{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:08:20Z","timestamp":1770044900012,"version":"3.49.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2020.584933","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T04:55:51Z","timestamp":1603342551000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Prolylcarboxypeptidase Mitigates Myocardial Ischemia\/Reperfusion Injury by Stabilizing Mitophagy"],"prefix":"10.3389","volume":"8","author":[{"given":"Panpan","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haipeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxiang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1182\/blood-2010-11-318527","article-title":"Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.","volume":"117","author":"Adams","year":"2011","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria.","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ."},{"key":"B3","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.bbrc.2010.12.036","article-title":"Highly selective hydrolysis of kinins by recombinant prolylcarboxypeptidase.","volume":"405","author":"Chajkowski","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.jacc.2011.09.071","article-title":"Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy.","volume":"59","author":"Dong","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.yjmcc.2019.09.001","article-title":"Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease.","volume":"136","author":"Dong","year":"2019","journal-title":"J. Mol. Cell Cardiol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003531","article-title":"Zofenopril Protects Against Myocardial Ischemia-Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability.","volume":"5","author":"Donnarumma","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"R897","DOI":"10.1152\/ajpregu.2000.278.4.R897","article-title":"Kinins in humans.","volume":"278","author":"Duncan","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1042\/CS20070160","article-title":"ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts.","volume":"113","author":"Grobe","year":"2007","journal-title":"Clin. Sci."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/srep08794","article-title":"Combination of angiotensin-(1-7) with perindopril is better than single therapy in ameliorating diabetic cardiomyopathy.","volume":"5","author":"Hao","year":"2015","journal-title":"Sci. Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"H1007","DOI":"10.1152\/ajpheart.00563.2014","article-title":"Angiotensin-(1-7) treatment mitigates right ventricular fibrosis as a distinctive feature of diabetic cardiomyopathy.","volume":"308","author":"Hao","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197603","article-title":"Prolyl carboxypeptidase activity in the circulation and its correlation with body weight and adipose tissue in lean and obese subjects.","volume":"13","author":"Kehoe","year":"2018","journal-title":"PLoS One"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00214","article-title":"Mitochondrial-Derived Vesicles Protect Cardiomyocytes Against Hypoxic Damage.","volume":"8","author":"Li","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1194-5","article-title":"Autophagy promotes angiogenesis via AMPK\/Akt\/mTOR signaling during the recovery of heat-denatured endothelial cells.","volume":"9","author":"Liang","year":"2018","journal-title":"Cell Death Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1159\/000480317","article-title":"Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia\/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways.","volume":"43","author":"Liu","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"626","DOI":"10.2119\/molmed.2015.00022","article-title":"Angiotensin-(1-7) Suppresses Hepatocellular Carcinoma Growth and Angiogenesis via Complex Interactions of Angiotensin II Type 1 Receptor. Angiotensin II Type 2 Receptor and Mas Receptor.","volume":"21","author":"Liu","year":"2015","journal-title":"Mol. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1093\/eurheartj\/ehq253","article-title":"Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia\/reperfusion injury: role of autophagy paradox and toxic aldehyde.","volume":"32","author":"Ma","year":"2011","journal-title":"Eur. Heart J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00109-017-1513-9","article-title":"Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and cardiac angiotensin II.","volume":"95","author":"Maier","year":"2017","journal-title":"J. Mol. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.biocel.2008.02.022","article-title":"Prolylcarboxypeptidase: a cardioprotective enzyme.","volume":"41","author":"Mallela","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1177\/1470320314554963","article-title":"Effects of acute angiotensin II on ischemia reperfusion injury following myocardial infarction.","volume":"16","author":"Mann","year":"2015","journal-title":"J. Renin. Angiotensin Aldosterone Syst."},{"key":"B20","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1093\/cvr\/cvr312","article-title":"New roles for mitochondria in cell death in the reperfused myocardium.","volume":"94","author":"Ong","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1160\/TH14-07-0592","article-title":"Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology.","volume":"113","author":"Ong","year":"2015","journal-title":"Thromb. Haemost."},{"key":"B22","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.jacc.2016.10.034","article-title":"ACC\/AATS\/AHA\/ASE\/ASNC\/SCAI\/SCCT\/STS 2016 Appropriate Use Criteria for Coronary Revascularization in Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and the Society of Thoracic Surgeons.","volume":"69","author":"Patel","year":"2017","journal-title":"J. Am. Coll Cardiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1002\/cphy.c100053","article-title":"The kallikrein-kinin system as a regulator of cardiovascular and renal function.","volume":"1","author":"Rhaleb","year":"2011","journal-title":"Compr. Physiol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33523-7","article-title":"Pro-opiomelanocortin and its Processing Enzymes Associate with Plaque Stability in Human Atherosclerosis - Tampere Vascular Study.","volume":"8","author":"Rinne","year":"2018","journal-title":"Sci. Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s11906-009-0032-7","article-title":"Hypertension and the bradykinin system.","volume":"11","author":"Sharma","year":"2009","journal-title":"Curr. Hypertens. Rep."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6807-10-16","article-title":"Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase.","volume":"10","author":"Soisson","year":"2010","journal-title":"BMC Struct. Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1161\/01.hyp.38.3.660","article-title":"Interactions between angiotensin-(1-7), kinins, and angiotensin II in kidney and blood vessels.","volume":"38","author":"Souza Dos, Santos","year":"2001","journal-title":"Hypertension"},{"key":"B28","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1177\/1470320312474854","article-title":"Different cross-talk sites between the renin-angiotensin and the kallikrein-kinin systems.","volume":"15","author":"Su","year":"2014","journal-title":"J. Renin. Angiotensin Aldoster. Syst."},{"key":"B29","doi-asserted-by":"crossref","first-page":"16631","DOI":"10.1016\/S0021-9258(19)85465-0","article-title":"Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families.","volume":"268","author":"Tan","year":"1993","journal-title":"J. Biol. Chem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ajog.2006.01.079","article-title":"Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia.","volume":"195","author":"Wang","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1038\/2181224a0","article-title":"New enzymatic route for the inactivation of angiotensin.","volume":"218","author":"Yang","year":"1968","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.3892\/ijmm.2019.4264","article-title":"Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I\/R injury via PINK-mediated autophagy.","volume":"44","author":"Yao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1161\/HYPERTENSIONAHA.110.155051","article-title":"Role of prolylcarboxypeptidase in angiotensin II type 2 receptor-mediated bradykinin release in mouse coronary artery endothelial cells.","volume":"56","author":"Zhu","year":"2010","journal-title":"Hypertension"},{"key":"B34","doi-asserted-by":"publisher","first-page":"H2553","DOI":"10.1152\/ajpheart.01157.2011","article-title":"Angiotensin II type 2 receptor-stimulated activation of plasma prekallikrein and bradykinin release: role of SHP-1.","volume":"302","author":"Zhu","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2020.584933\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T22:17:00Z","timestamp":1618006620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2020.584933\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":34,"alternative-id":["10.3389\/fcell.2020.584933"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.584933","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]},"article-number":"584933"}}