{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:17:30Z","timestamp":1792084650407,"version":"4.4.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["17-74-20068"],"award-info":[{"award-number":["17-74-20068"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["19-15-00425"],"award-info":[{"award-number":["19-15-00425"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["17-54-80006"],"award-info":[{"award-number":["17-54-80006"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011051","name":"Council on grants of the President of the Russian Federation","doi-asserted-by":"publisher","award":["MK-2335.2019.4"],"award-info":[{"award-number":["MK-2335.2019.4"]}],"id":[{"id":"10.13039\/501100011051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2020-795, local identifier 13.1902.21.0027"],"award-info":[{"award-number":["075-15-2020-795, local identifier 13.1902.21.0027"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Huntington's disease (HD) is a severe autosomal-dominant neurodegenerative disorder caused by a mutation within a gene, encoding huntingtin protein. Here we have used the induced pluripotent stem cell technology to produce patient-specific terminally differentiated GABA-ergic medium spiny neurons modeling a juvenile form of HD (HD76). We have shown that calcium signaling is dramatically disturbed in HD76 neurons, specifically demonstrating higher levels of store-operated and voltage-gated calcium uptakes. However, comparing the HD76 neurons with the previously described low-repeat HD models, we have demonstrated that the severity of calcium signaling alterations does not depend on the length of the polyglutamine tract of the mutant huntingtin. Here we have also observed greater expression of huntingtin and an activator of store-operated calcium channels STIM2 in HD76 neurons. Since shRNA-mediated suppression of STIM2 decreased store-operated calcium uptake, we have speculated that high expression of STIM2 underlies the excessive entry through store-operated calcium channels in HD pathology. Moreover, a previously described potential anti-HD drug EVP4593 has been found to attenuate high levels of both huntingtin and STIM2 that may contribute to its neuroprotective effect. Our results are fully supportive in favor of the crucial role of calcium signaling deregulation in the HD pathogenesis and indicate that the cornerstone of excessive calcium uptake in HD-specific neurons is a calcium sensor and store-operated calcium channels activator STIM2, which should become a molecular target for medical treatment and novel neuroprotective drug development.<\/jats:p>","DOI":"10.3389\/fcell.2021.625231","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T03:00:22Z","timestamp":1612234822000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease"],"prefix":"10.3389","volume":"9","author":[{"given":"Vladimir A.","family":"Vigont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy A.","family":"Grekhnev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga S.","family":"Lebedeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin O.","family":"Gusev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egor A.","family":"Volovikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton Yu.","family":"Skopin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra N.","family":"Bogomazova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia D.","family":"Shuvalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Zubkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina A.","family":"Khomyakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyubov N.","family":"Glushankova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey A.","family":"Klyushnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey N.","family":"Illarioshkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Lagarkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Kaznacheyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1399-0004.1993.tb03820.x","article-title":"DNA analysis of distinct populations suggests multiple origins for the mutation causing Huntington disease","volume":"43","author":"Andrew","year":"1993","journal-title":"Clin. Genet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-1-0716-0771-8_4","article-title":"Development of antisense oligonucleotide gapmers for the treatment of Huntington's disease","volume":"2176","author":"Aslesh","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5037","DOI":"10.1073\/pnas.93.10.5037","article-title":"Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin","volume":"93","author":"Bao","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B4","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/nn.4014","article-title":"A SNP in the HTT promoter alters NF-\u03baB binding and is a bidirectional genetic modifier of Huntington disease","volume":"18","author":"Be\u010danovi\u0107","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.molmed.2009.01.001","article-title":"Calcium signaling and neurodegenerative diseases","volume":"15","author":"Bezprozvanny","year":"2009","journal-title":"Trends Mol. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"478","DOI":"10.3389\/fnmol.2018.00478","article-title":"Altered synaptic vesicle release and Ca2+ influx at single presynaptic terminals of cortical neurons in a knock-in mouse model of Huntington's disease","volume":"11","author":"Chen","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/1750-1326-6-81","article-title":"Dantrolene is neuroprotective in Huntington's disease transgenic mouse model","volume":"6","author":"Chen","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"B8","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.neuroscience.2019.04.043","article-title":"Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1\u0394E9 mutant linked to familial Alzheimer disease","volume":"410","author":"Chernyuk","year":"2019","journal-title":"Neuroscience"},{"key":"B9","doi-asserted-by":"publisher","first-page":"54","DOI":"10.32607\/20758251-2014-6-1-54-60","article-title":"Patient-specific induced pluripotent stem cells for SOD1-associated amyotrophic lateral sclerosis pathogenesis studies","volume":"6","author":"Chestkov","year":"2014","journal-title":"Acta Naturae"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fnmol.2013.00042","article-title":"Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease","volume":"6","author":"Czeredys","year":"2013","journal-title":"Front. Mol. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3389\/fncel.2018.00381","article-title":"Huntingtin-associated protein 1A regulates store-operated calcium entry in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease","volume":"12","author":"Czeredys","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ceca.2007.02.006","article-title":"Biochemical properties and cellular localisation of STIM proteins","volume":"42","author":"Dziadek","year":"2007","journal-title":"Cell Calcium"},{"key":"B14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.semcdb.2015.03.010","article-title":"Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease","volume":"40","author":"Egorova","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3768","DOI":"10.1523\/JNEUROSCI.4356-06.2007","article-title":"Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease","volume":"27","author":"Fan","year":"2007","journal-title":"J. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/294462a0","article-title":"Multiple conductance states of single acetylcholine receptor channels in embryonic muscle cells","volume":"294","author":"Hamill","year":"1981","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/nn.4532","article-title":"Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice","volume":"20","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1016\/j.bbamcr.2018.05.009","article-title":"Ca2+ signaling and spinocerebellar ataxia","volume":"1865","author":"Hisatsune","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"16009","DOI":"10.1038\/npjparkd.2016.9","article-title":"Creation of a library of induced pluripotent stem cells from Parkinsonian patients","volume":"2","author":"Holmqvist","year":"2016","journal-title":"NPJ Parkinsons Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"723","DOI":"10.2147\/DDDT.S98156","article-title":"Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17","volume":"10","author":"Huang","year":"2016","journal-title":"Drug Des. Dev. Ther."},{"key":"B21","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/ana.410360412","article-title":"Trinucleotide repeat length and rate of progression of Huntington's disease","volume":"36","author":"Illarioshkin","year":"1994","journal-title":"Ann. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.celrep.2016.10.026","article-title":"Vulnerability of purkinje cells generated from spinocerebellar ataxia type 6 patient-derived iPSCs","volume":"17","author":"Ishida","year":"2016","journal-title":"Cell Rep."},{"key":"B23","doi-asserted-by":"publisher","first-page":"23655","DOI":"10.1074\/jbc.M608378200","article-title":"Suppression of TRPC3 leads to disappearance of store-operated channels and formation of a new type of store-independent channels in A431 cells","volume":"282","author":"Kaznacheyeva","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/ncomms2514","article-title":"Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex","volume":"4","author":"Krauss","year":"2013","journal-title":"Nat. Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1039\/C6MD00655H","article-title":"Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I","volume":"8","author":"Krishnathas","year":"2017","journal-title":"Medchemcomm."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1038\/s41467-019-10329-3","article-title":"Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters","volume":"10","author":"Lin","year":"2019","journal-title":"Nat. Commun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1096\/fj.12-219220","article-title":"A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration","volume":"27","author":"Lu","year":"2013","journal-title":"FASEB J."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","article-title":"Dysregulation of gene expression in the R6\/2 model of polyglutamine disease: parallel changes in muscle and brain","volume":"11","author":"Luthi-Carter","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.3390\/ijms21062146","article-title":"Huntingtin lowering strategies","volume":"21","author":"Marxreiter","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1759091419856811","DOI":"10.1177\/1759091419856811","article-title":"Alterations of calcium channels in a mouse model of Huntington's disease and neuroprotection by blockage of CaV1 channels","volume":"11","author":"Miranda","year":"2019","journal-title":"ASN Neuro"},{"key":"B31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.mcn.2015.11.010","article-title":"Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells","volume":"73","author":"Mungenast","year":"2016","journal-title":"Mol. Cell. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1007\/s13311-019-00810-8","article-title":"Modeling polyglutamine expansion diseases with induced pluripotent stem cells","volume":"16","author":"Naphade","year":"2019","journal-title":"Neurotherapeutics"},{"key":"B33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13024-016-0092-5","article-title":"Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons","volume":"11","author":"Nekrasov","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"B34","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.celrep.2019.02.008","article-title":"Unbiased profiling of isogenic Huntington disease hPSC-derived CNS and peripheral cells reveals strong cell-type specificity of CAG length effects","volume":"123","author":"Ooi","year":"2019","journal-title":"Cell Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1242\/jcs.118943","article-title":"Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1","volume":"126","author":"Pani","year":"2013","journal-title":"J. Cell Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1126\/science.1191027","article-title":"The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels","volume":"330","author":"Park","year":"2010","journal-title":"Science"},{"key":"B38","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1096\/fj.07-9449com","article-title":"STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation","volume":"22","author":"Parvez","year":"2008","journal-title":"FASEB J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"4667","DOI":"10.1007\/s12035-017-0674-4","article-title":"Presenilin-1 delta E9 mutant induces STIM1-driven store-operated calcium channel hyperactivation in hippocampal neurons","volume":"55","author":"Ryazantseva","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1111\/jnc.13495","article-title":"Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells","volume":"136","author":"Ryazantseva","year":"2016","journal-title":"J. Neurochem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.biochi.2013.04.009","article-title":"Familial Alzheimer's disease-linked presenilin-1 mutation M146V affects store-operated calcium entry: does gain look like loss?","volume":"95","author":"Ryazantseva","year":"2013","journal-title":"Biochimie"},{"key":"B42","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fnmol.2018.00087","article-title":"On the role of store-operated calcium entry in acute and chronic neurodegenerative diseases","volume":"11","author":"Secondo","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.1074\/jbc.M114.601856","article-title":"STIM1 and STIM2 proteins differently regulate endogenous store-operated channels in HEK293 cells","volume":"290","author":"Shalygin","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2017.03.015","article-title":"N-type Ca2+ channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington's disease","volume":"55","author":"Silva","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"B45","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1159\/000495229","article-title":"Inhibition of Lithium sensitive Orai1\/ STIM1 expression and store operated Ca2+ entry in chorea-acanthocytosis neurons by NF-\u03baB inhibitor Wogonin","volume":"51","author":"Sukkar","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neuron.2014.02.019","article-title":"Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice","volume":"82","author":"Sun","year":"2014","journal-title":"Neuron"},{"key":"B47","doi-asserted-by":"publisher","first-page":"528","DOI":"10.3389\/fncel.2018.00528","article-title":"Identification of altered developmental pathways in human juvenile HD iPSC with 71Q and 109Q using transcriptome profiling","volume":"12","author":"Swito\u0144ska","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1073\/pnas.0409402102","article-title":"Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease","volume":"102","author":"Tang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B49","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0896-6273(03)00366-0","article-title":"Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1","volume":"39","author":"Tang","year":"2003","journal-title":"Neuron"},{"key":"B50","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1016\/S0968-0896(03)00438-3","article-title":"A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives","volume":"11","author":"Tobe","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/nchembio.1308","article-title":"Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration","volume":"9","author":"Tsvetkov","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3389\/fphys.2015.00337","article-title":"Both Orai1 and TRPC1 are involved in excessive store-operated calcium entry in striatal neurons expressing mutant huntingtin exon 1","volume":"6","author":"Vigont","year":"2015","journal-title":"Front. Physiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"696","DOI":"10.3389\/fphar.2018.00696","article-title":"Patient-specific iPSC-based models of Huntington's disease as a tool to study store-operated calcium entry drug targeting","volume":"9","author":"Vigont","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.bcp.2019.07.002","article-title":"Olesoxime in neurodegenerative diseases: scrutinising a promising drug candidate","volume":"168","author":"Weber","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/gt.2009.149","article-title":"Lentiviral gene ontology (LeGO) vectors equipped with novel drug-selectable fluorescent proteins: new building blocks for cell marking and multi-gene analysis","volume":"17","author":"Weber","year":"2010","journal-title":"Gene Ther."},{"key":"B57","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.ceca.2018.07.001","article-title":"Neuronal calcium signaling via store-operated channels in health and disease","volume":"74","author":"Wegierski","year":"2018","journal-title":"Cell Calcium"},{"key":"B58","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3233\/JHD-170266","article-title":"Inhibition of TRPC1-dependent store-operated calcium entry improves synaptic stability and motor performance in a mouse model of Huntington's disease","volume":"7","author":"Wu","year":"2018","journal-title":"J. Huntingtons. Dis."},{"key":"B59","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1523\/JNEUROSCI.1038-15.2016","article-title":"Enhanced store-operated calcium entry leads to striatal synaptic loss in a Huntington's disease mouse model","volume":"36","author":"Wu","year":"2016","journal-title":"J. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.chembiol.2011.04.012","article-title":"Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment","volume":"18","author":"Wu","year":"2011","journal-title":"Chem. Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.nlm.2016.08.007","article-title":"STIM2 regulates AMPA receptor trafficking and plasticity at hippocampal synapses","volume":"138","author":"Yap","year":"2017","journal-title":"Neurobiol. Learn. Mem."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.625231\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T03:00:26Z","timestamp":1612234826000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.625231\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,2]]},"references-count":61,"alternative-id":["10.3389\/fcell.2021.625231"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.625231","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.739586103.793593625","asserted-by":"object"}]},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,2]]},"article-number":"625231"}}