.002","article-title":"Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer\u2019s disease dementia.","volume":"11","author":"Winston","year":"2019","journal-title":"Alzheimers Dement"},{"key":"B161","doi-asserted-by":"publisher","first-page":"171","DOI":"10.12998\/wjcc.v7.i2.171","article-title":"Clinical significance of exosomes as potential biomarkers in cancer.","volume":"7","author":"Wong","year":"2019","journal-title":"World J. Clin. Cases"},{"key":"B162","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.brainresbull.2020.07.013","article-title":"Astrocyte-derived exosome-transported microRNA-34c is neuroprotective against cerebral ischemia\/reperfusion injury via TLR7 and the NF-kappaB\/MAPK pathways.","volume":"163","author":"Wu","year":"2020","journal-title":"Brain Res. Bull."},{"key":"B163","doi-asserted-by":"publisher","first-page":"5956","DOI":"10.7150\/thno.33872","article-title":"Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.","volume":"9","author":"Xian","year":"2019","journal-title":"Theranostics"},{"key":"B164","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1002\/stem.1129","article-title":"Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth.","volume":"30","author":"Xin","year":"2012","journal-title":"Stem. Cells"},{"key":"B165","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/stem.1409","article-title":"MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles.","volume":"31","author":"Xin","year":"2013","journal-title":"Stem. Cells"},{"key":"B166","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.brainres.2019.04.009","article-title":"Exosome-shuttled miR-92b-3p from ischemic preconditioned astrocytes protects neurons against oxygen and glucose deprivation.","volume":"1717","author":"Xu","year":"2019","journal-title":"Brain Res."},{"key":"B167","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/s41571-018-0036-9","article-title":"Extracellular vesicles in cancer - implications for future improvements in cancer care.","volume":"15","author":"Xu","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions.","volume":"4","author":"Yanez-Mo","year":"2015","journal-title":"J. Extracell Vesicles"},{"key":"B169","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1177\/1758834017737471","article-title":"DNM3, p65 and p53 from exosomes represent potential clinical diagnosis markers for glioblastoma multiforme.","volume":"9","author":"Yang","year":"2017","journal-title":"Ther. Adv. Med. Oncol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.gendis.2017.12.001","article-title":"Recent advances in extracellular vesicles enriched with non-coding RNAs related to cancers.","volume":"5","author":"Yang","year":"2018","journal-title":"Genes Dis."},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00055","article-title":"MSCs-derived exosomes and neuroinflammation, neurogenesis and therapy of traumatic brain injury.","volume":"11","author":"Yang","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"B172","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.ebiom.2019.03.016","article-title":"Exosomal transfer of miR-1238 contributes to temozolomide-resistance in glioblastoma.","volume":"42","author":"Yin","year":"2019","journal-title":"EBioMedicine"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1706801","article-title":"Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing.","volume":"9","author":"You","year":"2020","journal-title":"J. Extracell Vesicles"},{"key":"B174","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.canlet.2018.06.041","article-title":"Delivery of MGMT mRNA to glioma cells by reactive astrocyte-derived exosomes confers a temozolomide resistance phenotype.","volume":"433","author":"Yu","year":"2018","journal-title":"Cancer Lett."},{"key":"B175","doi-asserted-by":"publisher","first-page":"10977","DOI":"10.1074\/jbc.M111.324616","article-title":"Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia.","volume":"287","author":"Yuyama","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B176","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1093\/biosci\/biv084","article-title":"Extracellular vesicles: composition, biological relevance, and methods of study.","volume":"65","author":"Zaborowski","year":"2015","journal-title":"Bioscience"},{"key":"B177","doi-asserted-by":"publisher","first-page":"279","DOI":"10.2174\/1389450118666170328115801","article-title":"The application of nanomaterials in stem cell therapy for some neurological diseases.","volume":"19","author":"Zhang","year":"2018","journal-title":"Curr. Drug Targets"},{"key":"B178","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/nature15376","article-title":"Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth.","volume":"527","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-019-0282-2","article-title":"Exosomes: biogenesis, biologic function and clinical potential.","volume":"9","author":"Zhang","year":"2019","journal-title":"Cell Biosci."},{"key":"B180","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41582-018-0126-4","article-title":"Exosomes - beyond stem cells for restorative therapy in stroke and neurological injury.","volume":"15","author":"Zhang","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41423-020-0391-1","article-title":"The function and clinical application of extracellular vesicles in innate immune regulation.","volume":"17","author":"Zhou","year":"2020","journal-title":"Cell Mol. Immunol."},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801899","article-title":"Embryonic stem cells-derived exosomes endowed with targeting properties as chemotherapeutics delivery vehicles for glioblastoma therapy.","volume":"6","author":"Zhu","year":"2019","journal-title":"Adv. Sci."},{"key":"B183","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1038\/mt.2011.164","article-title":"Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain.","volume":"19","author":"Zhuang","year":"2011","journal-title":"Mol. Ther."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.568889\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T22:06:10Z","timestamp":1617919570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.568889\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,15]]},"references-count":183,"alternative-id":["10.3389\/fcell.2020.568889"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.568889","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,15]]},"article-number":"568889"}}