{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:28:26Z","timestamp":1792254506505,"version":"4.4.0"},"reference-count":153,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-106581RB-I00"],"award-info":[{"award-number":["PID2019-106581RB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"Fundaci\u00f3n Bancaria Caixa d'Estalvis i Pensions de Barcelona","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00535"],"award-info":[{"award-number":["PI20\/00535"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["FPU01405265"],"award-info":[{"award-number":["FPU01405265"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>The substantial clinical burden and disability after stroke injury urges the need to explore therapeutic solutions. Recent compelling evidence supports that neurogenesis persists in the adult mammalian brain and is amenable to regulation in both physiological and pathological situations. Its ability to generate new neurons implies a potential to contribute to recovery after brain injury. However, post-stroke neurogenic response may have different functional consequences. On the one hand, the capacity of newborn neurons to replenish the damaged tissue may be limited. In addition, aberrant forms of neurogenesis have been identified in several insult settings. All these data suggest that adult neurogenesis is at a crossroads between the physiological and the pathological regulation of the neurological function in the injured central nervous system (CNS). Given the complexity of the CNS together with its interaction with the periphery, we ultimately lack in-depth understanding of the key cell types, cell\u2013cell interactions, and molecular pathways involved in the neurogenic response after brain damage and their positive or otherwise deleterious impact. Here we will review the evidence on the stroke-induced neurogenic response and on its potential repercussions on functional outcome. First, we will briefly describe subventricular zone (SVZ) neurogenesis after stroke beside the main evidence supporting its positive role on functional restoration after stroke. Then, we will focus on hippocampal subgranular zone (SGZ) neurogenesis due to the relevance of hippocampus in cognitive functions; we will outline compelling evidence that supports that, after stroke, SGZ neurogenesis may adopt a maladaptive plasticity response further contributing to the development of post-stroke cognitive impairment and dementia. Finally, we will discuss the therapeutic potential of specific steps in the neurogenic cascade that might ameliorate brain malfunctioning and the development of post-stroke cognitive impairment in the chronic phase.<\/jats:p>","DOI":"10.3389\/fcell.2021.657846","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T01:18:55Z","timestamp":1616462335000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":58,"title":["Post-stroke Neurogenesis: Friend or Foe?"],"prefix":"10.3389","volume":"9","author":[{"given":"Mar\u00eda Isabel","family":"Cuartero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Garc\u00eda-Culebras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Torres-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"V\u00e1zquez-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Jare\u00f1o-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Garc\u00eda-Segura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Lizasoain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Moro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1152\/physrev.00004.2014","article-title":"Regulation and function of adult neurogenesis: from genes to cognition.","volume":"94","author":"Aimone","year":"2014","journal-title":"Physiol. Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1126\/science.1248903","article-title":"Hippocampal neurogenesis regulates forgetting during adulthood and infancy.","volume":"344","author":"Akers","year":"2014","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.2147\/ndt.s67184","article-title":"Cognitive impairment and memory dysfunction after a stroke diagnosis: a post-stroke memory assessment.","volume":"10","author":"Al-Qazzaz","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B4","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1523\/jneurosci.22-03-00629.2002","article-title":"Neurogenesis in adult subventricular zone.","volume":"22","author":"Alvarez-Buylla","year":"2002","journal-title":"J. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1016\/j.celrep.2017.11.050","article-title":"Single-cell RNA sequencing study reveals cellular and molecular dynamics of the hippocampal neurogenic niche.","volume":"21","author":"Artegiani","year":"2017","journal-title":"Cell Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke.","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s0306-4522(01)00268-8","article-title":"Stroke induces widespread changes of gene expression for glial cell line-derived neurotrophic factor family receptors in the adult rat brain.","volume":"106","author":"Arvidsson","year":"","journal-title":"Neuroscience"},{"key":"B8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1046\/j.0953-816x.2001.01611.x","article-title":"N-methyl-D-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke.","volume":"14","author":"Arvidsson","year":"","journal-title":"Eur. J. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1093\/brain\/awp174","article-title":"Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms.","author":"Bacigaluppi","year":"2009","journal-title":"Brain"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/j.neuroscience.2010.05.075","article-title":"Dynamic imaging reveals that brain-derived neurotrophic factor can independently regulate motility and direction of neuroblasts within the rostral migratory stream.","volume":"169","author":"Bagley","year":"2010","journal-title":"Neuroscience"},{"key":"B11","doi-asserted-by":"publisher","first-page":"256","DOI":"10.5853\/jos.2016.01263","article-title":"Adult stem cell therapy for stroke: challenges and progress.","volume":"18","author":"Bang","year":"2016","journal-title":"J. Stroke"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1038\/sj.jcbfm.9600153","article-title":"Reappearance of hippocampal CA1 neurons after ischemia is associated with recovery of learning and memory.","volume":"25","author":"Bendel","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B13","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics-2017 update: a report from the American heart association.","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"B14","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.cell.2019.02.010","article-title":"A common embryonic origin of stem cells drives developmental and adult neurogenesis.","volume":"177","author":"Berg","year":"2019","journal-title":"Cell"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112032","article-title":"Insult-induced aberrant hippocampal neurogenesis: functional consequences and possible therapeutic strategies.","volume":"372","author":"Bielefeld","year":"2019","journal-title":"Behav. Brain Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.devcel.2015.01.010","article-title":"It takes a village: constructing the neurogenic niche.","volume":"32","author":"Bjornsson","year":"2015","journal-title":"Dev. Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1212\/wnl.0b013e31823ed0cc","article-title":"Memory after silent stroke: hippocampus and infarcts both matter.","volume":"78","author":"Blum","year":"2012","journal-title":"Neurology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41593-020-00759-4","article-title":"Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging.","volume":"24","author":"Bottes","year":"2020","journal-title":"Nat. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1111\/ene.12626","article-title":"Post-stroke cognitive decline: an update and perspectives for clinical research.","volume":"22","author":"Brainin","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1161\/strokeaha.116.014793","article-title":"Cannabinoid type-2 receptor drives neurogenesis and improves functional outcome after stroke.","volume":"48","author":"Bravo-Ferrer","year":"2017","journal-title":"Stroke"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1093\/brain\/aws194","article-title":"Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.","author":"Butti","year":"2012","journal-title":"Brain"},{"key":"B22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0140-6736(19)31053-0","article-title":"Extending thrombolysis to 4.5\u20139 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data.","volume":"394","author":"Campbell","year":"2019","journal-title":"Lancet"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1161\/strokeaha.110.600825","article-title":"Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment.","volume":"42","author":"Candelario-Jalil","year":"2011","journal-title":"Stroke"},{"key":"B24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s12975-016-0467-5","article-title":"Spontaneous and therapeutic-induced mechanisms of functional recovery after stroke.","volume":"8","author":"Cassidy","year":"2017","journal-title":"Transl. Stroke Res."},{"key":"B25","first-page":"1755","article-title":"Stroke accelerates and uncouples intrinsic and synaptic excitability maturation of mouse hippocampal DCX.","volume":"39","author":"Ceanga","year":"2019","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1523\/jneurosci.5071-04.2005","article-title":"Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice.","volume":"25","author":"Chen","year":"2005","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2012.00070","article-title":"Regulation of endogenous neural stem\/progenitor cells for neural repair-factors that promote neurogenesis and gliogenesis in the normal and damaged brain.","volume":"6","author":"Christie","year":"2012","journal-title":"Front. Cell. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1172\/jci120412","article-title":"Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice.","volume":"129","author":"Cuartero","year":"2019","journal-title":"J. Clin. Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1203\/01.pdr.0000113771.51317.37","article-title":"Neonatal hypoxia triggers transient apoptosis followed by neurogenesis in the rat CA1 hippocampus.","volume":"55","author":"Daval","year":"2004","journal-title":"Pediatr. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"19131","DOI":"10.1523\/jneurosci.2289-13.2013","article-title":"Distinct determinants of sparse activation during granule cell maturation.","volume":"33","author":"Dieni","year":"2013","journal-title":"J. Neurosci."},{"key":"B31","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11313","article-title":"Low excitatory innervation balances high intrinsic excitability of immature dentate neurons.","volume":"7","author":"Dieni","year":"2016","journal-title":"Nat. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/hipo.22557","article-title":"Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons.","volume":"26","author":"Drew","year":"2016","journal-title":"Hippocampus"},{"key":"B33","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.celrep.2016.12.060","article-title":"Single-cell transcriptomic analysis defines heterogeneity and transcriptional dynamics in the adult neural stem cell lineage.","volume":"18","author":"Dulken","year":"2017","journal-title":"Cell Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.stem.2011.03.010","article-title":"Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus.","volume":"8","author":"Encinas","year":"2011","journal-title":"Cell Stem Cell"},{"key":"B35","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus.","volume":"4","author":"Eriksson","year":"1998","journal-title":"Nat. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1016\/j.bbagen.2012.09.002","article-title":"Signaling mechanisms regulating adult neural stem cells and neurogenesis.","volume":"1830","author":"Faigle","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B37","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.stem.2015.08.002","article-title":"Adult neural stem cells from the subventricular zone give rise to reactive astrocytes in the cortex after stroke.","volume":"17","author":"Faiz","year":"2015","journal-title":"Cell Stem Cell"},{"key":"B38","first-page":"165","article-title":"Burden of neurological disorders across the US from 1990-2017: a global burden of disease study.","volume":"78","author":"Feigin","year":"2020","journal-title":"JAMA Neurol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells.","volume":"287","author":"Gage","year":"2000","journal-title":"Science"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tins.2006.11.001","article-title":"GABA sets the tempo for activity-dependent adult neurogenesis.","volume":"30","author":"Ge","year":"","journal-title":"Trends Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.neuron.2007.05.002","article-title":"critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.","volume":"54","author":"Ge","year":"","journal-title":"Neuron"},{"key":"B42","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/stem.2266","article-title":"Heterogeneity of radial glia-like cells in the adult hippocampus.","volume":"34","author":"Gebara","year":"2016","journal-title":"Stem Cells"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1002\/med.21400","article-title":"Stem cell-based therapies for ischemic stroke: preclinical results and the potential of imaging-assisted evaluation of donor cell fate and mechanisms of brain regeneration.","volume":"36","author":"Gervois","year":"2016","journal-title":"Med. Res. Rev."},{"key":"B44","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1159\/000087705","article-title":"Stroke units, tissue plasminogen activator, aspirin and neuroprotection: which stroke intervention could provide the greatest community benefit?","volume":"20","author":"Gilligan","year":"2005","journal-title":"Cerebrovasc. Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.cell.2016.10.021","article-title":"Adult neurogenesis in the hippocampus: from stem cells to behavior.","volume":"167","author":"Gon\u00e7alves","year":"2016","journal-title":"Cell"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1038\/nn.3260","article-title":"Optical controlling reveals time-dependent roles for adult-born dentate granule cells.","volume":"15","author":"Gu","year":"2012","journal-title":"Nat. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/s1474-4422(17)30046-7","article-title":"Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial.","volume":"16","author":"Hess","year":"2017","journal-title":"Lancet Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia.","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"B49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/dvg.20212","article-title":"Temporal regulation of Cre recombinase activity in neural stem cells.","volume":"44","author":"Imayoshi","year":"2006","journal-title":"Genesis"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1038\/nn.2185","article-title":"Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.","volume":"11","author":"Imayoshi","year":"2008","journal-title":"Nat. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.1073\/pnas.081011098","article-title":"Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat.","volume":"98","author":"Jin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B52","doi-asserted-by":"publisher","first-page":"7993","DOI":"10.1073\/pnas.1000154107","article-title":"Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice.","volume":"107","author":"Jin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s0003-9993(95)80038-7","article-title":"Recovery of walking function in stroke patients: the Copenhagen Stroke Study.","volume":"76","author":"J\u00f8rgensen","year":"1995","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"B54","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s002210000591","article-title":"Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat.","volume":"136","author":"Kee","year":"2001","journal-title":"Exp. Brain Res."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-11-146","article-title":"Contribution of constitutively proliferating precursor cell subtypes to dentate neurogenesis after cortical infarcts.","volume":"11","author":"Keiner","year":"2010","journal-title":"BMC Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"16803","DOI":"10.1073\/pnas.0807970105","article-title":"Sequential development of synapses in dendritic domains during adult neurogenesis.","volume":"105","author":"Kelsch","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B57","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.tins.2004.05.013","article-title":"Milestones of neuronal development in the adult hippocampus.","volume":"27","author":"Kempermann","year":"2004","journal-title":"Trends Neurosci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/386493a0","article-title":"More hippocampal neurons in adult mice living in an enriched environment.","volume":"386","author":"Kempermann","year":"1997","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018812","article-title":"Neurogenesis in the adult hippocampus.","volume":"7","author":"Kempermann","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.nbd.2009.11.002","article-title":"Forebrain neurogenesis after focal Ischemic and traumatic brain injury.","volume":"37","author":"Kernie","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010162","article-title":"Effects of fluoxetine on hippocampal neurogenesis and neuroprotection in the model of global cerebral ischemia in rats.","volume":"19","author":"Khodanovich","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nn.3614","article-title":"Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits.","volume":"17","author":"Kohara","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00656","article-title":"Cell-based therapies for stroke: are we there yet?","volume":"10","author":"Krause","year":"2019","journal-title":"Front. Neurol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1747-4949.2012.00967.x","article-title":"Predicting activities after stroke: what is clinically relevant?","volume":"8","author":"Kwakkel","year":"2013","journal-title":"Int. J. Stroke"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1161\/01.str.0000087172.16305.cd","article-title":"Probability of regaining dexterity in the flaccid upper limb: impact of severity of paresis and time since onset in acute stroke.","volume":"34","author":"Kwakkel","year":"2003","journal-title":"Stroke"},{"key":"B66","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1523\/jneurosci.4085-05.2006","article-title":"Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke.","volume":"26","author":"Lee","year":"2006","journal-title":"J. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1001\/jama.2015.6968","article-title":"Trajectory of cognitive decline after incident stroke.","volume":"314","author":"Levine","year":"2015","journal-title":"JAMA"},{"key":"B68","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/jnr.21829","article-title":"Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke.","volume":"87","author":"Li","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"935","DOI":"10.3892\/mmr.2013.1573","article-title":"Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia.","volume":"8","author":"Li","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"B70","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/stem.2947","article-title":"Systemic factors trigger vasculature cells to drive notch signaling and neurogenesis in neural stem cells in the adult brain.","volume":"37","author":"Lin","year":"2019","journal-title":"Stem Cells"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019034","article-title":"Neurogenesis following stroke affecting the adult brain.","volume":"7","author":"Lindvall","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"7768","DOI":"10.1523\/jneurosci.18-19-07768.1998","article-title":"Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils.","volume":"18","author":"Liu","year":"1998","journal-title":"J. Neurosci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.stem.2015.07.002","article-title":"Single-cell transcriptomics reveals a population of dormant neural stem cells that become activated upon brain injury.","volume":"17","author":"Llorens-Bobadilla","year":"2015","journal-title":"Cell Stem Cell"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00526","article-title":"The ever-changing morphology of hippocampal granule neurons in physiology and pathology.","volume":"9","author":"Llorens-Mart\u00edn","year":"2015","journal-title":"Front. Neurosci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1002\/jnr.21317","article-title":"Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke.","volume":"85","author":"Luo","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.cell.2015.04.001","article-title":"Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells.","volume":"161","author":"Luo","year":"2015","journal-title":"Cell"},{"key":"B77","first-page":"2050","article-title":"Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia.","volume":"8","author":"Ma","year":"2013","journal-title":"Neural Regen. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1126\/science.1214956","article-title":"Unique processing during a period of high excitation\/inhibition balance in adult-born neurons.","volume":"335","author":"Mar\u00edn-Burgin","year":"2012","journal-title":"Science"},{"key":"B79","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1212\/wnl.0b013e3181cbccec","article-title":"Proliferation in the human ipsilateral subventricular zone after ischemic stroke.","volume":"74","author":"Mart\u00ed-F\u00e0bregas","year":"2010","journal-title":"Neurology"},{"key":"B80","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12958","article-title":"Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus.","volume":"18","author":"Mart\u00edn-Su\u00e1rez","year":"2019","journal-title":"Aging Cell"},{"key":"B81","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/cne.10964","article-title":"Neural stem and progenitor cells in nestin-GFP transgenic mice.","volume":"469","author":"Mignone","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0779-7","article-title":"Post-stroke dementia \u2013 a comprehensive review.","volume":"15","author":"Mijajlovi\u0107","year":"2017","journal-title":"BMC Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions.","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"B84","doi-asserted-by":"publisher","first-page":"69","DOI":"10.2217\/17460751.2.1.69","article-title":"Endogenous neurogenesis in the human brain following cerebral infarction.","volume":"2","author":"Minger","year":"2007","journal-title":"Regen. Med."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107805","article-title":"Single-cell profiling and SCOPE-seq reveal lineage dynamics of adult ventricular-subventricular zone neurogenesis and NOTUM as a key regulator.","volume":"31","author":"Mizrak","year":"2020","journal-title":"Cell Rep."},{"key":"B86","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.celrep.2018.12.044","article-title":"Single-cell analysis of regional differences in adult V-SVZ neural stem cell lineages.","volume":"26","author":"Mizrak","year":"2019","journal-title":"Cell Rep."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005320","article-title":"Reliable activation of immature neurons in the adult hippocampus.","volume":"4","author":"Mongiat","year":"2009","journal-title":"PLoS One"},{"key":"B88","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0314-8","article-title":"Aging increases microglial proliferation, delays cell migration, and decreases cortical neurogenesis after focal cerebral ischemia.","volume":"12","author":"Moraga","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"B89","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.stemcr.2018.06.005","article-title":"Distinct molecular signatures of quiescent and activated adult neural stem cells reveal specific interactions with their microenvironment.","volume":"11","author":"Morizur","year":"2018","journal-title":"Stem Cell Rep."},{"key":"B90","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/s0092-8674(02)00862-0","article-title":"Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors.","volume":"110","author":"Nakatomi","year":"2002","journal-title":"Cell"},{"key":"B91","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/0003-9993(94)90161-9","article-title":"Recovery of upper extremity function in stroke patients: the Copenhagen Stroke Study.","volume":"75","author":"Nakayama","year":"1994","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1161\/strokeaha.112.660977","article-title":"Aberrant neurogenesis after stroke: a retroviral cell labeling study.","volume":"43","author":"Niv","year":"2012","journal-title":"Stroke"},{"key":"B93","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1177\/1073858407309545","article-title":"Poststroke neurogenesis: emerging principles of migration and localization of immature neurons.","volume":"14","author":"Ohab","year":"2008","journal-title":"Neuroscientist"},{"key":"B94","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.neuroscience.2008.10.043","article-title":"Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury.","volume":"158","author":"Oya","year":"2009","journal-title":"Neuroscience"},{"key":"B95","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16109-7","article-title":"Specific features of SVZ neurogenesis after cortical ischemia: a longitudinal study.","volume":"7","author":"Palma-Tortosa","year":"2017","journal-title":"Sci. Rep."},{"key":"B96","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.bbi.2019.05.002","article-title":"Toll-like receptor 4 regulates subventricular zone proliferation and neuroblast migration after experimental stroke.","volume":"80","author":"Palma-Tortosa","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"B97","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1177\/1073858403252680","article-title":"Injury-induced neurogenesis in the adult mammalian brain.","volume":"9","author":"Parent","year":"2003","journal-title":"Neuroscientist"},{"key":"B98","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/ana.10393","article-title":"Rat forebrain neurogenesis and striatal neuron replacement after focal stroke.","volume":"52","author":"Parent","year":"2002","journal-title":"Ann. Neurol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/s1474-4422(09)70236-4","article-title":"Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis.","volume":"8","author":"Pendlebury","year":"2009","journal-title":"Lancet Neurol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1126\/science.aao5056","article-title":"Live imaging of neurogenesis in the adult mouse hippocampus.","volume":"359","author":"Pilz","year":"2018","journal-title":"Science"},{"key":"B101","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.bbi.2016.11.013","article-title":"Reparative effects of interleukin-1 receptor antagonist in young and aged\/co-morbid rodents after cerebral ischemia.","volume":"61","author":"Pradillo","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"B102","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1093\/brain\/awh553","article-title":"Cerebral small-vessel disease and decline in information processing speed, executive function and memory.","author":"Prins","year":"2005","journal-title":"Brain"},{"key":"B103","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/ana.10853","article-title":"Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits.","volume":"55","author":"Raber","year":"2004","journal-title":"Ann. Neurol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12975-020-00841-w","article-title":"Neurogenesis after stroke: a therapeutic perspective.","volume":"12","author":"Rahman","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"B105","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4181","article-title":"Temporally selective contextual encoding in the dentate gyrus of the hippocampus.","volume":"5","author":"Rangel","year":"2014","journal-title":"Nat. Commun."},{"key":"B106","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature09817","article-title":"Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.","volume":"472","author":"Sahay","year":"2011","journal-title":"Nature"},{"key":"B107","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nature02553","article-title":"Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus.","volume":"429","author":"Schmidt-Hieber","year":"2004","journal-title":"Nature"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126261","article-title":"The temporal expression pattern of alpha-synuclein modulates olfactory neurogenesis in transgenic mice.","volume":"10","author":"Schreglmann","year":"2015","journal-title":"PLoS One"},{"key":"B109","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.neuroscience.2005.03.059","article-title":"Newly generated dentate granule cells from epileptic rats exhibit elongated hilar basal dendrites that align along GFAP-immunolabeled processes.","volume":"136","author":"Shapiro","year":"2005","journal-title":"Neuroscience"},{"key":"B110","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.brainres.2006.07.032","article-title":"Spatiotemporal profile of dendritic outgrowth from newly born granule cells in the adult rat dentate gyrus.","volume":"1149","author":"Shapiro","year":"2007","journal-title":"Brain Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/s0165-3806(01)00286-3","article-title":"Neurogenesis following brain ischemia.","volume":"134","author":"Sharp","year":"2002","journal-title":"Brain Res. Dev. Brain Res."},{"key":"B112","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-019-0521-1","article-title":"HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke.","volume":"26","author":"Sheu","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"B113","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.1111\/j.1460-9568.2007.05624.x","article-title":"Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels.","volume":"25","author":"Shi","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"8727","DOI":"10.1523\/jneurosci.20-23-08727.2000","article-title":"Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus.","volume":"20","author":"Shihabuddin","year":"2000","journal-title":"J. Neurosci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.stem.2015.07.013","article-title":"Single-cell RNA-seq with waterfall reveals molecular cascades underlying adult neurogenesis.","volume":"17","author":"Shin","year":"2015","journal-title":"Cell Stem Cell"},{"key":"B116","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.09.016","article-title":"The role of endogenous neurogenesis in functional recovery and motor map reorganization induced by rehabilitative therapy after stroke in rats.","volume":"26","author":"Shiromoto","year":"2017","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"B117","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.stem.2015.04.003","article-title":"Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis.","volume":"16","author":"Sierra","year":"2015","journal-title":"Cell Stem Cell"},{"key":"B118","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1002\/glia.20407","article-title":"Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis.","volume":"54","author":"Steiner","year":"2006","journal-title":"Glia"},{"key":"B119","doi-asserted-by":"publisher","first-page":"17314","DOI":"10.1523\/jneurosci.2129-13.2013","article-title":"Conditional ablation of neuroprogenitor cells in adult mice impedes recovery of poststroke cognitive function and reduces synaptic connectivity in the perforant pathway.","volume":"33","author":"Sun","year":"2013","journal-title":"J. Neurosci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/s0006-8993(99)01411-0","article-title":"Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice.","volume":"831","author":"Takagi","year":"1999","journal-title":"Brain Res."},{"key":"B121","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/00004647-200203000-00007","article-title":"Increased proliferation of neural progenitor cells but reduced survival of newborn cells in the contralateral hippocampus after focal cerebral ischemia in rats.","volume":"22","author":"Takasawa","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1161\/01.str.0000126480.40967.b3","article-title":"Neurogenesis after transient global ischemia in the adult hippocampus visualized by improved retroviral vector.","volume":"35","author":"Tanaka","year":"2004","journal-title":"Stroke"},{"key":"B123","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1136\/jnnp.57.2.202","article-title":"Cognitive impairment after stroke: frequency, patterns, and relationship to functional abilities.","volume":"57","author":"Tatemichi","year":"1994","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B124","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.stem.2008.07.025","article-title":"A specialized vascular niche for adult neural stem cells.","volume":"3","author":"Tavazoie","year":"2008","journal-title":"Cell Stem Cell"},{"key":"B125","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1634\/stemcells.2005-0281","article-title":"Persistent production of neurons from adult brain stem cells during recovery after stroke.","volume":"24","author":"Thored","year":"2006","journal-title":"Stem Cells"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1038\/jcbfm.2014.130","article-title":"Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here.","volume":"34","author":"Tobin","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018903","article-title":"Maturation and functional integration of new granule cells into the adult hippocampus.","volume":"8","author":"Toni","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/nn.2156","article-title":"Neurons born in the adult dentate gyrus form functional synapses with target cells.","volume":"11","author":"Toni","year":"2008","journal-title":"Nat. Neurosci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3171\/jns.2004.101.5.0799","article-title":"Transient focal cerebral ischemia-induced neurogenesis in the dentate gyrus of the adult mouse.","volume":"101","author":"T\u00fcreyen","year":"2004","journal-title":"J. Neurosurg."},{"key":"B130","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s12017-008-8028-z","article-title":"Neurogenesis and exercise: past and future directions.","volume":"10","author":"van Praag","year":"2008","journal-title":"Neuromolecular Med."},{"key":"B131","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/4151030a","article-title":"Functional neurogenesis in the adult hippocampus.","volume":"415","author":"van Praag","year":"2002","journal-title":"Nature"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.neuroscience.2010.05.035","article-title":"Differential stroke-induced proliferative response of distinct precursor cell subpopulations in the young and aged dentate gyrus.","volume":"169","author":"Walter","year":"2010","journal-title":"Neuroscience"},{"key":"B133","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/jnr.22237","article-title":"Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.","volume":"88","author":"Wang","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038932","article-title":"Conditional depletion of neurogenesis inhibits long-term recovery after experimental stroke in mice.","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183463","article-title":"Adult hippocampal neurogenesis poststroke: more new granule cells but aberrant morphology and impaired spatial memory.","volume":"12","author":"Woitke","year":"2017","journal-title":"PLoS One"},{"key":"B136","doi-asserted-by":"crossref","first-page":"52","DOI":"10.55782\/ane-2009-1729","article-title":"Neurogenesis in gerbil hippocampus following brain ischemia: focus on the involvement of metalloproteinases.","volume":"69","author":"Wojcik","year":"2009","journal-title":"Acta Neurobiol. Exp."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1177\/0963689717721230","article-title":"Improving neurorepair in stroke brain through endogenous neurogenesis-enhancing drugs.","volume":"26","author":"Wu","year":"2017","journal-title":"Cell Transplant."},{"key":"B138","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.1161\/strokeaha.107.485524","article-title":"Effects of skilled forelimb training on hippocampal neurogenesis and spatial learning after focal cortical infarcts in the adult rat brain.","volume":"38","author":"Wurm","year":"2007","journal-title":"Stroke"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1161\/01.str.32.8.1890","article-title":"Neurogenesis by progenitor cells in the ischemic adult rat hippocampus.","volume":"32","author":"Yagita","year":"2001","journal-title":"Stroke"},{"key":"B140","doi-asserted-by":"publisher","first-page":"6627","DOI":"10.1523\/jneurosci.0149-06.2006","article-title":"Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum.","volume":"26","author":"Yamashita","year":"2006","journal-title":"J. Neurosci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1460-9568.2006.04872.x","article-title":"Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation.","volume":"24","author":"Yan","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"5874","DOI":"10.1073\/pnas.101034998","article-title":"FGF-2 regulation of neurogenesis in adult hippocampus after brain injury.","volume":"98","author":"Yoshimura","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1172\/jci16618","article-title":"FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice.","volume":"112","author":"Yoshimura","year":"2003","journal-title":"J. Clin. Invest."},{"key":"B144","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1089\/ars.2010.3435","article-title":"Cellular and molecular determinants of stroke-induced changes in subventricular zone cell migration.","volume":"14","author":"Young","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"B145","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/s0306-4522(01)00117-8","article-title":"Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia.","volume":"105","author":"Zhang","year":"2001","journal-title":"Neuroscience"},{"key":"B146","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1097\/00004647-200404000-00009","article-title":"Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats.","volume":"24","author":"Zhang","year":"","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B147","doi-asserted-by":"publisher","first-page":"5810","DOI":"10.1523\/jneurosci.1109-04.2004","article-title":"Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat.","volume":"24","author":"Zhang","year":"","journal-title":"J. Neurosci."},{"key":"B148","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis.","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"B149","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1523\/jneurosci.3648-05.2006","article-title":"Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus.","volume":"26","author":"Zhao","year":"2006","journal-title":"J. Neurosci."},{"key":"B150","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.pneurobio.2018.01.004","article-title":"Enhancing endogenous capacity to repair a stroke-damaged brain: an evolving field for stroke research.","volume":"16","author":"Zhao","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1177\/0271678x17728162","article-title":"Strategic infarct location for post-stroke cognitive impairment: a multivariate lesion-symptom mapping study.","volume":"38","author":"Zhao","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B152","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1111\/j.1471-4159.2009.06413.x","article-title":"Irradiation to the immature brain attenuates neurogenesis and exacerbates subsequent hypoxic-ischemic brain injury in the adult.","volume":"111","author":"Zhu","year":"2009","journal-title":"J. Neurochem."},{"key":"B153","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.celrep.2018.11.003","article-title":"Single-cell transcriptomics characterizes cell types in the subventricular zone and uncovers molecular defects impairing adult neurogenesis.","volume":"25","author":"Zywitza","year":"2018","journal-title":"Cell Rep."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.657846\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T12:04:22Z","timestamp":1724673862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.657846\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":153,"alternative-id":["10.3389\/fcell.2021.657846"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.657846","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"article-number":"657846"}}