{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:38:43Z","timestamp":1790959123459,"version":"4.1.0"},"reference-count":169,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Depression is a common and debilitating mood disorder that increases in prevalence during pregnancy. Worldwide, 7 to 12% of pregnant women experience depression, in which the associated risk factors include socio-demographic, psychological, and socioeconomic variables. Maternal depression could have psychological, anatomical, and physiological consequences in the newborn. Depression has been related to a downregulation in serotonin levels in the brain. Accordingly, the most commonly prescribed pharmacotherapy is based on selective serotonin reuptake inhibitors (SSRIs), which increase local serotonin concentration. Even though the use of SSRIs has few adverse effects compared with other antidepressants, altering serotonin levels has been associated with the advent of anatomical and physiological changes <jats:italic>in utero<\/jats:italic>, leading to defects in craniofacial development, including craniosynostosis, cleft palate, and dental defects. Migration and proliferation of neural crest cells, which contribute to the formation of bone, cartilage, palate, teeth, and salivary glands in the craniofacial region, are regulated by serotonin. Specifically, craniofacial progenitor cells are affected by serotonin levels, producing a misbalance between their proliferation and differentiation. Thus, it is possible to hypothesize that craniofacial development will be affected by the changes in serotonin levels, happening during maternal depression or after the use of SSRIs, which cross the placental barrier, increasing the risk of craniofacial defects. In this review, we provide a synthesis of the current research on depression and the use of SSRI during pregnancy, and how this could be related to craniofacial defects using an interdisciplinary perspective integrating psychological, clinical, and developmental biology perspectives. We discuss the mechanisms by which serotonin could influence craniofacial development and stem\/progenitor cells, proposing some transcription factors as mediators of serotonin signaling, and craniofacial stem\/progenitor cell biology. We finally highlight the importance of non-pharmacological therapies for depression on fertile and pregnant women, and provide an individual analysis of the risk\u2013benefit balance for the use of antidepressants during pregnancy<\/jats:p>","DOI":"10.3389\/fcell.2021.632766","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T10:09:49Z","timestamp":1628762989000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Depression and Antidepressants During Pregnancy: Craniofacial Defects Due to Stem\/Progenitor Cell Deregulation Mediated by Serotonin"],"prefix":"10.3389","volume":"9","author":[{"given":"Natalia","family":"S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Ju\u00e1rez-Balarezo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Olhaberry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Gonz\u00e1lez-Oneto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Muzard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Mardonez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Gaete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.1242\/dev.00673","article-title":"Dissimilar regulation of cell differentiation in mesencephalic (cranial) and sacral (trunk) neural crest cells in vitro.","volume":"130","author":"Abzhanov","year":"2003","journal-title":"Development"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00049","article-title":"The nervous system orchestrates and integrates craniofacial development: a review.","volume":"7","author":"Adameyko","year":"2016","journal-title":"Front. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/s1534-5807(02)00410-0","article-title":"Tube or not tube: remodeling epithelial tissues by branching morphogenesis.","volume":"4","author":"Affolter","year":"2003","journal-title":"Dev. Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"27298","DOI":"10.1074\/jbc.M702811200","article-title":"Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.","volume":"282","author":"Almeida","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.1056\/NEJMoa066584","article-title":"Use of selective serotonin-reuptake inhibitors in pregnancy and the risk of birth defects.","volume":"356","author":"Alwan","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1095\/biolreprod.104.039313","article-title":"Serotonin and its antidepressant-sensitive transport in mouse cumulus-oocyte complexes and early embryos.","volume":"73","author":"Amireault","year":"2005","journal-title":"Biol. Reprod."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1111\/1471-0528.12682","article-title":"Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study.","volume":"121","author":"Ban","year":"2014","journal-title":"BJOG"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1002\/stem.2037","article-title":"Essential roles of dopamine and serotonin in tooth repair: functional interplay between odontogenic stem cells and platelets.","volume":"33","author":"Baudry","year":"2015","journal-title":"Stem Cells"},{"key":"B9","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.tig.2011.03.003","article-title":"Forkhead transcription factors: key players in health and disease.","volume":"27","author":"Benayoun","year":"2011","journal-title":"Trends Genet."},{"key":"B10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1089\/bioe.2018.0003","article-title":"Selective serotonin reuptake inhibitor use during pregnancy and major malformations: the importance of serotonin for embryonic development and the effect of serotonin inhibition on the occurrence of malformations.","volume":"1","author":"Berard","year":"2019","journal-title":"Bioelectricity"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e791","DOI":"10.1016\/j.ajog.2015.01.034","article-title":"Sertraline use during pregnancy and the risk of major malformations.","volume":"212","author":"Berard","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013372","article-title":"Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort.","volume":"7","author":"Berard","year":"2017","journal-title":"BMJ Open"},{"key":"B13","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","article-title":"The expanded biology of serotonin.","volume":"60","author":"Berger","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00429-004-0380-7","article-title":"Opposing regulation of cell proliferation by retinoic acid and the serotonin2B receptor in the mouse frontonasal mass.","volume":"208","author":"Bhasin","year":"2004","journal-title":"Anat. Embryol. (Berl.)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1007\/s00127-006-0101-z","article-title":"Adult attachment style as mediator between childhood neglect\/abuse and adult depression and anxiety.","volume":"41","author":"Bifulco","year":"2006","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"B16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0046-8177(74)80021-3","article-title":"The neurocristopathies: a unifying concept of disease arising in neural crest maldevelopment.","volume":"5","author":"Bolande","year":"1974","journal-title":"Hum. Pathol."},{"key":"B17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15513819709168343","article-title":"Neurocristopathy: its growth and development in 20 years.","volume":"17","author":"Bolande","year":"1997","journal-title":"Pediatr. Pathol. Lab. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2011.10.005","article-title":"Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain.","volume":"197","author":"Bonnin","year":"2011","journal-title":"Neuroscience"},{"key":"B19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/j.1552-6909.2006.00064.x","article-title":"Prevalence of antenatal depression in women enrolled in an outreach program in Canada.","volume":"35","author":"Bowen","year":"2006","journal-title":"J. Obstet. Gynecol. Neonatal. Nurs."},{"key":"B20","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.archoralbio.2009.09.005","article-title":"Multilevel complex interactions between genetic, epigenetic and environmental factors in the aetiology of anomalies of dental development.","volume":"54","author":"Brook","year":"2009","journal-title":"Arch. Oral. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/bdra.20752","article-title":"Maternal caffeine intake and risk of selected birth defects in the National Birth Defects Prevention Study.","volume":"91","author":"Browne","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/s0145-2134(01)00246-0","article-title":"Childhood sexual abuse, parenting and postpartum depression\u2013a 3-year follow-up study.","volume":"25","author":"Buist","year":"2001","journal-title":"Child Abuse Negl."},{"key":"B23","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s004410100408","article-title":"Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis.","volume":"305","author":"Buznikov","year":"2001","journal-title":"Cell Tissue Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1002\/bdr2.1660","article-title":"The teratogenic effects of sertraline in mice.","volume":"112","author":"Cabrera","year":"2020","journal-title":"Birth Defects Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.vascn.2015.02.003","article-title":"A novel whole-embryo culture model for pharmaceutical and developmental studies.","volume":"73","author":"Calibuso-Salazar","year":"2015","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"B26","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1002\/bdra.20294","article-title":"National estimates and race\/ethnic-specific variation of selected birth defects in the United States, 1999-2001.","volume":"76","author":"Canfield","year":"2006","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"B169","author":"Carlson","year":"2019","journal-title":"Human Embryology and Developmental Biology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/dbio.2002.0780","article-title":"Forkhead transcription factors: key players in development and metabolism.","volume":"250","author":"Carlsson","year":"2002","journal-title":"Dev. Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/bdra.20426","article-title":"Craniosynostosis and maternal smoking.","volume":"82","author":"Carmichael","year":"2008","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1111\/1471-0528.13143","article-title":"Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy: a population-based study in six European regions.","volume":"122","author":"Charlton","year":"2015","journal-title":"BJOG"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1242\/dev.146019","article-title":"Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development.","volume":"144","author":"Chatzeli","year":"2017","journal-title":"Development"},{"key":"B31","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1242\/dev.124.9.1745","article-title":"5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells.","volume":"124","author":"Choi","year":"1997","journal-title":"Development"},{"key":"B32","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/bdra.20773","article-title":"Dispensing patterns and pregnancy outcomes for women dispensed selective serotonin reuptake inhibitors in pregnancy.","volume":"91","author":"Colvin","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1073\/pnas.0606722104","article-title":"Maternal serotonin is crucial for murine embryonic development.","volume":"104","author":"Cote","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B34","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1242\/dev.129.4.1061","article-title":"Interactions between Hox-negative cephalic neural crest cells and the foregut endoderm in patterning the facial skeleton in the vertebrate head.","volume":"129","author":"Couly","year":"2002","journal-title":"Development"},{"key":"B35","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1002\/bdra.23323","article-title":"Selective serotonin reuptake inhibitor exposure alters osteoblast gene expression and craniofacial development in mice.","volume":"100","author":"Cray","year":"2014","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"483","DOI":"10.2174\/157340609789117868","article-title":"Effects of fluoxetine and venlafaxine and pilocarpine on rat parotid glands.","volume":"5","author":"da Silva","year":"2009","journal-title":"Med. Chem."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-02859-2","article-title":"Antenatal depression and its potential causal mechanisms among pregnant mothers in Gondar town: application of structural equation model.","volume":"20","author":"Dadi","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"key":"B38","doi-asserted-by":"publisher","first-page":"F355","DOI":"10.1136\/adc.2004.062810","article-title":"EUROCAT: 25 years of European surveillance of congenital anomalies.","volume":"90","author":"Dolk","year":"2005","journal-title":"Arch. Dis. Child. Fetal Neonatal. Ed."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.lfs.2007.09.034","article-title":"Local serotonergic signaling in mammalian follicles, oocytes and early embryos.","volume":"81","author":"Dube","year":"2007","journal-title":"Life Sci."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101528","article-title":"Pharmacological exposures may precipitate craniosynostosis through targeted stem cell depletion.","volume":"40","author":"Durham","year":"2019","journal-title":"Stem Cell Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/ocr.12153","article-title":"Gene\/environment interactions in craniosynostosis: a brief review.","volume":"20","author":"Durham","year":"2017","journal-title":"Orthod. Craniofac. Res."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26620","article-title":"SOX2 regulates acinar cell development in the salivary gland.","volume":"6","author":"Emmerson","year":"2017","journal-title":"Elife"},{"key":"B43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1196\/annals.1376.036","article-title":"Maternal depression and psychotropic medication effects on the human fetus.","volume":"1094","author":"Emory","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1136\/jech.2007.063016","article-title":"Factors related to depression during pregnancy: are there gender differences?","volume":"62","author":"Escribe-Aguir","year":"2008","journal-title":"J. Epidemiol. Community Health"},{"key":"B45","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00737-016-0704-7","article-title":"The prevalence and incidence of perinatal anxiety disorders among women experiencing a medically complicated pregnancy.","volume":"20","author":"Fairbrother","year":"2017","journal-title":"Arch. Womens Ment. Health"},{"key":"B46","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00737-006-0164-6","article-title":"Prevalence of anxiety and depression during pregnancy in a private setting sample.","volume":"10","author":"Faisal-Cury","year":"2007","journal-title":"Arch. Womens Ment. Health"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.infbeh.2010.09.008","article-title":"Prenatal depression effects on early development: a review.","volume":"34","author":"Field","year":"2011","journal-title":"Infant Behav. Dev."},{"key":"B48","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.infbeh.2017.08.008","article-title":"Prenatal anxiety effects: a review.","volume":"49","author":"Field","year":"","journal-title":"Infant Behav. Dev."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4172\/2376-127X.1000301","article-title":"Prenatal depression risk factors, developmental effects and interventions: a review.","volume":"4","author":"Field","year":"","journal-title":"J. Pregnancy Child. Health"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.155","article-title":"Citalopram and sertraline exposure compromises embryonic bone development.","volume":"21","author":"Fraher","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1242\/bio.013672","article-title":"Epithelial topography for repetitive tooth formation.","volume":"4","author":"Gaete","year":"2015","journal-title":"Biol. Open"},{"key":"B52","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/j.1600-0765.2011.01354.x","article-title":"FoxOs, Wnts and oxidative stress-induced bone loss: new players in the periodontitis arena?","volume":"46","author":"Galli","year":"2011","journal-title":"J. Periodontal Res."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1193-5","article-title":"Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births.","volume":"16","author":"Gao","year":"2018","journal-title":"BMC Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1053\/j.gastro.2006.11.002","article-title":"The serotonin signaling system: from basic understanding to drug development for functional GI disorders.","volume":"132","author":"Gershon","year":"2007","journal-title":"Gastroenterology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017.","volume":"392","year":"2017","journal-title":"Glob. Health Metrics"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001026","article-title":"Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview.","volume":"8","author":"Golder","year":"2011","journal-title":"PLoS Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1002\/da.20421","article-title":"Recurrence of depression during pregnancy: psychosocial and personal functioning correlates.","volume":"26","author":"Goodman","year":"2009","journal-title":"Depress. Anxiety"},{"key":"B58","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00737-003-0024-6","article-title":"The effect of postpartum depression on child cognitive development and behavior: a review and critical analysis of the literature.","volume":"6","author":"Grace","year":"2003","journal-title":"Arch. Womens Ment. Health"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004381","article-title":"Relationship between neural crest cells and cranial mesoderm during head muscle development.","volume":"4","author":"Grenier","year":"2009","journal-title":"PLoS One"},{"key":"B60","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/bdra.20461","article-title":"Maternal periconceptional smoking and alcohol consumption and risk for select congenital anomalies.","volume":"82","author":"Grewal","year":"2008","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/jcb.20734","article-title":"Serotonin and fluoxetine modulate bone cell function in vitro.","volume":"98","author":"Gustafsson","year":"2006","journal-title":"J. Cell Biochem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/s0306-4522(98)00281-4","article-title":"Serotonin transporter messenger RNA expression in neural crest-derived structures and sensory pathways of the developing rat embryo.","volume":"89","author":"Hansson","year":"1999","journal-title":"Neuroscience"},{"key":"B63","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/bs.ctdb.2015.07.029","article-title":"Regulatory mechanisms driving salivary gland organogenesis.","volume":"115","author":"Hauser","year":"2015","journal-title":"Curr. Top. Dev. Biol."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-023281","article-title":"MAGDALENA: study protocol of a randomised, placebo-controlled trial on cognitive development at 2 years of age in children exposed to SSRI in utero.","volume":"8","author":"Heinonen","year":"2018","journal-title":"BMJ Open"},{"key":"B65","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.archoralbio.2009.04.010","article-title":"Influence of antidepressant drugs on Ecto-nucleotide pyrophosphatase\/phosphodiesterases (E-NPPs) from salivary glands of rats.","volume":"54","author":"Henz","year":"2009","journal-title":"Arch. Oral Biol."},{"key":"B66","article-title":"Serotonin effectors expressed during palatogenesis: an immunohistochemical study.","volume":"6","author":"Hirata","year":"2018","journal-title":"JSM Dent."},{"key":"B67","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s10880-019-09632-4","article-title":"Associations between depression symptoms, psychological intervention and perinatal complications.","volume":"27","author":"Hompoth","year":"2020","journal-title":"J. Clin. Psychol. Med. Settings"},{"key":"B68","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/s0091-3057(01)00746-8","article-title":"Molecular, pharmacological and functional diversity of 5-HT receptors.","volume":"71","author":"Hoyer","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1002\/jcp.29178","article-title":"Role of forkhead box gene family in bone metabolism.","volume":"235","author":"Huang","year":"2020","journal-title":"J. Cell Physiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/0003-9969(95)00079-5","article-title":"The effects of antidepressant drugs on salivary flow and content of sodium and potassium ions in human parotid saliva.","volume":"40","author":"Hunter","year":"1995","journal-title":"Arch. Oral Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1001\/jama.2015.5605","article-title":"Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn.","volume":"313","author":"Huybrechts","year":"2015","journal-title":"JAMA"},{"key":"B72","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.1172\/JCI68049","article-title":"FOXOs attenuate bone formation by suppressing Wnt signaling.","volume":"123","author":"Iyer","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00107","article-title":"Stem cell fate determination during development and regeneration of ectodermal organs.","volume":"3","author":"Jimenez-Rojo","year":"2012","journal-title":"Front. Physiol."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063034","article-title":"Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study.","volume":"8","author":"Jimenez-Solem","year":"2013","journal-title":"PLoS One"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116459","article-title":"The effect of antenatal depression and selective serotonin reuptake inhibitor treatment on nerve growth factor signaling in human placenta.","volume":"10","author":"Kaihola","year":"2015","journal-title":"PLoS One"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00160","article-title":"Effects of fluoxetine on human embryo development.","volume":"10","author":"Kaihola","year":"2016","journal-title":"Front. Cell Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1387\/ijdb.150192ao","article-title":"Expression of Sox genes in tooth development.","volume":"59","author":"Kawasaki","year":"2015","journal-title":"Int. J. Dev. Biol."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-019-2418-7","article-title":"Treatment patterns and sequences of pharmacotherapy for patients diagnosed with depression in the United States: 2014 through 2019.","volume":"20","author":"Kern","year":"2020","journal-title":"BMC Psychiatry"},{"key":"B79","doi-asserted-by":"crossref","DOI":"10.29046\/JJP.012.1.001","article-title":"The serotonin theory of depression.","volume":"12","author":"Kerr","year":"1994","journal-title":"Jefferson J. Psychiatry"},{"key":"B80","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.brs.2018.09.005","article-title":"Randomized controlled trial of transcranial magnetic stimulation in pregnant women with major depressive disorder.","volume":"12","author":"Kim","year":"2019","journal-title":"Brain Stimul."},{"key":"B81","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/01376517-199706000-00007","article-title":"Serotonergic receptors as targets for pharmacotherapy.","volume":"29","author":"Kirk","year":"1997","journal-title":"J. Neurosci. Nurs."},{"key":"B82","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/ajmg.c.31382","article-title":"Developmental disorders of the dentition: an update.","author":"Klein","year":"2013","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"B83","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/wdev.4","article-title":"Salivary gland organogenesis.","volume":"1","author":"Knosp","year":"2012","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1172\/JCI64906","article-title":"FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin.","volume":"122","author":"Kode","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B85","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2147\/clep.s9256","article-title":"Use of selective serotonin-reuptake inhibitors during early pregnancy and risk of congenital malformations: updated analysis.","volume":"2","author":"Kornum","year":"2010","journal-title":"Clin. Epidemiol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s00127-013-0758-z","article-title":"Antenatal maternal mental health as determinant of postpartum depression in a population based mother-child cohort (Rhea Study) in Crete, Greece.","volume":"49","author":"Koutra","year":"2014","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/7854_2010_108","article-title":"Animal models of depression: molecular perspectives.","volume":"7","author":"Krishnan","year":"2011","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"17555","DOI":"10.1074\/jbc.RA119.009409","article-title":"FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor beta1 signaling.","volume":"294","author":"Kurakazu","year":"2019","journal-title":"J. Biol. Chem."},{"key":"B89","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.sleh.2020.05.001","article-title":"A pilot longitudinal sleep education intervention from early pregnancy and its effect on optimizing sleep and minimizing depressive symptoms.","volume":"6","author":"Ladyman","year":"2020","journal-title":"Sleep Health"},{"key":"B90","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1159\/000017372","article-title":"Serotonin receptor agonists that increase cyclic AMP positively regulate IGF-I in mouse mandibular mesenchymal cells.","volume":"21","author":"Lambert","year":"1999","journal-title":"Dev. Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/s0736-5748(00)00032-0","article-title":"Expression of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors in the mouse embryo.","volume":"18","author":"Lauder","year":"2000","journal-title":"Int. J. Dev. Neurosci."},{"key":"B92","first-page":"265","article-title":"Sites of serotonin uptake in epithelia of the developing mouse palate, oral cavity, and face: possible role in morphogenesis.","volume":"8","author":"Lauder","year":"1988","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1242\/dev.01350","article-title":"Neural crest cell plasticity and its limits.","volume":"131","author":"Le Douarin","year":"2004","journal-title":"Development"},{"key":"B94","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000091915","article-title":"Of minds and embryos: left-right asymmetry and the serotonergic controls of pre-neural morphogenesis.","volume":"28","author":"Levin","year":"2006","journal-title":"Dev. Neurosci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.cmet.2006.11.004","article-title":"Serotonin targets the DAF-16\/FOXO signaling pathway to modulate stress responses.","volume":"4","author":"Liang","year":"2006","journal-title":"Cell Metab."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00631-3","article-title":"The BDNF-FoxO1 Axis in the medial prefrontal cortex modulates depressive-like behaviors induced by chronic unpredictable stress in postpartum female mice.","volume":"13","author":"Liu","year":"2020","journal-title":"Mol. Brain"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1056\/NEJMoa067407","article-title":"First-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defects.","volume":"356","author":"Louik","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"B98","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.joim.2020.07.007","article-title":"Mindfulness interventions during pregnancy: a narrative review.","volume":"18","author":"Lucena","year":"2020","journal-title":"J. Integr. Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1084\/jem.20150906","article-title":"5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.","volume":"214","author":"Lv","year":"2017","journal-title":"J. Exp. Med."},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030692","article-title":"The roles of FoxO transcription factors in regulation of bone cells function.","volume":"21","author":"Ma","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/AOG.0b013e318220edcc","article-title":"Selective serotonin reuptake inhibitors and risk for major congenital anomalies.","volume":"118","author":"Malm","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/dvg.20710","article-title":"Mechanisms that underlie co-variation of the brain and face.","volume":"49","author":"Marcucio","year":"2011","journal-title":"Genesis"},{"key":"B103","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/03004430.2017.1292398","article-title":"Emotional development in offspring from infancy to adolescence.","volume":"189","author":"McAndrew","year":"2019","journal-title":"Early Child. Dev. Care"},{"key":"B104","doi-asserted-by":"publisher","first-page":"E40","DOI":"10.1210\/jc.2010-0978","article-title":"Elevated corticotropin releasing hormone (CRH) during pregnancy and risk of postpartum depression (PPD).","volume":"96","author":"Meltzer-Brody","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B105","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.neuropharm.2018.08.023","article-title":"Fluoxetine or Sox2 reactivate proliferation-defective stem and progenitor cells of the adult and aged dentate gyrus.","volume":"141","author":"Micheli","year":"2018","journal-title":"Neuropharmacology"},{"key":"B106","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jad.2007.10.014","article-title":"Antenatal risk factors for postnatal depression: a large prospective study.","volume":"108","author":"Milgrom","year":"2008","journal-title":"J. Affect. Disord."},{"key":"B107","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.tips.2008.06.007","article-title":"Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.","volume":"29","author":"Millan","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"B108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7764\/psykhe.26.1.916","article-title":"Intervenci\u00f3n grupal en embarazadas: respuestas diferenciales de acuerdo al tipo de depresi\u00f3n y patr\u00f3n de apego.","volume":"26","author":"Miranda","year":"2017","journal-title":"Revista Psykhe"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184388","article-title":"Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt\/beta-catenin signaling.","volume":"12","author":"Miyamoto","year":"2017","journal-title":"PLoS One"},{"key":"B110","doi-asserted-by":"publisher","first-page":"7182","DOI":"10.1073\/pnas.92.16.7182","article-title":"Serotonin regulates mouse cranial neural crest migration.","volume":"92","author":"Moiseiwitsch","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B111","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0003-9969(95)00117-4","article-title":"Stimulation of murine tooth development in organotypic culture by the neurotransmitter serotonin.","volume":"41","author":"Moiseiwitsch","year":"1996","journal-title":"Arch. Oral Biol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s004290050026","article-title":"Regulation of gene expression in cultured embryonic mouse mandibular mesenchyme by serotonin antagonists.","volume":"195","author":"Moiseiwitsch","year":"1997","journal-title":"Anat. Embryol. (Berl.)"},{"key":"B113","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/s0003-9969(98)00067-3","article-title":"Regulation by serotonin of tooth-germ morphogenesis and gene expression in mouse mandibular explant cultures.","volume":"43","author":"Moiseiwitsch","year":"1998","journal-title":"Arch. Oral Biol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jad.2019.12.014","article-title":"The international prevalence of antidepressant use before, during, and after pregnancy: a systematic review and meta-analysis of timing, type of prescriptions and geographical variability.","volume":"264","author":"Molenaar","year":"2020","journal-title":"J. Affect. Disord."},{"key":"B115","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1034\/j.1399-0004.2002.610402.x","article-title":"Gene\/environment causes of cleft lip and\/or palate.","volume":"61","author":"Murray","year":"2002","journal-title":"Clin. Genet."},{"key":"B116","first-page":"1","article-title":"\u201cChapter 143 \u2013 clefting, dental, and craniofacial syndromes,\u201d in","author":"Murray","year":"2013","journal-title":"Emery and Rimoin\u2019s Principles and Practice of Medical Genetics"},{"key":"B117","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1469-8749.1996.tb12082.x","article-title":"The role of infant factors in postnatal depression and mother-infant interactions.","volume":"38","author":"Murray","year":"1996","journal-title":"Dev. Med. Child. Neurol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.fsc.2014.08.002","article-title":"Craniofacial anomalies.","volume":"22","author":"Nagy","year":"2014","journal-title":"Facial Plast. Surg. Clin. North. Am."},{"key":"B119","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.neuropharm.2008.08.020","article-title":"Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs).","volume":"55","author":"Narboux-Neme","year":"2008","journal-title":"Neuropharmacology"},{"key":"B120","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1001\/archpsyc.59.2.139","article-title":"Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study.","volume":"59","author":"Nelson","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"key":"B121","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1001\/jama.2015.18948","article-title":"Primary care screening for and treatment of depression in pregnant and postpartum women: evidence report and systematic review for the US Preventive Services Task Force.","volume":"315","author":"O\u2019Connor","year":"2016","journal-title":"JAMA"},{"key":"B122","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.celrep.2015.06.013","article-title":"Distinct transcriptional programs underlie Sox9 regulation of the mammalian chondrocyte.","volume":"12","author":"Ohba","year":"2015","journal-title":"Cell Rep."},{"key":"B123","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.mhp.2014.09.001","article-title":"Antenatal depression and its relationship with problem-solving strategies, childhood abuse, social support, and attachment styles in a low-income Chilean sample.","volume":"2","author":"Olhaberry","year":"2014","journal-title":"Ment. Health Prev."},{"key":"B124","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1387\/ijdb.130204mo","article-title":"Unraveling new roles for serotonin receptor 2B in development: key findings from Xenopus.","volume":"57","author":"Ori","year":"2013","journal-title":"Int. J. Dev. Biol."},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076345","article-title":"Sox2 expression is regulated by a negative feedback loop in embryonic stem cells that involves AKT signaling and FoxO1.","volume":"8","author":"Ormsbee Golden","year":"2013","journal-title":"PLoS One"},{"key":"B126","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3109\/15622975.2013.795242","article-title":"Parotid gland flow activity and inorganic composition in purging bulimic patients treated with fluoxetine.","volume":"14","author":"Paszynska","year":"2013","journal-title":"World J. Biol. Psychiatry"},{"key":"B127","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1432-0436.2006.00088.x","article-title":"Salivary gland branching morphogenesis.","volume":"74","author":"Patel","year":"2006","journal-title":"Differentiation"},{"key":"B128","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jad.2008.05.018","article-title":"Antenatal depression predicts depression in adolescent offspring: prospective longitudinal community-based study.","volume":"113","author":"Pawlby","year":"2009","journal-title":"J. Affect. Disord."},{"key":"B129","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.infbeh.2012.07.020","article-title":"Disruption to the development of maternal responsiveness? The impact of prenatal depression on mother-infant interactions.","volume":"35","author":"Pearson","year":"2012","journal-title":"Infant Behav. Dev."},{"key":"B130","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/syn.890180310","article-title":"Molecular biology of serotonin (5-HT) receptors.","volume":"18","author":"Peroutka","year":"1994","journal-title":"Synapse"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s00702-019-02084-y","article-title":"Animal models of major depression: drawbacks and challenges.","volume":"126","author":"Planchez","year":"2019","journal-title":"J. Neural. Transm. (Vienna)"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030357","article-title":"Transcription factor FoxO1 is essential for enamel biomineralization.","volume":"7","author":"Poche","year":"2012","journal-title":"PLoS One"},{"key":"B133","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.biopsych.2008.08.005","article-title":"Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.","volume":"65","author":"Polter","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1111\/j.1471-0528.2007.01387.x","article-title":"Prevalence and predictors of antidepressant use in a cohort of pregnant women.","volume":"114","author":"Ramos","year":"2007","journal-title":"BJOG"},{"key":"B135","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1055\/s-0028-1103296","article-title":"Placental transfer of SSRI and SNRI antidepressants and effects on the neonate.","volume":"42","author":"Rampono","year":"2009","journal-title":"Pharmacopsychiatry"},{"key":"B136","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.whi.2016.02.002","article-title":"Depression trajectories of antenatally depressed and nondepressed young mothers: implications for child socioemotional development.","volume":"26","author":"Raskin","year":"2016","journal-title":"Womens Health Issues"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h3190","article-title":"Specific SSRIs and birth defects: Bayesian analysis to interpret new data in the context of previous reports.","volume":"351","author":"Reefhuis","year":"2015","journal-title":"BMJ"},{"key":"B138","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1242\/dev.041079","article-title":"Serotonin 2B receptor signaling is required for craniofacial morphogenesis and jaw joint formation in Xenopus.","volume":"137","author":"Reisoli","year":"2010","journal-title":"Development"},{"key":"B139","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/j.1600-0722.2010.00778.x","article-title":"Serotonin and fluoxetine receptors are expressed in enamel organs and LS8 cells and modulate gene expression in LS8 cells.","volume":"118","author":"Riksen","year":"2010","journal-title":"Eur. J. Oral. Sci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1242\/dev.002501","article-title":"Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis.","volume":"134","author":"Rinon","year":"2007","journal-title":"Development"},{"key":"B141","doi-asserted-by":"publisher","first-page":"424","DOI":"10.4067\/S0034-98872015000400002","article-title":"[Barriers restricting postpartum depression treatment in Chile].","volume":"143","author":"Rojas","year":"2015","journal-title":"Rev. Med. Chil."},{"key":"B142","first-page":"51","article-title":"Odontoblast differentiation.","volume":"39","author":"Ruch","year":"1995","journal-title":"Int. J. Dev. Biol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s12079-018-0482-2","article-title":"The 5-Hydroxytryptamine signaling map: an overview of serotonin-serotonin receptor mediated signaling network.","volume":"12","author":"Sahu","year":"2018","journal-title":"J. Cell Commun. Signal."},{"key":"B144","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.mod.2018.07.005","article-title":"Tracking morphological complexities of organ development in culture.","volume":"154","author":"S\u00e1nchez","year":"2018","journal-title":"Mech. Dev."},{"key":"B145","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1148\/rg.2019190086","article-title":"Neurocristopathies: enigmatic appearances of neural crest cell-derived abnormalities.","volume":"39","author":"Sato","year":"2019","journal-title":"Radiographics"},{"key":"B146","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1002\/tera.1420460407","article-title":"Serotonin as a regulator of craniofacial morphogenesis: site specific malformations following exposure to serotonin uptake inhibitors.","volume":"46","author":"Shuey","year":"1992","journal-title":"Teratology"},{"key":"B147","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BF00208198","article-title":"Serotonin and morphogenesis. Transient expression of serotonin uptake and binding protein during craniofacial morphogenesis in the mouse.","volume":"187","author":"Shuey","year":"1993","journal-title":"Anat. Embryol. (Berl.)"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088917","article-title":"Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro.","volume":"9","author":"Sousa-Ferreira","year":"2014","journal-title":"PLoS One"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1111\/mcn.12235","article-title":"The role of diet and nutritional supplementation in perinatal depression: a systematic review.","volume":"13","author":"Sparling","year":"2017","journal-title":"Matern. Child. Nutr."},{"key":"B150","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/s0165-0327(98)00221-3","article-title":"Mechanism of action of serotonin selective reuptake inhibitors. Serotonin receptors and pathways mediate therapeutic effects and side effects.","volume":"51","author":"Stahl","year":"1998","journal-title":"J. Affect. Disord."},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.324","article-title":"Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development.","author":"Takenoshita","year":"2021","journal-title":"Dev. Dyn."},{"key":"B152","doi-asserted-by":"publisher","first-page":"31055","DOI":"10.1074\/jbc.M109.079962","article-title":"Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis.","volume":"285","author":"Teixeira","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1242\/jcs.00410","article-title":"Epithelial-mesenchymal signalling regulating tooth morphogenesis.","volume":"116","author":"Thesleff","year":"2003","journal-title":"J. Cell Sci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/s0925-4773(97)00115-9","article-title":"Signalling networks regulating dental development.","volume":"67","author":"Thesleff","year":"1997","journal-title":"Mech. Dev."},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00855","article-title":"Unusual conditions impairing saliva secretion: developmental anomalies of salivary glands.","volume":"10","author":"Togni","year":"2019","journal-title":"Front. Physiol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.eurpsy.2010.10.006","article-title":"The adverse skeletal effects of selective serotonin reuptake inhibitors.","volume":"27","author":"Tsapakis","year":"2012","journal-title":"Eur. Psychiatry"},{"key":"B157","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1177\/00220345960750031101","article-title":"A regulatory role in mammalian salivary glands for 5-hydroxytryptamine receptors coupled to increased cyclic AMP production.","volume":"75","author":"Turner","year":"1996","journal-title":"J. Dent. Res."},{"key":"B158","doi-asserted-by":"publisher","first-page":"R50","DOI":"10.1093\/hmg\/ddv228","article-title":"New insights into craniofacial malformations.","volume":"24","author":"Twigg","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B159","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1080\/14740338.2020.1832080","article-title":"Selective serotonin reuptake inhibitors and the risk of congenital anomalies: a systematic review of current meta-analyses.","volume":"19","author":"Uguz","year":"2020","journal-title":"Expert. Opin. Drug Saf."},{"key":"B160","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.toxlet.2017.08.012","article-title":"Impact of selective serotonin reuptake inhibitors on neural crest stem cell formation.","volume":"281","author":"Vichier-Guerre","year":"2017","journal-title":"Toxicol. Lett."},{"key":"B161","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.neuropharm.2015.08.020","article-title":"Forkhead box O transcription factors as possible mediators in the development of major depression.","volume":"99","author":"Wang","year":"2015","journal-title":"Neuropharmacology"},{"key":"B162","first-page":"75","article-title":"Palate morphogenesis. IV. Effects of serotonin and its antagonists on rotation in embryo culture.","volume":"53","author":"Wee","year":"1979","journal-title":"J. Embryol. Exp. Morphol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/BF00233833","article-title":"Palate morphogenesis. VI. Identification of stellate cells in culture.","volume":"217","author":"Wee","year":"1981","journal-title":"Cell Tissue Res."},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1242\/dev.165498","article-title":"Fox proteins are modular competency factors for facial cartilage and tooth specification.","volume":"145","author":"Xu","year":"2018","journal-title":"Development"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63595","article-title":"Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation.","volume":"10","author":"Xu","year":"2021","journal-title":"Elife"},{"key":"B166","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/tera.1420470609","article-title":"Serotonin and cardiac morphogenesis in the mouse embryo.","volume":"47","author":"Yavarone","year":"1993","journal-title":"Teratology"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1038\/ncb2293","article-title":"FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.","volume":"13","author":"Zhang","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"B168","first-page":"233","article-title":"Presence of serotonin in the palate just prior to shelf elevation.","volume":"64","author":"Zimmerman","year":"1981","journal-title":"J. Embryol. Exp. Morphol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.632766\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T10:10:03Z","timestamp":1628763003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.632766\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,12]]},"references-count":169,"alternative-id":["10.3389\/fcell.2021.632766"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.632766","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,12]]},"article-number":"632766"}}