{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:18:23Z","timestamp":1778512703382,"version":"3.51.4"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011852","name":"Paracelsus Medizinische Privatuniversit\u00e4t","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011852","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2020.583131","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T06:12:00Z","timestamp":1605247920000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Acid- and Volume-Sensitive Chloride Currents in Human Chondrocytes"],"prefix":"10.3389","volume":"8","author":[{"given":"Michael","family":"Kittl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Winklmayr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Helm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Lettner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gaisberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Jakab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1085\/jgp.103.2.153","article-title":"Hypotonicity Activates a Native Chloride Current in Xenopus-Oocytes.","volume":"103","author":"Ackerman","year":"1994","journal-title":"J. Gen. Physiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1002\/jcb.10715","article-title":"Increases in cytosolic calcium, but not fluid flow, affect aggrecan mRNA levels in articular chondrocytes.","volume":"90","author":"Alford","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"19230","DOI":"10.1074\/jbc.M301096200","article-title":"novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells.","volume":"278","author":"Auzanneau","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060562","article-title":"TTYH1 and TTYH2 Serve as LRRC8A-Independent Volume-Regulated Anion Channels in Cancer Cells.","volume":"8","author":"Bae","year":"2019","journal-title":"Cells"},{"key":"B5","doi-asserted-by":"publisher","first-page":"H1512","DOI":"10.1152\/ajpheart.2000.279.4.H1512","article-title":"Mechanisms of endothelial cell swelling from lactacidosis studied in vitro.","volume":"279","author":"Behmanesh","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1007\/s00424-016-1862-1","article-title":"Relationship between TMEM16A\/anoctamin 1 and LRRC8A.","volume":"468","author":"Benedetto","year":"2016","journal-title":"Pflug. Arch."},{"key":"B7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.bbrc.2012.05.015","article-title":"Osmolarity regulates chondrogenic differentiation potential of synovial fluid derived mesenchymal progenitor cells.","volume":"422","author":"Bertram","year":"2012","journal-title":"Biochem. Biophy. Res. Comm."},{"key":"B8","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1053\/S1063-4584-(02)00369-2","article-title":"The volume and morphology of chondrocytes within non-degenerate and degenerate human articular cartilage.","volume":"11","author":"Bush","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"B9","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/jcp.20294","article-title":"Passive osmotic properties of in situ human articular chondrocytes within non-degenerate and degenerate cartilage.","volume":"204","author":"Bush","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbamem.2014.10.008","article-title":"Functional analysis of acid-activated Cl\u2013 channels: Properties and mechanisms of regulation.","volume":"1848","author":"Capurro","year":"2015","journal-title":"Bba Biomembranes"},{"key":"B11","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41586-018-0134-y","article-title":"Structure of a volume-regulated anion channel of the LRRC8 family.","volume":"558","author":"Deneka","year":"2018","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.1002\/art.11341","article-title":"Molecular Phenotyping of Human Chondrocyte Cell Lines T\/C-28a2. T\/C-28a4, and C-28\/I2.","volume":"48","author":"Finger","year":"2003","journal-title":"Arthritis Rheum."},{"key":"B13","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1254\/jphs.10026sc","article-title":"Contribution of Chloride Channel Conductance to the Regulation of Resting Membrane Potential in Chondrocytes.","volume":"113","author":"Funabashi","year":"2010","journal-title":"J. Pharmacol. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1172\/jci117595","article-title":"Interleukin-1\u03b2-modulated Gene Expression in Immortalized Human Chondrocytes.","volume":"94","author":"Goldring","year":"1994","journal-title":"J. Clin. Invest."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-019-0837-6","article-title":"The Role of Chondrocyte Morphology and Volume in Controlling Phenotype-Implications for Osteoarthritis, Cartilage Repair, and Cartilage Engineering.","volume":"21","author":"Hall","year":"2019","journal-title":"Curr. Rheumatol. Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1113\/expphysiol.1996.sp003956","article-title":"The cellular physiology of articular cartilage.","volume":"81","author":"Hall","year":"1996","journal-title":"Exp. Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1159\/000343370","article-title":"Chloride channel blockers suppress formation of engulfment pseudopodia in microglial cells.","volume":"31","author":"Harl","year":"2013","journal-title":"Cell Physiol. Biochem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1159\/000460910","article-title":"In Vitro Cell Death Discrimination and Screening Method by Simple and Cost-Effective Viability Analysis.","volume":"221","author":"Helm","year":"2017","journal-title":"Acta Physiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1159\/000335843","article-title":"Ion channels involved in cell volume regulation: effects on migration, proliferation, and programmed cell death in non adherent EAT cells and adherent ELA cells.","volume":"28","author":"Hoffmann","year":"2011","journal-title":"Cell Physiol. Biochem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1152\/physrev.00037.2007","article-title":"Physiology of cell volume regulation in vertebrates.","volume":"89","author":"Hoffmann","year":"2009","journal-title":"Physiol. Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"26035","DOI":"10.3390\/ijms161125943","article-title":"Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis.","volume":"16","author":"Hwang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1254\/jphs.08278fp","article-title":"Swelling-Activated Cl\u2013 Current in Isolated Rabbit Articular Chondrocytes: Inhibition by Arachidonic Acid.","volume":"109","author":"Isoya","year":"2009","journal-title":"J. Pharmacol. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1085\/jgp.105.5.661","article-title":"Characterization of the Voltage-Dependent Properties of a Volume-Sensitive Anion Conductance.","volume":"105","author":"Jackson","year":"1995","journal-title":"J. Gen. Physiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000096322","article-title":"Cell Volume Regulatory Ion Transport in the Regulation of Cell Migration.","volume":"152","author":"Jakab","year":"2006","journal-title":"Contrib. Nephrol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00424-015-1766-5","article-title":"molecular identification as LRRC8 heteromers with differential functions.","volume":"468","author":"Jentsch","year":"2016","journal-title":"Pflug. Arch."},{"key":"B26","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1152\/physrev.00029.2001","article-title":"Molecular structure and physiological function of chloride channels.","volume":"82","author":"Jentsch","year":"2002","journal-title":"Physiol. Rev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1007\/s00424-009-0689-4","article-title":"Characteristics of ClC7 Cl\u2013 channels and their inhibition in mutant (G215R) associated with autosomal dominant osteopetrosis type II in native osteoclasts and hClcn7 gene-expressing cells.","volume":"458","author":"Kajiya","year":"2009","journal-title":"Pflug. Arch. Eur. J. Phy."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1159\/000494646","article-title":"Glycine Induces Migration of Microglial BV-2 Cells via SNAT-Mediated Cell Swelling.","volume":"50","author":"Kittl","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143475","article-title":"Acid- and Volume-Sensitive Chloride Currents in Microglial Cells.","volume":"20","author":"Kittl","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1002\/art.10185","article-title":"Acidic Cysteine Endoproteinase Cathepsin K in the Degeneration of the Superficial Articular Hyaline Cartilage in Osteoarthritis.","volume":"46","author":"Konttinen","year":"2002","journal-title":"Arthritis Rheum."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00232-009-9179-z","article-title":"Acid-Sensitive Outwardly Rectifying Anion Channels in Human Erythrocytes.","volume":"230","author":"Kucherenko","year":"2009","journal-title":"J. Membr. Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1016\/j.joca.2016.05.019","article-title":"Activation of a chondrocyte volume-sensitive Cl\u2013 conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament transection osteoarthritis model.","volume":"24","author":"Kumagai","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"B33","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1124\/mol.115.098160","article-title":"The ClC-7 Chloride Channel Is Downregulated by Hypoosmotic Stress in Human Chondrocytes.","volume":"88","author":"Kurita","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1113\/jphysiol.2005.089888","article-title":"Characterization of a proton-activated, outwardly rectifying anion channel.","volume":"567","author":"Lambert","year":"2005","journal-title":"J. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1152\/physrev.1998.78.1.247","article-title":"Functional Significance of Cell Volume Regulatory Mechanisms.","volume":"78","author":"Lang","year":"1998","journal-title":"Physiol. Rev."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1002\/jcp.22646","article-title":"The Role of the Membrane Potential in Chondrocyte Volume Regulation.","volume":"226","author":"Lewis","year":"","journal-title":"J. Cell Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1159\/000335847","article-title":"Cell Volume Regulation in Chondrocytes.","volume":"28","author":"Lewis","year":"","journal-title":"Cell. Physiol. Biochem."},{"key":"B38","first-page":"37","article-title":"Osteoarthritis pathogenesis \u2013 a complex process that involves the entire joint.","volume":"7","author":"Man","year":"2014","journal-title":"J. Med. Life"},{"key":"B39","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0304-4165(91)90133-2","article-title":"The Effect of Osmotic and Mechanical Pressures on Water Partitioning in Articular-Cartilage.","volume":"1073","author":"Maroudas","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"B40","doi-asserted-by":"publisher","first-page":"567","DOI":"10.5772\/1487pp","article-title":"Cellular Physiology of Articular Cartilage in Health and Disease","author":"Milner","year":"2012","journal-title":"Principles of Osteoarthritis \u2013 Its Definition, Character, Derivation and Modality-Related Recognition"},{"key":"B41","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1007\/s004240050697","article-title":"Modulation of volume-regulated anion channels by extra- and intracellular pH.","volume":"436","author":"Nilius","year":"1998","journal-title":"Pflug. Arch. Eur. J. Phy."},{"key":"B42","doi-asserted-by":"publisher","first-page":"C1426","DOI":"10.1152\/ajpcell.00549.2002","article-title":"Extracellular acidification elicits a chloride current that shares characteristics with ICl(swell).","volume":"287","author":"Nobles","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"131","DOI":"10.5607\/en.2019.28.2.131","article-title":"Tweety Homologs (TTYH) Freshly Join the Journey of Molecular Identification of the VRAC\/VSOR Channel Pore.","volume":"28","author":"Okada","year":"2019","journal-title":"Exp. Neurobiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00232-005-0836-6","article-title":"Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death.","volume":"209","author":"Okada","year":"2006","journal-title":"J. Membr. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.rehab.2016.01.006","article-title":"Risk factors and burden of osteoarthritis.","volume":"59","author":"Palazzo","year":"2016","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1111\/apha.12450","article-title":"The identification of a volume-regulated anion channel: an amazing Odyssey.","volume":"213","author":"Pedersen","year":"2015","journal-title":"Acta Physiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00424-015-1781-6","article-title":"Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)\/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR).","volume":"468","author":"Pedersen","year":"2016","journal-title":"Pflug. Arch. Eur. J. Phy."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.5772\/1487","author":"Perez-Hernandez","year":"2012","journal-title":"Principles of Osteoarthritis- Its Definition, Character, Derivation and Modality-Related Recognition."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1159\/000343316","article-title":"The Role of Swelling-Activated Chloride Currents (ICL,swell) in the Regulatory Volume Decrease Response of Freshly Dissociated Rat Articular Chondrocytes.","volume":"30","author":"Ponce","year":"2012","journal-title":"Cell Physiol. Biochem."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07726-5","article-title":"Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement.","volume":"9","author":"Puppulin","year":"2018","journal-title":"Nat. Commun."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaw4847","article-title":"TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.","volume":"12","author":"Qian","year":"2019","journal-title":"Sci. Signal"},{"key":"B52","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cell.2014.03.024","article-title":"SWELL1, a Plasma Membrane Protein. Is an Essential Component of Volume-Regulated Anion Channel.","volume":"157","author":"Qiu","year":"2014","journal-title":"Cell"},{"key":"B53","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1023\/b:appt.0000025803.17498.26","article-title":"Chondroptosis: a Variant of Apoptotic Cell Death in Chondrocytes?","volume":"9","author":"Roach","year":"2004","journal-title":"Apoptosis"},{"key":"B54","doi-asserted-by":"publisher","first-page":"278","DOI":"10.4161\/chan.27748","article-title":"Temperature sensitivity of acid-sensitive outwardly rectifying (ASOR) anion channels in cortical neurons is involved in hypothermic neuroprotection against acidotoxic necrosis.","volume":"8","author":"Sato-Numata","year":"2014","journal-title":"Channels"},{"key":"B55","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00424-015-1786-1","article-title":"Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel.","volume":"468","author":"Sato-Numata","year":"2016","journal-title":"Pflug. Arch. Eur. J. Phy."},{"key":"B56","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1080\/19336950.2016.1230574","article-title":"Distinct contributions of LRRC8A and its paralogs to the VSOR anion channel from those of the ASOR anion channel.","volume":"11","author":"Sato-Numata","year":"2017","journal-title":"Channels"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1007\/s00424-013-1296-y","article-title":"Acid-sensitive outwardly rectifying (ASOR) anion channels in human epithelial cells are highly sensitive to temperature and independent of ClC-3.","volume":"465","author":"Sato-Numata","year":"2013","journal-title":"Pflug. Arch. Eur. J. Phy."},{"key":"B58","doi-asserted-by":"publisher","first-page":"6939","DOI":"10.1113\/JP275053","article-title":"Molecular composition and heterogeneity of the LRRC8-containing swelling-activated osmolyte channels in primary rat astrocytes.","volume":"595","author":"Schober","year":"2017","journal-title":"J. Physiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1177\/1941738109350438","article-title":"The basic science of articular cartilage: structure, composition, and function.","volume":"1","author":"Sophia Fox","year":"2009","journal-title":"Sports Health"},{"key":"B60","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1515\/hsz-2015-0127","article-title":"The volume-regulated anion channel is formed by LRRC8 heteromers - molecular identification and roles in membrane transport and physiology.","volume":"396","author":"Stauber","year":"2015","journal-title":"Biol. Chem."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-013-0378-z","article-title":"Ion Channels and Osteoarthritic Pain: Potential for Novel Analgesics.","volume":"17","author":"Staunton","year":"2013","journal-title":"Curr. Pain Headache. Rep."},{"key":"B62","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11010-017-3212-9","article-title":"Acid-sensing ion channel 1a mediates acid-induced inhibition of matrix metabolism of rat articular chondrocytes via the MAPK signaling pathway.","volume":"443","author":"Sun","year":"2018","journal-title":"Mole. Cell. Biochem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"22461","DOI":"10.1074\/jbc.M313813200","article-title":"Novel Human Cl\u2013 Channel Family Related to Drosophila flightless Locus.","volume":"279","author":"Suzuki","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B64","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.cell.2015.12.031","article-title":"LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.","volume":"164","author":"Syeda","year":"2016","journal-title":"Cell"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49187.001","article-title":"Identification of TMEM206 proteins as pore of PAORAC\/ASOR acid-sensitive chloride channels.","volume":"8","author":"Ullrich","year":"2019","journal-title":"Elife"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1016\/j.bbagen.2017.05.004","article-title":"Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells.","volume":"1861","author":"Valinsky","year":"2017","journal-title":"Bba. Gen. Subjects"},{"key":"B67","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1085\/jgp.110.3.313","article-title":"Modulation of voltage-dependent properties of a swelling-activated Cl\u2013 current.","volume":"110","author":"Voets","year":"1997","journal-title":"J. Gen. Physiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"B69","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1126\/science.1252826","article-title":"Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC.","volume":"344","author":"Voss","year":"2014","journal-title":"Science"},{"key":"B70","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00424-006-0193-z","article-title":"Role of acid-sensitive outwardly rectifying anion channels in acidosis-induced cell death in human epithelial cells.","volume":"454","author":"Wang","year":"2007","journal-title":"Pflug. Arch. Eur. J. Phy."},{"key":"B71","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s002320001103","article-title":"Surviving in a Matrix: Membrane Transport in Articular Chondrocytes.","volume":"177","author":"Wilkins","year":"2000","journal-title":"J. Membr. Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1002\/jor.24430","article-title":"Dose-Dependent Cannabidiol-Induced Elevation of Intracellular Calcium and Apoptosis in Human Articular Chondrocytes.","volume":"37","author":"Winklmayr","year":"2019","journal-title":"J. Orthop. Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1021\/bp060024v","article-title":"Effect of extracellular pH on matrix synthesis by chondrocytes in 3D agarose gel.","volume":"23","author":"Wu","year":"2007","journal-title":"Biotechnol. Prog."},{"key":"B74","doi-asserted-by":"publisher","first-page":"H1905","DOI":"10.1152\/ajpheart.00965.2005","article-title":"Acidic extracellular pH-activated outwardly rectifying chloride current in mammalian cardiac myocytes.","volume":"290","author":"Yamamoto","year":"2006","journal-title":"Am. J. Physiol. Heart C"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1248\/bpb.b18-00152","article-title":"Physiological and Pathological Functions of Cl\u2013 Channels in Chondrocytes.","volume":"41","author":"Yamamura","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9739","article-title":"PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel.","volume":"364","author":"Yang","year":"2019","journal-title":"Science"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2020.583131\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T06:12:02Z","timestamp":1605247922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2020.583131\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":76,"alternative-id":["10.3389\/fcell.2020.583131"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.583131","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]},"article-number":"583131"}}