{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:06:25Z","timestamp":1789013185342,"version":"build-2803163510"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G.0202.09"],"award-info":[{"award-number":["G.0202.09"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G.0869.10N"],"award-info":[{"award-number":["G.0869.10N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["3G055013N"],"award-info":[{"award-number":["3G055013N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["3G056413N"],"award-info":[{"award-number":["3G056413N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G037918N"],"award-info":[{"award-number":["G037918N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["3GA00113N"],"award-info":[{"award-number":["3GA00113N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["3G065614"],"award-info":[{"award-number":["3G065614"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G.0C47.13N"],"award-info":[{"award-number":["G.0C47.13N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0B2913N"],"award-info":[{"award-number":["G0B2913N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G037514N"],"award-info":[{"award-number":["G037514N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["3G002711"],"award-info":[{"award-number":["3G002711"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Odysseus program"],"award-info":[{"award-number":["Odysseus program"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","award":["BOF18-GOA-024"],"award-info":[{"award-number":["BOF18-GOA-024"]}],"id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","award":["01G01910"],"award-info":[{"award-number":["01G01910"]}],"id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","award":["BOF"],"award-info":[{"award-number":["BOF"]}],"id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005026","name":"Stichting Tegen Kanker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003132","name":"Agentschap voor Innovatie door Wetenschap en Technologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"DOI":"10.3389\/fcell.2020.599472","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T05:05:11Z","timestamp":1604466311000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation"],"prefix":"10.3389","volume":"8","author":[{"given":"Siebe","family":"Loontiens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Catherine","family":"Dolens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Strubbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Van de Walle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finola E.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Depestel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Vanhauwaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Matthijssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Langenau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Speleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Van Vlierberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaat","family":"Durinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Taghon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00032","article-title":"Loss of CD44dim expression from early progenitor cells marks T-cell lineage commitment in the human thymus.","volume":"8","author":"Cant\u00e9-Barrett","year":"2017","journal-title":"Front. Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/ni.3299","article-title":"Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B Cell and t cell lineages.","volume":"16","author":"Casero","year":"2015","journal-title":"Nat. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/MOH.0000000000000254","article-title":"Oncogenic notch signaling in T-Cell and B-Cell lymphoproliferative disorders.","volume":"23","author":"Chiang","year":"2016","journal-title":"Curr. Opin. Hematol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.immuni.2006.05.010","article-title":"Stage-Specific and differential notch dependency at the A\u03b2 and \u0393\u03b4 T lineage bifurcation.","volume":"25","author":"Ciofani","year":"2006","journal-title":"Immunity"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1038\/ni.2760","article-title":"T Cell Development requires constraint of the myeloid regulator C\/EBP-\u03b1 by the notch target and transcriptional repressor Hes1.","volume":"14","author":"De Obaldia","year":"2013","journal-title":"Nat. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1146\/annurev-immunol-032414-112032","article-title":"Transcriptional regulation of innate and adaptive lymphocyte lineages.","volume":"33","author":"De Obaldia","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1182\/blood-2007-03-082206","article-title":"Notch signaling induces Cytoplasmic CD3 epsilon expression in human differentiating NK cells.","volume":"110","author":"De Smedt","year":"2007","journal-title":"Blood"},{"key":"B8","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/imr.12209","article-title":"Mi-2\/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function.","volume":"261","author":"Dege","year":"2014","journal-title":"Immunol. Rev."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949006","article-title":"Distinct Notch1 and BCL11B requirements mediate human \u0393\u03b4\/A\u03b2 T cell development.","volume":"21","author":"Dolens","year":"2020","journal-title":"EMBO Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.3324\/haematol.2014.115683","article-title":"The notch driven long non-coding RNA repertoire in T-Cell acute lymphoblastic leukemia.","volume":"99","author":"Durinck","year":"2014","journal-title":"Haematologica"},{"key":"B11","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1182\/asheducation-2009.1.353","article-title":"The role of NOTCH1 signaling in T-ALL.","volume":"2009","author":"Ferrando","year":"2009","journal-title":"Hematol. Educ. Prog. Am. Soc. Hematol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9510","article-title":"Notch signal strength controls cell fate in the Haemogenic endothelium.","volume":"6","author":"Gama-Norton","year":"2015","journal-title":"Nat. Commun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1182\/bloodadvances.2019000391","article-title":"Phf6-Null hematopoietic stem cells have enhanced self-renewal capacity and Oncogenic potentials.","volume":"3","author":"Hsu","year":"2019","journal-title":"Blood Adv."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1242\/dev.083147","article-title":"Hematopoiesis.","volume":"140","author":"Jagannathan-Bogdan","year":"2013","journal-title":"Development"},{"key":"B15","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1242\/dmm.006791","article-title":"Zebrafish as a model for normal and malignant Hematopoiesis.","volume":"4","author":"Jing","year":"2011","journal-title":"Dis. Models Mech."},{"key":"B16","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/nature09999","article-title":"A novel tumour-suppressor function for the notch pathway in myeloid Leukaemia.","volume":"473","author":"Klinakis","year":"2011","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3892\/ol.2016.4581","article-title":"Co-existence of PHF6 and NOTCH1 mutations in adult T-Cell acute lymphoblastic leukemia.","volume":"12","author":"Li","year":"2016","journal-title":"Oncol. Lett."},{"key":"B18","doi-asserted-by":"publisher","first-page":"6630","DOI":"10.1074\/jbc.M114.610196","article-title":"Structural basis of plant Homeodomain finger 6 (PHF6) recognition by the retinoblastoma binding protein 4 (RBBP4) component of the nucleosome remodeling and deacetylase (NuRD) complex.","volume":"290","author":"Liu","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-019-5608-2","article-title":"Purification of high-quality RNA from a small number of fluorescence activated cell sorted zebrafish cells for RNA sequencing purposes.","volume":"20","author":"Loontiens","year":"2019","journal-title":"BMC Genom."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0938-2","article-title":"A Novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models.","author":"Loontiens","year":"2020","journal-title":"Leukemia"},{"key":"B21","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.dci.2011.12.013","article-title":"Regulatory mechanisms of thymus and T cell development.","volume":"39","author":"Ma","year":"2013","journal-title":"Dev. Compar. Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1182\/blood-2018-07-860726","article-title":"PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.","volume":"133","author":"McRae","year":"2019","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1101\/gad.254151.114","article-title":"A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.","volume":"29","author":"Meacham","year":"2015","journal-title":"Genes Dev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology.","volume":"172","author":"Mestas","year":"2004","journal-title":"J. Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1182\/blood.2019000468","article-title":"The Chromatin-binding protein Phf6 restricts the self-renewal of Hematopoietic stem cells.","volume":"133","author":"Miyagi","year":"2019","journal-title":"Blood"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037877","article-title":"Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).","volume":"7","author":"Moore","year":"2012","journal-title":"PLoS One"},{"key":"B27","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.stem.2013.05.015","article-title":"In vivo mapping of notch pathway activity in normal and stress hematopoiesis.","volume":"13","author":"Oh","year":"2013","journal-title":"Cell Stem Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1038\/leu.2011.127","article-title":"Notch signaling in mammalian hematopoietic stem cells.","volume":"25","author":"Pajcini","year":"2011","journal-title":"Leukemia"},{"key":"B29","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.immuni.2007.05.011","article-title":"Immune-cell lineage commitment: translation from mice to humans.","volume":"26","author":"Payne","year":"2007","journal-title":"Immun. Cell Press"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1056\/NEJMoa1509164","article-title":"Multisystem anomalies in severe combined immunodeficiency with mutant BCL11B.","volume":"375","author":"Punwani","year":"2016","journal-title":"New Engl. J. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nri3445","article-title":"Regulation of innate and adaptive immunity by notch.","volume":"13","author":"Radtke","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S1074-7613(00)80054-80050","article-title":"Deficient T cell fate specification in mice with an induced inactivation of Notch1.","volume":"10","author":"Radtke","year":"1999","journal-title":"Immunity"},{"key":"B33","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/ni.2545","article-title":"The transcription factor T-Bet is essential for the development of NKp46+ innate lymphocytes via the notch pathway.","volume":"14","author":"Rankin","year":"2013","journal-title":"Nat. Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/imr.12417","article-title":"Hematopoiesis and T-Cell specification as a model developmental system.","volume":"271","author":"Rothenberg","year":"2016","journal-title":"Immunol. Rev."},{"key":"B35","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S1074-7613(03)00111-110","article-title":"Notch2 is preferentially expressed in mature B cells and indispensable for marginal Zone B lineage development.","volume":"18","author":"Saito","year":"2003","journal-title":"Immunity"},{"key":"B36","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/S1074-7613(02)00474-470","article-title":"Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.","volume":"17","author":"Schmitt","year":"2002","journal-title":"Immunity"},{"key":"B37","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1101\/gad.295857.117","article-title":"PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.","volume":"31","author":"Soto-Feliciano","year":"2017","journal-title":"Genes Dev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.immuni.2005.11.012","article-title":"Developmental and molecular characterization of emerging \u03b2- and \u0393\u03b4-selected Pre-T Cells in the adult mouse thymus.","volume":"24","author":"Taghon","year":"2006","journal-title":"Immunity"},{"key":"B39","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/82_2012_230","article-title":"Notch signaling during human T cell development.","volume":"360","author":"Taghon","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1084\/JEM.20170488","article-title":"The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells.","volume":"214","author":"Tian","year":"2017","journal-title":"J. Exper. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3390\/genes6020325","article-title":"PHF6 degrees of separation: the multifaceted roles of a chromatin adaptor protein.","volume":"6","author":"Todd","year":"2015","journal-title":"Genes"},{"key":"B42","doi-asserted-by":"publisher","first-page":"4326","DOI":"10.1021\/pr3004369","article-title":"PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex.","volume":"11","author":"Todd","year":"2012","journal-title":"J. Proteome Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1182\/blood-2008-06-164871","article-title":"An early decrease in notch activation is required for human TCR-A\u03b2 lineage differentiation at the expense of TCR-\u0393\u03b4 T cells.","volume":"113","author":"Van de Walle","year":"2009","journal-title":"Blood"},{"key":"B44","doi-asserted-by":"publisher","first-page":"4449","DOI":"10.1182\/blood-2010-06-290049","article-title":"Jagged2 Acts as a delta-like notch ligand during early hematopoietic cell fate decisions.","volume":"117","author":"Van de Walle","year":"2011","journal-title":"Blood"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11171","article-title":"GATA3 induces human T-cell commitment by restraining notch activity and repressing NK-cell fate.","volume":"7","author":"Van de Walle","year":"2016","journal-title":"Nat. Commun."},{"key":"B46","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1084\/jem.20121798","article-title":"Specific notch receptor-ligand interactions control human TCR-A\u03b2\/\u0393\u03b4 development by inducing differential notch signal strength.","volume":"210","author":"Van de Walle","year":"2013","journal-title":"J. Exper. Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/ng.542","article-title":"PHF6 mutations in T-Cell acute lymphoblastic leukemia.","volume":"42","author":"Van Vlierberghe","year":"2010","journal-title":"Nat. Genet."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.3324\/haematol.2015.130179","article-title":"Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia.","volume":"100","author":"Vicente","year":"2015","journal-title":"Haematologica"},{"key":"B49","doi-asserted-by":"publisher","first-page":"D246","DOI":"10.1093\/nar\/gks915","article-title":"LNCipedia: a database for annotated human IncRNA transcript sequences and structures.","volume":"41","author":"Volders","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"5997","DOI":"10.4049\/jimmunol.1400764","article-title":"Notch3 activation is sufficient but not required for inducing human T-lineage specification.","volume":"193","author":"Waegemans","year":"2014","journal-title":"J. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1074\/jbc.M112.414839","article-title":"PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis.","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.3324\/haematol.2011.043083","article-title":"Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-Cell acute lymphoblastic leukemia.","volume":"96","author":"Wang","year":"2011","journal-title":"Haematologica"},{"key":"B53","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1158\/2159-8290.CD-18-1005","article-title":"Phf6 loss enhances HSC self-renewal driving tumor initiation and leukemia stem cell activity in T-ALL.","volume":"9","author":"Wendorff","year":"2019","journal-title":"Cancer Discov."},{"key":"B54","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute Lymphoblastic leukemia.","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1084\/jem.194.7.1003","article-title":"Notch 1-deficient common lymphoid precursors adopt a B Cell fate in the thymus.","volume":"194","author":"Wilson","year":"2001","journal-title":"J. Exper. Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.smim.2010.04.015","article-title":"Notch regulation of early thymocyte development.","volume":"22","author":"Yashiro-Ohtani","year":"2010","journal-title":"Semin. Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.neuron.2013.04.021","article-title":"The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain.","volume":"78","author":"Zhang","year":"2013","journal-title":"Neuron"},{"key":"B58","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/978-1-4939-2809-5_22","article-title":"Using the zebrafish model to study T cell development.","volume":"1323","author":"Zhang","year":"2016","journal-title":"Methods Mol. Biol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2020.599472\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T05:05:16Z","timestamp":1604466316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2020.599472\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"references-count":58,"alternative-id":["10.3389\/fcell.2020.599472"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2020.599472","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,4]]},"article-number":"599472"}}