{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:42:47Z","timestamp":1789767767687,"version":"4.0.1"},"reference-count":107,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009103","name":"Von-Behring-R\u00f6ntgen-Stiftung","doi-asserted-by":"publisher","award":["61-0040"],"award-info":[{"award-number":["61-0040"]}],"id":[{"id":"10.13039\/100009103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009103","name":"Von-Behring-R\u00f6ntgen-Stiftung","doi-asserted-by":"publisher","award":["62-0002"],"award-info":[{"award-number":["62-0002"]}],"id":[{"id":"10.13039\/100009103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["031L0140"],"award-info":[{"award-number":["031L0140"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2020.576491","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T13:53:33Z","timestamp":1599227613000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Endothelial Ribonuclease 1 in Cardiovascular and Systemic Inflammation"],"prefix":"10.3389","volume":"8","author":[{"given":"Katrin","family":"Bedenbender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd T.","family":"Schmeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling.","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ejphar.2009.06.067","article-title":"Ribonucleases as potential modalities in anticancer therapy.","volume":"625","author":"Ardelt","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"B3","first-page":"1","article-title":"Haemostasis","author":"Arnout","year":"2006","journal-title":"The Vascular Endothelium II. Handbook of Experimental Pharmacology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1615\/critrevbiomedeng.v29.i2.20","article-title":"Mechanics of endothelial cell architecture and vascular permeability.","volume":"29","author":"Baldwin","year":"2001","journal-title":"Crit. Rev. Biomed. Eng."},{"key":"B5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/1098-1128(200103)21:2<129::aid-med1003>3.0.co;2-h","article-title":"Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia.","volume":"21","author":"Barone","year":"2001","journal-title":"Med. Res. Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1093\/glycob\/cwm002","article-title":"Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer.","volume":"17","author":"Barrabes","year":"2007","journal-title":"Glycobiology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"9017","DOI":"10.1096\/fj.201900451r","article-title":"Inflammation-mediated deacetylation of the ribonuclease 1 promoter via histone deacetylase 2 in endothelial cells.","volume":"33","author":"Bedenbender","year":"2019","journal-title":"FASEB J."},{"key":"B8","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1089\/aid.2006.22.897","article-title":"Ribonucleases in HIV type 1 inhibition: effect of recombinant RNases on infection of primary T cells and immune activation-induced RNase gene and protein expression.","volume":"22","author":"Bedoya","year":"2006","journal-title":"AIDS Res. Hum. Retrovirus."},{"key":"B9","first-page":"501","article-title":"Differences in glycosylation pattern of human secretory ribonucleases.","volume":"255","author":"Beintema","year":"1988","journal-title":"Biochem. J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1189\/jlb.0306164","article-title":"DAMPs, PAMPs and alarmins: all we need to know about danger.","volume":"81","author":"Bianchi","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1055\/s-0038-1675614","article-title":"Role of endothelial cells in acute and chronic thrombosis.","volume":"39","author":"Bochenek","year":"2019","journal-title":"Hamostaseologie"},{"key":"B12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1042\/bc20080158","article-title":"Histone deacetylases: salesmen and customers in the post-translational modification market.","volume":"101","author":"Brandl","year":"2009","journal-title":"Biol. Cell"},{"key":"B13","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nri3834","article-title":"Regulation of tumour necrosis factor signalling: live or let die.","volume":"15","author":"Brenner","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/leu.2017.301","article-title":"Therapeutic targeting of CK2 in acute and chronic leukemias.","volume":"32","author":"Buontempo","year":"2018","journal-title":"Leukemia"},{"key":"B15","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1093\/ejcts\/ezu519","article-title":"RNase1 as a potential mediator of remote ischaemic preconditioning for cardioprotectiondagger.","volume":"48","author":"Cabrera-Fuentes","year":"2015","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1160\/th14-08-0703","article-title":"RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-alpha in cardiac ischaemia\/reperfusion injury.","volume":"112","author":"Cabrera-Fuentes","year":"2014","journal-title":"Thromb. Haemost."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1172\/jci62423","article-title":"Alarmins: awaiting a clinical response.","volume":"122","author":"Chan","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"8374","DOI":"10.1021\/bi2009079","article-title":"Mechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides.","volume":"50","author":"Chao","year":"2011","journal-title":"Biochemistry"},{"key":"B19","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000683","article-title":"Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury.","volume":"3","author":"Chen","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"B20","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1172\/jci118074","article-title":"Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.","volume":"96","author":"De Caterina","year":"1995","journal-title":"J. Clin. Invest."},{"key":"B21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0079-6603(05)80009-1","article-title":"Ribonuclease inhibitor: structure and function.","volume":"80","author":"Dickson","year":"2005","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"5480","DOI":"10.1021\/bi00341a030","article-title":"Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma-cells.","volume":"24","author":"Fett","year":"1985","journal-title":"Biochemistry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1161\/atvbaha.110.221952","article-title":"Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition.","volume":"31","author":"Findeisen","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00441-014-1850-8","article-title":"Impact of extracellular RNA on endothelial barrier function.","volume":"355","author":"Fischer","year":"2014","journal-title":"Cell Tissue Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1182\/blood-2006-08-040691","article-title":"Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor.","volume":"110","author":"Fischer","year":"2007","journal-title":"Blood"},{"key":"B26","doi-asserted-by":"publisher","first-page":"5080","DOI":"10.1158\/0008-5472.can-12-4657","article-title":"Extracellular RNA liberates tumor necrosis factor-alpha to promote tumor cell trafficking and progression.","volume":"73","author":"Fischer","year":"2013","journal-title":"Cancer Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1160\/th10-06-0345","article-title":"Expression and localisation of vascular ribonucleases in endothelial cells.","volume":"105","author":"Fischer","year":"2011","journal-title":"Thromb. Haemost."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1096\/fj.08-121608","article-title":"Signaling mechanism of extracellular RNA in endothelial cells.","volume":"23","author":"Fischer","year":"2009","journal-title":"FASEB J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.5482\/hamo-13-01-0001","article-title":"Extracellular nucleic acids as novel alarm signals in the vascular system mediators of defence and disease.","volume":"33","author":"Fischer","year":"2013","journal-title":"Hamostaseologie"},{"key":"B30","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1089\/dna.1997.16.413","article-title":"Tissue-specific expression of pancreatic-type RNases and RNase inhibitor in humans.","volume":"16","author":"Futami","year":"1997","journal-title":"DNA Cell Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1096\/fj.13-238600","article-title":"Influence of proinflammatory stimuli on the expression of vascular ribonuclease 1 in endothelial cells.","volume":"28","author":"Gansler","year":"2014","journal-title":"FASEB J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1261\/rna.070433.119","article-title":"Phenotype of ribonuclease 1 deficiency in mice.","volume":"25","author":"Garnett","year":"2019","journal-title":"RNA"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1096\/fj.08-108548","article-title":"Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice.","volume":"22","author":"Granger","year":"2008","journal-title":"FASEB J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/01.atv.0000258867.79411.96","article-title":"Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-gamma-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis.","volume":"27","author":"Harvey","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/ni888","article-title":"Angiogenins: a new class of microbicidal proteins involved in innate immunity.","volume":"4","author":"Hooper","year":"2003","journal-title":"Nat. Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"4626","DOI":"10.1074\/jbc.m607321200","article-title":"The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity.","volume":"282","author":"Huang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.jmb.2007.02.005","article-title":"Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein.","volume":"368","author":"Johnson","year":"2007","journal-title":"J. Mol. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"15524","DOI":"10.1074\/jbc.m313717200","article-title":"Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo.","volume":"279","author":"Kaiser","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B39","doi-asserted-by":"crossref","first-page":"H2747","DOI":"10.1152\/ajpheart.01280.2004","article-title":"Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion.","volume":"289","author":"Kaiser","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"6388","DOI":"10.1073\/pnas.0608647104","article-title":"Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation.","volume":"104","author":"Kannemeier","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B41","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/sj.cdd.4401850","article-title":"TLR signaling.","volume":"13","author":"Kawai","year":"2006","journal-title":"Cell Death. Differ."},{"key":"B42","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1046\/j.1432-1327.2000.01037.x","article-title":"Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A.","volume":"267","author":"Klink","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081278","article-title":"The ribonuclease A superfamily in humans: canonical RNases as the buttress of innate immunity.","volume":"17","author":"Koczera","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1749-6632.2001.tb03882.x","article-title":"Circulating RNA as a tumor marker - Detection of 5T4 mRNA in breast and lung cancer patient serum.","volume":"945","author":"Kopreski","year":"2001","journal-title":"Circ. Nucleic Acids Plasma Serum Ii"},{"key":"B45","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function.","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"B46","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/nrd1177","article-title":"p38 map kinases: key signalling molecules as therapeutic targets for inflammatory diseases.","volume":"2","author":"Kumar","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"B47","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/jcb.10234","article-title":"Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1).","volume":"86","author":"Landre","year":"2002","journal-title":"J. Cell. Biochem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0006-291x(89)91569-6","article-title":"Characterization of ribonucleolytic activity of angiogenin towards tRNA.","volume":"161","author":"Lee","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.2174\/092986705774462914","article-title":"MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38alpha protein.","volume":"12","author":"Lee","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"B50","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/3-540-36028-x_4","article-title":"Leucocyte-endothelial interactions in health and disease","author":"Ley","year":"2006","journal-title":"The Vascular Endothelium II. Handbook of Experimental Pharmacology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s10456-012-9322-9","article-title":"Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress.","volume":"16","author":"Li","year":"2013","journal-title":"Angiogenesis"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1128\/jvi.72.4.2752-2759.1998","article-title":"RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection.","volume":"72","author":"Li","year":"1998","journal-title":"J. Virol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1080\/15216540600838232","article-title":"RNase L: its biological roles and regulation.","volume":"58","author":"Liang","year":"2006","journal-title":"IUBMB Life"},{"key":"B54","article-title":"Atherosclerosis.","volume":"5","author":"Libby","year":"2019","journal-title":"Nat Rev Dis Prim."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj20021469","article-title":"Protein kinase CK2: structure, regulation and role in cellular decisions of life and death.","volume":"369","author":"Litchfield","year":"2003","journal-title":"Biochem. J."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1042\/bcj20170173","article-title":"Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology.","volume":"474","author":"Lomax","year":"2017","journal-title":"Biochem. J."},{"key":"B57","doi-asserted-by":"crossref","DOI":"10.1186\/s41544-019-0020-2","article-title":"Extracellular RNA: mechanisms of it\u2019s transporting into target cells.","volume":"1","author":"Lu","year":"2019","journal-title":"ExRNA"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01012","article-title":"Immune modulation by human secreted rnases at the extracellular space.","volume":"9","author":"Lu","year":"2018","journal-title":"Front. Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.biopha.2017.02.094","article-title":"Ribonuclease attenuates hepatic ischemia reperfusion induced cognitive impairment through the inhibition of inflammatory cytokines in aged mice.","volume":"90","author":"Ma","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1634\/theoncologist.12-10-1247","article-title":"FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma.","volume":"12","author":"Mann","year":"2007","journal-title":"Oncologist"},{"key":"B61","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/nri2417","article-title":"Mammalian glycosylation in immunity.","volume":"8","author":"Marth","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"B62","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/jcp.10333","article-title":"Endothelial cell functions.","volume":"196","author":"Michiels","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/3-540-32967-6_4","article-title":"Transport across the endothelium: regulation of endothelial permeability.","volume":"176","author":"Minshall","year":"2006","journal-title":"Handb. Exp. Pharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/oxfordjournals.jbchem.a135456","article-title":"Distribution of two urinary ribonuclease-like enzymes in human organs and body fluids.","volume":"99","author":"Morita","year":"1986","journal-title":"J. Biochem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.2174\/1389201020666190102150216","article-title":"The role of extracellular nucleic acids in rheumatoid arthritis.","volume":"19","author":"Neumann","year":"2018","journal-title":"Curr. Pharm. Biotechnol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1093\/glycob\/cwg019","article-title":"Glycosylation of human pancreatic ribonuclease: differences between normal and tumor states.","volume":"13","author":"Peracaula","year":"2003","journal-title":"Glycobiology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1093\/emboj\/cdf470","article-title":"Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.","volume":"21","author":"Petrova","year":"2002","journal-title":"EMBO J."},{"key":"B68","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation.","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"B69","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000073580","article-title":"Endothelial dysfunction and cardiovascular disease.","volume":"32","author":"Poredos","year":"2002","journal-title":"Pathophysiol. Haemost. Thromb."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1093\/protein\/11.12.1285","article-title":"Human pancreatic RNase1-human epidermal growth factor fusion: an entirely human \u2018immunotoxin analog\u2019 with cytotoxic properties against squamous cell carcinomas.","volume":"11","author":"Psarras","year":"1998","journal-title":"Protein Eng."},{"key":"B71","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.7150\/ijbs.7502","article-title":"The vascular endothelium and human diseases.","volume":"9","author":"Rajendran","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"B72","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41581-019-0129-4","article-title":"Glycosylation in health and disease.","volume":"15","author":"Reily","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1021\/acs.biochem.8b01246","article-title":"Consequences of the endogenous N-Glycosylation of human ribonuclease 1.","volume":"58","author":"Ressler","year":"2019","journal-title":"Biochemistry"},{"key":"B74","first-page":"357","article-title":"Heterogeneity in the glycosylation pattern of human pancreatic ribonuclease.","volume":"375","author":"Ribo","year":"1994","journal-title":"Biol. Chem. Hoppe Seyler."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1161\/01.atv.0000209501.56852.6c","article-title":"Dynamics and plasticity of Weibel-Palade bodies in endothelial cells.","volume":"26","author":"Rondaij","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1097\/00002030-200303070-00002","article-title":"Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognition.","volume":"17","author":"Rugeles","year":"2003","journal-title":"Aids"},{"key":"B77","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.1073\/pnas.91.8.2920","article-title":"Role of glutamine-117 in the ribonucleolytic activity of human angiogenin.","volume":"91","author":"Russo","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B78","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/jth.14322","article-title":"Exocytosis of Weibel-Palade bodies: how to unpack a vascular emergency kit.","volume":"17","author":"Schillemans","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines6040076","article-title":"The immunomodulatory and antimicrobial properties of the vertebrate ribonuclease A superfamily.","volume":"6","author":"Schwartz","year":"2018","journal-title":"Vaccines"},{"key":"B80","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/690848","article-title":"Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2.","volume":"2011","author":"Segre","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/jcb.20179","article-title":"Regulation of histone deacetylase activities.","volume":"93","author":"Sengupta","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"B82","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1161\/circulationaha.113.002562","article-title":"Role of extracellular RNA in atherosclerotic plaque formation in mice.","volume":"129","author":"Simsekyilmaz","year":"2014","journal-title":"Circulation"},{"key":"B83","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.autrev.2010.07.016","article-title":"From endothelial dysfunction to atherosclerosis.","volume":"9","author":"Sitia","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1016\/j.febslet.2010.04.018","article-title":"The eight human \u201ccanonical\u201d ribonucleases: molecular diversity, catalytic properties, and special biological actions of the enzyme proteins.","volume":"584","author":"Sorrentino","year":"2010","journal-title":"FEBS Lett."},{"key":"B85","doi-asserted-by":"publisher","first-page":"10182","DOI":"10.1021\/bi030040q","article-title":"Degradation of double-stranded RNA by human pancreatic ribonuclease: crucial role of noncatalytic basic amino acid residues.","volume":"42","author":"Sorrentino","year":"2003","journal-title":"Biochemistry"},{"key":"B86","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004541","article-title":"Targeting of Extracellular RNA reduces edema formation and infarct size and improves survival after myocardial infarction in mice.","volume":"6","author":"Stieger","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"B87","doi-asserted-by":"publisher","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A gene atlas of the mouse and human protein-encoding transcriptomes.","volume":"101","author":"Su","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B88","doi-asserted-by":"publisher","first-page":"33227","DOI":"10.1074\/jbc.m703549200","article-title":"Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin.","volume":"282","author":"Sun","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B89","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/27699","article-title":"Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.","volume":"395","author":"Tong","year":"1998","journal-title":"Nature"},{"key":"B90","doi-asserted-by":"publisher","first-page":"31826","DOI":"10.1074\/jbc.m204149200","article-title":"Regulation of histone deacetylase 2 by protein kinase CK2.","volume":"277","author":"Tsai","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B91","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.1182\/blood-2010-09-267492","article-title":"Functional architecture of Weibel-palade bodies.","volume":"117","author":"Valentijn","year":"2011","journal-title":"Blood"},{"key":"B92","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1111\/j.1742-4658.2011.08015.x","article-title":"TNFR1-induced activation of the classical NF-kappaB pathway.","volume":"278","author":"Wajant","year":"2011","journal-title":"FEBS J."},{"key":"B93","doi-asserted-by":"publisher","first-page":"12","DOI":"10.2174\/156720209787466037","article-title":"RNase therapy assessed by magnetic resonance imaging reduces cerebral edema and infarction size in acute stroke.","volume":"6","author":"Walberer","year":"2009","journal-title":"Curr. Neurovasc. Res."},{"key":"B94","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/ng.154","article-title":"Combinatorial patterns of histone acetylations and methylations in the human genome.","volume":"40","author":"Wang","year":"2008","journal-title":"Nat. Genet."},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3105cm1","article-title":"Interleukin-1 (IL-1) pathway.","volume":"3","author":"Weber","year":"2010","journal-title":"Sci. Signal."},{"key":"B96","first-page":"1682","article-title":"Immunological assay of pancreatic ribonuclease in serum as an indicator of pancreatic-cancer.","volume":"44","author":"Weickmann","year":"1984","journal-title":"Cancer Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1111\/j.1349-7006.2006.00336.x","article-title":"Anti-tumor effect in an in vivo model by human-derived pancreatic RNase with basic fibroblast growth factor insertional fusion protein through antiangiogenic properties.","volume":"97","author":"Yagi","year":"2006","journal-title":"Cancer Sci."},{"key":"B98","doi-asserted-by":"publisher","first-page":"6134","DOI":"10.4049\/jimmunol.173.10.6134","article-title":"Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation.","volume":"173","author":"Yang","year":"2004","journal-title":"J. Immunol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/nrm2346","article-title":"The Rpd3\/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.","volume":"9","author":"Yang","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4068\/cmj.2016.52.1.1","article-title":"HDAC and HDAC inhibitor: from cancer to cardiovascular diseases.","volume":"52","author":"Yoon","year":"2016","journal-title":"Chonnam. Med. J."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1073\/pnas.98.4.1454","article-title":"CoREST is an integral component of the CoREST- human histone deacetylase complex.","volume":"98","author":"You","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B102","doi-asserted-by":"crossref","DOI":"10.1038\/srep37758","article-title":"Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.","volume":"6","author":"Zakrzewicz","year":"2016","journal-title":"Sci. Rep."},{"key":"B103","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131571","article-title":"Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis.","volume":"5","author":"Zechendorf","year":"2020","journal-title":"JCI Insight"},{"key":"B104","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1161\/circresaha.115.307961","article-title":"Extracellular ribonucleic acids (RNA) enter the stage in cardiovascular disease.","volume":"118","author":"Zernecke","year":"2016","journal-title":"Circ. Res."},{"key":"B105","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/s0092-8674(00)80216-0","article-title":"Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.","volume":"89","author":"Zhang","year":"1997","journal-title":"Cell"},{"key":"B106","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1034\/j.1600-0463.2002.100604.x","article-title":"Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL.","volume":"110","author":"Zhao","year":"2002","journal-title":"APMIS"},{"key":"B107","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.4049\/jimmunol.1501580","article-title":"Influence of Extracellular RNAs, released by rheumatoid arthritis synovial fibroblasts, on their adhesive and invasive properties.","volume":"197","author":"Zimmermann-Geller","year":"2016","journal-title":"J. Immunol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.576491\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T13:53:42Z","timestamp":1599227622000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcell.2020.576491\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,4]]},"references-count":107,"alternative-id":["10.3389\/fcell.2020.576491"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.576491","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,4]]},"article-number":"576491"}}