{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:16:40Z","timestamp":1790759800923,"version":"4.1.0"},"reference-count":111,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1173882"],"award-info":[{"award-number":["1173882"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    The human endometrium undergoes approximately 450 cycles of proliferation, differentiation, shedding and regeneration over a woman\u2019s reproductive lifetime. The regenerative capacity of the endometrium is attributed to stem\/progenitor cells residing in the basalis layer of the tissue. Mesenchymal stem cells have been extensively studied in the endometrium, whereas endometrial epithelial stem\/progenitor cells have remained more elusive. This review details the discovery of human and mouse endometrial epithelial stem\/progenitor cells. It highlights recent significant developments identifying putative markers of these epithelial stem\/progenitor cells that reveal their\n                    <jats:italic>in vivo<\/jats:italic>\n                    identity, location in both human and mouse endometrium, raising common but also different viewpoints. The review also outlines the techniques used to identify epithelial stem\/progenitor cells, specifically\n                    <jats:italic>in vitro<\/jats:italic>\n                    functional assays and\n                    <jats:italic>in vivo<\/jats:italic>\n                    lineage tracing. We will also discuss their known interactions and hierarchy and known roles in endometrial dynamics across the menstrual or estrous cycle including re-epithelialization at menses and regeneration of the tissue during the proliferative phase. We also detail their potential role in endometrial proliferative disorders such as endometriosis.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2021.640319","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T03:14:32Z","timestamp":1617938072000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":84,"title":["The Elusive Endometrial Epithelial Stem\/Progenitor Cells"],"prefix":"10.3389","volume":"9","author":[{"given":"Fiona L.","family":"Cousins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Pandoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Gargett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/jnci\/djj267","article-title":"Steroid hormone receptor status of mouse mammary stem cells.","volume":"98","author":"Asselin-Labat","year":"2006","journal-title":"J. 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